GREMLIN Database
PYRF - Orotidine 5'-phosphate decarboxylase
UniProt: P25971 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 239 (224)
Sequences: 2663 (1702)
Seq/√Len: 113.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_A53_R3.4351.00
89_A118_A3.2241.00
14_S17_E3.1311.00
222_D225_K3.0731.00
51_K83_D3.0601.00
127_E140_L2.4641.00
126_S195_V2.4291.00
163_V198_A2.3671.00
91_G95_M2.3591.00
45_S48_K2.3341.00
93_K133_E2.2691.00
220_A226_A2.1851.00
170_Y209_S2.1441.00
93_K97_Q2.1181.00
71_N101_E2.1161.00
94_K195_V2.0391.00
19_L49_Q2.0341.00
6_P213_V2.0171.00
100_L104_E1.9711.00
189_D216_S1.9521.00
201_A233_E1.9411.00
96_M156_L1.8791.00
36_M40_Y1.8561.00
198_A206_K1.8421.00
15_A49_Q1.8111.00
170_Y179_T1.8071.00
224_V228_K1.8021.00
127_E131_K1.7991.00
201_A205_E1.7761.00
152_E174_S1.7451.00
186_M216_S1.7121.00
186_M189_D1.7011.00
93_K153_E1.6841.00
202_I205_E1.6751.00
145_V172_A1.6701.00
12_F21_F1.6661.00
225_K229_A1.6341.00
63_L77_L1.5891.00
21_F25_F1.5751.00
130_M136_I1.5621.00
208_S211_I1.5601.00
127_E139_S1.5591.00
94_K97_Q1.5581.00
94_K129_I1.5501.00
71_N102_G1.5491.00
169_I179_T1.5491.00
139_S142_D1.5441.00
28_E228_K1.5321.00
93_K154_S1.5261.00
15_A42_E1.4671.00
149_K172_A1.4541.00
126_S129_I1.4471.00
7_I31_F1.4471.00
74_M85_V1.4451.00
38_L42_E1.4231.00
72_K75_K1.4161.00
104_E113_R1.4031.00
22_L32_V1.3911.00
202_I206_K1.3841.00
41_Q76_R1.3781.00
188_E229_A1.3611.00
113_R157_D1.3591.00
186_M230_V1.3391.00
161_C179_T1.3271.00
115_S178_L1.3141.00
163_V184_I1.3101.00
9_A214_G1.3011.00
152_E173_V1.2940.99
56_E83_D1.2930.99
6_P227_Y1.2920.99
93_K150_Q1.2880.99
181_T208_S1.2750.99
117_I156_L1.2670.99
17_E20_A1.2610.99
229_A233_E1.2530.99
138_K146_H1.2530.99
34_V50_L1.2400.99
68_T72_K1.2370.99
138_K142_D1.2320.99
179_T209_S1.2120.99
191_A197_V1.2070.99
75_K105_E1.2030.99
15_A19_L1.1940.99
38_L46_I1.1920.99
86_N119_V1.1900.99
24_P222_D1.1720.99
166_A208_S1.1720.99
20_A24_P1.1660.99
115_S157_D1.1630.99
70_V99_A1.1290.99
121_Q125_T1.1280.99
24_P223_P1.1200.98
125_T129_I1.1190.98
135_L146_H1.1140.98
166_A179_T1.1060.98
8_I218_T1.1060.98
167_K206_K1.0980.98
90_A147_Y1.0930.98
40_Y63_L1.0880.98
228_K232_L1.0770.98
204_R211_I1.0770.98
70_V95_M1.0730.98
121_Q143_T1.0710.98
32_V55_C1.0670.98
86_N117_I1.0550.98
159_V177_F1.0530.98
188_E192_N1.0510.98
72_K76_R1.0510.98
7_I210_A1.0510.98
84_L115_S1.0460.98
15_A46_I1.0430.98
31_F56_E1.0420.98
