GREMLIN Database
COMGB - ComG operon protein 2
UniProt: P25954 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (275)
Sequences: 4759 (3602)
Seq/√Len: 217.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_R133_M4.4241.00
215_K228_E4.0121.00
169_A225_C3.5461.00
82_A280_Q3.1721.00
266_R269_R3.1061.00
130_S307_L3.0851.00
198_S272_F2.8601.00
230_L244_I2.8501.00
117_S139_Q2.4961.00
129_R132_D2.4841.00
162_V167_S2.4041.00
195_L279_L2.3731.00
84_A88_K2.3611.00
132_D136_A2.3401.00
163_F171_Q2.3401.00
79_R283_E2.3361.00
106_Y110_S2.3111.00
157_I161_L2.2671.00
233_R238_E2.2411.00
212_N231_I2.1831.00
211_L227_A2.1441.00
233_R246_G2.1061.00
156_G160_W2.0961.00
99_F103_V2.0951.00
103_V107_M2.0921.00
202_K268_D2.0801.00
187_L281_R2.0801.00
140_H148_L2.0511.00
86_Q287_Q2.0191.00
65_E68_A2.0151.00
160_W164_K1.9921.00
303_A307_L1.9741.00
53_A73_S1.9701.00
107_M111_I1.9341.00
172_M221_P1.9271.00
53_A77_L1.9071.00
233_R243_A1.9041.00
197_L210_S1.8731.00
126_E132_D1.8651.00
313_L317_Y1.8301.00
170_R174_I1.8171.00
130_S314_V1.8121.00
86_Q283_E1.7821.00
81_I85_D1.7771.00
318_Q321_N1.7451.00
130_S133_M1.7391.00
115_Q118_G1.7011.00
229_Q247_S1.6991.00
62_T209_D1.6871.00
98_I102_A1.6791.00
215_K231_I1.6721.00
238_E242_S1.6661.00
95_L99_F1.6441.00
139_Q142_D1.6201.00
147_L151_F1.6021.00
144_V147_L1.5931.00
134_L311_S1.5881.00
172_M175_C1.5861.00
170_R173_L1.5771.00
231_I235_K1.5761.00
193_F227_A1.5721.00
221_P224_R1.5381.00
209_D212_N1.5351.00
146_I150_L1.5331.00
140_H144_V1.4891.00
189_N223_Y1.4851.00
50_H77_L1.4531.00
172_M220_L1.4521.00
59_F63_H1.4411.00
50_H53_A1.4341.00
161_L164_K1.4311.00
226_E247_S1.4211.00
71_I75_E1.4201.00
93_Y97_L1.4101.00
187_L285_K1.4061.00
162_V165_K1.3901.00
159_Y171_Q1.3671.00
155_I159_Y1.3651.00
185_V189_N1.3591.00
133_M136_A1.3551.00
153_A157_I1.3411.00
195_L275_S1.3391.00
194_S254_L1.3321.00
207_I240_I1.3151.00
92_R96_F1.3081.00
218_T227_A1.2991.00
200_L210_S1.2801.00
183_K187_L1.2651.00
152_T156_G1.2641.00
190_S254_L1.2591.00
168_P221_P1.2571.00
105_F304_M1.2501.00
191_Y282_L1.2441.00
136_A140_H1.2331.00
139_Q143_L1.2301.00
79_R279_L1.2281.00
195_L276_Q1.2221.00
76_L80_K1.2121.00
193_F197_L1.2111.00
229_Q232_E1.2101.00
133_M137_F1.1911.00
169_A222_F1.1801.00
202_K272_F1.1791.00
294_Q298_Y1.1721.00
97_L301_V1.1641.00
116_F313_L1.1631.00
158_Y162_V1.1591.00
197_L207_I1.1571.00
169_A221_P1.1561.00
162_V170_R1.1291.00
306_L310_L1.1121.00
197_L271_L1.1101.00
89_R287_Q1.1101.00
215_K227_A1.1071.00
58_Y62_T1.0911.00
244_I258_I1.0861.00
117_S121_Q1.0811.00
173_L177_R1.0651.00
157_I160_W1.0581.00
191_Y279_L1.0581.00
108_L308_V1.0541.00
239_S242_S1.0521.00
116_F317_Y1.0491.00
280_Q284_H1.0461.00
187_L282_L1.0441.00
75_E79_R1.0431.00
227_A230_L1.0391.00
211_L234_L1.0371.00
57_C70_M1.0361.00
93_Y295_P1.0351.00
82_A86_Q1.0281.00
316_M320_M1.0271.00
245_C259_S1.0271.00
128_S131_T1.0271.00
85_D280_Q1.0231.00
110_S141_I1.0191.00
226_E249_F1.0151.00
228_E231_I1.0121.00
175_C185_V1.0021.00
