GREMLIN Database
COMGA - ComG operon protein 1
UniProt: P25953 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (318)
Sequences: 9331 (5610)
Seq/√Len: 314.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_F267_A3.4591.00
277_A307_G3.3981.00
129_L157_L3.3241.00
135_H266_I3.1791.00
170_V203_I3.1611.00
57_I103_L2.9971.00
172_L199_G2.9931.00
335_K339_L2.9021.00
130_L160_Y2.8981.00
141_I237_T2.8751.00
102_S168_N2.8591.00
143_T239_L2.7951.00
243_D246_G2.7241.00
115_S118_K2.7051.00
36_F45_K2.4731.00
282_E305_L2.4651.00
283_N308_K2.4421.00
167_R210_M2.4211.00
20_A38_V2.3311.00
14_E18_T2.2811.00
93_S206_H2.2391.00
163_K183_V2.2281.00
98_I176_V2.2111.00
24_H207_D2.1731.00
195_T198_A2.1491.00
336_G341_Y2.1451.00
41_A275_D2.1261.00
133_L157_L2.0801.00
153_T271_Q2.0341.00
15_A20_A2.0051.00
117_D130_L2.0031.00
146_T208_P1.9911.00
284_G303_E1.9831.00
41_A166_N1.9121.00
154_L236_L1.8921.00
280_F312_Q1.8901.00
126_G130_L1.8881.00
33_I44_K1.8831.00
278_C281_C1.8711.00
90_L105_I1.8011.00
112_N118_K1.7961.00
285_C306_Y1.7861.00
38_V43_L1.7811.00
283_N306_Y1.7721.00
142_F153_T1.7661.00
216_I237_T1.7461.00
285_C304_L1.7301.00
49_K52_E1.7251.00
13_E17_L1.7161.00
11_L23_I1.7081.00
37_R207_D1.7021.00
108_M178_T1.6971.00
216_I225_A1.6841.00
201_K218_D1.6811.00
277_A282_E1.6701.00
163_K166_N1.6611.00
329_L337_I1.6561.00
95_L186_V1.6381.00
140_L234_L1.6381.00
252_L258_M1.6331.00
86_G109_P1.6221.00
90_L107_V1.5981.00
211_I228_A1.5801.00
219_A223_E1.5551.00
62_F65_A1.5531.00
297_R302_Y1.5511.00
102_S184_L1.5511.00
143_T270_A1.5441.00
124_K128_T1.5381.00
146_T233_H1.5371.00
8_S60_F1.5181.00
92_M105_I1.5171.00
131_S328_T1.5151.00
122_F125_T1.5121.00
54_V58_S1.5091.00
310_L313_C1.5081.00
269_A326_Y1.5041.00
44_K47_D1.4971.00
332_I335_K1.4791.00
200_L224_I1.4681.00
12_I16_Y1.4641.00
216_I222_A1.4591.00
19_K318_K1.4571.00
15_A23_I1.4531.00
172_L203_I1.4481.00
143_T241_T1.4481.00
125_T324_Y1.4441.00
57_I101_E1.4401.00
154_L212_I1.4321.00
159_Q163_K1.4261.00
134_K160_Y1.4171.00
222_A254_F1.4071.00
248_I265_V1.3941.00
292_Q327_Q1.3761.00
8_S56_L1.3671.00
140_L267_A1.3641.00
125_T326_Y1.3581.00
189_N192_A1.3471.00
159_Q183_V1.3311.00
158_V212_I1.3201.00
276_L281_C1.3091.00
132_F140_L1.2961.00
131_S135_H1.2701.00
69_G101_E1.2601.00
148_S271_Q1.2551.00
161_A210_M1.2531.00
137_H266_I1.2471.00
245_K327_Q1.2451.00
97_T184_L1.2381.00
74_P202_A1.2341.00
35_H44_K1.2321.00
162_K169_I1.2261.00
66_M94_T1.2221.00
139_M235_V1.2161.00
73_K192_A1.2101.00
142_F154_L1.1961.00
215_E240_H1.1901.00
265_V268_I1.1881.00
