COMGA - BACSU - GREMLIN Contacts

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COMGA - ComG operon protein 1

UniProt:	P25953	Sequences: MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLKKRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEESLVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQYAKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRDAETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDLACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIRKGIALGYLTTNNYDRWVYHEKD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	356 (318)
Sequences:	9331 (5610)
Seq/√Len:	314.6

ECOLI - GSPE HOFB YGGR
BACSU - COMGA
HALSA - Q9HQY3 Q9HR79
SULSO - Q97WB7 Q97VE6 Q7LXX6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
132_F	267_A	3.459	1.00
277_A	307_G	3.398	1.00
129_L	157_L	3.324	1.00
135_H	266_I	3.179	1.00
170_V	203_I	3.161	1.00
57_I	103_L	2.997	1.00
172_L	199_G	2.993	1.00
335_K	339_L	2.902	1.00
130_L	160_Y	2.898	1.00
141_I	237_T	2.875	1.00
102_S	168_N	2.859	1.00
143_T	239_L	2.795	1.00
243_D	246_G	2.724	1.00
115_S	118_K	2.705	1.00
36_F	45_K	2.473	1.00
282_E	305_L	2.465	1.00
283_N	308_K	2.442	1.00
167_R	210_M	2.421	1.00
20_A	38_V	2.331	1.00
14_E	18_T	2.281	1.00
93_S	206_H	2.239	1.00
163_K	183_V	2.228	1.00
98_I	176_V	2.211	1.00
24_H	207_D	2.173	1.00
195_T	198_A	2.149	1.00
336_G	341_Y	2.145	1.00
41_A	275_D	2.126	1.00
133_L	157_L	2.080	1.00
153_T	271_Q	2.034	1.00
15_A	20_A	2.005	1.00
117_D	130_L	2.003	1.00
146_T	208_P	1.991	1.00
284_G	303_E	1.983	1.00
41_A	166_N	1.912	1.00
154_L	236_L	1.892	1.00
280_F	312_Q	1.890	1.00
126_G	130_L	1.888	1.00
33_I	44_K	1.883	1.00
278_C	281_C	1.871	1.00
90_L	105_I	1.801	1.00
112_N	118_K	1.796	1.00
285_C	306_Y	1.786	1.00
38_V	43_L	1.781	1.00
283_N	306_Y	1.772	1.00
142_F	153_T	1.766	1.00
216_I	237_T	1.746	1.00
285_C	304_L	1.730	1.00
49_K	52_E	1.725	1.00
13_E	17_L	1.716	1.00
11_L	23_I	1.708	1.00
37_R	207_D	1.702	1.00
108_M	178_T	1.697	1.00
216_I	225_A	1.684	1.00
201_K	218_D	1.681	1.00
277_A	282_E	1.670	1.00
163_K	166_N	1.661	1.00
329_L	337_I	1.656	1.00
95_L	186_V	1.638	1.00
140_L	234_L	1.638	1.00
252_L	258_M	1.633	1.00
86_G	109_P	1.622	1.00
90_L	107_V	1.598	1.00
211_I	228_A	1.580	1.00
219_A	223_E	1.555	1.00
62_F	65_A	1.553	1.00
297_R	302_Y	1.551	1.00
102_S	184_L	1.551	1.00
143_T	270_A	1.544	1.00
124_K	128_T	1.538	1.00
146_T	233_H	1.537	1.00
8_S	60_F	1.518	1.00
92_M	105_I	1.517	1.00
131_S	328_T	1.515	1.00
