PYRK - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

PYRK - Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit

UniProt:	P25983	Sequences: MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSEAVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVNEVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDTYVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERMGCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	256 (203)
Sequences:	19926 (13979)
Seq/√Len:	981.1

ECOLI - HCR YEAX PAAE FRE HMP FENR
BACSU - PYRK HMP
HALSA - Q9HRZ4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
109_T	135_N	3.452	1.00
22_V	65_E	2.867	1.00
9_C	24_K	2.825	1.00
84_Q	87_E	2.715	1.00
11_N	19_F	2.647	1.00
20_Q	67_T	2.624	1.00
151_E	155_R	2.606	1.00
22_V	67_T	2.534	1.00
14_I	20_Q	2.472	1.00
7_T	88_L	2.446	1.00
128_R	132_K	2.418	1.00
10_S	22_V	2.408	1.00
5_Y	88_L	2.395	1.00
7_T	24_K	2.361	1.00
5_Y	90_D	2.353	1.00
13_Q	19_F	2.248	1.00
127_K	153_E	2.236	1.00
38_L	68_I	2.130	1.00
12_Q	20_Q	2.124	1.00
8_V	83_K	2.083	1.00
115_G	194_P	2.073	1.00
6_L	91_V	2.069	1.00
41_K	90_D	2.032	1.00
114_G	122_L	2.014	1.00
39_H	53_P	2.010	1.00
137_I	161_Y	2.005	1.00
10_S	85_Q	1.937	1.00
57_A	69_I	1.922	1.00
142_F	148_V	1.880	1.00
177_D	180_K	1.873	1.00
114_G	140_L	1.835	1.00
23_L	68_I	1.758	1.00
109_T	137_I	1.740	1.00
137_I	159_D	1.690	1.00
111_L	189_L	1.678	1.00
109_T	187_D	1.673	1.00
6_L	23_L	1.673	1.00
144_S	147_D	1.651	1.00
72_V	78_R	1.633	1.00
16_D	146_K	1.589	1.00
9_C	65_E	1.588	1.00
191_S	201_L	1.557	1.00
148_V	164_T	1.541	1.00
108_K	188_I	1.495	1.00
72_V	81_S	1.483	1.00
119_V	138_H	1.461	1.00
21_M	80_L	1.434	1.00
38_L	91_V	1.412	1.00
115_G	197_M	1.410	1.00
24_K	65_E	1.380	1.00
177_D	181_R	1.377	1.00
58_D	127_K	1.373	1.00
141_G	197_M	1.365	1.00
123_Q	127_K	1.355	1.00
180_K	207_H	1.346	1.00
113_V	197_M	1.345	1.00
191_S	198_L	1.340	1.00
19_F	81_S	1.339	1.00
135_N	159_D	1.325	1.00
113_V	201_L	1.323	1.00
20_Q	69_I	1.314	1.00
145_A	151_E	1.298	1.00
36_Q	96_G	1.296	1.00
6_L	25_G	1.277	1.00
189_L	205_Y	1.270	1.00
112_L	122_L	1.263	1.00
11_N	84_Q	1.260	1.00
11_N	21_M	1.251	1.00
20_Q	150_Y	1.245	1.00
123_Q	153_E	1.226	1.00
174_F	177_D	1.226	1.00
8_V	23_L	1.223	1.00
69_I	149_F	1.209	1.00
148_V	151_E	1.202	1.00
196_P	200_A	1.195	1.00
69_I	150_Y	1.170	1.00
12_Q	22_V	1.159	1.00
202_K	206_A	1.153	1.00
108_K	186_F	1.144	1.00
39_H	92_L	1.139	1.00
11_N	85_Q	1.122	1.00
17_R	147_D	1.111	1.00
79_L	82_L	1.085	1.00
18_V	117_V	1.081	1.00
195_T	199_K	1.079	1.00
17_R	71_R	1.071	1.00
41_K	51_R	1.067	1.00
114_G	138_H	1.062	1.00
178_V	181_R	1.061	1.00
83_K	87_E	1.050	1.00
38_L	56_I	1.044	1.00
