GREMLIN Database
MNME - tRNA modification GTPase MnmE
UniProt: P25811 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 459 (442)
Sequences: 4718 (3527)
Seq/√Len: 167.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_I70_S4.7411.00
17_A95_V4.0321.00
289_I292_E4.0171.00
25_E28_Q3.7881.00
29_I107_A3.4021.00
78_F116_T3.1661.00
251_D285_I3.1271.00
128_S157_S3.0301.00
5_A99_L3.0151.00
240_S368_I2.9971.00
267_R376_Q2.8591.00
46_E49_T2.8531.00
21_L30_A2.6911.00
305_L375_I2.6861.00
367_G370_D2.6341.00
374_A377_S2.6141.00
206_E405_K2.5981.00
180_Y457_L2.5651.00
335_N362_L2.5371.00
305_L333_I2.4901.00
356_P374_A2.4051.00
5_A102_A2.3761.00
202_K405_K2.3431.00
35_K56_V2.3181.00
307_V335_N2.2831.00
27_I71_V2.2681.00
70_S87_N2.2671.00
202_K409_E2.2621.00
252_I284_D2.2511.00
80_R124_R2.2381.00
21_L102_A2.1721.00
195_V416_E2.1641.00
10_P14_G2.1581.00
52_Y66_E2.1331.00
58_R61_D2.1201.00
199_T412_L2.0991.00
310_Y334_L2.0961.00
205_I401_L2.0911.00
62_R146_N2.0761.00
227_I298_L2.0591.00
34_Y53_G2.0491.00
222_L379_F2.0491.00
101_L105_E2.0331.00
282_T291_V2.0311.00
296_Q300_E2.0171.00
399_T403_Q2.0151.00
202_K412_L1.9871.00
3_T25_E1.9541.00
259_V274_V1.9401.00
240_S365_E1.9041.00
333_I358_V1.8901.00
116_T133_V1.8871.00
166_E197_K1.8771.00
161_R441_D1.8731.00
3_T26_A1.8571.00
26_A84_I1.8281.00
18_I87_N1.8241.00
450_Q454_Q1.8141.00
405_K409_E1.8131.00
295_R324_A1.7861.00
166_E204_E1.7681.00
111_E117_K1.7531.00
136_L145_M1.7501.00
292_E296_Q1.7431.00
316_E319_V1.7321.00
78_F133_V1.7261.00
50_I68_M1.7131.00
159_L204_E1.7031.00
54_H63_V1.7011.00
134_M138_R1.6831.00
187_E190_T1.6741.00
68_M72_L1.6701.00
225_V301_A1.6571.00
67_V86_I1.6501.00
303_L375_I1.6491.00
202_K408_I1.6471.00
166_E200_A1.6431.00
32_K105_E1.6391.00
403_Q437_E1.6161.00
319_V323_E1.6141.00
195_V412_L1.6041.00
337_T359_T1.6001.00
373_E377_S1.5991.00
269_V380_Y1.5861.00
164_R168_L1.5841.00
55_I67_V1.5841.00
77_T80_R1.5841.00
288_R292_E1.5841.00
145_M149_M1.5761.00
407_A430_R1.5761.00
246_K262_E1.5751.00
142_D145_M1.5631.00
250_T286_V1.5471.00
206_E210_R1.5311.00
26_A30_A1.5271.00
238_L247_A1.5251.00
285_I288_R1.5231.00
403_Q434_L1.4961.00
93_V145_M1.4851.00
7_I95_V1.4671.00
407_A427_D1.4591.00
103_L109_L1.4571.00
21_L86_I1.4551.00
206_E409_E1.4531.00
224_T271_L1.4461.00
310_Y337_T1.4371.00
117_K121_L1.4351.00
309_N312_E1.4291.00
172_A450_Q1.4081.00
243_H372_E1.4081.00
57_D62_R1.3981.00
223_S272_R1.3961.00
259_V297_V1.3801.00
202_K206_E1.3801.00
30_A84_I1.3771.00
413_S417_Q1.3701.00
242_V246_K1.3701.00
337_T366_E1.3641.00
58_R101_L1.3591.00
157_S161_R1.3541.00
45_V71_V1.3501.00
3_T29_I1.3481.00
411_A424_V1.3401.00
74_A82_D1.3381.00
434_L437_E1.3351.00
334_L359_T1.3271.00
331_I374_A1.3221.00
230_P253_P1.3211.00
267_R373_E1.3111.00