122_F	125_T	1.512	1.00
54_V	58_S	1.509	1.00
310_L	313_C	1.508	1.00
269_A	326_Y	1.504	1.00
44_K	47_D	1.497	1.00
332_I	335_K	1.479	1.00
200_L	224_I	1.468	1.00
12_I	16_Y	1.464	1.00
216_I	222_A	1.459	1.00
19_K	318_K	1.457	1.00
15_A	23_I	1.453	1.00
172_L	203_I	1.448	1.00
143_T	241_T	1.448	1.00
125_T	324_Y	1.444	1.00
57_I	101_E	1.440	1.00
154_L	212_I	1.432	1.00
159_Q	163_K	1.426	1.00
134_K	160_Y	1.417	1.00
222_A	254_F	1.407	1.00
248_I	265_V	1.394	1.00
292_Q	327_Q	1.376	1.00
8_S	56_L	1.367	1.00
140_L	267_A	1.364	1.00
125_T	326_Y	1.358	1.00
189_N	192_A	1.347	1.00
159_Q	183_V	1.331	1.00
158_V	212_I	1.320	1.00
276_L	281_C	1.309	1.00
132_F	140_L	1.296	1.00
131_S	135_H	1.270	1.00
69_G	101_E	1.260	1.00
148_S	271_Q	1.255	1.00
161_A	210_M	1.253	1.00
137_H	266_I	1.247	1.00
245_K	327_Q	1.245	1.00
97_T	184_L	1.238	1.00
74_P	202_A	1.234	1.00
35_H	44_K	1.232	1.00
162_K	169_I	1.226	1.00
66_M	94_T	1.222	1.00
139_M	235_V	1.216	1.00
73_K	192_A	1.210	1.00
142_F	154_L	1.196	1.00
215_E	240_H	1.190	1.00
265_V	268_I	1.188	1.00
18_T	43_L	1.185	1.00
94_T	103_L	1.174	1.00
117_D	126_G	1.170	1.00
239_L	247_A	1.169	1.00
19_K	39_D	1.162	1.00
301_V	313_C	1.159	1.00
39_D	276_L	1.155	1.00
227_R	253_E	1.150	1.00
24_H	37_R	1.142	1.00
143_T	247_A	1.137	1.00
24_H	42_L	1.132	1.00
167_R	185_Q	1.130	1.00
223_E	227_R	1.125	1.00
116_I	130_L	1.119	1.00
20_A	36_F	1.113	1.00
114_P	118_K	1.107	1.00
12_I	90_L	1.104	1.00
14_E	17_L	1.104	1.00
64_S	92_M	1.096	1.00
186_V	203_I	1.090	1.00
19_K	38_V	1.088	1.00
203_I	211_I	1.088	1.00
50_K	54_V	1.086	1.00
246_G	263_Q	1.086	1.00
68_I	72_R	1.079	1.00
145_P	272_R	1.073	1.00
99_N	187_Q	1.071	1.00
11_L	34_I	1.064	1.00
15_A	36_F	1.063	1.00
199_G	203_I	1.060	1.00
58_S	66_M	1.058	1.00
334_R	338_A	1.049	1.00
298_R	301_V	1.048	1.00
229_A	235_V	1.048	1.00
125_T	128_T	1.045	1.00
151_T	178_T	1.036	1.00
327_Q	332_I	1.034	1.00
241_T	247_A	1.028	1.00
116_I	156_S	1.024	1.00
272_R	329_L	1.023	1.00
201_K	220_E	1.021	1.00
292_Q	296_T	1.021	1.00
141_I	239_L	1.015	1.00
73_K	96_P	1.012	1.00
102_S	170_V	1.009	1.00
279_P	282_E	1.006	1.00
16_Y	90_L	1.006	1.00
222_A	251_L	1.003	1.00
226_V	256_I	1.000	1.00
281_C	313_C	0.998	1.00
61_K	75_Q	0.998	1.00
222_A	256_I	0.994	1.00
123_P	127_A	0.994	1.00
280_F	318_K	0.994	1.00
50_K	53_C	0.992	1.00
79_L	90_L	0.992	1.00
28_R	33_I	0.988	1.00
303_E	307_G	0.986	1.00
231_T	250_R	0.985	1.00
60_F	92_M	0.983	1.00
127_A	131_S	0.982	1.00
44_K	165_F	0.972	1.00