154_G158_Y1.0021.00
272_F276_Q0.9991.00
69_S73_S0.9981.00
158_Y161_L0.9951.00
105_F308_V0.9931.00
232_E235_K0.9871.00
109_Q137_F0.9761.00
174_I178_I0.9761.00
233_R236_A0.9681.00
169_A173_L0.9611.00
135_F139_Q0.9531.00
315_P318_Q0.9531.00
79_R82_A0.9531.00
215_K224_R0.9531.00
51_K216_H0.9521.00
304_M307_L0.9471.00
232_E236_A0.9421.00
218_T223_Y0.9411.00
198_S275_S0.9361.00
226_E229_Q0.9180.99
258_I267_L0.9160.99
92_R95_L0.9150.99
60_A69_S0.9130.99
254_L274_Y0.9110.99
188_F282_L0.9110.99
241_E259_S0.9070.99
54_V58_Y0.9050.99
226_E250_Y0.8930.99
107_M112_I0.8930.99
126_E130_S0.8920.99
289_W293_L0.8880.99
224_R228_E0.8850.99
117_S135_F0.8780.99
182_G186_K0.8760.99
69_S199_S0.8760.99
72_Q202_K0.8630.99
161_L165_K0.8610.99
240_I244_I0.8590.99
230_L243_A0.8580.99
127_T131_T0.8570.99
238_E246_G0.8560.99
242_S246_G0.8520.99
98_I297_I0.8520.99
62_T213_A0.8510.99
61_E64_G0.8490.99
58_Y216_H0.8480.99
87_L293_L0.8470.99
191_Y275_S0.8400.99
298_Y301_V0.8390.99
183_K285_K0.8380.99
282_L286_A0.8350.99
56_I69_S0.8350.99
241_E262_Q0.8340.99
193_F244_I0.8310.99
92_R291_G0.8280.99
82_A283_E0.8270.99
176_I220_L0.8240.99
59_F196_Q0.8240.99
88_K92_R0.8240.99
109_Q113_I0.8170.99
234_L240_I0.8160.99
97_L101_V0.8140.99
131_T311_S0.8130.99
244_I255_S0.8120.99
92_R288_K0.8120.99
188_F192_F0.8090.99
160_W163_F0.8060.99
178_I181_V0.8040.98
89_R288_K0.7960.98
143_L146_I0.7940.98
168_P172_M0.7930.98
85_D284_H0.7930.98
68_A202_K0.7890.98
196_Q217_Q0.7880.98
97_L305_I0.7870.98
257_V274_Y0.7870.98
313_L316_M0.7860.98
190_S274_Y0.7800.98
76_L196_Q0.7660.98
116_F120_Y0.7640.98
174_I177_R0.7590.98
178_I182_G0.7540.98
283_E287_Q0.7540.98
100_T299_G0.7520.98
120_Y319_M0.7510.98
106_Y141_I0.7490.98
173_L222_F0.7480.98
167_S170_R0.7480.98
273_T276_Q0.7440.98
57_C66_L0.7420.97
111_I115_Q0.7410.97
309_Y317_Y0.7360.97
159_Y163_F0.7350.97
140_H143_L0.7350.97
206_S210_S0.7340.97
261_G265_G0.7340.97
229_Q233_R0.7330.97
72_Q272_F0.7320.97
134_L301_V0.7300.97
222_F226_E0.7240.97
288_K291_G0.7210.97
87_L91_L0.7170.97
189_N219_F0.7170.97
112_I116_F0.7100.97
216_H224_R0.7100.97
206_S209_D0.7090.97
134_L307_L0.7070.97
167_S171_Q0.7050.97
228_E232_E0.6960.96
245_C255_S0.6950.96
74_G78_E0.6950.96
171_Q175_C0.6940.96
193_F218_T0.6910.96
248_L255_S0.6900.96
307_L314_V0.6900.96
293_L297_I0.6890.96
51_K224_R0.6890.96
166_K221_P0.6880.96
133_M307_L0.6820.96
100_T104_M0.6820.96
194_S282_L0.6810.96
130_S311_S0.6800.96
292_I296_M0.6780.96
251_E278_I0.6770.96
104_M108_L0.6750.96
238_E243_A0.6720.95
136_A139_Q0.6690.95
186_K223_Y0.6680.95
64_G265_G0.6660.95
306_L311_S0.6590.95
222_F225_C0.6580.95
147_L150_L0.6550.95
113_I125_M0.6500.95
226_E248_L0.6480.95
60_A63_H0.6470.94
201_L268_D0.6460.94
65_E202_K0.6460.94
49_F54_V0.6460.94
57_C60_A0.6450.94
201_L210_S0.6450.94
242_S245_C0.6440.94
189_N224_R0.6400.94
125_M319_M0.6390.94
134_L308_V0.6330.94
291_G294_Q0.6320.94
50_H80_K0.6310.94
151_F155_I0.6310.94
313_L320_M0.6300.94
96_F292_I0.6290.94
130_S134_L0.6280.94