8_V	21_M	1.036	1.00
111_L	187_D	1.033	1.00
112_L	126_S	1.027	1.00
44_E	79_L	1.025	1.00
123_Q	150_Y	1.023	1.00
59_V	127_K	1.018	1.00
153_E	156_Q	1.014	1.00
26_E	88_L	1.011	1.00
7_T	26_E	0.997	1.00
40_L	68_I	0.992	1.00
25_G	28_V	0.989	1.00
141_G	165_A	0.983	1.00
34_P	128_R	0.973	1.00
148_V	162_V	0.964	1.00
33_T	100_P	0.964	1.00
140_L	149_F	0.952	1.00
74_G	77_T	0.948	1.00
58_D	67_T	0.946	1.00
171_E	181_R	0.944	1.00
145_A	169_Y	0.936	1.00
152_E	155_R	0.934	1.00
122_L	138_H	0.927	1.00
171_E	174_F	0.927	1.00
32_T	56_I	0.926	1.00
13_Q	16_D	0.922	1.00
126_S	136_V	0.919	1.00
117_V	120_P	0.919	1.00
129_L	136_V	0.918	1.00
18_V	149_F	0.917	1.00
150_Y	153_E	0.913	1.00
204_E	207_H	0.911	1.00
25_G	29_Q	0.901	1.00
112_L	136_V	0.900	1.00
70_Y	80_L	0.895	1.00
80_L	83_K	0.891	1.00
112_L	125_L	0.884	1.00
143_Q	165_A	0.882	1.00
154_C	160_T	0.875	1.00
15_A	147_D	0.873	1.00
129_L	134_V	0.872	1.00
200_A	203_Q	0.870	1.00
125_L	190_L	0.868	1.00
174_F	178_V	0.865	1.00
126_S	138_H	0.864	1.00
110_A	136_V	0.858	1.00
183_K	187_D	0.858	1.00
168_S	172_T	0.857	1.00
142_F	147_D	0.855	1.00
173_G	176_T	0.855	1.00
8_V	11_N	0.848	1.00
70_Y	81_S	0.845	1.00
173_G	178_V	0.845	1.00
14_I	69_I	0.842	1.00
50_L	76_G	0.837	1.00
130_I	157_Y	0.836	1.00
160_T	164_T	0.831	1.00
16_D	147_D	0.823	1.00
75_E	78_R	0.819	1.00
24_K	64_N	0.810	1.00
142_F	164_T	0.809	1.00
199_K	203_Q	0.806	1.00
155_R	162_V	0.804	1.00
43_S	49_L	0.802	1.00
128_R	131_E	0.802	1.00
115_G	196_P	0.799	1.00
23_L	89_V	0.795	1.00
161_Y	171_E	0.791	1.00
203_Q	207_H	0.789	1.00
21_M	70_Y	0.782	1.00
101_V	110_A	0.781	1.00
9_C	22_V	0.778	1.00
52_R	76_G	0.777	1.00
61_F	131_E	0.775	1.00
145_A	164_T	0.770	1.00
10_S	20_Q	0.765	1.00
126_S	154_C	0.764	1.00
42_V	76_G	0.763	1.00
57_A	67_T	0.758	1.00
141_G	175_V	0.756	1.00
92_L	95_L	0.753	1.00
39_H	51_R	0.746	1.00
174_F	196_P	0.745	1.00
113_V	139_V	0.744	1.00
130_I	136_V	0.744	1.00
5_Y	26_E	0.741	1.00
33_T	36_Q	0.741	1.00
51_R	92_L	0.739	1.00
152_E	156_Q	0.739	1.00
139_V	163_A	0.738	1.00
141_G	163_A	0.738	1.00
168_S	173_G	0.733	1.00
69_I	120_P	0.720	1.00
18_V	69_I	0.720	1.00
59_V	131_E	0.720	1.00
38_L	66_V	0.719	1.00
48_P	75_E	0.718	1.00
40_L	80_L	0.714	1.00
27_L	30_G	0.712	1.00
141_G	173_G	0.712	1.00
153_E	157_Y	0.710	1.00
101_V	125_L	0.709	1.00
110_A	129_L	0.708	1.00
43_S	79_L	0.707	1.00
83_K	89_V	0.707	1.00
54_I	77_T	0.705	1.00
161_Y	165_A	0.703	1.00
110_A	188_I	0.693	1.00
42_V	79_L	0.693	1.00
203_Q	206_A	0.690	1.00
52_R	75_E	0.686	1.00
107_G	110_A	0.685	1.00
60_N	128_R	0.682	1.00
126_S	157_Y	0.681	1.00
60_N	63_K	0.681	1.00
62_E	65_E	0.680	1.00
56_I	66_V	0.680	1.00
115_G	200_A	0.679	1.00
