GREMLIN Database
HRCA - Heat-inducible transcription repressor HrcA
UniProt: P25499 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 343 (335)
Sequences: 2347 (1643)
Seq/√Len: 89.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_T62_S7.5561.00
27_R31_K6.1471.00
27_R48_D5.7941.00
13_I46_M5.5331.00
3_T6_Q4.8041.00
13_I55_I4.2011.00
75_V280_I4.1701.00
188_V196_R3.7201.00
79_L323_V3.1531.00
143_Q146_M3.0041.00
37_F41_T2.9221.00
311_I322_V2.8991.00
31_K48_D2.8781.00
72_R76_D2.8331.00
133_Y154_N2.7401.00
16_D32_K2.7151.00
72_R283_E2.6201.00
170_D173_D2.5731.00
127_P299_Y2.5261.00
294_L312_I2.5261.00
188_V192_E2.4941.00
27_R30_S2.4571.00
21_A244_P2.4501.00
6_Q45_E2.4191.00
278_I323_V2.4141.00
7_L73_Y2.3891.00
248_D251_R2.3821.00
120_Y317_M2.3171.00
251_R291_N2.3151.00
68_E282_K2.2621.00
56_E67_S2.2571.00
54_F73_Y2.2111.00
313_G317_M2.1871.00
21_A246_F2.1841.00
279_K284_N2.1531.00
145_D168_K2.1371.00
30_S42_I2.1171.00
175_E179_N2.0581.00
189_P192_E2.0381.00
178_V182_N2.0251.00
141_P171_L1.9421.00
16_D33_D1.9361.00
245_E316_R1.9281.00
88_D321_R1.9271.00
242_N253_R1.9251.00
134_L190_M1.8501.00
73_Y77_H1.8221.00
18_I71_Y1.7921.00
243_Q246_F1.7761.00
8_L11_Q1.7661.00
295_I317_M1.7601.00
55_I70_G1.7341.00
85_T88_D1.7311.00
54_F69_K1.7311.00
41_T44_N1.7241.00
139_I174_I1.7161.00
327_Q331_S1.7161.00
4_N8_L1.7041.00
2_L6_Q1.6671.00
179_N183_D1.6411.00
280_I284_N1.6401.00
31_K51_E1.6161.00
296_T310_A1.6051.00
21_A243_Q1.5851.00
21_A245_E1.5611.00
280_I283_E1.5591.00
89_L93_H1.5521.00
293_S315_T1.5291.00
146_M164_N1.5131.00
295_I312_I1.5111.00
234_F237_K1.4971.00
72_R75_V1.4901.00
147_A165_F1.4771.00
121_T240_M1.4570.99
172_S179_N1.4440.99
46_M239_N1.4300.99
112_Q261_K1.4220.99
309_I333_L1.4030.99
71_Y315_T1.4020.99
55_I231_K1.4020.99
17_F21_A1.3920.99
33_D37_F1.3870.99
25_G28_T1.3690.99
121_T322_V1.3490.99
70_G78_L1.3400.99
144_P168_K1.3230.99
84_L88_D1.3110.99
184_R200_E1.3110.99
214_N218_A1.3040.99
141_P144_P1.2900.99
139_I178_V1.2870.99
2_L152_V1.2840.99
330_T334_S1.2780.99
8_L35_I1.2700.99
147_A174_I1.2660.99
27_R51_E1.2640.98
6_Q74_Y1.2620.98
57_K237_K1.2570.98
106_T333_L1.2550.98
171_L175_E1.2450.98
287_E290_E1.2420.98
145_D167_T1.2390.98
255_L269_V1.2390.98
321_R325_L1.2250.98
289_M292_C1.2200.98
89_L92_I1.2140.98
299_Y307_G1.1950.98
147_A178_V1.1860.98
120_Y318_N1.1790.98
18_I21_A1.1760.98
219_L223_F1.1740.98
295_I326_L1.1700.97
62_S229_V1.1570.97
239_N242_N1.1530.97
27_R46_M1.1440.97
18_I308_S1.1390.97
22_Q328_H1.1310.97
58_T316_R1.1300.97
4_N7_L1.1210.97
21_A316_R1.1180.97
136_Q152_V1.1140.97
20_S24_V1.0900.96
121_T259_I1.0900.96
284_N315_T1.0670.96
