GREMLIN Database
RSMG - Ribosomal RNA small subunit methyltransferase G
UniProt: P25813 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 239 (203)
Sequences: 3148 (2290)
Seq/√Len: 160.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_E216_R3.4811.00
106_I123_F2.8971.00
102_L105_R2.7851.00
74_C144_V2.6321.00
74_C99_V2.6211.00
126_D130_T2.5951.00
35_W38_K2.4041.00
27_L115_A2.3591.00
88_K120_N2.3131.00
84_S98_I2.3081.00
76_V159_C2.3031.00
113_S121_T2.2671.00
160_L193_G2.2621.00
31_M115_A2.2571.00
59_I90_C2.1461.00
72_T95_H2.1261.00
113_S123_F2.1201.00
46_E49_E2.1071.00
178_E182_N2.0981.00
193_G215_I2.0181.00
95_H122_T1.9961.00
29_Y50_V1.8681.00
35_W39_I1.8671.00
142_D164_K1.8461.00
97_T141_Y1.8441.00
18_S21_Q1.8251.00
62_A91_F1.7891.00
151_R183_A1.7591.00
78_A98_I1.7521.00
168_L216_R1.7221.00
159_C169_F1.7211.00
97_T124_C1.7021.00
99_V131_F1.7011.00
17_L90_C1.6931.00
31_M112_L1.6781.00
27_L30_D1.6681.00
20_R24_Q1.6621.00
28_Y85_L1.6561.00
21_Q24_Q1.6441.00
95_H120_N1.6331.00
31_M111_K1.6321.00
110_E123_F1.6271.00
26_E30_D1.6241.00
73_I96_V1.6051.00
74_C162_L1.5951.00
146_A155_L1.5381.00
188_I193_G1.5371.00
60_T201_F1.4961.00
168_L214_V1.4831.00
35_W111_K1.4661.00
194_E216_R1.4651.00
199_H214_V1.4481.00
111_K115_A1.4311.00
144_V163_V1.4101.00
100_D125_H1.4041.00
25_F86_P1.3931.00
61_A172_L1.3881.00
107_T110_E1.3881.00
32_L50_V1.3861.00
152_L171_A1.3761.00
100_D106_I1.3761.00
150_A154_V1.3311.00
61_A145_T1.3251.00
151_R154_V1.3101.00
177_A211_N1.3051.00
70_V93_H1.2971.00
163_V167_G1.2871.00
91_F94_L1.2711.00
103_N107_T1.2701.00
108_F112_L1.2491.00
200_S209_D1.2431.00
78_A84_S1.2351.00
98_I109_L1.2171.00
74_C141_Y1.2151.00
21_Q89_I1.2031.00
88_K121_T1.1861.00
87_I96_V1.1861.00
173_K180_E1.1701.00
174_A177_A1.1681.00
29_Y33_V1.1681.00
198_I213_M1.1641.00
186_K190_T1.1591.00
23_E27_L1.1481.00
29_Y55_F1.1441.00
111_K114_E1.1321.00
31_M35_W1.1321.00
194_E218_I1.1251.00
110_E114_E1.1181.00
98_I121_T1.1091.00
64_Y199_H1.1051.00
24_Q92_P1.0860.99
28_Y109_L1.0840.99
11_A16_S1.0810.99
156_S188_I1.0800.99
106_I125_H1.0710.99
73_I94_L1.0710.99
33_V47_K1.0710.99
10_L17_L1.0580.99
88_K96_V1.0530.99
71_N143_I1.0510.99
168_L196_E1.0510.99
195_L213_M1.0510.99
10_L15_I1.0390.99
106_I110_E1.0370.99
20_R23_E1.0330.99
44_I53_K1.0200.99
100_D123_F1.0130.99
182_N185_K1.0060.99
73_I145_T1.0030.99
28_Y82_F1.0010.99
197_N214_V0.9940.99
33_V50_V0.9850.99
32_L42_T0.9770.99
44_I49_E0.9690.99
200_S211_N0.9620.99
150_A155_L0.9600.99
126_D131_F0.9580.99
52_L206_E0.9570.99
198_I211_N0.9530.99
51_Y56_Y0.9510.99
26_E51_Y0.9430.99
39_I111_K0.9400.99
143_I170_V0.9250.98
105_R109_L0.9200.98
103_N125_H0.9190.98
24_Q89_I0.9190.98
31_M34_E0.9190.98
80_A108_F0.9130.98
179_E183_A0.9120.98
62_A87_I0.8990.98
149_V155_L0.8950.98
55_F82_F0.8910.98
132_G162_L0.8890.98
131_F141_Y0.8880.98
28_Y108_F0.8810.98
160_L215_I0.8800.98
131_F162_L0.8780.98
52_L205_I0.8780.98
78_A109_L0.8740.98
71_N93_H0.8730.98
85_L121_T0.8730.98
101_S127_R0.8670.97
34_E38_K0.8490.97
178_E200_S0.8480.97
22_L26_E0.8390.97
58_S86_P0.8320.97
176_S179_E0.8250.97
177_A213_M0.8240.97
19_P23_E0.8200.96
41_L80_A0.8200.96
175_A209_D0.8190.96
34_E37_E0.8040.96
152_L215_I0.8010.96
70_V143_I0.8010.96
154_V157_E0.8000.96
110_E113_S0.7850.95
49_E53_K0.7830.95
152_L180_E0.7790.95
201_F212_I0.7740.95
128_A162_L0.7720.95