18_T43_L1.1851.00
94_T103_L1.1741.00
117_D126_G1.1701.00
239_L247_A1.1691.00
19_K39_D1.1621.00
301_V313_C1.1591.00
39_D276_L1.1551.00
227_R253_E1.1501.00
24_H37_R1.1421.00
143_T247_A1.1371.00
24_H42_L1.1321.00
167_R185_Q1.1301.00
223_E227_R1.1251.00
116_I130_L1.1191.00
20_A36_F1.1131.00
114_P118_K1.1071.00
12_I90_L1.1041.00
14_E17_L1.1041.00
64_S92_M1.0961.00
186_V203_I1.0901.00
19_K38_V1.0881.00
203_I211_I1.0881.00
50_K54_V1.0861.00
246_G263_Q1.0861.00
68_I72_R1.0791.00
145_P272_R1.0731.00
99_N187_Q1.0711.00
11_L34_I1.0641.00
15_A36_F1.0631.00
199_G203_I1.0601.00
58_S66_M1.0581.00
334_R338_A1.0491.00
298_R301_V1.0481.00
229_A235_V1.0481.00
125_T128_T1.0451.00
151_T178_T1.0361.00
327_Q332_I1.0341.00
241_T247_A1.0281.00
116_I156_S1.0241.00
272_R329_L1.0231.00
201_K220_E1.0211.00
292_Q296_T1.0211.00
141_I239_L1.0151.00
73_K96_P1.0121.00
102_S170_V1.0091.00
279_P282_E1.0061.00
16_Y90_L1.0061.00
222_A251_L1.0031.00
226_V256_I1.0001.00
281_C313_C0.9981.00
61_K75_Q0.9981.00
222_A256_I0.9941.00
123_P127_A0.9941.00
280_F318_K0.9941.00
50_K53_C0.9921.00
79_L90_L0.9921.00
28_R33_I0.9881.00
303_E307_G0.9861.00
231_T250_R0.9851.00
60_F92_M0.9831.00
127_A131_S0.9821.00
44_K165_F0.9721.00
205_R217_R0.9691.00
331_Q334_R0.9651.00
15_A107_V0.9631.00
112_N115_S0.9631.00
61_K101_E0.9621.00
37_R209_D0.9571.00
14_E45_K0.9521.00
247_A268_I0.9461.00
117_D123_P0.9351.00
252_L261_I0.9341.00
278_C313_C0.9201.00
16_Y88_V0.9161.00
67_D70_E0.9141.00
196_Y213_L0.9111.00
204_L228_A0.9091.00
88_V107_V0.9041.00
18_T38_V0.9021.00
295_N301_V0.8991.00
332_I336_G0.8931.00
300_S303_E0.8891.00
67_D71_R0.8881.00
309_N312_Q0.8871.00
284_G292_Q0.8871.00
328_T331_Q0.8861.00
316_E319_G0.8841.00
128_T131_S0.8801.00
227_R230_M0.8771.00
23_I107_V0.8761.00
14_E46_R0.8731.00
25_I53_C0.8681.00
131_S134_K0.8671.00
98_I179_R0.8631.00
10_N14_E0.8611.00
117_D160_Y0.8581.00
150_K240_H0.8581.00
322_A335_K0.8571.00
197_S220_E0.8561.00
26_V35_H0.8501.00
92_M103_L0.8461.00
24_H104_V0.8441.00
277_A305_L0.8411.00
161_A236_L0.8411.00
125_T269_A0.8401.00
121_L324_Y0.8381.00
128_T328_T0.8351.00
281_C310_L0.8301.00
11_L25_I0.8221.00
195_T220_E0.8181.00
117_D127_A0.8181.00
140_L236_L0.8131.00
166_N184_L0.8111.00
76_N93_S0.8101.00
170_V186_V0.8081.00
142_F269_A0.8041.00
162_K166_N0.8041.00
23_I36_F0.8041.00
91_R202_A0.8001.00
159_Q180_D0.7971.00
230_M260_E0.7971.00
309_N313_C0.7951.00
301_V316_E0.7951.00
130_L157_L0.7941.00
261_I265_V0.7931.00
102_S206_H0.7931.00
162_K182_D0.7921.00
237_T242_R0.7891.00
210_M234_L0.7851.00