398_I402_Q1.3091.00
410_D413_S1.2971.00
297_V300_E1.2961.00
310_Y340_E1.2921.00
410_D427_D1.2871.00
198_A408_I1.2831.00
414_G427_D1.2811.00
161_R165_S1.2781.00
135_D219_R1.2771.00
56_V63_V1.2741.00
75_P82_D1.2721.00
165_S450_Q1.2671.00
409_E412_L1.2641.00
334_L357_V1.2641.00
187_E191_H1.2461.00
125_I133_V1.2441.00
176_V180_Y1.2421.00
308_L332_V1.2421.00
265_N268_G1.2411.00
252_I285_I1.2361.00
236_S362_L1.2351.00
396_R400_I1.2311.00
392_V401_L1.2291.00
358_V374_A1.2251.00
240_S362_L1.2241.00
5_A103_L1.2231.00
165_S169_E1.2201.00
293_R297_V1.2171.00
296_Q299_K1.2131.00
47_S73_K1.2131.00
178_I183_Y1.2101.00
400_I434_L1.2101.00
263_Y270_P1.2071.00
286_V289_I1.2031.00
229_R315_S1.2011.00
27_I73_K1.1931.00
141_T265_N1.1921.00
364_K367_G1.1841.00
395_T399_T1.1821.00
303_L331_I1.1821.00
126_D130_A1.1811.00
282_T285_I1.1811.00
331_I375_I1.1801.00
265_N270_P1.1801.00
30_A69_V1.1681.00
263_Y272_R1.1621.00
47_S71_V1.1591.00
102_A107_A1.1581.00
26_A29_I1.1541.00
74_A80_R1.1501.00
127_L131_E1.1461.00
73_K82_D1.1441.00
64_V101_L1.1411.00
101_L104_R1.1411.00
28_Q32_K1.1411.00
312_E315_S1.1381.00
133_V137_I1.1371.00
62_R97_Q1.1221.00
394_N397_H1.1161.00
57_D104_R1.1131.00
407_A410_D1.1071.00
7_I17_A1.1061.00
72_L77_T1.1021.00
132_A136_L1.1011.00
97_Q142_D1.1001.00
67_V70_S1.0971.00
28_Q31_D1.0951.00
248_I289_I1.0911.00
142_D146_N1.0891.00
86_I98_V1.0871.00
108_R111_E1.0861.00
229_R318_D1.0831.00
147_V151_Q1.0831.00
45_V51_H1.0821.00
317_E320_K1.0821.00
325_V330_V1.0811.00
162_R166_E1.0791.00
36_G53_G1.0771.00
131_E396_R1.0721.00
229_R317_E1.0671.00
5_A21_L1.0630.99
29_I102_A1.0610.99
158_A162_R1.0610.99
15_A83_V1.0600.99
130_A133_V1.0550.99
447_L451_L1.0540.99
93_V97_Q1.0510.99
399_T402_Q1.0500.99
179_D182_E1.0440.99
180_Y183_Y1.0430.99
141_T144_A1.0380.99
311_S339_L1.0380.99
271_L375_I1.0370.99
57_D101_L1.0300.99
3_T24_P1.0290.99
125_I129_Q1.0280.99
310_Y341_P1.0220.99
316_E320_K1.0190.99
80_R125_I1.0180.99
224_T273_L1.0170.99
95_V98_V1.0170.99
88_C98_V1.0120.99
306_L332_V1.0060.99
175_E429_T1.0050.99
7_I99_L1.0030.99
151_Q393_S1.0010.99
224_T303_L1.0000.99
120_F127_L0.9920.99
395_T398_I0.9860.99
129_Q133_V0.9860.99
15_A18_I0.9860.99
115_F119_A0.9850.99
190_T193_I0.9840.99
143_R146_N0.9810.99
436_G440_G0.9790.99
120_F124_R0.9790.99
241_L368_I0.9770.99
116_T120_F0.9710.99
171_L432_W0.9630.99
123_G127_L0.9620.99
129_Q132_A0.9610.99
148_A152_M0.9590.99
185_D190_T0.9580.99
406_R410_D0.9580.99
374_A378_L0.9560.99
110_A114_E0.9510.99
289_I293_R0.9490.99
285_I289_I0.9480.99
175_E182_E0.9450.99
137_I141_T0.9440.99
198_A411_A0.9430.99
33_I102_A0.9410.99
436_G442_S0.9380.99
261_E297_V0.9310.99
390_T393_S0.9260.99
100_Q395_T0.9260.99
160_V435_L0.9110.98
193_I197_K0.9110.98
56_V61_D0.9100.98
150_N155_R0.9090.98