113_S118_L0.7690.95
66_D71_N0.7690.95
52_L56_Y0.7670.95
60_T172_L0.7650.95
29_Y47_K0.7650.95
132_G138_R0.7610.95
76_V99_V0.7600.95
73_I143_I0.7570.95
153_S183_A0.7570.95
26_E47_K0.7550.94
156_S191_L0.7530.94
32_L55_F0.7520.94
160_L169_F0.7440.94
126_D162_L0.7430.94
185_K189_T0.7420.94
80_A105_R0.7410.94
25_F90_C0.7340.94
153_S157_E0.7330.94
170_V212_I0.7320.93
72_T97_T0.7310.93
88_K94_L0.7310.93
133_Q139_E0.7290.93
69_Q93_H0.7260.93
28_Y112_L0.7250.93
138_R157_E0.7200.93
156_S215_I0.7200.93
99_V126_D0.7190.93
87_I145_T0.7170.93
40_N104_K0.7130.93
72_T140_S0.7130.93
195_L215_I0.7110.92
211_N214_V0.7100.92
37_E104_K0.7090.92
160_L163_V0.7080.92
18_S24_Q0.7080.92
96_V120_N0.7070.92
145_T172_L0.6990.92
57_D210_R0.6930.92
203_L210_R0.6890.91
177_A181_L0.6860.91
30_D33_V0.6850.91
45_T50_V0.6800.91
144_V159_C0.6700.90
170_V214_V0.6660.90
152_L173_K0.6650.90
153_S187_A0.6640.90
85_L113_S0.6630.90
71_N94_L0.6610.89
106_I109_L0.6590.89
153_S184_G0.6580.89
99_V102_L0.6550.89
109_L123_F0.6550.89
58_S82_F0.6500.89
25_F55_F0.6500.89
174_A211_N0.6490.89
78_A106_I0.6490.89
27_L31_M0.6400.88
109_L113_S0.6400.88
132_G139_E0.6370.88
64_Y212_I0.6340.87
74_C100_D0.6310.87
118_L121_T0.6310.87
53_K208_S0.6250.87
66_D91_F0.6240.87
202_K208_S0.6230.87
139_E165_K0.6230.87
72_T142_D0.6180.86
76_V144_V0.6150.86
156_S193_G0.6140.86
35_W108_F0.6110.85
101_S125_H0.6100.85
28_Y89_I0.6070.85
55_F86_P0.6070.85
196_E199_H0.6060.85
61_A65_V0.6050.85
165_K168_L0.6040.85
164_K167_G0.6030.85
12_E202_K0.6020.85
52_L203_L0.6000.84
188_I215_I0.6000.84
20_R117_Q0.6000.84
43_S54_H0.6000.84
85_L118_L0.6000.84
105_R125_H0.5970.84
156_S160_L0.5960.84
195_L198_I0.5950.84
160_L188_I0.5950.84
44_I54_H0.5940.84
42_T50_V0.5940.84
202_K209_D0.5930.84
71_N91_F0.5930.84
204_P208_S0.5890.83
25_F82_F0.5880.83
47_K51_Y0.5780.82
150_A158_L0.5780.82
205_I208_S0.5780.82
66_D69_Q0.5750.82
63_F199_H0.5730.82
10_L22_L0.5710.81
58_S172_L0.5700.81
13_K60_T0.5690.81
101_S105_R0.5680.81
10_L59_I0.5670.81
156_S184_G0.5660.81
18_S90_C0.5630.81
184_G188_I0.5570.80
179_E182_N0.5560.80
152_L213_M0.5550.80
102_L109_L0.5550.80
157_E187_A0.5550.80
133_Q138_R0.5530.79
76_V128_A0.5520.79
94_L170_V0.5510.79
84_S112_L0.5500.79
100_D109_L0.5490.79
203_L206_E0.5480.79
128_A149_V0.5460.79
31_M108_F0.5460.79
146_A159_C0.5410.78
24_Q27_L0.5400.78
74_C145_T0.5330.77
110_E122_T0.5310.77
89_I118_L0.5300.76
160_L217_K0.5240.76
17_L21_Q0.5240.76
39_I80_A0.5210.75
202_K207_E0.5200.75
157_E191_L0.5200.75
50_V55_F0.5190.75
13_K63_F0.5190.75
65_V168_L0.5180.75
35_W107_T0.5140.74
89_I116_L0.5130.74
175_A211_N0.5110.74
109_L145_T0.5110.74
61_A87_I0.5100.74
38_K111_K0.5100.74
148_A174_A0.5080.73
55_F88_K0.5070.73
62_A90_C0.5060.73
128_A158_L0.5040.73
107_T111_K0.5040.73
21_Q90_C0.5000.72
32_L80_A0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xdzA 1 0.9916 100 0.542 Contact Map
3g89A 1 0.9498 100 0.562 Contact Map
1jsxA 1 0.8075 99.9 0.683 Contact Map
4pwyA 2 0.8954 99.8 0.747 Contact Map
3hp7A 1 0.9749 99.7 0.765 Contact Map
2b3tA 1 0.8452 99.6 0.775 Contact Map
4p7cA 1 0.9498 99.6 0.776 Contact Map
3ocjA 1 0.8787 99.5 0.789 Contact Map
2gpyA 2 0.7824 99.5 0.796 Contact Map
3bwcA 2 0.9791 99.5 0.797 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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