32_T	124_E	0.675	1.00
33_T	128_R	0.666	1.00
180_K	204_E	0.665	1.00
184_L	187_D	0.660	1.00
207_H	210_V	0.657	1.00
99_F	121_P	0.657	1.00
62_E	131_E	0.650	1.00
205_Y	210_V	0.647	1.00
70_Y	77_T	0.641	1.00
183_K	186_F	0.641	1.00
6_L	66_V	0.640	1.00
111_L	137_I	0.639	1.00
171_E	178_V	0.639	1.00
37_F	53_P	0.638	1.00
59_V	62_E	0.636	1.00
113_V	189_L	0.635	1.00
112_L	190_L	0.635	1.00
162_V	165_A	0.632	1.00
41_K	49_L	0.628	1.00
76_G	80_L	0.628	1.00
165_A	174_F	0.626	1.00
11_N	14_I	0.625	1.00
66_V	91_V	0.625	1.00
161_Y	164_T	0.625	1.00
111_L	186_F	0.624	1.00
41_K	92_L	0.623	1.00
11_N	70_Y	0.623	1.00
163_A	171_E	0.622	1.00
14_I	150_Y	0.621	1.00
25_G	66_V	0.619	1.00
71_R	147_D	0.616	1.00
32_T	58_D	0.615	1.00
139_V	161_Y	0.614	1.00
102_N	188_I	0.614	1.00
58_D	124_E	0.611	1.00
61_F	128_R	0.611	1.00
32_T	59_V	0.608	1.00
206_A	210_V	0.607	1.00
119_V	154_C	0.603	1.00
19_F	72_V	0.600	1.00
50_L	75_E	0.598	1.00
55_S	122_L	0.593	1.00
169_Y	173_G	0.592	1.00
119_V	140_L	0.588	1.00
123_Q	154_C	0.585	1.00
142_F	162_V	0.584	1.00
21_M	81_S	0.584	1.00
78_R	82_L	0.581	1.00
110_A	190_L	0.576	1.00
35_G	96_G	0.576	1.00
196_P	199_K	0.576	1.00
160_T	165_A	0.575	1.00
100_P	103_E	0.574	1.00
23_L	91_V	0.574	1.00
79_L	83_K	0.572	1.00
7_T	86_G	0.572	1.00
63_K	127_K	0.570	1.00
67_T	153_E	0.568	1.00
161_Y	178_V	0.567	1.00
159_D	162_V	0.567	1.00
151_E	162_V	0.563	1.00
117_V	149_F	0.558	1.00
37_F	96_G	0.557	1.00
119_V	150_Y	0.555	1.00
165_A	172_T	0.555	1.00
103_E	128_R	0.553	1.00
34_P	60_N	0.551	1.00
17_R	72_V	0.547	1.00
107_G	188_I	0.545	1.00
204_E	208_K	0.544	1.00
32_T	60_N	0.543	1.00
101_V	129_L	0.542	1.00
103_E	132_K	0.542	1.00
138_H	154_C	0.540	1.00
109_T	184_L	0.540	1.00
109_T	186_F	0.538	1.00
6_L	26_E	0.536	1.00
36_Q	100_P	0.536	1.00
176_T	180_K	0.535	1.00
124_E	128_R	0.534	1.00
21_M	72_V	0.526	1.00
145_A	168_S	0.525	1.00
30_G	63_K	0.525	1.00
127_K	157_Y	0.523	1.00
74_G	78_R	0.521	1.00
15_A	18_V	0.520	1.00
194_P	198_L	0.520	1.00
78_R	81_S	0.519	1.00
106_P	188_I	0.518	1.00
69_I	117_V	0.518	1.00
38_L	93_G	0.509	1.00
174_F	200_A	0.507	1.00
111_L	139_V	0.506	1.00
174_F	180_K	0.504	1.00
102_N	106_P	0.501	1.00
151_E	160_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ep3B	2	0.9922	100	0.172	Contact Map
4ylfA	1	0.9648	100	0.231	Contact Map
2piaA	1	0.9609	100	0.279	Contact Map
2b5oA	1	0.9062	100	0.369	Contact Map
2bgiA	1	0.8477	100	0.385	Contact Map
3lo8A	1	0.8867	100	0.391	Contact Map
4fk8A	1	0.8164	100	0.393	Contact Map
4p6vF	1	0.8516	100	0.393	Contact Map
2qdxA	1	0.8477	100	0.394	Contact Map
1tvcA	1	0.8594	100	0.396	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.