HRCA - BACSU - GREMLIN Contacts

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HRCA - Heat-inducible transcription repressor HrcA

UniProt:	P25499	Sequences: MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRNEMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFELEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVENKTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDALRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGISIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLSKALTSLYDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	343 (335)
Sequences:	2347 (1643)
Seq/√Len:	89.8

BACSU - HRCA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
58_T	62_S	7.556	1.00
27_R	31_K	6.147	1.00
27_R	48_D	5.794	1.00
13_I	46_M	5.533	1.00
3_T	6_Q	4.804	1.00
13_I	55_I	4.201	1.00
75_V	280_I	4.170	1.00
188_V	196_R	3.720	1.00
79_L	323_V	3.153	1.00
143_Q	146_M	3.004	1.00
37_F	41_T	2.922	1.00
311_I	322_V	2.899	1.00
31_K	48_D	2.878	1.00
72_R	76_D	2.833	1.00
133_Y	154_N	2.740	1.00
16_D	32_K	2.715	1.00
72_R	283_E	2.620	1.00
170_D	173_D	2.573	1.00
127_P	299_Y	2.526	1.00
294_L	312_I	2.526	1.00
188_V	192_E	2.494	1.00
27_R	30_S	2.457	1.00
21_A	244_P	2.450	1.00
6_Q	45_E	2.419	1.00
278_I	323_V	2.414	1.00
7_L	73_Y	2.389	1.00
248_D	251_R	2.382	1.00
120_Y	317_M	2.317	1.00
251_R	291_N	2.315	1.00
68_E	282_K	2.262	1.00
56_E	67_S	2.257	1.00
54_F	73_Y	2.211	1.00
313_G	317_M	2.187	1.00
21_A	246_F	2.184	1.00
279_K	284_N	2.153	1.00
145_D	168_K	2.137	1.00
30_S	42_I	2.117	1.00
175_E	179_N	2.058	1.00
189_P	192_E	2.038	1.00
178_V	182_N	2.025	1.00
141_P	171_L	1.942	1.00
16_D	33_D	1.936	1.00
245_E	316_R	1.928	1.00
88_D	321_R	1.927	1.00
242_N	253_R	1.925	1.00
134_L	190_M	1.850	1.00
73_Y	77_H	1.822	1.00
18_I	71_Y	1.792	1.00
243_Q	246_F	1.776	1.00
8_L	11_Q	1.766	1.00
295_I	317_M	1.760	1.00
55_I	70_G	1.734	1.00
85_T	88_D	1.731	1.00
54_F	69_K	1.731	1.00
41_T	44_N	1.724	1.00
139_I	174_I	1.716	1.00
327_Q	331_S	1.716	1.00
4_N	8_L	1.704	1.00
2_L	6_Q	1.667	1.00
179_N	183_D	1.641	1.00
280_I	284_N	1.640	1.00
31_K	51_E	1.616	1.00
296_T	310_A	1.605	1.00
21_A	243_Q	1.585	1.00
21_A	245_E	1.561	1.00
280_I	283_E	1.559	1.00
89_L	93_H	1.552	1.00
293_S	315_T	1.529	1.00
146_M	164_N	1.513	1.00
295_I	312_I	1.511	1.00
234_F	237_K	1.497	1.00
72_R	75_V	1.490	1.00
147_A	165_F	1.477	1.00
121_T	240_M	1.457	0.99
