GREMLIN Database
PYRE - Orotate phosphoribosyltransferase
UniProt: P25972 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (190)
Sequences: 3298 (1840)
Seq/√Len: 133.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_G181_D4.1581.00
30_T36_L3.9551.00
28_P36_L3.6731.00
142_L147_C3.5991.00
121_K148_E3.4661.00
154_S176_S2.7011.00
117_Q120_Q2.5421.00
165_E169_K2.4981.00
64_V123_V2.4251.00
9_Q189_E2.3551.00
58_S91_H2.3511.00
164_E168_A2.3421.00
198_L202_Q2.2141.00
166_A169_K2.2021.00
140_A144_A2.1451.00
139_C172_L2.0431.00
140_A170_A1.9581.00
85_A96_M1.9301.00
13_K190_N1.9241.00
75_A97_C1.8131.00
102_K105_A1.7951.00
188_L202_Q1.7831.00
13_K17_D1.7731.00
22_F29_F1.7571.00
165_E168_A1.7061.00
121_K150_L1.6981.00
61_S92_L1.6971.00
188_L198_L1.6931.00
70_E121_K1.6791.00
72_E120_Q1.6781.00
87_L90_D1.6681.00
143_Q172_L1.6481.00
151_G175_Y1.6411.00
57_A87_L1.6381.00
14_H55_D1.6351.00
199_K202_Q1.5991.00
159_G179_D1.5921.00
73_M120_Q1.5921.00
63_L175_Y1.5641.00
46_T56_V1.5581.00
195_S199_K1.5401.00
135_V152_V1.5171.00
151_G173_P1.4911.00
54_N91_H1.4781.00
129_I174_Y1.4761.00
116_V120_Q1.4741.00
129_I163_A1.4691.00
41_C156_F1.4331.00
64_V153_V1.4231.00
18_I52_V1.4231.00
31_W37_S1.4091.00
10_I55_D1.4051.00
54_N93_N1.4031.00
73_M97_C1.3801.00
86_A96_M1.3801.00
116_V147_C1.3781.00
143_Q148_E1.3721.00
179_D182_T1.3721.00
188_L195_S1.3691.00
111_Q141_A1.3641.00
78_A82_I1.3181.00
51_E93_N1.3081.00
140_A143_Q1.3061.00
76_G85_A1.2931.00
72_E121_K1.2911.00
72_E119_G1.2901.00
71_A123_V1.2811.00
126_E129_I1.2461.00
180_Y201_L1.2421.00
59_G177_L1.2361.00
8_K179_D1.2251.00
59_G62_K1.2181.00
124_V135_V1.2151.00
111_Q144_A1.2081.00
124_V149_V1.2041.00
99_V141_A1.1870.99
67_H175_Y1.1700.99
154_S174_Y1.1670.99
62_K66_E1.1480.99
129_I154_S1.0940.99
14_H17_D1.0920.99
124_V139_C1.0900.99
199_K203_T1.0870.99
57_A88_A1.0860.99
60_I153_V1.0840.99
14_H52_V1.0700.99
28_P38_P1.0610.99
167_F174_Y1.0560.99
68_F175_Y1.0550.99
12_A178_T1.0470.99
45_L115_A1.0460.99
152_V172_L1.0410.99
162_K165_E1.0400.99
32_A105_A1.0350.99
161_P165_E1.0320.98
8_K182_T1.0210.98
80_A83_P1.0130.98
120_Q147_C1.0060.98
200_K203_T1.0020.98
136_L170_A0.9830.98
57_A91_H0.9720.98
197_D200_K0.9720.98
139_C143_Q0.9700.98
22_F108_K0.9640.98
186_V189_E0.9540.97
89_A95_P0.9530.97
9_Q185_E0.9380.97
185_E188_L0.9360.97
54_N58_S0.9300.97
134_S139_C0.9090.97
149_V172_L0.9050.97
39_I180_Y0.9030.97
161_P164_E0.8990.96
10_I13_K0.8970.96
143_Q170_A0.8950.96
123_V151_G0.8820.96
88_A125_I0.8710.96
143_Q149_V0.8700.96
103_P111_Q0.8680.96
82_I98_Y0.8670.96
77_T80_A0.8650.96
60_I88_A0.8480.95
97_C147_C0.8460.95
12_A187_A0.8440.95
43_N128_L0.8440.95
10_I14_H0.8430.95
74_I85_A0.8370.95
32_A133_G0.8270.94
20_A46_T0.8250.94
133_G137_E0.8230.94
136_L166_A0.8220.94
157_T162_K0.8180.94
99_V142_L0.8160.94
155_I177_L0.8130.94
17_D190_N0.8090.94
31_W130_S0.8080.94
138_A141_A0.8080.94
156_F183_L0.8050.93
126_E135_V0.8030.93
13_K186_V0.8020.93
162_K166_A0.7970.93
137_E140_A0.7970.93
62_K65_K0.7920.93
185_E189_E0.7840.93
61_S88_A0.7810.92
33_S130_S0.7780.92
67_H173_P0.7740.92
157_T179_D0.7730.92