139_M225_A0.7851.00
95_L188_V0.7761.00
205_R240_H0.7670.99
64_S77_G0.7650.99
59_H63_L0.7610.99
150_K215_E0.7610.99
121_L153_T0.7600.99
57_I94_T0.7590.99
53_C57_I0.7580.99
116_I121_L0.7580.99
314_I317_A0.7560.99
26_V188_V0.7540.99
145_P148_S0.7510.99
9_K13_E0.7480.99
52_E55_R0.7470.99
312_Q315_Q0.7460.99
208_P233_H0.7440.99
311_Q315_Q0.7430.99
284_G305_L0.7410.99
278_C310_L0.7370.99
140_L266_I0.7350.99
319_G324_Y0.7350.99
97_T100_E0.7320.99
48_M52_E0.7280.99
54_V101_E0.7280.99
306_Y311_Q0.7240.99
272_R282_E0.7210.99
217_R240_H0.7200.99
22_D104_V0.7200.99
329_L333_I0.7200.99
58_S70_E0.7190.99
133_L160_Y0.7170.99
16_Y107_V0.7120.99
277_A281_C0.7090.99
180_D183_V0.7080.99
141_I216_I0.7020.99
39_D281_C0.7010.99
106_R240_H0.6950.99
34_I48_M0.6920.99
26_V182_D0.6910.99
211_I233_H0.6910.99
301_V304_L0.6890.99
177_E240_H0.6890.99
215_E238_S0.6880.99
205_R215_E0.6880.99
158_V236_L0.6870.99
76_N91_R0.6860.99
218_D221_T0.6860.99
299_A302_Y0.6830.99
132_F326_Y0.6830.99
251_L261_I0.6810.99
214_G240_H0.6810.99
25_I103_L0.6800.99
338_A341_Y0.6790.99
106_R177_E0.6780.99
177_E215_E0.6760.99
172_L188_V0.6740.99
303_E306_Y0.6740.99
64_S71_R0.6710.99
176_V187_Q0.6680.99
93_S104_V0.6680.99
138_G266_I0.6640.98
63_L79_L0.6640.98
21_S104_V0.6610.98
39_D278_C0.6610.98
76_N202_A0.6600.98
14_E36_F0.6580.98
48_M53_C0.6540.98
106_R215_E0.6530.98
334_R337_I0.6530.98
276_L280_F0.6510.98
161_A167_R0.6510.98
95_L104_V0.6510.98
146_T231_T0.6500.98
53_C103_L0.6440.98
310_L317_A0.6440.98
298_R302_Y0.6430.98
113_I159_Q0.6430.98
330_R334_R0.6420.98
79_L92_M0.6400.98
216_I224_I0.6400.98
227_R250_R0.6390.98
115_S156_S0.6380.98
243_D270_A0.6380.98
170_V184_L0.6360.98
88_V109_P0.6360.98
163_K167_R0.6330.98
61_K77_G0.6330.98
23_I34_I0.6320.98
19_K109_P0.6310.98
25_I34_I0.6300.98
241_T244_A0.6290.98
159_Q162_K0.6280.98
212_I236_L0.6280.98
244_A270_A0.6270.98
51_E55_R0.6250.98
139_M266_I0.6250.98
292_Q295_N0.6230.98
140_L269_A0.6230.98
276_L341_Y0.6220.98
18_T45_K0.6180.98
327_Q335_K0.6180.98
87_N110_Q0.6160.98
217_R238_S0.6150.97
166_N185_Q0.6140.97
123_P126_G0.6100.97
27_P100_E0.6100.97
18_T36_F0.6090.97
293_S296_T0.6080.97
137_H242_R0.6070.97
39_D275_D0.6050.97
130_L134_K0.6030.97
331_Q335_K0.6020.97
146_T240_H0.6010.97
327_Q333_I0.5980.97
42_L207_D0.5980.97
226_V230_M0.5960.97
283_N341_Y0.5940.97
281_C285_C0.5940.97
146_T209_D0.5940.97
230_M264_T0.5940.97
233_H250_R0.5940.97
252_L340_G0.5930.97
128_T294_R0.5930.97
213_L225_A0.5930.97
78_S89_H0.5900.97
335_K338_A0.5890.97
304_L307_G0.5870.97