172_S	179_N	1.444	0.99
46_M	239_N	1.430	0.99
112_Q	261_K	1.422	0.99
309_I	333_L	1.403	0.99
71_Y	315_T	1.402	0.99
55_I	231_K	1.402	0.99
17_F	21_A	1.392	0.99
33_D	37_F	1.387	0.99
25_G	28_T	1.369	0.99
121_T	322_V	1.349	0.99
70_G	78_L	1.340	0.99
144_P	168_K	1.323	0.99
84_L	88_D	1.311	0.99
184_R	200_E	1.311	0.99
214_N	218_A	1.304	0.99
141_P	144_P	1.290	0.99
139_I	178_V	1.287	0.99
2_L	152_V	1.284	0.99
330_T	334_S	1.278	0.99
8_L	35_I	1.270	0.99
147_A	174_I	1.266	0.99
27_R	51_E	1.264	0.98
6_Q	74_Y	1.262	0.98
57_K	237_K	1.257	0.98
106_T	333_L	1.255	0.98
171_L	175_E	1.245	0.98
287_E	290_E	1.242	0.98
145_D	167_T	1.239	0.98
255_L	269_V	1.239	0.98
321_R	325_L	1.225	0.98
289_M	292_C	1.220	0.98
89_L	92_I	1.214	0.98
299_Y	307_G	1.195	0.98
147_A	178_V	1.186	0.98
120_Y	318_N	1.179	0.98
18_I	21_A	1.176	0.98
219_L	223_F	1.174	0.98
295_I	326_L	1.170	0.97
62_S	229_V	1.157	0.97
239_N	242_N	1.153	0.97
27_R	46_M	1.144	0.97
18_I	308_S	1.139	0.97
22_Q	328_H	1.131	0.97
58_T	316_R	1.130	0.97
4_N	7_L	1.121	0.97
21_A	316_R	1.118	0.97
136_Q	152_V	1.114	0.97
20_S	24_V	1.090	0.96
121_T	259_I	1.090	0.96
284_N	315_T	1.067	0.96
58_T	65_V	1.063	0.96
12_V	33_D	1.051	0.95
30_S	48_D	1.050	0.95
54_F	70_G	1.048	0.95
18_I	153_T	1.047	0.95
37_F	45_E	1.045	0.95
54_F	57_K	1.044	0.95
30_S	39_S	1.042	0.95
78_L	323_V	1.038	0.95
146_M	162_T	1.037	0.95
120_Y	322_V	1.037	0.95
241_L	307_G	1.028	0.95
195_E	203_M	1.022	0.95
52_L	56_E	1.017	0.94
180_I	201_V	1.014	0.94
10_L	14_I	1.010	0.94
167_T	173_D	1.008	0.94
241_L	253_R	1.007	0.94
232_L	265_V	1.001	0.94
93_H	328_H	0.995	0.94
210_K	214_N	0.995	0.94
12_V	29_L	0.994	0.94
6_Q	52_L	0.993	0.94
27_R	42_I	0.991	0.94
87_S	90_D	0.989	0.94
96_F	110_S	0.989	0.94
176_K	179_N	0.983	0.93
126_G	233_F	0.978	0.93
91_Q	267_K	0.977	0.93
208_H	212_Y	0.972	0.93
72_R	280_I	0.969	0.93
104_E	126_G	0.965	0.93
295_I	322_V	0.964	0.93
144_P	170_D	0.957	0.92
289_M	333_L	0.956	0.92
284_N	293_S	0.949	0.92
68_E	315_T	0.949	0.92
50_E	57_K	0.946	0.92
29_L	42_I	0.945	0.92
12_V	22_Q	0.943	0.92
106_T	215_I	0.936	0.92
132_N	155_T	0.918	0.91
16_D	20_S	0.917	0.91
114_L	330_T	0.916	0.91
33_D	36_T	0.910	0.90
30_S	37_F	0.910	0.90
9_I	13_I	0.908	0.90
138_Q	178_V	0.905	0.90
158_V	161_K	0.902	0.90
198_F	202_V	0.897	0.90
144_P	151_L	0.890	0.89
23_P	236_G	0.888	0.89
114_L	127_P	0.885	0.89
165_F	169_M	0.884	0.89
246_F	316_R	0.881	0.89