58_T65_V1.0630.96
12_V33_D1.0510.95
30_S48_D1.0500.95
54_F70_G1.0480.95
18_I153_T1.0470.95
37_F45_E1.0450.95
54_F57_K1.0440.95
30_S39_S1.0420.95
78_L323_V1.0380.95
146_M162_T1.0370.95
120_Y322_V1.0370.95
241_L307_G1.0280.95
195_E203_M1.0220.95
52_L56_E1.0170.94
180_I201_V1.0140.94
10_L14_I1.0100.94
167_T173_D1.0080.94
241_L253_R1.0070.94
232_L265_V1.0010.94
93_H328_H0.9950.94
210_K214_N0.9950.94
12_V29_L0.9940.94
6_Q52_L0.9930.94
27_R42_I0.9910.94
87_S90_D0.9890.94
96_F110_S0.9890.94
176_K179_N0.9830.93
126_G233_F0.9780.93
91_Q267_K0.9770.93
208_H212_Y0.9720.93
72_R280_I0.9690.93
104_E126_G0.9650.93
295_I322_V0.9640.93
144_P170_D0.9570.92
289_M333_L0.9560.92
284_N293_S0.9490.92
68_E315_T0.9490.92
50_E57_K0.9460.92
29_L42_I0.9450.92
12_V22_Q0.9430.92
106_T215_I0.9360.92
132_N155_T0.9180.91
16_D20_S0.9170.91
114_L330_T0.9160.91
33_D36_T0.9100.90
30_S37_F0.9100.90
9_I13_I0.9080.90
138_Q178_V0.9050.90
158_V161_K0.9020.90
198_F202_V0.8970.90
144_P151_L0.8900.89
23_P236_G0.8880.89
114_L127_P0.8850.89
165_F169_M0.8840.89
246_F316_R0.8810.89
136_Q269_V0.8800.89
94_S150_I0.8770.89
57_K62_S0.8760.89
223_F252_V0.8750.89
13_I239_N0.8730.88
130_S191_D0.8730.88
41_T45_E0.8690.88
139_I162_T0.8640.88
14_I159_E0.8590.88
8_L34_E0.8590.88
204_Y212_Y0.8580.88
252_V256_L0.8570.87
14_I311_I0.8550.87
150_I336_A0.8540.87
22_Q28_T0.8540.87
246_F292_C0.8510.87
101_F105_K0.8490.87
153_T156_G0.8460.87
23_P72_R0.8410.86
123_I312_I0.8400.86
45_E118_T0.8390.86
18_I32_K0.8370.86
103_L177_L0.8340.86
217_D249_I0.8310.86
132_N289_M0.8280.86
52_L69_K0.8260.85
297_A326_L0.8200.85
57_K74_Y0.8190.85
10_L18_I0.8190.85
188_V197_I0.8190.85
111_A296_T0.8170.85
184_R204_Y0.8120.84
217_D221_S0.8070.84
4_N128_K0.8030.84
9_I42_I0.8020.84
48_D51_E0.8020.84
18_I280_I0.8020.84
26_S43_R0.7990.84
75_V283_E0.7970.83
267_K271_S0.7960.83
65_V157_H0.7940.83
86_K89_L0.7930.83
140_I148_V0.7930.83
11_Q15_N0.7930.83
181_L185_L0.7930.83
272_P303_Q0.7920.83
129_L157_H0.7920.83
254_S257_S0.7870.83
180_I206_R0.7850.82
23_P67_S0.7840.82
300_S303_Q0.7830.82
92_I335_K0.7830.82
295_I311_I0.7830.82
76_D280_I0.7810.82
236_G239_N0.7800.82
114_L299_Y0.7790.82
174_I275_G0.7760.82
75_V284_N0.7670.81
67_S205_L0.7640.81
22_Q57_K0.7640.81
148_V326_L0.7630.81
177_L210_K0.7620.81
156_G260_E0.7590.80
68_E284_N0.7510.80
39_S82_V0.7500.79
209_I213_D0.7500.79
25_G29_L0.7490.79
154_N189_P0.7460.79
244_P316_R0.7440.79
302_D305_Q0.7430.79
137_I218_A0.7420.79
311_I315_T0.7420.79
150_I204_Y0.7400.79
140_I175_E0.7350.78
203_M207_Q0.7330.78
114_L239_N0.7290.78
111_A285_D0.7280.77
139_I147_A0.7270.77
12_V37_F0.7270.77
7_L77_H0.7240.77
