CARA - BACSU - GREMLIN Contacts

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CARA - Carbamoyl-phosphate synthase pyrimidine-specific small chain

UniProt:	P25993	Sequences: MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDPSYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKMKNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAKTAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSNGPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKELATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASPGPEDANHLFDRFIEMIETTEKEGEAVCQNA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	364 (350)
Sequences:	4091 (2039)
Seq/√Len:	109.0

ECOLI - CARA
BACSU - CARA CARX
HALSA - CARA
SULSO - CARA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
171_R	193_D	4.095	1.00
94_Y	102_M	4.085	1.00
233_I	251_L	3.984	1.00
190_R	344_D	3.921	1.00
173_V	197_V	3.507	1.00
28_V	128_G	3.388	1.00
50_I	79_I	3.089	1.00
53_L	78_L	2.928	1.00
302_E	317_K	2.916	1.00
224_K	259_N	2.869	1.00
172_I	350_I	2.803	1.00
158_S	199_Y	2.669	1.00
260_T	293_V	2.654	1.00
253_A	293_V	2.615	1.00
171_R	195_I	2.471	1.00
20_S	104_N	2.447	1.00
8_E	127_K	2.376	1.00
302_E	319_K	2.319	1.00
87_P	92_S	2.306	1.00
31_N	46_Y	2.237	1.00
163_Y	196_V	2.227	1.00
261_E	292_T	2.209	1.00
9_N	119_M	2.206	1.00
295_S	306_I	2.195	1.00
97_D	101_K	2.124	1.00
268_R	290_G	2.117	1.00
261_E	294_S	2.117	1.00
182_G	185_R	2.107	1.00
22_E	106_P	2.096	1.00
33_G	270_S	2.095	1.00
174_L	215_M	2.092	1.00
243_F	342_L	2.075	1.00
202_T	205_E	2.068	1.00
253_A	316_L	1.968	1.00
300_E	320_T	1.968	1.00
192_C	347_I	1.963	1.00
252_F	325_T	1.960	1.00
23_H	143_R	1.937	1.00
65_R	93_A	1.926	1.00
300_E	319_K	1.923	1.00
18_F	107_G	1.913	1.00
159_A	163_Y	1.910	1.00
303_V	313_I	1.909	1.00
175_V	197_V	1.862	1.00
84_C	87_P	1.853	1.00
40_I	51_V	1.837	1.00
197_V	201_I	1.821	1.00
252_F	323_A	1.815	1.00
316_L	325_T	1.808	1.00
122_T	265_F	1.799	1.00
177_F	229_A	1.762	1.00
142_K	146_E	1.758	1.00
170_K	351_E	1.758	1.00
204_E	235_G	1.754	1.00
259_N	294_S	1.753	1.00
207_L	240_V	1.745	1.00
174_L	179_M	1.731	1.00
68_F	99_Y	1.717	1.00
13_F	119_M	1.698	1.00
214_I	240_V	1.681	1.00
141_L	145_N	1.671	1.00
275_K	280_G	1.669	1.00
317_K	345_R	1.652	1.00
79_I	108_L	1.642	1.00
11_A	119_M	1.641	1.00
237_L	323_A	1.641	1.00
152_N	155_S	1.633	1.00
175_V	232_M	1.632	1.00
170_K	350_I	1.627	1.00
16_E	110_G	1.626	1.00
239_K	321_L	1.625	1.00
73_P	103_K	1.602	1.00
318_H	322_P	1.599	1.00
136_D	139_A	1.590	1.00
111_I	116_L	1.579	1.00
54_T	117_T	1.578	1.00
231_E	234_K	1.558	1.00
301_L	318_H	1.556	1.00
186_E	340_N	1.551	1.00
278_A	302_E	1.551	1.00
6_V	141_L	1.538	1.00
50_I	128_G	1.532	1.00