205_R	217_R	0.969	1.00
331_Q	334_R	0.965	1.00
15_A	107_V	0.963	1.00
112_N	115_S	0.963	1.00
61_K	101_E	0.962	1.00
37_R	209_D	0.957	1.00
14_E	45_K	0.952	1.00
247_A	268_I	0.946	1.00
117_D	123_P	0.935	1.00
252_L	261_I	0.934	1.00
278_C	313_C	0.920	1.00
16_Y	88_V	0.916	1.00
67_D	70_E	0.914	1.00
196_Y	213_L	0.911	1.00
204_L	228_A	0.909	1.00
88_V	107_V	0.904	1.00
18_T	38_V	0.902	1.00
295_N	301_V	0.899	1.00
332_I	336_G	0.893	1.00
300_S	303_E	0.889	1.00
67_D	71_R	0.888	1.00
309_N	312_Q	0.887	1.00
284_G	292_Q	0.887	1.00
328_T	331_Q	0.886	1.00
316_E	319_G	0.884	1.00
128_T	131_S	0.880	1.00
227_R	230_M	0.877	1.00
23_I	107_V	0.876	1.00
14_E	46_R	0.873	1.00
25_I	53_C	0.868	1.00
131_S	134_K	0.867	1.00
98_I	179_R	0.863	1.00
10_N	14_E	0.861	1.00
117_D	160_Y	0.858	1.00
150_K	240_H	0.858	1.00
322_A	335_K	0.857	1.00
197_S	220_E	0.856	1.00
26_V	35_H	0.850	1.00
92_M	103_L	0.846	1.00
24_H	104_V	0.844	1.00
277_A	305_L	0.841	1.00
161_A	236_L	0.841	1.00
125_T	269_A	0.840	1.00
121_L	324_Y	0.838	1.00
128_T	328_T	0.835	1.00
281_C	310_L	0.830	1.00
11_L	25_I	0.822	1.00
195_T	220_E	0.818	1.00
117_D	127_A	0.818	1.00
140_L	236_L	0.813	1.00
166_N	184_L	0.811	1.00
76_N	93_S	0.810	1.00
170_V	186_V	0.808	1.00
142_F	269_A	0.804	1.00
162_K	166_N	0.804	1.00
23_I	36_F	0.804	1.00
91_R	202_A	0.800	1.00
159_Q	180_D	0.797	1.00
230_M	260_E	0.797	1.00
309_N	313_C	0.795	1.00
301_V	316_E	0.795	1.00
130_L	157_L	0.794	1.00
261_I	265_V	0.793	1.00
102_S	206_H	0.793	1.00
162_K	182_D	0.792	1.00
237_T	242_R	0.789	1.00
210_M	234_L	0.785	1.00
139_M	225_A	0.785	1.00
95_L	188_V	0.776	1.00
205_R	240_H	0.767	0.99
64_S	77_G	0.765	0.99
59_H	63_L	0.761	0.99
150_K	215_E	0.761	0.99
121_L	153_T	0.760	0.99
57_I	94_T	0.759	0.99
53_C	57_I	0.758	0.99
116_I	121_L	0.758	0.99
314_I	317_A	0.756	0.99
26_V	188_V	0.754	0.99
145_P	148_S	0.751	0.99
9_K	13_E	0.748	0.99
52_E	55_R	0.747	0.99
312_Q	315_Q	0.746	0.99
208_P	233_H	0.744	0.99
311_Q	315_Q	0.743	0.99
284_G	305_L	0.741	0.99
278_C	310_L	0.737	0.99
140_L	266_I	0.735	0.99
319_G	324_Y	0.735	0.99
97_T	100_E	0.732	0.99
48_M	52_E	0.728	0.99
54_V	101_E	0.728	0.99
306_Y	311_Q	0.724	0.99
272_R	282_E	0.721	0.99
217_R	240_H	0.720	0.99
22_D	104_V	0.720	0.99
329_L	333_I	0.720	0.99
58_S	70_E	0.719	0.99
133_L	160_Y	0.717	0.99
16_Y	107_V	0.712	0.99
277_A	281_C	0.709	0.99
180_D	183_V	0.708	0.99
141_I	216_I	0.702	0.99
39_D	281_C	0.701	0.99
106_R	240_H	0.695	0.99
34_I	48_M	0.692	0.99
26_V	182_D	0.691	0.99