8_S16_I0.9080.98
360_T363_L0.8950.98
131_E135_D0.8910.98
175_E179_D0.8910.98
229_R232_V0.8910.98
282_T288_R0.8870.98
236_S360_T0.8840.98
216_K244_E0.8840.98
175_E178_I0.8830.98
183_Y186_V0.8830.98
185_D189_M0.8820.98
320_K324_A0.8820.98
242_V262_E0.8760.98
140_K144_A0.8730.98
298_L304_I0.8700.98
115_F118_R0.8680.98
426_I432_W0.8680.98
19_V99_L0.8670.98
100_Q142_D0.8660.98
203_K206_E0.8660.98
27_I31_D0.8650.98
37_P45_V0.8640.98
179_D186_V0.8570.98
405_K408_I0.8480.97
90_G94_T0.8480.97
333_I371_L0.8470.97
128_S132_A0.8470.97
159_L163_L0.8460.97
97_Q101_L0.8430.97
155_R159_L0.8430.97
113_G116_T0.8430.97
124_R128_S0.8420.97
205_I404_A0.8420.97
98_V102_A0.8410.97
123_G126_D0.8390.97
209_L402_Q0.8300.97
205_I408_I0.8290.97
264_V273_L0.8260.97
162_R204_E0.8260.97
274_V297_V0.8250.97
174_V425_Q0.8240.97
169_E454_Q0.8210.97
122_N126_D0.8190.97
115_F137_I0.8160.97
124_R127_L0.8160.97
91_G98_V0.8140.97
91_G95_V0.8140.97
195_V199_T0.8090.97
223_S297_V0.8090.97
118_R122_N0.8080.97
175_E451_L0.8070.97
196_E199_T0.8060.97
155_R158_A0.8060.97
108_R113_G0.8050.97
130_A134_M0.8030.96
114_E118_R0.8030.96
252_I286_V0.8020.96
333_I360_T0.8010.96
80_R122_N0.8010.96
406_R409_E0.8000.96
136_L149_M0.8000.96
320_K323_E0.8000.96
410_D430_R0.7980.96
126_D154_G0.7950.96
25_E29_I0.7910.96
223_S300_E0.7900.96
173_H177_N0.7900.96
266_V372_E0.7890.96
306_L322_F0.7890.96
193_I196_E0.7890.96
154_G157_S0.7880.96
323_E453_S0.7870.96
411_A428_L0.7840.96
173_H176_V0.7820.96
237_L307_V0.7820.96
135_D394_N0.7820.96
409_E413_S0.7820.96
393_S397_H0.7800.96
371_L375_I0.7800.96
114_E119_A0.7790.96
146_N150_N0.7790.96
271_L379_F0.7780.96
72_L83_V0.7760.96
141_T148_A0.7760.96
108_R112_P0.7750.96
199_T202_K0.7700.96
113_G118_R0.7700.96
238_L260_I0.7700.96
407_A434_L0.7670.95
370_D374_A0.7650.95
91_G96_N0.7650.95
260_I294_S0.7640.95
141_T149_M0.7640.95
158_A161_R0.7620.95
48_H51_H0.7620.95
135_D139_A0.7610.95
163_L201_V0.7600.95
71_V74_A0.7600.95
308_L334_L0.7590.95
26_A83_V0.7580.95
85_E90_G0.7550.95
307_V360_T0.7540.95
133_V136_L0.7530.95
197_K200_A0.7530.95
120_F126_D0.7520.95
331_I358_V0.7500.95
96_N100_Q0.7500.95
186_V193_I0.7480.95
169_E450_Q0.7460.95
412_L416_E0.7440.95
33_I36_G0.7410.95
67_V88_C0.7410.95
113_G126_D0.7390.94
401_L404_A0.7370.94
187_E192_Q0.7370.94
110_A118_R0.7350.94
177_N181_P0.7340.94
189_M192_Q0.7320.94
238_L246_K0.7310.94
323_E326_E0.7310.94
113_G117_K0.7280.94
109_L113_G0.7260.94
261_E272_R0.7250.94
69_V86_I0.7210.94
123_G131_E0.7200.94
308_L343_I0.7200.94
11_M14_G0.7190.94
229_R312_E0.7190.94
294_S297_V0.7180.94
19_V98_V0.7160.93
116_T130_A0.7160.93
27_I30_A0.7150.93
144_A148_A0.7150.93
125_I130_A0.7100.93
151_Q156_L0.7080.93
31_D45_V0.7080.93
21_L26_A0.7060.93
131_E139_A0.7050.93
363_L366_E0.7040.93