103_L302_D0.7240.77
210_K213_D0.7230.77
175_E178_V0.7220.77
13_I67_S0.7220.77
13_I44_N0.7190.77
201_V205_L0.7180.76
32_K51_E0.7180.76
135_K138_Q0.7130.76
162_T190_M0.7120.76
281_G315_T0.7060.75
210_K217_D0.7060.75
28_T31_K0.7050.75
65_V166_P0.7040.75
97_K295_I0.7030.75
151_L190_M0.7030.75
151_L306_I0.7030.75
55_I92_I0.7010.75
63_G66_P0.7000.75
9_I45_E0.6990.75
119_N239_N0.6990.75
147_A171_L0.6980.74
45_E297_A0.6970.74
205_L208_H0.6970.74
108_Q311_I0.6950.74
71_Y245_E0.6950.74
89_L328_H0.6920.74
121_T247_H0.6920.74
143_Q267_K0.6900.74
76_D283_E0.6900.74
27_R52_L0.6890.73
152_V160_N0.6820.73
318_N321_R0.6820.73
173_D176_K0.6820.73
160_N262_E0.6810.73
133_Y189_P0.6800.73
5_R41_T0.6790.72
6_Q57_K0.6770.72
122_S332_D0.6760.72
14_I71_Y0.6730.72
117_L169_M0.6660.71
270_Q312_I0.6620.70
54_F287_E0.6610.70
2_L21_A0.6590.70
57_K67_S0.6570.70
185_L193_L0.6560.70
267_K286_Y0.6560.70
82_V88_D0.6540.70
178_V309_I0.6520.69
118_T122_S0.6520.69
195_E199_K0.6510.69
74_Y161_K0.6510.69
72_R281_G0.6500.69
57_K261_K0.6480.69
295_I337_L0.6440.68
80_S204_Y0.6440.68
44_N187_G0.6430.68
160_N293_S0.6420.68
245_E251_R0.6420.68
68_E240_M0.6410.68
201_V204_Y0.6390.68
37_F175_E0.6380.68
29_L211_N0.6370.68
134_L154_N0.6360.67
225_S229_V0.6360.67
92_I180_I0.6350.67
109_K112_Q0.6330.67
48_D52_L0.6320.67
145_D164_N0.6320.67
113_I327_Q0.6310.67
8_L39_S0.6310.67
131_E191_D0.6290.67
13_I92_I0.6280.66
292_C297_A0.6280.66
231_K262_E0.6260.66
182_N276_I0.6250.66
324_S330_T0.6250.66
141_P153_T0.6240.66
240_M315_T0.6230.66
39_S322_V0.6230.66
115_S303_Q0.6230.66
152_V282_K0.6200.65
271_S308_S0.6200.65
173_D180_I0.6200.65
225_S334_S0.6190.65
25_G47_A0.6190.65
170_D203_M0.6170.65
134_L192_E0.6160.65
80_S287_E0.6140.65
18_I163_I0.6130.65
196_R200_E0.6130.65
110_S129_L0.6120.64
30_S33_D0.6120.64
263_Q267_K0.6110.64
96_F120_Y0.6090.64
111_A120_Y0.6090.64
181_L186_S0.6090.64
280_I299_Y0.6080.64
113_I181_L0.6070.64
257_S289_M0.6060.64
255_L279_K0.6050.64
212_Y216_L0.6040.63
111_A190_M0.6040.63
70_G127_P0.6040.63
106_T136_Q0.6010.63
181_L330_T0.6010.63
139_I254_S0.5990.63
6_Q48_D0.5970.63
153_T190_M0.5970.63
269_V285_D0.5960.62
38_S49_L0.5950.62
114_L326_L0.5950.62
37_F192_E0.5950.62
108_Q228_H0.5950.62
103_L106_T0.5940.62
11_Q257_S0.5930.62
77_H80_S0.5920.62
134_L218_A0.5920.62
106_T224_H0.5910.62
12_V259_I0.5910.62
22_Q46_M0.5890.62
86_K91_Q0.5880.61
107_V244_P0.5880.61
281_G299_Y0.5850.61
29_L35_I0.5840.61
11_Q78_L0.5830.61
88_D215_I0.5810.60
131_E288_E0.5810.60
97_K250_T0.5810.60
7_L148_V0.5780.60
104_E112_Q0.5780.60
20_S185_L0.5770.60
142_I329_V0.5770.60
133_Y142_I0.5770.60
119_N242_N0.5760.60
17_F58_T0.5740.60