57_A90_D0.7710.92
71_A94_L0.7700.92
97_C116_V0.7670.92
73_M147_C0.7650.92
196_D199_K0.7640.92
84_H125_I0.7630.92
23_L39_I0.7620.91
14_H59_G0.7570.91
48_S93_N0.7520.91
124_V142_L0.7470.91
64_V88_A0.7470.91
22_F45_L0.7410.90
22_F77_T0.7370.90
116_V122_T0.7360.90
63_L67_H0.7270.89
19_Q22_F0.7270.89
8_K178_T0.7260.89
69_P72_E0.7190.89
126_E138_A0.7170.89
57_A84_H0.7140.89
32_A106_H0.7130.89
97_C112_I0.7120.88
168_A173_P0.7120.88
78_A81_G0.7100.88
79_T98_Y0.7100.88
73_M116_V0.7090.88
61_S65_K0.7050.88
115_A120_Q0.7030.88
56_V177_L0.7030.88
42_D110_N0.7020.88
19_Q49_F0.6940.87
81_G98_Y0.6930.87
98_Y126_E0.6930.87
186_V190_N0.6910.87
153_V175_Y0.6870.87
190_N195_S0.6850.86
119_G146_G0.6830.86
58_S62_K0.6790.86
103_P109_G0.6770.86
87_L91_H0.6750.86
60_I177_L0.6740.86
176_S179_D0.6710.85
61_S91_H0.6670.85
54_N90_D0.6660.85
197_D201_L0.6590.84
11_I178_T0.6500.84
89_A96_M0.6460.83
65_K92_L0.6390.82
31_W158_Y0.6370.82
189_E196_D0.6340.82
20_A45_L0.6320.82
150_L173_P0.6310.82
128_L156_F0.6300.82
83_P86_A0.6290.81
77_T138_A0.6280.81
15_L46_T0.6240.81
48_S97_C0.6220.81
72_E94_L0.6220.81
196_D200_K0.6210.81
180_Y184_T0.6150.80
8_K13_K0.6140.80
62_K191_G0.6140.80
58_S61_S0.6120.80
21_V41_C0.6110.80
60_I84_H0.6070.79
19_Q115_A0.6000.78
105_A144_A0.5950.78
79_T82_I0.5910.77
8_K11_I0.5900.77
46_T84_H0.5900.77
195_S198_L0.5900.77
15_L20_A0.5870.77
188_L196_D0.5840.76
75_A138_A0.5830.76
96_M113_E0.5800.76
124_V172_L0.5790.76
106_H109_G0.5780.76
69_P151_G0.5780.76
159_G162_K0.5760.76
47_L87_L0.5760.76
126_E154_S0.5760.76
31_W201_L0.5760.76
184_T191_G0.5750.75
98_Y113_E0.5740.75
56_V155_I0.5730.75
184_T198_L0.5650.74
100_R104_K0.5650.74
152_V167_F0.5650.74
165_E170_A0.5610.74
122_T142_L0.5580.73
41_C128_L0.5540.73
189_E202_Q0.5540.73
74_I88_A0.5540.73
46_T155_I0.5530.73
161_P168_A0.5530.73
80_A99_V0.5510.72
54_N87_L0.5480.72
135_V167_F0.5480.72
110_N113_E0.5480.72
55_D58_S0.5470.72
189_E192_N0.5470.72
162_K168_A0.5470.72
102_K137_E0.5430.71
105_A137_E0.5410.71
74_I125_I0.5380.71
189_E198_L0.5360.70
117_Q142_L0.5360.70
32_A135_V0.5350.70
104_K107_G0.5350.70
191_G195_S0.5340.70
185_E196_D0.5340.70
86_A90_D0.5330.70
77_T101_S0.5330.70
33_S37_S0.5320.70
57_A61_S0.5310.70
196_D203_T0.5300.69
32_A77_T0.5300.69
143_Q171_E0.5280.69
195_S202_Q0.5270.69
181_D202_Q0.5260.69
42_D77_T0.5250.69
44_R113_E0.5180.68
43_N155_I0.5170.67
198_L201_L0.5150.67
32_A134_S0.5130.67
171_E190_N0.5090.66
63_L66_E0.5090.66
157_T163_A0.5090.66
71_A121_K0.5080.66
182_T185_E0.5070.66
69_P123_V0.5070.66
40_Y44_R0.5070.66
59_G63_L0.5050.66
15_L41_C0.5050.66
81_G97_C0.5030.65
12_A186_V0.5010.65
29_F37_S0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m3hA 2 0.9352 100 0.342 Contact Map
3qw4B 4 0.912 100 0.35 Contact Map
3n2lA 4 0.8889 100 0.361 Contact Map
3dezA 2 0.9213 100 0.366 Contact Map
4ohcA 5 0.9907 100 0.369 Contact Map
3mjdA 2 0.9074 100 0.37 Contact Map
2wnsA 2 0.9259 100 0.371 Contact Map
2aeeA 4 0.9491 100 0.379 Contact Map
1lh0A 2 0.9259 100 0.381 Contact Map
2ps1A 2 0.9444 100 0.397 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0078 seconds.