GREMLIN Database
PYRK - Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit
UniProt: P25983 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (203)
Sequences: 19926 (13979)
Seq/√Len: 981.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_T135_N3.4521.00
22_V65_E2.8671.00
9_C24_K2.8251.00
84_Q87_E2.7151.00
11_N19_F2.6471.00
20_Q67_T2.6241.00
151_E155_R2.6061.00
22_V67_T2.5341.00
14_I20_Q2.4721.00
7_T88_L2.4461.00
128_R132_K2.4181.00
10_S22_V2.4081.00
5_Y88_L2.3951.00
7_T24_K2.3611.00
5_Y90_D2.3531.00
13_Q19_F2.2481.00
127_K153_E2.2361.00
38_L68_I2.1301.00
12_Q20_Q2.1241.00
8_V83_K2.0831.00
115_G194_P2.0731.00
6_L91_V2.0691.00
41_K90_D2.0321.00
114_G122_L2.0141.00
39_H53_P2.0101.00
137_I161_Y2.0051.00
10_S85_Q1.9371.00
57_A69_I1.9221.00
142_F148_V1.8801.00
177_D180_K1.8731.00
114_G140_L1.8351.00
23_L68_I1.7581.00
109_T137_I1.7401.00
137_I159_D1.6901.00
111_L189_L1.6781.00
109_T187_D1.6731.00
6_L23_L1.6731.00
144_S147_D1.6511.00
72_V78_R1.6331.00
16_D146_K1.5891.00
9_C65_E1.5881.00
191_S201_L1.5571.00
148_V164_T1.5411.00
108_K188_I1.4951.00
72_V81_S1.4831.00
119_V138_H1.4611.00
21_M80_L1.4341.00
38_L91_V1.4121.00
115_G197_M1.4101.00
24_K65_E1.3801.00
177_D181_R1.3771.00
58_D127_K1.3731.00
141_G197_M1.3651.00
123_Q127_K1.3551.00
180_K207_H1.3461.00
113_V197_M1.3451.00
191_S198_L1.3401.00
19_F81_S1.3391.00
135_N159_D1.3251.00
113_V201_L1.3231.00
20_Q69_I1.3141.00
145_A151_E1.2981.00
36_Q96_G1.2961.00
6_L25_G1.2771.00
189_L205_Y1.2701.00
112_L122_L1.2631.00
11_N84_Q1.2601.00
11_N21_M1.2511.00
20_Q150_Y1.2451.00
123_Q153_E1.2261.00
174_F177_D1.2261.00
8_V23_L1.2231.00
69_I149_F1.2091.00
148_V151_E1.2021.00
196_P200_A1.1951.00
69_I150_Y1.1701.00
12_Q22_V1.1591.00
202_K206_A1.1531.00
108_K186_F1.1441.00
39_H92_L1.1391.00
11_N85_Q1.1221.00
17_R147_D1.1111.00
79_L82_L1.0851.00
18_V117_V1.0811.00
195_T199_K1.0791.00
17_R71_R1.0711.00
41_K51_R1.0671.00
114_G138_H1.0621.00
178_V181_R1.0611.00
83_K87_E1.0501.00
38_L56_I1.0441.00
8_V21_M1.0361.00
111_L187_D1.0331.00
112_L126_S1.0271.00
44_E79_L1.0251.00
123_Q150_Y1.0231.00
59_V127_K1.0181.00
153_E156_Q1.0141.00
26_E88_L1.0111.00
7_T26_E0.9971.00
40_L68_I0.9921.00
25_G28_V0.9891.00
141_G165_A0.9831.00
34_P128_R0.9731.00
148_V162_V0.9641.00
33_T100_P0.9641.00
140_L149_F0.9521.00
74_G77_T0.9481.00
58_D67_T0.9461.00
171_E181_R0.9441.00
145_A169_Y0.9361.00
152_E155_R0.9341.00
122_L138_H0.9271.00
171_E174_F0.9271.00
32_T56_I0.9261.00
13_Q16_D0.9221.00
126_S136_V0.9191.00
117_V120_P0.9191.00
129_L136_V0.9181.00
18_V149_F0.9171.00
150_Y153_E0.9131.00
204_E207_H0.9111.00
25_G29_Q0.9011.00
112_L136_V0.9001.00
70_Y80_L0.8951.00
80_L83_K0.8911.00
112_L125_L0.8841.00
143_Q165_A0.8821.00
154_C160_T0.8751.00
15_A147_D0.8731.00
129_L134_V0.8721.00
200_A203_Q0.8701.00
125_L190_L0.8681.00
174_F178_V0.8651.00
126_S138_H0.8641.00
110_A136_V0.8581.00
183_K187_D0.8581.00
168_S172_T0.8571.00
142_F147_D0.8551.00
173_G176_T0.8551.00
8_V11_N0.8481.00
70_Y81_S0.8451.00
173_G178_V0.8451.00
14_I69_I0.8421.00
50_L76_G0.8371.00
130_I157_Y0.8361.00
160_T164_T0.8311.00
16_D147_D0.8231.00
75_E78_R0.8191.00
24_K64_N0.8101.00
142_F164_T0.8091.00
199_K203_Q0.8061.00
155_R162_V0.8041.00
43_S49_L0.8021.00
128_R131_E0.8021.00
115_G196_P0.7991.00
23_L89_V0.7951.00
161_Y171_E0.7911.00
203_Q207_H0.7891.00