110_S296_T0.5730.59
308_S336_A0.5720.59
240_M292_C0.5720.59
192_E203_M0.5710.59
131_E231_K0.5700.59
238_I257_S0.5690.59
180_I205_L0.5690.59
88_D92_I0.5680.59
296_T333_L0.5680.59
75_V193_L0.5670.59
145_D302_D0.5650.58
85_T320_S0.5640.58
72_R127_P0.5630.58
19_K265_V0.5620.58
45_E52_L0.5620.58
286_Y322_V0.5620.58
288_E294_L0.5620.58
277_S292_C0.5610.58
293_S313_G0.5600.58
119_N333_L0.5580.57
45_E122_S0.5580.57
247_H271_S0.5560.57
181_L279_K0.5550.57
13_I22_Q0.5550.57
11_Q70_G0.5540.57
229_V250_T0.5530.57
27_R39_S0.5520.57
189_P196_R0.5510.56
35_I70_G0.5500.56
277_S309_I0.5490.56
315_T320_S0.5480.56
22_Q25_G0.5460.56
101_F109_K0.5450.56
94_S183_D0.5450.56
202_V222_T0.5440.56
93_H321_R0.5440.56
22_Q310_A0.5430.55
173_D207_Q0.5430.55
17_F325_L0.5430.55
150_I159_E0.5420.55
44_N48_D0.5420.55
261_K299_Y0.5420.55
92_I110_S0.5420.55
137_I260_E0.5420.55
86_K228_H0.5420.55
111_A124_V0.5420.55
95_I259_I0.5400.55
56_E65_V0.5390.55
274_T293_S0.5390.55
16_D316_R0.5360.54
195_E202_V0.5350.54
194_N242_N0.5340.54
149_A190_M0.5330.54
232_L240_M0.5330.54
24_V76_D0.5330.54
240_M289_M0.5310.54
36_T117_L0.5310.54
232_L262_E0.5310.54
65_V261_K0.5300.54
71_Y258_L0.5290.53
103_L129_L0.5290.53
295_I313_G0.5290.53
43_R63_G0.5280.53
31_K46_M0.5280.53
238_I301_V0.5270.53
313_G319_Y0.5250.53
134_L219_L0.5240.53
217_D225_S0.5240.53
155_T308_S0.5240.53
93_H97_K0.5230.53
275_G327_Q0.5220.53
172_S175_E0.5210.52
295_I328_H0.5180.52
132_N153_T0.5180.52
322_V326_L0.5170.52
31_K109_K0.5170.52
29_L71_Y0.5170.52
18_I324_S0.5160.52
183_D295_I0.5150.52
140_I337_L0.5120.51
55_I259_I0.5110.51
18_I126_G0.5100.51
190_M213_D0.5090.51
200_E203_M0.5080.51
79_L241_L0.5080.51
238_I338_T0.5080.51
188_V193_L0.5080.51
81_P327_Q0.5070.50
31_K44_N0.5070.50
136_Q182_N0.5070.50
135_K187_G0.5060.50
86_K304_K0.5060.50
30_S135_K0.5050.50
224_H274_T0.5050.50
113_I333_L0.5050.50
18_I182_N0.5050.50
13_I292_C0.5050.50
141_P148_V0.5040.50
17_F20_S0.5030.50
30_S62_S0.5030.50
151_L273_H0.5020.50
137_I320_S0.5020.50
283_E315_T0.5020.50
150_I211_N0.5010.50
15_N147_A0.5010.50
152_V158_V0.5010.50
298_S306_I0.5000.50
60_S136_Q0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.9417 100 0.272 Contact Map
2o0mA 1 0.5714 98.1 0.91 Contact Map
2p8tA 1 0.516 97.9 0.914 Contact Map
2jt1A 1 0.2041 97.5 0.921 Contact Map
4ou0A 1 0.1895 97.4 0.923 Contact Map
1on2A 2 0.379 97.3 0.925 Contact Map
1i1gA 5 0.3965 97.3 0.925 Contact Map
1oyiA 1 0.1778 97 0.928 Contact Map
2x4hA 3 0.3528 96.9 0.928 Contact Map
1okrA 2 0.2682 96.9 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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