136_Q	269_V	0.880	0.89
94_S	150_I	0.877	0.89
57_K	62_S	0.876	0.89
223_F	252_V	0.875	0.89
13_I	239_N	0.873	0.88
130_S	191_D	0.873	0.88
41_T	45_E	0.869	0.88
139_I	162_T	0.864	0.88
14_I	159_E	0.859	0.88
8_L	34_E	0.859	0.88
204_Y	212_Y	0.858	0.88
252_V	256_L	0.857	0.87
14_I	311_I	0.855	0.87
150_I	336_A	0.854	0.87
22_Q	28_T	0.854	0.87
246_F	292_C	0.851	0.87
101_F	105_K	0.849	0.87
153_T	156_G	0.846	0.87
23_P	72_R	0.841	0.86
123_I	312_I	0.840	0.86
45_E	118_T	0.839	0.86
18_I	32_K	0.837	0.86
103_L	177_L	0.834	0.86
217_D	249_I	0.831	0.86
132_N	289_M	0.828	0.86
52_L	69_K	0.826	0.85
297_A	326_L	0.820	0.85
57_K	74_Y	0.819	0.85
10_L	18_I	0.819	0.85
188_V	197_I	0.819	0.85
111_A	296_T	0.817	0.85
184_R	204_Y	0.812	0.84
217_D	221_S	0.807	0.84
4_N	128_K	0.803	0.84
9_I	42_I	0.802	0.84
48_D	51_E	0.802	0.84
18_I	280_I	0.802	0.84
26_S	43_R	0.799	0.84
75_V	283_E	0.797	0.83
267_K	271_S	0.796	0.83
65_V	157_H	0.794	0.83
86_K	89_L	0.793	0.83
140_I	148_V	0.793	0.83
11_Q	15_N	0.793	0.83
181_L	185_L	0.793	0.83
272_P	303_Q	0.792	0.83
129_L	157_H	0.792	0.83
254_S	257_S	0.787	0.83
180_I	206_R	0.785	0.82
23_P	67_S	0.784	0.82
300_S	303_Q	0.783	0.82
92_I	335_K	0.783	0.82
295_I	311_I	0.783	0.82
76_D	280_I	0.781	0.82
236_G	239_N	0.780	0.82
114_L	299_Y	0.779	0.82
174_I	275_G	0.776	0.82
75_V	284_N	0.767	0.81
67_S	205_L	0.764	0.81
22_Q	57_K	0.764	0.81
148_V	326_L	0.763	0.81
177_L	210_K	0.762	0.81
156_G	260_E	0.759	0.80
68_E	284_N	0.751	0.80
39_S	82_V	0.750	0.79
209_I	213_D	0.750	0.79
25_G	29_L	0.749	0.79
154_N	189_P	0.746	0.79
244_P	316_R	0.744	0.79
302_D	305_Q	0.743	0.79
137_I	218_A	0.742	0.79
311_I	315_T	0.742	0.79
150_I	204_Y	0.740	0.79
140_I	175_E	0.735	0.78
203_M	207_Q	0.733	0.78
114_L	239_N	0.729	0.78
111_A	285_D	0.728	0.77
139_I	147_A	0.727	0.77
12_V	37_F	0.727	0.77
7_L	77_H	0.724	0.77
103_L	302_D	0.724	0.77
210_K	213_D	0.723	0.77
175_E	178_V	0.722	0.77
13_I	67_S	0.722	0.77
13_I	44_N	0.719	0.77
201_V	205_L	0.718	0.76
32_K	51_E	0.718	0.76
135_K	138_Q	0.713	0.76
162_T	190_M	0.712	0.76
281_G	315_T	0.706	0.75
210_K	217_D	0.706	0.75
28_T	31_K	0.705	0.75
65_V	166_P	0.704	0.75
97_K	295_I	0.703	0.75
151_L	190_M	0.703	0.75
151_L	306_I	0.703	0.75
55_I	92_I	0.701	0.75
63_G	66_P	0.700	0.75
9_I	45_E	0.699	0.75
119_N	239_N	0.699	0.75
147_A	171_L	0.698	0.74
45_E	297_A	0.697	0.74
205_L	208_H	0.697	0.74
108_Q	311_I	0.695	0.74