318_H	321_L	1.524	1.00
173_V	209_L	1.520	1.00
50_I	77_G	1.508	1.00
51_V	75_V	1.507	1.00
203_A	207_L	1.505	1.00
197_V	209_L	1.500	1.00
142_K	145_N	1.472	1.00
87_P	95_T	1.466	1.00
95_T	98_E	1.462	1.00
256_C	318_H	1.450	1.00
77_G	130_F	1.446	1.00
31_N	40_I	1.436	1.00
175_V	206_V	1.434	1.00
173_V	211_P	1.431	1.00
200_N	228_E	1.429	1.00
177_F	216_L	1.421	1.00
47_C	74_F	1.418	1.00
249_H	325_T	1.410	1.00
232_M	235_G	1.409	1.00
258_A	297_S	1.398	1.00
80_I	83_L	1.396	1.00
277_L	306_I	1.395	1.00
203_A	235_G	1.380	1.00
16_E	109_Q	1.379	1.00
214_I	236_V	1.374	1.00
276_E	345_R	1.369	1.00
283_A	341_H	1.367	1.00
256_C	301_L	1.361	1.00
94_Y	98_E	1.357	1.00
3_R	108_L	1.350	1.00
11_A	115_K	1.349	1.00
201_I	205_E	1.335	1.00
174_L	194_V	1.334	1.00
41_L	75_V	1.309	0.99
192_C	350_I	1.300	0.99
205_E	208_Q	1.295	0.99
230_I	254_L	1.287	0.99
169_G	351_E	1.287	0.99
278_A	317_K	1.264	0.99
67_D	91_R	1.250	0.99
261_E	312_T	1.249	0.99
174_L	184_L	1.231	0.99
6_V	12_V	1.215	0.99
215_M	243_F	1.213	0.99
275_K	306_I	1.211	0.99
283_A	339_A	1.211	0.99
154_V	247_L	1.210	0.99
47_C	156_Q	1.206	0.99
237_L	256_C	1.202	0.99
172_I	192_C	1.198	0.99
175_V	201_I	1.193	0.99
179_M	184_L	1.188	0.99
171_R	209_L	1.186	0.99
278_A	345_R	1.175	0.99
139_A	142_K	1.171	0.99
224_K	260_T	1.170	0.99
8_E	126_L	1.164	0.99
236_V	242_L	1.162	0.99
348_E	351_E	1.158	0.99
295_S	303_V	1.156	0.99
294_S	297_S	1.156	0.99
213_G	350_I	1.152	0.99
164_P	193_D	1.151	0.99
21_L	101_K	1.146	0.99
188_N	194_V	1.143	0.98
231_E	235_G	1.141	0.98
224_K	254_L	1.138	0.98
64_N	67_D	1.135	0.98
41_L	78_L	1.130	0.98
305_H	328_Y	1.130	0.98
71_I	74_F	1.129	0.98
22_E	104_N	1.111	0.98
216_L	233_I	1.103	0.98
301_L	316_L	1.102	0.98
276_E	283_A	1.094	0.98
159_A	162_A	1.090	0.98
207_L	239_K	1.086	0.98
65_R	94_Y	1.075	0.98
73_P	105_I	1.070	0.98
243_F	324_F	1.069	0.98
3_R	17_A	1.066	0.98
158_S	200_N	1.054	0.97
63_I	94_Y	1.049	0.97
28_V	120_I	1.047	0.97
83_L	97_D	1.042	0.97
154_V	226_V	1.040	0.97
5_L	108_L	1.036	0.97
275_K	308_I	1.028	0.97
235_G	238_G	1.026	0.97
33_G	40_I	1.024	0.97
168_R	193_D	1.018	0.97
69_E	185_R	1.012	0.97
3_R	132_S	1.009	0.97
242_L	252_F	1.008	0.97
348_E	352_T	1.008	0.97
252_F	316_L	1.007	0.97
172_I	347_I	0.994	0.96
24_N	77_G	0.993	0.96
6_V	144_L	0.988	0.96
195_I	209_L	0.987	0.96
141_L	144_L	0.987	0.96
270_S	286_S	0.984	0.96
324_F	342_L	0.979	0.96
24_N	130_F	0.979	0.96
115_K	119_M	0.972	0.96
175_V	202_T	0.970	0.96
203_A	232_M	0.968	0.96
131_A	140_V	0.966	0.96
187_L	192_C	0.964	0.96
232_M	236_V	0.952	0.95
300_E	318_H	0.947	0.95
186_E	189_K	0.945	0.95
233_I	242_L	0.945	0.95
40_I	53_L	0.941	0.95
120_I	128_G	0.934	0.95
48_G	76_K	0.931	0.95