211_I	233_H	0.691	0.99
301_V	304_L	0.689	0.99
177_E	240_H	0.689	0.99
215_E	238_S	0.688	0.99
205_R	215_E	0.688	0.99
158_V	236_L	0.687	0.99
76_N	91_R	0.686	0.99
218_D	221_T	0.686	0.99
299_A	302_Y	0.683	0.99
132_F	326_Y	0.683	0.99
251_L	261_I	0.681	0.99
214_G	240_H	0.681	0.99
25_I	103_L	0.680	0.99
338_A	341_Y	0.679	0.99
106_R	177_E	0.678	0.99
177_E	215_E	0.676	0.99
172_L	188_V	0.674	0.99
303_E	306_Y	0.674	0.99
64_S	71_R	0.671	0.99
176_V	187_Q	0.668	0.99
93_S	104_V	0.668	0.99
138_G	266_I	0.664	0.98
63_L	79_L	0.664	0.98
21_S	104_V	0.661	0.98
39_D	278_C	0.661	0.98
76_N	202_A	0.660	0.98
14_E	36_F	0.658	0.98
48_M	53_C	0.654	0.98
106_R	215_E	0.653	0.98
334_R	337_I	0.653	0.98
276_L	280_F	0.651	0.98
161_A	167_R	0.651	0.98
95_L	104_V	0.651	0.98
146_T	231_T	0.650	0.98
53_C	103_L	0.644	0.98
310_L	317_A	0.644	0.98
298_R	302_Y	0.643	0.98
113_I	159_Q	0.643	0.98
330_R	334_R	0.642	0.98
79_L	92_M	0.640	0.98
216_I	224_I	0.640	0.98
227_R	250_R	0.639	0.98
115_S	156_S	0.638	0.98
243_D	270_A	0.638	0.98
170_V	184_L	0.636	0.98
88_V	109_P	0.636	0.98
163_K	167_R	0.633	0.98
61_K	77_G	0.633	0.98
23_I	34_I	0.632	0.98
19_K	109_P	0.631	0.98
25_I	34_I	0.630	0.98
241_T	244_A	0.629	0.98
159_Q	162_K	0.628	0.98
212_I	236_L	0.628	0.98
244_A	270_A	0.627	0.98
51_E	55_R	0.625	0.98
139_M	266_I	0.625	0.98
292_Q	295_N	0.623	0.98
140_L	269_A	0.623	0.98
276_L	341_Y	0.622	0.98
18_T	45_K	0.618	0.98
327_Q	335_K	0.618	0.98
87_N	110_Q	0.616	0.98
217_R	238_S	0.615	0.97
166_N	185_Q	0.614	0.97
123_P	126_G	0.610	0.97
27_P	100_E	0.610	0.97
18_T	36_F	0.609	0.97
293_S	296_T	0.608	0.97
137_H	242_R	0.607	0.97
39_D	275_D	0.605	0.97
130_L	134_K	0.603	0.97
331_Q	335_K	0.602	0.97
146_T	240_H	0.601	0.97
327_Q	333_I	0.598	0.97
42_L	207_D	0.598	0.97
226_V	230_M	0.596	0.97
283_N	341_Y	0.594	0.97
281_C	285_C	0.594	0.97
146_T	209_D	0.594	0.97
230_M	264_T	0.594	0.97
233_H	250_R	0.594	0.97
252_L	340_G	0.593	0.97
128_T	294_R	0.593	0.97
213_L	225_A	0.593	0.97
78_S	89_H	0.590	0.97
335_K	338_A	0.589	0.97
304_L	307_G	0.587	0.97
80_T	87_N	0.587	0.97
174_D	217_R	0.584	0.97
76_N	201_K	0.584	0.97
95_L	202_A	0.582	0.97
329_L	334_R	0.582	0.97
196_Y	237_T	0.580	0.96
60_F	77_G	0.579	0.96
133_L	267_A	0.579	0.96
224_I	228_A	0.577	0.96
124_K	127_A	0.575	0.96
113_I	127_A	0.574	0.96
302_Y	305_L	0.574	0.96
295_N	317_A	0.574	0.96
116_I	126_G	0.571	0.96
18_T	314_I	0.571	0.96
144_G	232_G	0.571	0.96
268_I	327_Q	0.570	0.96
109_P	112_N	0.570	0.96