21_M70_Y0.7821.00
101_V110_A0.7811.00
9_C22_V0.7781.00
52_R76_G0.7771.00
61_F131_E0.7751.00
145_A164_T0.7701.00
10_S20_Q0.7651.00
126_S154_C0.7641.00
42_V76_G0.7631.00
57_A67_T0.7581.00
141_G175_V0.7561.00
92_L95_L0.7531.00
39_H51_R0.7461.00
174_F196_P0.7451.00
113_V139_V0.7441.00
130_I136_V0.7441.00
5_Y26_E0.7411.00
33_T36_Q0.7411.00
51_R92_L0.7391.00
152_E156_Q0.7391.00
139_V163_A0.7381.00
141_G163_A0.7381.00
168_S173_G0.7331.00
69_I120_P0.7201.00
18_V69_I0.7201.00
59_V131_E0.7201.00
38_L66_V0.7191.00
48_P75_E0.7181.00
40_L80_L0.7141.00
27_L30_G0.7121.00
141_G173_G0.7121.00
153_E157_Y0.7101.00
101_V125_L0.7091.00
110_A129_L0.7081.00
43_S79_L0.7071.00
83_K89_V0.7071.00
54_I77_T0.7051.00
161_Y165_A0.7031.00
110_A188_I0.6931.00
42_V79_L0.6931.00
203_Q206_A0.6901.00
52_R75_E0.6861.00
107_G110_A0.6851.00
60_N128_R0.6821.00
126_S157_Y0.6811.00
60_N63_K0.6811.00
62_E65_E0.6801.00
56_I66_V0.6801.00
115_G200_A0.6791.00
32_T124_E0.6751.00
33_T128_R0.6661.00
180_K204_E0.6651.00
184_L187_D0.6601.00
207_H210_V0.6571.00
99_F121_P0.6571.00
62_E131_E0.6501.00
205_Y210_V0.6471.00
70_Y77_T0.6411.00
183_K186_F0.6411.00
6_L66_V0.6401.00
111_L137_I0.6391.00
171_E178_V0.6391.00
37_F53_P0.6381.00
59_V62_E0.6361.00
113_V189_L0.6351.00
112_L190_L0.6351.00
162_V165_A0.6321.00
41_K49_L0.6281.00
76_G80_L0.6281.00
165_A174_F0.6261.00
11_N14_I0.6251.00
66_V91_V0.6251.00
161_Y164_T0.6251.00
111_L186_F0.6241.00
41_K92_L0.6231.00
11_N70_Y0.6231.00
163_A171_E0.6221.00
14_I150_Y0.6211.00
25_G66_V0.6191.00
71_R147_D0.6161.00
32_T58_D0.6151.00
139_V161_Y0.6141.00
102_N188_I0.6141.00
58_D124_E0.6111.00
61_F128_R0.6111.00
32_T59_V0.6081.00
206_A210_V0.6071.00
119_V154_C0.6031.00
19_F72_V0.6001.00
50_L75_E0.5981.00
55_S122_L0.5931.00
169_Y173_G0.5921.00
119_V140_L0.5881.00
123_Q154_C0.5851.00
142_F162_V0.5841.00
21_M81_S0.5841.00
78_R82_L0.5811.00
110_A190_L0.5761.00
35_G96_G0.5761.00
196_P199_K0.5761.00
160_T165_A0.5751.00
100_P103_E0.5741.00
23_L91_V0.5741.00
79_L83_K0.5721.00
7_T86_G0.5721.00
63_K127_K0.5701.00
67_T153_E0.5681.00
161_Y178_V0.5671.00
159_D162_V0.5671.00
151_E162_V0.5631.00
117_V149_F0.5581.00
37_F96_G0.5571.00
119_V150_Y0.5551.00
165_A172_T0.5551.00
103_E128_R0.5531.00
34_P60_N0.5511.00
17_R72_V0.5471.00
107_G188_I0.5451.00
204_E208_K0.5441.00
32_T60_N0.5431.00
101_V129_L0.5421.00
103_E132_K0.5421.00
138_H154_C0.5401.00
109_T184_L0.5401.00
109_T186_F0.5381.00
6_L26_E0.5361.00
36_Q100_P0.5361.00
176_T180_K0.5351.00
124_E128_R0.5341.00
21_M72_V0.5261.00
145_A168_S0.5251.00
30_G63_K0.5251.00
127_K157_Y0.5231.00
74_G78_R0.5211.00
15_A18_V0.5201.00
194_P198_L0.5201.00
78_R81_S0.5191.00
106_P188_I0.5181.00
69_I117_V0.5181.00
38_L93_G0.5091.00
174_F200_A0.5071.00
111_L139_V0.5061.00
174_F180_K0.5041.00
102_N106_P0.5011.00
151_E160_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ep3B 2 0.9922 100 0.172 Contact Map
4ylfA 1 0.9648 100 0.231 Contact Map
2piaA 1 0.9609 100 0.279 Contact Map
2b5oA 1 0.9062 100 0.369 Contact Map
2bgiA 1 0.8477 100 0.385 Contact Map
3lo8A 1 0.8867 100 0.391 Contact Map
4fk8A 1 0.8164 100 0.393 Contact Map
4p6vF 1 0.8516 100 0.393 Contact Map
2qdxA 1 0.8477 100 0.394 Contact Map
1tvcA 1 0.8594 100 0.396 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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