GREMLIN Database
COMGC - ComG operon protein 3
UniProt: P25955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 98 (89)
Sequences: 398 (301)
Seq/√Len: 31.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_C81_C3.7401.00
67_A71_S2.6231.00
11_M14_V2.5011.00
15_L19_S2.4810.99
20_I36_I2.0950.98
16_F20_I1.9780.97
45_Q49_K1.9270.97
19_S40_G1.9060.97
3_E20_I1.8930.97
35_T39_K1.8240.96
17_I90_T1.7580.95
26_I29_V1.7410.95
75_V79_A1.7150.94
59_H72_E1.7050.94
14_V21_L1.6280.92
49_K52_M1.5480.90
36_I40_G1.5450.90
40_G47_M1.4860.88
70_Q80_V1.4830.88
9_V47_M1.4310.86
70_Q77_K1.4250.86
37_Q59_H1.4220.86
68_D71_S1.4170.86
64_P68_D1.3650.83
32_H57_L1.3370.82
71_S85_K1.3230.81
68_D84_G1.3220.81
37_Q56_E1.3080.81
23_L64_P1.2910.80
53_T56_E1.2890.80
32_H79_A1.2850.80
55_F69_L1.2810.79
35_T38_K1.2690.79
44_L52_M1.2470.77
13_I50_A1.2410.77
31_K46_N1.2240.76
40_G44_L1.1880.74
15_L78_D1.1870.74
66_L89_I1.1780.73
66_L75_V1.1500.71
62_Q68_D1.1390.71
73_G78_D1.1310.70
16_F53_T1.1260.70
83_N87_I1.1080.68
77_K81_C1.0960.68
13_I26_I1.0950.68
33_N56_E1.0840.67
47_M79_A1.0830.67
60_E68_D1.0570.65
14_V19_S1.0360.63
20_I40_G1.0360.63
44_L79_A1.0230.62
12_L39_K1.0150.62
36_I48_V1.0140.61
49_K53_T1.0050.61
32_H35_T1.0000.60
44_L75_V0.9900.60
5_G67_A0.9740.58
15_L47_M0.9010.52
47_M54_A0.8940.52
19_S26_I0.8860.51
12_L24_I0.8850.51
9_V84_G0.8840.51
9_V35_T0.8640.49
16_F29_V0.8640.49
67_A91_G0.8550.49
36_I47_M0.8400.47
32_H44_L0.8350.47
55_F75_V0.8320.47
66_L72_E0.8250.46
22_L35_T0.8160.45
76_K79_A0.8020.44
88_I92_G0.7810.43
56_E78_D0.7780.42
16_F36_I0.7740.42
31_K72_E0.7590.41
16_F33_N0.7530.40
18_I36_I0.7460.40
53_T58_D0.7350.39
67_A70_Q0.7310.39
48_V83_N0.7250.38
11_M21_L0.7230.38
17_I36_I0.7200.38
26_I57_L0.7190.38
38_K67_A0.7160.38
26_I75_V0.7100.37
25_T44_L0.7010.36
4_K77_K0.6770.35
41_C84_G0.6750.34
22_L30_T0.6730.34
86_R91_G0.6690.34
32_H53_T0.6440.32
18_I25_T0.6430.32
52_M89_I0.6380.32
38_K59_H0.6330.31
40_G57_L0.6270.31
55_F62_Q0.6270.31
22_L39_K0.6260.31
64_P67_A0.6250.31
32_H76_K0.6090.30
14_V32_H0.6080.30
12_L25_T0.6000.29
48_V82_P0.6000.29
37_Q50_A0.5880.28
16_F75_V0.5880.28
12_L57_L0.5870.28
52_M63_T0.5830.28
20_I33_N0.5810.28
18_I34_Q0.5810.28
12_L75_V0.5730.27
12_L40_G0.5730.27
43_G46_N0.5730.27
47_M53_T0.5670.27
7_T10_E0.5590.26
6_F10_E0.5590.26
37_Q54_A0.5540.26
72_E76_K0.5460.26
50_A56_E0.5450.26
50_A58_D0.5440.26
44_L47_M0.5430.25
26_I54_A0.5380.25
32_H47_M0.5360.25
23_L43_G0.5340.25
51_Q54_A0.5340.25
59_H62_Q0.5330.25
12_L36_I0.5320.25
38_K70_Q0.5320.25
17_I38_K0.5300.25
47_M87_I0.5220.24
4_K67_A0.5220.24
5_G15_L0.5210.24
72_E91_G0.5160.24
45_Q48_V0.5110.24
19_S47_M0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hi2A 1 0.9388 99.1 0.684 Contact Map
3sokA 1 0.949 99 0.695 Contact Map
2m7gA 1 0.6224 98.9 0.707 Contact Map
1oqwA 1 0.9184 98.7 0.725 Contact Map
3g20A 1 0.7755 98.3 0.758 Contact Map
3gn9A 1 0.6939 94.2 0.85 Contact Map
1t92A 2 0.6939 93.7 0.853 Contact Map
2kepA 1 0.7041 93 0.857 Contact Map
4ixjA 1 0.6939 23.5 0.922 Contact Map
3j27B 2 0.2755 22.9 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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