408_I431_C0.7030.93
369_N372_E0.7030.93
196_E200_A0.7030.93
120_F137_I0.7030.93
410_D414_G0.7020.93
90_G99_L0.7010.93
241_L372_E0.6950.92
58_R104_R0.6900.92
151_Q397_H0.6890.92
16_I68_M0.6850.92
426_I429_T0.6840.92
127_L135_D0.6830.92
130_A137_I0.6790.92
366_E370_D0.6780.92
164_R432_W0.6770.91
153_E158_A0.6760.91
7_I19_V0.6760.91
307_V362_L0.6740.91
225_V297_V0.6720.91
186_V191_H0.6690.91
111_E115_F0.6680.91
8_S83_V0.6670.91
287_E290_G0.6670.91
172_A175_E0.6660.91
362_L365_E0.6660.91
86_I90_G0.6650.91
104_R402_Q0.6640.91
430_R434_L0.6640.91
227_I304_I0.6640.91
123_G130_A0.6630.91
175_E181_P0.6630.91
329_D378_L0.6630.91
293_R296_Q0.6580.90
111_E114_E0.6580.90
121_L124_R0.6570.90
110_A119_A0.6570.90
209_L398_I0.6550.90
132_A151_Q0.6540.90
236_S240_S0.6530.90
313_E342_K0.6510.90
198_A202_K0.6500.90
48_H52_Y0.6490.90
159_L162_R0.6490.90
139_A148_A0.6480.90
70_S77_T0.6480.90
156_L160_V0.6470.90
100_Q104_R0.6460.89
315_S318_D0.6460.89
365_E368_I0.6440.89
127_L139_A0.6440.89
116_T122_N0.6430.89
46_E51_H0.6430.89
226_I294_S0.6420.89
172_A176_V0.6410.89
201_V208_L0.6410.89
114_E122_N0.6410.89
120_F123_G0.6400.89
314_L318_D0.6400.89
141_T145_M0.6400.89
226_I238_L0.6400.89
5_A107_A0.6390.89
82_D90_G0.6370.89
77_T81_E0.6360.89
21_L107_A0.6340.89
160_V163_L0.6340.89
74_A77_T0.6340.89
247_A260_I0.6340.89
110_A116_T0.6330.88
141_T270_P0.6330.88
360_T368_I0.6320.88
268_G373_E0.6320.88
192_Q196_E0.6320.88
163_L167_I0.6290.88
164_R167_I0.6290.88
185_D191_H0.6290.88
345_T359_T0.6280.88
227_I306_L0.6280.88
115_F126_D0.6270.88
166_E169_E0.6270.88
318_D321_L0.6250.88
113_G120_F0.6250.88
136_L140_K0.6240.88
225_V274_V0.6220.88
420_P423_M0.6220.88
127_L137_I0.6210.88
402_Q405_K0.6210.88
171_L425_Q0.6200.87
75_P79_T0.6190.87
90_G113_G0.6170.87
139_A143_R0.6160.87
411_A414_G0.6150.87
115_F127_L0.6140.87
108_R118_R0.6140.87
75_P83_V0.6130.87
150_N154_G0.6120.87
115_F120_F0.6120.87
283_E288_R0.6110.87
127_L132_A0.6100.87
368_I372_E0.6090.87
118_R124_R0.6080.86
154_G158_A0.6050.86
143_R147_V0.6050.86
397_H438_I0.6030.86
303_L379_F0.6020.86
232_V279_I0.6010.86
442_S446_S0.6000.86
48_H76_R0.5990.86
8_S15_A0.5980.86
286_V293_R0.5980.86
5_A19_V0.5960.85
226_I307_V0.5960.85
192_Q195_V0.5950.85
403_Q406_R0.5950.85
405_K412_L0.5940.85
116_T123_G0.5930.85
456_C459_K0.5920.85
55_I101_L0.5920.85
124_R129_Q0.5910.85
433_E442_S0.5890.85
54_H66_E0.5890.85
52_Y67_V0.5880.85
267_R372_E0.5870.84
50_I87_N0.5870.84
393_S398_I0.5860.84
113_G119_A0.5860.84
174_V179_D0.5850.84
132_A137_I0.5840.84
108_R114_E0.5830.84
119_A123_G0.5800.84
81_E89_H0.5800.84
439_I442_S0.5790.84
118_R127_L0.5780.84
266_V269_V0.5770.83
202_K205_I0.5770.83
118_R126_D0.5760.83
103_L106_G0.5760.83
153_E157_S0.5760.83
171_L175_E0.5750.83
86_I89_H0.5750.83
