GREMLIN Database
CARA - Carbamoyl-phosphate synthase pyrimidine-specific small chain
UniProt: P25993 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 364 (350)
Sequences: 4091 (2039)
Seq/√Len: 109.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_R193_D4.0951.00
94_Y102_M4.0851.00
233_I251_L3.9841.00
190_R344_D3.9211.00
173_V197_V3.5071.00
28_V128_G3.3881.00
50_I79_I3.0891.00
53_L78_L2.9281.00
302_E317_K2.9161.00
224_K259_N2.8691.00
172_I350_I2.8031.00
158_S199_Y2.6691.00
260_T293_V2.6541.00
253_A293_V2.6151.00
171_R195_I2.4711.00
20_S104_N2.4471.00
8_E127_K2.3761.00
302_E319_K2.3191.00
87_P92_S2.3061.00
31_N46_Y2.2371.00
163_Y196_V2.2271.00
261_E292_T2.2091.00
9_N119_M2.2061.00
295_S306_I2.1951.00
97_D101_K2.1241.00
268_R290_G2.1171.00
261_E294_S2.1171.00
182_G185_R2.1071.00
22_E106_P2.0961.00
33_G270_S2.0951.00
174_L215_M2.0921.00
243_F342_L2.0751.00
202_T205_E2.0681.00
253_A316_L1.9681.00
300_E320_T1.9681.00
192_C347_I1.9631.00
252_F325_T1.9601.00
23_H143_R1.9371.00
65_R93_A1.9261.00
300_E319_K1.9231.00
18_F107_G1.9131.00
159_A163_Y1.9101.00
303_V313_I1.9091.00
175_V197_V1.8621.00
84_C87_P1.8531.00
40_I51_V1.8371.00
197_V201_I1.8211.00
252_F323_A1.8151.00
316_L325_T1.8081.00
122_T265_F1.7991.00
177_F229_A1.7621.00
142_K146_E1.7581.00
170_K351_E1.7581.00
204_E235_G1.7541.00
259_N294_S1.7531.00
207_L240_V1.7451.00
174_L179_M1.7311.00
68_F99_Y1.7171.00
13_F119_M1.6981.00
214_I240_V1.6811.00
141_L145_N1.6711.00
275_K280_G1.6691.00
317_K345_R1.6521.00
79_I108_L1.6421.00
11_A119_M1.6411.00
237_L323_A1.6411.00
152_N155_S1.6331.00
175_V232_M1.6321.00
170_K350_I1.6271.00
16_E110_G1.6261.00
239_K321_L1.6251.00
73_P103_K1.6021.00
318_H322_P1.5991.00
136_D139_A1.5901.00
111_I116_L1.5791.00
54_T117_T1.5781.00
231_E234_K1.5581.00
301_L318_H1.5561.00
186_E340_N1.5511.00
278_A302_E1.5511.00
6_V141_L1.5381.00
50_I128_G1.5321.00
318_H321_L1.5241.00
173_V209_L1.5201.00
50_I77_G1.5081.00
51_V75_V1.5071.00
203_A207_L1.5051.00
197_V209_L1.5001.00
142_K145_N1.4721.00
87_P95_T1.4661.00
95_T98_E1.4621.00
256_C318_H1.4501.00
77_G130_F1.4461.00
31_N40_I1.4361.00
175_V206_V1.4341.00
173_V211_P1.4311.00
200_N228_E1.4291.00
177_F216_L1.4211.00
47_C74_F1.4181.00
249_H325_T1.4101.00
232_M235_G1.4091.00
258_A297_S1.3981.00
80_I83_L1.3961.00
277_L306_I1.3951.00
203_A235_G1.3801.00
16_E109_Q1.3791.00
214_I236_V1.3741.00
276_E345_R1.3691.00
283_A341_H1.3671.00
256_C301_L1.3611.00
94_Y98_E1.3571.00
3_R108_L1.3501.00
11_A115_K1.3491.00
201_I205_E1.3351.00
174_L194_V1.3341.00
41_L75_V1.3090.99
192_C350_I1.3000.99
205_E208_Q1.2950.99
230_I254_L1.2870.99
169_G351_E1.2870.99
278_A317_K1.2640.99
67_D91_R1.2500.99
261_E312_T1.2490.99
174_L184_L1.2310.99
6_V12_V1.2150.99
215_M243_F1.2130.99
275_K306_I1.2110.99
283_A339_A1.2110.99