210_K	240_V	0.929	0.95
98_E	101_K	0.927	0.95
4_R	14_E	0.922	0.94
345_R	348_E	0.918	0.94
165_S	168_R	0.913	0.94
13_F	115_K	0.911	0.94
276_E	281_K	0.908	0.94
182_G	186_E	0.907	0.94
151_R	156_Q	0.901	0.94
23_H	133_S	0.893	0.93
72_T	103_K	0.890	0.93
246_C	329_H	0.890	0.93
4_R	137_I	0.889	0.93
155_S	200_N	0.889	0.93
226_V	229_A	0.889	0.93
201_I	209_L	0.884	0.93
18_F	80_I	0.884	0.93
38_Q	64_N	0.884	0.93
57_L	82_E	0.882	0.93
170_K	192_C	0.875	0.93
170_K	347_I	0.874	0.93
9_N	123_A	0.865	0.92
179_M	215_M	0.862	0.92
152_N	229_A	0.861	0.92
71_I	181_H	0.860	0.92
227_P	231_E	0.860	0.92
80_I	109_Q	0.858	0.92
328_Y	339_A	0.858	0.92
66_D	91_R	0.855	0.92
79_I	111_I	0.855	0.92
304_T	317_K	0.854	0.92
127_K	148_E	0.852	0.92
63_I	68_F	0.851	0.92
238_G	321_L	0.842	0.91
204_E	208_Q	0.841	0.91
85_E	109_Q	0.841	0.91
274_V	314_E	0.841	0.91
164_P	168_R	0.836	0.91
159_A	196_V	0.826	0.90
26_G	50_I	0.823	0.90
194_V	215_M	0.823	0.90
190_R	347_I	0.819	0.90
202_T	232_M	0.819	0.90
4_R	134_D	0.819	0.90
19_G	107_G	0.816	0.90
306_I	311_D	0.812	0.90
45_S	246_C	0.812	0.90
186_E	190_R	0.809	0.90
92_S	95_T	0.807	0.89
174_L	217_S	0.800	0.89
237_L	252_F	0.800	0.89
347_I	350_I	0.799	0.89
167_G	193_D	0.799	0.89
4_R	12_V	0.799	0.89
152_N	228_E	0.797	0.89
139_A	143_R	0.792	0.89
100_L	105_I	0.786	0.88
12_V	137_I	0.785	0.88
14_E	137_I	0.782	0.88
119_M	123_A	0.782	0.88
189_K	340_N	0.779	0.88
28_V	52_T	0.779	0.88
206_V	214_I	0.777	0.88
256_C	323_A	0.776	0.88
276_E	279_T	0.774	0.87
24_N	76_K	0.774	0.87
129_T	140_V	0.771	0.87
218_N	246_C	0.770	0.87
6_V	131_A	0.769	0.87
150_P	225_D	0.767	0.87
216_L	242_L	0.763	0.87
177_F	251_L	0.760	0.86
17_A	132_S	0.760	0.86
41_L	96_L	0.760	0.86
268_R	272_H	0.759	0.86
165_S	188_N	0.756	0.86
41_L	100_L	0.755	0.86
48_G	156_Q	0.751	0.86
344_D	347_I	0.751	0.86
272_H	309_N	0.746	0.85
206_V	211_P	0.745	0.85
318_H	323_A	0.745	0.85
42_S	68_F	0.743	0.85
228_E	231_E	0.739	0.85
181_H	185_R	0.736	0.85
25_M	129_T	0.734	0.84
98_E	102_M	0.731	0.84
172_I	213_G	0.731	0.84
259_N	297_S	0.728	0.84
270_S	307_A	0.728	0.84
247_L	254_L	0.727	0.84
79_I	128_G	0.727	0.84
199_Y	228_E	0.726	0.84
131_A	135_E	0.723	0.84
7_L	116_L	0.723	0.84
100_L	107_G	0.722	0.83
295_S	313_I	0.722	0.83
97_D	107_G	0.721	0.83
99_Y	103_K	0.721	0.83
149_L	224_K	0.719	0.83
234_K	238_G	0.719	0.83
19_G	97_D	0.718	0.83
201_I	206_V	0.713	0.83
172_I	187_L	0.709	0.82
258_A	301_L	0.707	0.82
231_E	238_G	0.705	0.82
328_Y	341_H	0.704	0.82
148_E	151_R	0.703	0.82
150_P	291_Y	0.703	0.82
162_A	197_V	0.696	0.81
150_P	153_Q	0.696	0.81
23_H	131_A	0.694	0.81
256_C	321_L	0.693	0.81
120_I	125_A	0.693	0.81
183_I	332_A	0.691	0.81
207_L	235_G	0.691	0.81
206_V	232_M	0.690	0.81