192_N219_K1.0410.98
169_I173_V1.0400.98
48_K52_E1.0370.98
19_L23_A1.0320.97
131_K138_K1.0280.97
100_L157_D1.0270.97
87_V96_M1.0250.97
225_K228_K1.0200.97
59_L82_V1.0180.97
100_L113_R1.0170.97
178_L209_S1.0080.97
50_L55_C1.0060.97
143_T147_Y0.9950.97
30_L55_C0.9880.97
131_K137_E0.9830.97
129_I133_E0.9820.97
84_L117_I0.9800.96
141_I168_A0.9780.96
229_A232_L0.9770.96
87_V116_L0.9760.96
29_P227_Y0.9700.96
86_N96_M0.9690.96
70_V91_G0.9680.96
6_P234_W0.9670.96
90_A143_T0.9660.96
98_A101_E0.9600.96
97_Q101_E0.9590.96
90_A121_Q0.9570.96
13_A17_E0.9510.96
72_K219_K0.9500.96
204_R234_W0.9500.96
74_M103_L0.9490.96
98_A102_G0.9460.96
161_C169_I0.9450.96
31_F84_L0.9430.96
168_A172_A0.9320.95
63_L70_V0.9300.95
192_N216_S0.9260.95
145_V168_A0.9180.95
8_I29_P0.9070.95
37_E72_K0.9010.94
226_A229_A0.8950.94
159_V179_T0.8880.94
167_K171_Q0.8840.94
94_K98_A0.8810.94
39_F61_L0.8780.94
135_L138_K0.8770.94
145_V149_K0.8690.93
71_N75_K0.8680.93
96_M154_S0.8670.93
47_V80_L0.8650.93
118_A156_L0.8560.93
24_P224_V0.8550.93
198_A202_I0.8500.92
187_S233_E0.8500.92
49_Q52_E0.8450.92
90_A125_T0.8430.92
149_K173_V0.8370.92
30_L227_Y0.8350.92
6_P231_R0.8330.92
89_A151_A0.8330.92
41_Q79_S0.8300.92
37_E218_T0.8260.91
117_I180_V0.8230.91
63_L73_A0.8220.91
100_L116_L0.8180.91
36_M73_A0.8170.91
211_I234_W0.8170.91
39_F44_P0.8120.91
47_V57_L0.8120.91
34_V38_L0.8110.91
149_K153_E0.8050.90
42_E46_I0.8050.90
4_N56_E0.8010.90
40_Y77_L0.7980.90
18_T38_L0.7960.90
85_V103_L0.7950.90
12_F18_T0.7840.89
164_H198_A0.7830.89
118_A151_A0.7770.89
28_E224_V0.7760.89
162_S165_E0.7750.89
5_L204_R0.7710.88
50_L53_R0.7710.88
57_L82_V0.7690.88
191_A195_V0.7630.88
93_K96_M0.7630.88
120_T159_V0.7600.88
89_A144_V0.7590.88
136_I143_T0.7590.88
32_V50_L0.7570.87
74_M99_A0.7570.87
224_V227_Y0.7530.87
76_R79_S0.7510.87
49_Q53_R0.7470.87
216_S230_V0.7420.86
119_V122_L0.7420.86
217_I227_Y0.7410.86
84_L210_A0.7370.86
31_F83_D0.7320.86
8_I21_F0.7320.86
12_F218_T0.7310.85
64_H125_T0.7250.85
19_L22_L0.7190.85
19_L53_R0.7110.84
227_Y231_R0.7090.84
4_N30_L0.7090.84
151_A156_L0.7060.83
21_F32_V0.7000.83
10_L22_L0.7000.83
26_Q32_V0.6940.82
28_E231_R0.6930.82
89_A147_Y0.6930.82
15_A45_S0.6890.82
10_L34_V0.6890.82
46_I49_Q0.6840.81
200_P211_I0.6830.81
138_K143_T0.6810.81
7_I180_V0.6750.81
73_A76_R0.6750.81
86_N177_F0.6700.80
134_L143_T0.6670.80
16_E20_A0.6660.80
186_M233_E0.6640.80
145_V173_V0.6630.79
90_A136_I0.6600.79