154_V247_L1.2100.99
47_C156_Q1.2060.99
237_L256_C1.2020.99
172_I192_C1.1980.99
175_V201_I1.1930.99
179_M184_L1.1880.99
171_R209_L1.1860.99
278_A345_R1.1750.99
139_A142_K1.1710.99
224_K260_T1.1700.99
8_E126_L1.1640.99
236_V242_L1.1620.99
348_E351_E1.1580.99
295_S303_V1.1560.99
294_S297_S1.1560.99
213_G350_I1.1520.99
164_P193_D1.1510.99
21_L101_K1.1460.99
188_N194_V1.1430.98
231_E235_G1.1410.98
224_K254_L1.1380.98
64_N67_D1.1350.98
41_L78_L1.1300.98
305_H328_Y1.1300.98
71_I74_F1.1290.98
22_E104_N1.1110.98
216_L233_I1.1030.98
301_L316_L1.1020.98
276_E283_A1.0940.98
159_A162_A1.0900.98
207_L239_K1.0860.98
65_R94_Y1.0750.98
73_P105_I1.0700.98
243_F324_F1.0690.98
3_R17_A1.0660.98
158_S200_N1.0540.97
63_I94_Y1.0490.97
28_V120_I1.0470.97
83_L97_D1.0420.97
154_V226_V1.0400.97
5_L108_L1.0360.97
275_K308_I1.0280.97
235_G238_G1.0260.97
33_G40_I1.0240.97
168_R193_D1.0180.97
69_E185_R1.0120.97
3_R132_S1.0090.97
242_L252_F1.0080.97
348_E352_T1.0080.97
252_F316_L1.0070.97
172_I347_I0.9940.96
24_N77_G0.9930.96
6_V144_L0.9880.96
195_I209_L0.9870.96
141_L144_L0.9870.96
270_S286_S0.9840.96
324_F342_L0.9790.96
24_N130_F0.9790.96
115_K119_M0.9720.96
175_V202_T0.9700.96
203_A232_M0.9680.96
131_A140_V0.9660.96
187_L192_C0.9640.96
232_M236_V0.9520.95
300_E318_H0.9470.95
186_E189_K0.9450.95
233_I242_L0.9450.95
40_I53_L0.9410.95
120_I128_G0.9340.95
48_G76_K0.9310.95
210_K240_V0.9290.95
98_E101_K0.9270.95
4_R14_E0.9220.94
345_R348_E0.9180.94
165_S168_R0.9130.94
13_F115_K0.9110.94
276_E281_K0.9080.94
182_G186_E0.9070.94
151_R156_Q0.9010.94
23_H133_S0.8930.93
72_T103_K0.8900.93
246_C329_H0.8900.93
4_R137_I0.8890.93
155_S200_N0.8890.93
226_V229_A0.8890.93
201_I209_L0.8840.93
18_F80_I0.8840.93
38_Q64_N0.8840.93
57_L82_E0.8820.93
170_K192_C0.8750.93
170_K347_I0.8740.93
9_N123_A0.8650.92
179_M215_M0.8620.92
152_N229_A0.8610.92
71_I181_H0.8600.92
227_P231_E0.8600.92
80_I109_Q0.8580.92
328_Y339_A0.8580.92
66_D91_R0.8550.92
79_I111_I0.8550.92
304_T317_K0.8540.92
127_K148_E0.8520.92
63_I68_F0.8510.92
238_G321_L0.8420.91
204_E208_Q0.8410.91
85_E109_Q0.8410.91
274_V314_E0.8410.91
164_P168_R0.8360.91
159_A196_V0.8260.90
26_G50_I0.8230.90
194_V215_M0.8230.90
190_R347_I0.8190.90
202_T232_M0.8190.90
4_R134_D0.8190.90
19_G107_G0.8160.90
306_I311_D0.8120.90
45_S246_C0.8120.90
186_E190_R0.8090.90
92_S95_T0.8070.89
174_L217_S0.8000.89
237_L252_F0.8000.89
347_I350_I0.7990.89
167_G193_D0.7990.89
4_R12_V0.7990.89
152_N228_E0.7970.89
139_A143_R0.7920.89
100_L105_I0.7860.88
12_V137_I0.7850.88
14_E137_I0.7820.88
119_M123_A0.7820.88
189_K340_N0.7790.88
28_V52_T0.7790.88
206_V214_I0.7770.88
256_C323_A0.7760.88
276_E279_T0.7740.87
24_N76_K0.7740.87
129_T140_V0.7710.87
218_N246_C0.7700.87
6_V131_A0.7690.87
150_P225_D0.7670.87
216_L242_L0.7630.87