75_Q	78_S	0.569	0.96
293_S	297_R	0.569	0.96
312_Q	318_K	0.569	0.96
67_D	72_R	0.565	0.96
216_I	254_F	0.565	0.96
214_G	232_G	0.564	0.96
277_A	308_K	0.563	0.96
157_L	160_Y	0.563	0.96
78_S	98_I	0.563	0.96
253_E	260_E	0.562	0.96
335_K	341_Y	0.562	0.96
317_A	328_T	0.561	0.96
152_T	178_T	0.561	0.96
292_Q	332_I	0.559	0.96
56_L	59_H	0.557	0.96
243_D	272_R	0.556	0.95
134_K	165_F	0.556	0.95
13_E	87_N	0.554	0.95
170_V	208_P	0.553	0.95
190_E	195_T	0.551	0.95
35_H	42_L	0.551	0.95
228_A	235_V	0.551	0.95
137_H	243_D	0.550	0.95
257_N	260_E	0.549	0.95
93_S	202_A	0.549	0.95
91_R	175_P	0.549	0.95
279_P	284_G	0.548	0.95
121_L	129_L	0.548	0.95
50_K	101_E	0.547	0.95
313_C	317_A	0.547	0.95
216_I	251_L	0.546	0.95
246_G	249_Y	0.546	0.95
146_T	215_E	0.544	0.95
285_C	336_G	0.544	0.95
213_L	224_I	0.544	0.95
116_I	157_L	0.544	0.95
131_S	160_Y	0.542	0.95
177_E	214_G	0.539	0.95
22_D	147_G	0.539	0.95
202_A	206_H	0.539	0.95
274_V	333_I	0.536	0.95
205_R	214_G	0.535	0.94
139_M	265_V	0.534	0.94
61_K	94_T	0.534	0.94
175_P	271_Q	0.533	0.94
119_L	156_S	0.533	0.94
141_I	268_I	0.532	0.94
144_G	214_G	0.531	0.94
65_A	75_Q	0.531	0.94
197_S	218_D	0.528	0.94
194_V	199_G	0.528	0.94
313_C	316_E	0.528	0.94
95_L	206_H	0.527	0.94
69_G	72_R	0.527	0.94
102_S	186_V	0.526	0.94
305_L	308_K	0.526	0.94
298_R	305_L	0.526	0.94
336_G	339_L	0.523	0.94
73_K	198_A	0.519	0.94
20_A	23_I	0.518	0.93
96_P	101_E	0.516	0.93
282_E	285_C	0.514	0.93
97_T	102_S	0.514	0.93
245_K	249_Y	0.513	0.93
302_Y	306_Y	0.513	0.93
156_S	160_Y	0.513	0.93
248_I	337_I	0.512	0.93
322_A	331_Q	0.512	0.93
76_N	79_L	0.511	0.93
280_F	311_Q	0.511	0.93
281_C	284_G	0.511	0.93
300_S	304_L	0.509	0.93
132_F	266_I	0.508	0.93
132_F	269_A	0.508	0.93
145_P	242_R	0.508	0.93
77_G	94_T	0.506	0.93
295_N	298_R	0.505	0.93
227_R	257_N	0.504	0.93
161_A	169_I	0.503	0.92
309_N	317_A	0.503	0.92
68_I	75_Q	0.502	0.92
86_G	111_Y	0.501	0.92
177_E	205_R	0.501	0.92
22_D	106_R	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4phtA	1	0.9691	100	0.265	Contact Map
4ksrA	3	0.9579	100	0.275	Contact Map
1p9rA	1	0.9691	100	0.307	Contact Map
2ewvA	3	0.9185	100	0.376	Contact Map
3jvvA	3	0.9157	100	0.403	Contact Map
2oap1	3	0.9635	100	0.445	Contact Map
4ihqA	3	0.9719	100	0.472	Contact Map
2gzaA	3	0.7949	100	0.553	Contact Map
2eyuA	1	0.6489	100	0.577	Contact Map
4bloA	4	0.7051	99.9	0.691	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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