305_H	341_H	0.687	0.80
47_C	76_K	0.686	0.80
33_G	286_S	0.686	0.80
47_C	72_T	0.686	0.80
169_G	193_D	0.683	0.80
148_E	291_Y	0.682	0.80
75_V	78_L	0.680	0.80
46_Y	49_Q	0.680	0.80
192_C	213_G	0.679	0.80
164_P	167_G	0.676	0.79
165_S	193_D	0.672	0.79
299_T	319_K	0.671	0.79
61_Y	309_N	0.671	0.79
229_A	232_M	0.671	0.79
58_I	80_I	0.670	0.79
31_N	53_L	0.670	0.79
138_E	142_K	0.670	0.79
143_R	146_E	0.669	0.79
22_E	132_S	0.669	0.79
283_A	328_Y	0.667	0.78
294_S	313_I	0.664	0.78
203_A	236_V	0.664	0.78
162_A	209_L	0.662	0.78
21_L	106_P	0.662	0.78
75_V	105_I	0.661	0.78
173_V	195_I	0.660	0.78
163_Y	184_L	0.659	0.78
242_L	323_A	0.656	0.77
8_E	123_A	0.654	0.77
106_P	130_F	0.654	0.77
183_I	245_I	0.652	0.77
25_M	147_T	0.651	0.77
53_L	58_I	0.651	0.77
42_S	99_Y	0.648	0.76
175_V	216_L	0.646	0.76
287_Q	314_E	0.646	0.76
70_S	74_F	0.645	0.76
61_Y	64_N	0.644	0.76
175_V	229_A	0.643	0.76
322_P	349_M	0.641	0.76
171_R	212_D	0.641	0.76
52_T	117_T	0.641	0.76
127_K	149_L	0.637	0.75
44_P	331_E	0.637	0.75
213_G	346_F	0.636	0.75
40_I	46_Y	0.636	0.75
268_R	328_Y	0.634	0.75
263_M	292_T	0.631	0.74
319_K	322_P	0.630	0.74
214_I	242_L	0.629	0.74
225_D	291_Y	0.628	0.74
204_E	207_L	0.628	0.74
34_M	61_Y	0.627	0.74
253_A	258_A	0.627	0.74
206_V	236_V	0.624	0.74
173_V	206_V	0.622	0.73
228_E	232_M	0.621	0.73
31_N	272_H	0.621	0.73
108_L	111_I	0.621	0.73
122_T	264_K	0.620	0.73
6_V	137_I	0.616	0.73
73_P	99_Y	0.613	0.72
246_C	265_F	0.612	0.72
230_I	234_K	0.611	0.72
207_L	236_V	0.611	0.72
78_L	100_L	0.611	0.72
183_I	246_C	0.609	0.72
83_L	109_Q	0.608	0.72
134_D	139_A	0.605	0.71
153_Q	291_Y	0.605	0.71
5_L	111_I	0.605	0.71
117_T	307_A	0.603	0.71
254_L	259_N	0.602	0.71
47_C	157_V	0.601	0.71
48_G	151_R	0.601	0.71
184_L	196_V	0.600	0.71
18_F	83_L	0.599	0.71
125_A	291_Y	0.599	0.71
258_A	316_L	0.599	0.71
29_V	268_R	0.599	0.71
170_K	191_K	0.595	0.70
66_D	93_A	0.595	0.70
287_Q	307_A	0.594	0.70
170_K	212_D	0.593	0.70
116_L	128_G	0.593	0.70
190_R	340_N	0.592	0.70
247_L	251_L	0.589	0.69
275_K	311_D	0.589	0.69
227_P	230_I	0.588	0.69
69_E	182_G	0.587	0.69
213_G	243_F	0.587	0.69
246_C	266_G	0.586	0.69
47_C	153_Q	0.585	0.69
270_S	333_S	0.583	0.69
38_Q	305_H	0.583	0.69
33_G	268_R	0.581	0.68
57_L	61_Y	0.581	0.68
154_V	177_F	0.580	0.68
52_T	79_I	0.580	0.68
184_L	215_M	0.579	0.68
155_S	228_E	0.577	0.68
276_E	341_H	0.577	0.68
20_S	101_K	0.575	0.67
268_R	314_E	0.575	0.67
329_H	336_P	0.575	0.67
182_G	340_N	0.575	0.67
135_E	143_R	0.574	0.67
63_I	92_S	0.573	0.67
333_S	337_E	0.570	0.67
246_C	336_P	0.570	0.67
130_F	300_E	0.569	0.67
200_N	205_E	0.568	0.67
165_S	169_G	0.568	0.67
5_L	28_V	0.568	0.67
137_I	141_L	0.568	0.67
154_V	225_D	0.567	0.66