177_F251_L0.7600.86
17_A132_S0.7600.86
41_L96_L0.7600.86
268_R272_H0.7590.86
165_S188_N0.7560.86
41_L100_L0.7550.86
48_G156_Q0.7510.86
344_D347_I0.7510.86
272_H309_N0.7460.85
206_V211_P0.7450.85
318_H323_A0.7450.85
42_S68_F0.7430.85
228_E231_E0.7390.85
181_H185_R0.7360.85
25_M129_T0.7340.84
98_E102_M0.7310.84
172_I213_G0.7310.84
259_N297_S0.7280.84
270_S307_A0.7280.84
247_L254_L0.7270.84
79_I128_G0.7270.84
199_Y228_E0.7260.84
131_A135_E0.7230.84
7_L116_L0.7230.84
100_L107_G0.7220.83
295_S313_I0.7220.83
97_D107_G0.7210.83
99_Y103_K0.7210.83
149_L224_K0.7190.83
234_K238_G0.7190.83
19_G97_D0.7180.83
201_I206_V0.7130.83
172_I187_L0.7090.82
258_A301_L0.7070.82
231_E238_G0.7050.82
328_Y341_H0.7040.82
148_E151_R0.7030.82
150_P291_Y0.7030.82
162_A197_V0.6960.81
150_P153_Q0.6960.81
23_H131_A0.6940.81
256_C321_L0.6930.81
120_I125_A0.6930.81
183_I332_A0.6910.81
207_L235_G0.6910.81
206_V232_M0.6900.81
305_H341_H0.6870.80
47_C76_K0.6860.80
33_G286_S0.6860.80
47_C72_T0.6860.80
169_G193_D0.6830.80
148_E291_Y0.6820.80
75_V78_L0.6800.80
46_Y49_Q0.6800.80
192_C213_G0.6790.80
164_P167_G0.6760.79
165_S193_D0.6720.79
299_T319_K0.6710.79
61_Y309_N0.6710.79
229_A232_M0.6710.79
58_I80_I0.6700.79
31_N53_L0.6700.79
138_E142_K0.6700.79
143_R146_E0.6690.79
22_E132_S0.6690.79
283_A328_Y0.6670.78
294_S313_I0.6640.78
203_A236_V0.6640.78
162_A209_L0.6620.78
21_L106_P0.6620.78
75_V105_I0.6610.78
173_V195_I0.6600.78
163_Y184_L0.6590.78
242_L323_A0.6560.77
8_E123_A0.6540.77
106_P130_F0.6540.77
183_I245_I0.6520.77
25_M147_T0.6510.77
53_L58_I0.6510.77
42_S99_Y0.6480.76
175_V216_L0.6460.76
287_Q314_E0.6460.76
70_S74_F0.6450.76
61_Y64_N0.6440.76
175_V229_A0.6430.76
322_P349_M0.6410.76
171_R212_D0.6410.76
52_T117_T0.6410.76
127_K149_L0.6370.75
44_P331_E0.6370.75
213_G346_F0.6360.75
40_I46_Y0.6360.75
268_R328_Y0.6340.75
263_M292_T0.6310.74
319_K322_P0.6300.74
214_I242_L0.6290.74
225_D291_Y0.6280.74
204_E207_L0.6280.74
34_M61_Y0.6270.74
253_A258_A0.6270.74
206_V236_V0.6240.74
173_V206_V0.6220.73
228_E232_M0.6210.73
31_N272_H0.6210.73
108_L111_I0.6210.73
122_T264_K0.6200.73
6_V137_I0.6160.73
73_P99_Y0.6130.72
246_C265_F0.6120.72
230_I234_K0.6110.72
207_L236_V0.6110.72
78_L100_L0.6110.72
183_I246_C0.6090.72
83_L109_Q0.6080.72
134_D139_A0.6050.71
153_Q291_Y0.6050.71
5_L111_I0.6050.71
117_T307_A0.6030.71
254_L259_N0.6020.71
47_C157_V0.6010.71
48_G151_R0.6010.71
184_L196_V0.6000.71
18_F83_L0.5990.71
125_A291_Y0.5990.71
258_A316_L0.5990.71
29_V268_R0.5990.71
170_K191_K0.5950.70
66_D93_A0.5950.70
287_Q307_A0.5940.70
170_K212_D0.5930.70
116_L128_G0.5930.70
190_R340_N0.5920.70
247_L251_L0.5890.69
275_K311_D0.5890.69
227_P230_I0.5880.69
69_E182_G0.5870.69
213_G243_F0.5870.69
246_C266_G0.5860.69
47_C153_Q0.5850.69
270_S333_S0.5830.69
38_Q305_H0.5830.69