74_M102_G0.6560.79
25_F224_V0.6520.78
16_E19_L0.6500.78
10_L50_L0.6480.78
170_Y210_A0.6470.78
121_Q147_Y0.6460.78
23_A27_Q0.6440.77
143_T146_H0.6440.77
67_P95_M0.6430.77
63_L74_M0.6390.77
178_L210_A0.6380.77
44_P80_L0.6350.76
166_A181_T0.6340.76
71_N98_A0.6330.76
230_V233_E0.6330.76
189_D192_N0.6320.76
116_L156_L0.6320.76
179_T210_A0.6270.76
29_P231_R0.6260.75
168_A171_Q0.6260.75
47_V51_K0.6240.75
99_A102_G0.6220.75
8_I217_I0.6200.75
34_V46_I0.6180.75
117_I160_V0.6150.74
84_L160_V0.6140.74
159_V169_I0.6130.74
74_M116_L0.6110.74
27_Q224_V0.6080.73
22_L50_L0.6070.73
222_D226_A0.6040.73
213_V230_V0.6030.73
22_L42_E0.6000.72
84_L180_V0.6000.72
159_V173_V0.5920.71
36_M77_L0.5910.71
8_I30_L0.5900.71
25_F227_Y0.5890.71
10_L18_T0.5870.71
152_E177_F0.5870.71
45_S52_E0.5820.70
37_E69_T0.5820.70
103_L116_L0.5810.70
96_M151_A0.5740.69
18_T46_I0.5740.69
174_S177_F0.5720.69
125_T147_Y0.5720.69
21_F24_P0.5690.68
81_G114_P0.5690.68
39_F76_R0.5660.68
26_Q55_C0.5650.68
200_P230_V0.5590.67
65_D69_T0.5590.67
21_F223_P0.5580.67
188_E233_E0.5580.67
100_L156_L0.5560.67
31_F55_C0.5530.66
134_L138_K0.5520.66
68_T71_N0.5500.66
19_L46_I0.5490.66
129_I195_V0.5460.65
59_L77_L0.5460.65
125_T143_T0.5430.65
103_L114_P0.5430.65
36_M63_L0.5420.65
78_A81_G0.5410.65
64_H90_A0.5400.64
143_T169_I0.5390.64
173_V177_F0.5390.64
164_H197_V0.5370.64
29_P55_C0.5350.64
133_E150_Q0.5340.64
42_E45_S0.5310.63
130_M140_L0.5310.63
37_E75_K0.5290.63
162_S196_R0.5270.63
51_K81_G0.5260.62
187_S201_A0.5250.62
152_E176_S0.5250.62
46_I50_L0.5200.62
95_M122_L0.5200.62
141_I164_H0.5190.61
26_Q29_P0.5190.61
188_E191_A0.5180.61
29_P32_V0.5180.61
75_K98_A0.5160.61
101_E105_E0.5150.61
214_G218_T0.5140.61
22_L53_R0.5130.60
9_A218_T0.5100.60
189_D233_E0.5090.60
20_A23_A0.5090.60
101_E104_E0.5040.59
180_V212_V0.5030.59
7_I84_L0.5030.59
189_D226_A0.5010.59
78_A103_L0.5000.59
145_V171_Q0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gdmA 2 0.9289 100 0.313 Contact Map
3ldvA 2 0.9665 100 0.329 Contact Map
1dbtA 2 0.9916 100 0.334 Contact Map
3tr2A 2 0.9289 100 0.338 Contact Map
1eixA 2 0.9707 100 0.338 Contact Map
2yyuA 2 0.9582 100 0.344 Contact Map
3qw4B 4 0.9079 100 0.345 Contact Map
3tfxA 2 0.9456 100 0.346 Contact Map
3v75A 2 0.9205 100 0.362 Contact Map
3r89A 2 0.9331 100 0.363 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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