80_T87_N0.5870.97
174_D217_R0.5840.97
76_N201_K0.5840.97
95_L202_A0.5820.97
329_L334_R0.5820.97
196_Y237_T0.5800.96
60_F77_G0.5790.96
133_L267_A0.5790.96
224_I228_A0.5770.96
124_K127_A0.5750.96
113_I127_A0.5740.96
302_Y305_L0.5740.96
295_N317_A0.5740.96
116_I126_G0.5710.96
18_T314_I0.5710.96
144_G232_G0.5710.96
268_I327_Q0.5700.96
109_P112_N0.5700.96
75_Q78_S0.5690.96
293_S297_R0.5690.96
312_Q318_K0.5690.96
67_D72_R0.5650.96
216_I254_F0.5650.96
214_G232_G0.5640.96
277_A308_K0.5630.96
157_L160_Y0.5630.96
78_S98_I0.5630.96
253_E260_E0.5620.96
335_K341_Y0.5620.96
317_A328_T0.5610.96
152_T178_T0.5610.96
292_Q332_I0.5590.96
56_L59_H0.5570.96
243_D272_R0.5560.95
134_K165_F0.5560.95
13_E87_N0.5540.95
170_V208_P0.5530.95
190_E195_T0.5510.95
35_H42_L0.5510.95
228_A235_V0.5510.95
137_H243_D0.5500.95
257_N260_E0.5490.95
93_S202_A0.5490.95
91_R175_P0.5490.95
279_P284_G0.5480.95
121_L129_L0.5480.95
50_K101_E0.5470.95
313_C317_A0.5470.95
216_I251_L0.5460.95
246_G249_Y0.5460.95
146_T215_E0.5440.95
285_C336_G0.5440.95
213_L224_I0.5440.95
116_I157_L0.5440.95
131_S160_Y0.5420.95
177_E214_G0.5390.95
22_D147_G0.5390.95
202_A206_H0.5390.95
274_V333_I0.5360.95
205_R214_G0.5350.94
139_M265_V0.5340.94
61_K94_T0.5340.94
175_P271_Q0.5330.94
119_L156_S0.5330.94
141_I268_I0.5320.94
144_G214_G0.5310.94
65_A75_Q0.5310.94
197_S218_D0.5280.94
194_V199_G0.5280.94
313_C316_E0.5280.94
95_L206_H0.5270.94
69_G72_R0.5270.94
102_S186_V0.5260.94
305_L308_K0.5260.94
298_R305_L0.5260.94
336_G339_L0.5230.94
73_K198_A0.5190.94
20_A23_I0.5180.93
96_P101_E0.5160.93
282_E285_C0.5140.93
97_T102_S0.5140.93
245_K249_Y0.5130.93
302_Y306_Y0.5130.93
156_S160_Y0.5130.93
248_I337_I0.5120.93
322_A331_Q0.5120.93
76_N79_L0.5110.93
280_F311_Q0.5110.93
281_C284_G0.5110.93
300_S304_L0.5090.93
132_F266_I0.5080.93
132_F269_A0.5080.93
145_P242_R0.5080.93
77_G94_T0.5060.93
295_N298_R0.5050.93
227_R257_N0.5040.93
161_A169_I0.5030.92
309_N317_A0.5030.92
68_I75_Q0.5020.92
86_G111_Y0.5010.92
177_E205_R0.5010.92
22_D106_R0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4phtA 1 0.9691 100 0.265 Contact Map
4ksrA 3 0.9579 100 0.275 Contact Map
1p9rA 1 0.9691 100 0.307 Contact Map
2ewvA 3 0.9185 100 0.376 Contact Map
3jvvA 3 0.9157 100 0.403 Contact Map
2oap1 3 0.9635 100 0.445 Contact Map
4ihqA 3 0.9719 100 0.472 Contact Map
2gzaA 3 0.7949 100 0.553 Contact Map
2eyuA 1 0.6489 100 0.577 Contact Map
4bloA 4 0.7051 99.9 0.691 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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