72_L124_R0.5720.83
99_L102_A0.5710.83
170_T181_P0.5700.83
75_P80_R0.5700.83
132_A135_D0.5690.83
359_T370_D0.5690.83
119_A131_E0.5690.83
85_E113_G0.5670.82
148_A151_Q0.5650.82
223_S274_V0.5650.82
89_H94_T0.5650.82
294_S298_L0.5650.82
33_I55_I0.5640.82
85_E130_A0.5640.82
191_H194_L0.5630.82
171_L428_L0.5630.82
304_I330_V0.5600.82
91_G94_T0.5570.81
201_V205_I0.5560.81
241_L264_V0.5560.81
126_D129_Q0.5560.81
75_P81_E0.5560.81
110_A115_F0.5540.81
426_I430_R0.5530.81
9_T12_G0.5520.81
85_E89_H0.5520.81
110_A122_N0.5520.81
115_F124_R0.5510.81
321_L325_V0.5510.81
111_E437_E0.5500.80
126_D137_I0.5500.80
304_I328_M0.5490.80
210_R213_E0.5480.80
177_N185_D0.5480.80
148_A154_G0.5470.80
211_T214_Q0.5460.80
243_H365_E0.5440.80
356_P378_L0.5440.80
89_H127_L0.5430.80
167_I428_L0.5430.80
225_V294_S0.5430.80
34_Y69_V0.5430.80
299_K328_M0.5420.80
203_K207_T0.5420.80
87_N91_G0.5410.79
89_H108_R0.5410.79
35_K61_D0.5400.79
15_A21_L0.5400.79
132_A148_A0.5400.79
128_S133_V0.5380.79
167_I431_C0.5380.79
162_R165_S0.5370.79
114_E124_R0.5370.79
113_G121_L0.5360.79
174_V178_I0.5350.79
120_F131_E0.5330.78
218_L270_P0.5330.78
143_R149_M0.5320.78
340_E344_D0.5310.78
110_A126_D0.5310.78
81_E91_G0.5310.78
72_L79_T0.5300.78
34_Y55_I0.5280.78
149_M153_E0.5280.78
344_D359_T0.5270.78
79_T82_D0.5260.77
306_L325_V0.5260.77
370_D373_E0.5260.77
171_L178_I0.5260.77
89_H99_L0.5240.77
22_S81_E0.5240.77
45_V49_T0.5230.77
383_A386_S0.5230.77
110_A113_G0.5230.77
21_L84_I0.5220.77
176_V181_P0.5220.77
291_V295_R0.5220.77
80_R90_G0.5210.77
113_G137_I0.5200.77
31_D37_P0.5190.77
21_L29_I0.5180.76
122_N128_S0.5170.76
87_N90_G0.5170.76
178_I182_E0.5160.76
246_K259_V0.5160.76
91_G99_L0.5150.76
115_F123_G0.5150.76
89_H110_A0.5150.76
332_V357_V0.5150.76
200_A203_K0.5150.76
169_E197_K0.5140.76
90_G119_A0.5140.76
392_V398_I0.5140.76
455_F458_G0.5130.76
176_V183_Y0.5130.76
306_L321_L0.5120.76
229_R321_L0.5120.76
237_L360_T0.5120.76
25_E32_K0.5110.75
443_V448_I0.5100.75
118_R131_E0.5070.75
432_W439_I0.5070.75
141_T146_N0.5060.75
318_D324_A0.5060.75
127_L130_A0.5060.75
103_L107_A0.5060.75
279_I295_R0.5050.75
433_E441_D0.5050.75
16_I87_N0.5050.75
30_A45_V0.5040.74
119_A122_N0.5030.74
145_M148_A0.5030.74
64_V97_Q0.5030.74
440_G451_L0.5010.74
48_H71_V0.5000.74
358_V371_L0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gehA 2 0.9455 100 0.174 Contact Map
1xzpA 4 0.976 100 0.179 Contact Map
3geeA 2 0.9063 100 0.183 Contact Map
3j4jA 1 0.6558 100 0.716 Contact Map
3j65o 1 0.695 100 0.723 Contact Map
4kjzA 1 0.6318 100 0.727 Contact Map
4b43A 1 0.6253 100 0.733 Contact Map
2qtfA 1 0.6187 100 0.743 Contact Map
2e87A 1 0.7146 100 0.744 Contact Map
3wbiA 1 0.4662 100 0.746 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0128 seconds.