344_D	348_E	0.567	0.66
28_V	79_I	0.565	0.66
152_N	225_D	0.564	0.66
307_A	314_E	0.564	0.66
129_T	144_L	0.563	0.66
202_T	236_V	0.562	0.66
120_I	126_L	0.561	0.66
17_A	21_L	0.561	0.66
52_T	120_I	0.560	0.65
230_I	255_A	0.557	0.65
187_L	194_V	0.554	0.65
68_F	103_K	0.554	0.65
68_F	181_H	0.553	0.65
80_I	107_G	0.550	0.64
163_Y	188_N	0.550	0.64
164_P	195_I	0.549	0.64
239_K	322_P	0.549	0.64
125_A	290_G	0.547	0.64
293_V	316_L	0.547	0.64
200_N	229_A	0.544	0.63
45_S	329_H	0.544	0.63
46_Y	246_C	0.543	0.63
182_G	333_S	0.543	0.63
249_H	293_V	0.542	0.63
25_M	143_R	0.542	0.63
76_K	156_Q	0.542	0.63
149_L	225_D	0.541	0.63
345_R	349_M	0.541	0.63
149_L	153_Q	0.541	0.63
218_N	329_H	0.540	0.63
314_E	328_Y	0.540	0.63
329_H	335_G	0.539	0.63
215_M	325_T	0.537	0.62
29_V	265_F	0.537	0.62
136_D	143_R	0.537	0.62
215_M	324_F	0.536	0.62
18_F	109_Q	0.535	0.62
276_E	304_T	0.534	0.62
166_P	169_G	0.534	0.62
222_D	260_T	0.534	0.62
3_R	106_P	0.534	0.62
246_C	250_Q	0.533	0.62
180_K	335_G	0.533	0.62
4_R	131_A	0.531	0.61
98_E	104_N	0.531	0.61
326_V	342_L	0.529	0.61
136_D	140_V	0.529	0.61
31_N	183_I	0.528	0.61
276_E	305_H	0.528	0.61
131_A	136_D	0.528	0.61
57_L	314_E	0.527	0.61
17_A	107_G	0.525	0.61
40_I	272_H	0.525	0.61
45_S	218_N	0.524	0.60
174_L	243_F	0.523	0.60
138_E	141_L	0.523	0.60
41_L	53_L	0.523	0.60
272_H	291_Y	0.523	0.60
61_Y	246_C	0.523	0.60
229_A	251_L	0.521	0.60
59_G	62_G	0.521	0.60
268_R	309_N	0.520	0.60
226_V	247_L	0.520	0.60
31_N	52_T	0.520	0.60
186_E	268_R	0.519	0.60
253_A	256_C	0.519	0.60
292_T	313_I	0.519	0.60
187_L	347_I	0.518	0.60
13_F	111_I	0.518	0.60
199_Y	229_A	0.518	0.60
127_K	147_T	0.516	0.59
166_P	193_D	0.514	0.59
250_Q	329_H	0.514	0.59
253_A	301_L	0.513	0.59
119_M	126_L	0.512	0.59
154_V	158_S	0.512	0.59
324_F	345_R	0.511	0.58
283_A	305_H	0.510	0.58
29_V	264_K	0.510	0.58
185_R	216_L	0.510	0.58
18_F	263_M	0.509	0.58
19_G	106_P	0.509	0.58
169_G	191_K	0.508	0.58
55_Y	61_Y	0.507	0.58
175_V	236_V	0.507	0.58
181_H	184_L	0.506	0.58
25_M	144_L	0.506	0.58
305_H	342_L	0.504	0.57
64_N	305_H	0.503	0.57
211_P	214_I	0.502	0.57
50_I	75_V	0.501	0.57
218_N	250_Q	0.501	0.57
160_K	234_K	0.500	0.57
7_L	128_G	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a9xB	1	0.978	100	0.217	Contact Map
1vcoA	4	0.9093	100	0.653	Contact Map
1s1mA	4	0.9231	100	0.667	Contact Map
3nvaA	2	0.9066	100	0.693	Contact Map
4zdjA	4	0.9121	100	0.713	Contact Map
2vxoA	2	0.5192	100	0.789	Contact Map
2h2wA	2	0.6676	100	0.795	Contact Map
1qdlB	2	0.4918	100	0.797	Contact Map
1i1qB	1	0.478	100	0.798	Contact Map
3tqiA	3	0.4945	100	0.798	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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