71_Y	245_E	0.695	0.74
89_L	328_H	0.692	0.74
121_T	247_H	0.692	0.74
143_Q	267_K	0.690	0.74
76_D	283_E	0.690	0.74
27_R	52_L	0.689	0.73
152_V	160_N	0.682	0.73
318_N	321_R	0.682	0.73
173_D	176_K	0.682	0.73
160_N	262_E	0.681	0.73
133_Y	189_P	0.680	0.73
5_R	41_T	0.679	0.72
6_Q	57_K	0.677	0.72
122_S	332_D	0.676	0.72
14_I	71_Y	0.673	0.72
117_L	169_M	0.666	0.71
270_Q	312_I	0.662	0.70
54_F	287_E	0.661	0.70
2_L	21_A	0.659	0.70
57_K	67_S	0.657	0.70
185_L	193_L	0.656	0.70
267_K	286_Y	0.656	0.70
82_V	88_D	0.654	0.70
178_V	309_I	0.652	0.69
118_T	122_S	0.652	0.69
195_E	199_K	0.651	0.69
74_Y	161_K	0.651	0.69
72_R	281_G	0.650	0.69
57_K	261_K	0.648	0.69
295_I	337_L	0.644	0.68
80_S	204_Y	0.644	0.68
44_N	187_G	0.643	0.68
160_N	293_S	0.642	0.68
245_E	251_R	0.642	0.68
68_E	240_M	0.641	0.68
201_V	204_Y	0.639	0.68
37_F	175_E	0.638	0.68
29_L	211_N	0.637	0.68
134_L	154_N	0.636	0.67
225_S	229_V	0.636	0.67
92_I	180_I	0.635	0.67
109_K	112_Q	0.633	0.67
48_D	52_L	0.632	0.67
145_D	164_N	0.632	0.67
113_I	327_Q	0.631	0.67
8_L	39_S	0.631	0.67
131_E	191_D	0.629	0.67
13_I	92_I	0.628	0.66
292_C	297_A	0.628	0.66
231_K	262_E	0.626	0.66
182_N	276_I	0.625	0.66
324_S	330_T	0.625	0.66
141_P	153_T	0.624	0.66
240_M	315_T	0.623	0.66
39_S	322_V	0.623	0.66
115_S	303_Q	0.623	0.66
152_V	282_K	0.620	0.65
271_S	308_S	0.620	0.65
173_D	180_I	0.620	0.65
225_S	334_S	0.619	0.65
25_G	47_A	0.619	0.65
170_D	203_M	0.617	0.65
134_L	192_E	0.616	0.65
80_S	287_E	0.614	0.65
18_I	163_I	0.613	0.65
196_R	200_E	0.613	0.65
110_S	129_L	0.612	0.64
30_S	33_D	0.612	0.64
263_Q	267_K	0.611	0.64
96_F	120_Y	0.609	0.64
111_A	120_Y	0.609	0.64
181_L	186_S	0.609	0.64
280_I	299_Y	0.608	0.64
113_I	181_L	0.607	0.64
257_S	289_M	0.606	0.64
255_L	279_K	0.605	0.64
212_Y	216_L	0.604	0.63
111_A	190_M	0.604	0.63
70_G	127_P	0.604	0.63
106_T	136_Q	0.601	0.63
181_L	330_T	0.601	0.63
139_I	254_S	0.599	0.63
6_Q	48_D	0.597	0.63
153_T	190_M	0.597	0.63
269_V	285_D	0.596	0.62
38_S	49_L	0.595	0.62
114_L	326_L	0.595	0.62
37_F	192_E	0.595	0.62
108_Q	228_H	0.595	0.62
103_L	106_T	0.594	0.62
11_Q	257_S	0.593	0.62
77_H	80_S	0.592	0.62
134_L	218_A	0.592	0.62
106_T	224_H	0.591	0.62
12_V	259_I	0.591	0.62
22_Q	46_M	0.589	0.62
86_K	91_Q	0.588	0.61
107_V	244_P	0.588	0.61
281_G	299_Y	0.585	0.61
29_L	35_I	0.584	0.61
11_Q	78_L	0.583	0.61
88_D	215_I	0.581	0.60
131_E	288_E	0.581	0.60