221_P225_C0.6260.93
230_L234_L0.6250.93
116_F312_M0.6240.93
257_V278_I0.6240.93
141_I148_L0.6240.93
61_E265_G0.6240.93
194_S274_Y0.6230.93
145_I149_V0.6230.93
75_E272_F0.6220.93
200_L205_L0.6180.93
113_I135_F0.6180.93
172_M176_I0.6170.93
56_I60_A0.6150.93
51_K219_F0.6090.92
225_C228_E0.6090.92
101_V304_M0.6080.92
251_E254_L0.6070.92
108_L312_M0.6060.92
49_F57_C0.6040.92
230_L258_I0.6030.92
198_S201_L0.6030.92
78_E82_A0.6030.92
211_L230_L0.6030.92
138_F142_D0.6030.92
137_F140_H0.6020.92
102_A106_Y0.6010.92
67_P268_D0.5980.92
186_K190_S0.5980.92
181_V185_V0.5970.92
82_A85_D0.5960.92
131_T315_P0.5960.92
190_S194_S0.5950.92
253_D257_V0.5940.92
296_M299_G0.5940.92
118_G122_S0.5930.91
287_Q291_G0.5920.91
295_P302_A0.5900.91
255_S274_Y0.5900.91
200_L213_A0.5880.91
155_I161_L0.5870.91
118_G121_Q0.5870.91
195_L198_S0.5820.91
107_M110_S0.5810.91
190_S278_I0.5810.91
270_E298_Y0.5800.91
94_P295_P0.5790.91
159_Y167_S0.5760.90
302_A320_M0.5710.90
119_I201_L0.5680.90
194_S271_L0.5670.90
284_H287_Q0.5670.90
104_M317_Y0.5660.90
63_H69_S0.5650.89
116_F119_I0.5650.89
177_R186_K0.5640.89
208_Y235_K0.5630.89
78_E273_T0.5630.89
193_F214_F0.5630.89
95_L98_I0.5600.89
88_K95_L0.5580.89
108_L112_I0.5570.89
56_I298_Y0.5540.89
297_I300_F0.5530.88
113_I138_F0.5520.88
109_Q138_F0.5510.88
183_K186_K0.5510.88
295_P315_P0.5490.88
76_L108_L0.5490.88
108_L115_Q0.5490.88
207_I267_L0.5490.88
159_Y162_V0.5480.88
155_I166_K0.5470.88
233_R247_S0.5470.88
186_K249_F0.5460.88
111_I302_A0.5440.88
260_H263_L0.5440.88
142_D146_I0.5430.88
166_K169_A0.5430.88
306_L309_Y0.5420.87
116_F316_M0.5420.87
264_S267_L0.5410.87
60_A64_G0.5400.87
261_G267_L0.5400.87
262_Q265_G0.5390.87
150_L154_G0.5360.87
159_Y175_C0.5360.87
230_L255_S0.5350.87
258_I262_Q0.5300.86
163_F168_P0.5290.86
106_Y111_I0.5290.86
104_M112_I0.5290.86
67_P285_K0.5280.86
290_T293_L0.5270.86
317_Y320_M0.5250.86
119_I319_M0.5250.86
72_Q199_S0.5250.86
194_S275_S0.5250.86
149_V153_A0.5240.86
210_S214_F0.5240.86
269_R272_F0.5240.86
73_S192_F0.5230.86
61_E262_Q0.5210.85
94_P97_L0.5200.85
101_V317_Y0.5180.85
186_K189_N0.5160.85
285_K288_K0.5100.84
115_Q319_M0.5100.84
108_L302_A0.5080.84
237_G261_G0.5080.84
128_S132_D0.5070.84
50_H56_I0.5060.84
212_N216_H0.5060.84
231_I234_L0.5060.84
309_Y316_M0.5060.84
149_V152_T0.5050.84
123_M319_M0.5040.83
194_S258_I0.5030.83
50_H54_V0.5030.83
284_H288_K0.5030.83
270_E273_T0.5010.83
93_Y294_Q0.5010.83
242_S259_S0.5000.83
300_F304_M0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2whnA 1 0.3406 99.7 0.707 Contact Map
4hhxA 1 0.2477 99.7 0.711 Contact Map
3c1qA 2 0.3003 99.6 0.72 Contact Map
4ev6A 3 0.4272 28.9 0.947 Contact Map
4i0uA 4 0.4334 25.9 0.948 Contact Map
3tweA 2 0.0805 13.2 0.954 Contact Map
2m8rA 1 0.3127 12 0.955 Contact Map
2kogA 1 0.2972 9.7 0.957 Contact Map
3hd7A 1 0.2817 9.7 0.957 Contact Map
1c3cA 4 0.1981 9.7 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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