33_G268_R0.5810.68
57_L61_Y0.5810.68
154_V177_F0.5800.68
52_T79_I0.5800.68
184_L215_M0.5790.68
155_S228_E0.5770.68
276_E341_H0.5770.68
20_S101_K0.5750.67
268_R314_E0.5750.67
329_H336_P0.5750.67
182_G340_N0.5750.67
135_E143_R0.5740.67
63_I92_S0.5730.67
333_S337_E0.5700.67
246_C336_P0.5700.67
130_F300_E0.5690.67
200_N205_E0.5680.67
165_S169_G0.5680.67
5_L28_V0.5680.67
137_I141_L0.5680.67
154_V225_D0.5670.66
344_D348_E0.5670.66
28_V79_I0.5650.66
152_N225_D0.5640.66
307_A314_E0.5640.66
129_T144_L0.5630.66
202_T236_V0.5620.66
120_I126_L0.5610.66
17_A21_L0.5610.66
52_T120_I0.5600.65
230_I255_A0.5570.65
187_L194_V0.5540.65
68_F103_K0.5540.65
68_F181_H0.5530.65
80_I107_G0.5500.64
163_Y188_N0.5500.64
164_P195_I0.5490.64
239_K322_P0.5490.64
125_A290_G0.5470.64
293_V316_L0.5470.64
200_N229_A0.5440.63
45_S329_H0.5440.63
46_Y246_C0.5430.63
182_G333_S0.5430.63
249_H293_V0.5420.63
25_M143_R0.5420.63
76_K156_Q0.5420.63
149_L225_D0.5410.63
345_R349_M0.5410.63
149_L153_Q0.5410.63
218_N329_H0.5400.63
314_E328_Y0.5400.63
329_H335_G0.5390.63
215_M325_T0.5370.62
29_V265_F0.5370.62
136_D143_R0.5370.62
215_M324_F0.5360.62
18_F109_Q0.5350.62
276_E304_T0.5340.62
166_P169_G0.5340.62
222_D260_T0.5340.62
3_R106_P0.5340.62
246_C250_Q0.5330.62
180_K335_G0.5330.62
4_R131_A0.5310.61
98_E104_N0.5310.61
326_V342_L0.5290.61
136_D140_V0.5290.61
31_N183_I0.5280.61
276_E305_H0.5280.61
131_A136_D0.5280.61
57_L314_E0.5270.61
17_A107_G0.5250.61
40_I272_H0.5250.61
45_S218_N0.5240.60
174_L243_F0.5230.60
138_E141_L0.5230.60
41_L53_L0.5230.60
272_H291_Y0.5230.60
61_Y246_C0.5230.60
229_A251_L0.5210.60
59_G62_G0.5210.60
268_R309_N0.5200.60
226_V247_L0.5200.60
31_N52_T0.5200.60
186_E268_R0.5190.60
253_A256_C0.5190.60
292_T313_I0.5190.60
187_L347_I0.5180.60
13_F111_I0.5180.60
199_Y229_A0.5180.60
127_K147_T0.5160.59
166_P193_D0.5140.59
250_Q329_H0.5140.59
253_A301_L0.5130.59
119_M126_L0.5120.59
154_V158_S0.5120.59
324_F345_R0.5110.58
283_A305_H0.5100.58
29_V264_K0.5100.58
185_R216_L0.5100.58
18_F263_M0.5090.58
19_G106_P0.5090.58
169_G191_K0.5080.58
55_Y61_Y0.5070.58
175_V236_V0.5070.58
181_H184_L0.5060.58
25_M144_L0.5060.58
305_H342_L0.5040.57
64_N305_H0.5030.57
211_P214_I0.5020.57
50_I75_V0.5010.57
218_N250_Q0.5010.57
160_K234_K0.5000.57
7_L128_G0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a9xB 1 0.978 100 0.217 Contact Map
1vcoA 4 0.9093 100 0.653 Contact Map
1s1mA 4 0.9231 100 0.667 Contact Map
3nvaA 2 0.9066 100 0.693 Contact Map
4zdjA 4 0.9121 100 0.713 Contact Map
2vxoA 2 0.5192 100 0.789 Contact Map
2h2wA 2 0.6676 100 0.795 Contact Map
1qdlB 2 0.4918 100 0.797 Contact Map
1i1qB 1 0.478 100 0.798 Contact Map
3tqiA 3 0.4945 100 0.798 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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