97_K	250_T	0.581	0.60
7_L	148_V	0.578	0.60
104_E	112_Q	0.578	0.60
20_S	185_L	0.577	0.60
142_I	329_V	0.577	0.60
133_Y	142_I	0.577	0.60
119_N	242_N	0.576	0.60
17_F	58_T	0.574	0.60
110_S	296_T	0.573	0.59
308_S	336_A	0.572	0.59
240_M	292_C	0.572	0.59
192_E	203_M	0.571	0.59
131_E	231_K	0.570	0.59
238_I	257_S	0.569	0.59
180_I	205_L	0.569	0.59
88_D	92_I	0.568	0.59
296_T	333_L	0.568	0.59
75_V	193_L	0.567	0.59
145_D	302_D	0.565	0.58
85_T	320_S	0.564	0.58
72_R	127_P	0.563	0.58
19_K	265_V	0.562	0.58
45_E	52_L	0.562	0.58
286_Y	322_V	0.562	0.58
288_E	294_L	0.562	0.58
277_S	292_C	0.561	0.58
293_S	313_G	0.560	0.58
119_N	333_L	0.558	0.57
45_E	122_S	0.558	0.57
247_H	271_S	0.556	0.57
181_L	279_K	0.555	0.57
13_I	22_Q	0.555	0.57
11_Q	70_G	0.554	0.57
229_V	250_T	0.553	0.57
27_R	39_S	0.552	0.57
189_P	196_R	0.551	0.56
35_I	70_G	0.550	0.56
277_S	309_I	0.549	0.56
315_T	320_S	0.548	0.56
22_Q	25_G	0.546	0.56
101_F	109_K	0.545	0.56
94_S	183_D	0.545	0.56
202_V	222_T	0.544	0.56
93_H	321_R	0.544	0.56
22_Q	310_A	0.543	0.55
173_D	207_Q	0.543	0.55
17_F	325_L	0.543	0.55
150_I	159_E	0.542	0.55
44_N	48_D	0.542	0.55
261_K	299_Y	0.542	0.55
92_I	110_S	0.542	0.55
137_I	260_E	0.542	0.55
86_K	228_H	0.542	0.55
111_A	124_V	0.542	0.55
95_I	259_I	0.540	0.55
56_E	65_V	0.539	0.55
274_T	293_S	0.539	0.55
16_D	316_R	0.536	0.54
195_E	202_V	0.535	0.54
194_N	242_N	0.534	0.54
149_A	190_M	0.533	0.54
232_L	240_M	0.533	0.54
24_V	76_D	0.533	0.54
240_M	289_M	0.531	0.54
36_T	117_L	0.531	0.54
232_L	262_E	0.531	0.54
65_V	261_K	0.530	0.54
71_Y	258_L	0.529	0.53
103_L	129_L	0.529	0.53
295_I	313_G	0.529	0.53
43_R	63_G	0.528	0.53
31_K	46_M	0.528	0.53
238_I	301_V	0.527	0.53
313_G	319_Y	0.525	0.53
134_L	219_L	0.524	0.53
217_D	225_S	0.524	0.53
155_T	308_S	0.524	0.53
93_H	97_K	0.523	0.53
275_G	327_Q	0.522	0.53
172_S	175_E	0.521	0.52
295_I	328_H	0.518	0.52
132_N	153_T	0.518	0.52
322_V	326_L	0.517	0.52
31_K	109_K	0.517	0.52
29_L	71_Y	0.517	0.52
18_I	324_S	0.516	0.52
183_D	295_I	0.515	0.52
140_I	337_L	0.512	0.51
55_I	259_I	0.511	0.51
18_I	126_G	0.510	0.51
190_M	213_D	0.509	0.51
200_E	203_M	0.508	0.51
79_L	241_L	0.508	0.51
238_I	338_T	0.508	0.51
188_V	193_L	0.508	0.51
81_P	327_Q	0.507	0.50
31_K	44_N	0.507	0.50
136_Q	182_N	0.507	0.50
135_K	187_G	0.506	0.50
86_K	304_K	0.506	0.50
30_S	135_K	0.505	0.50
224_H	274_T	0.505	0.50
113_I	333_L	0.505	0.50
18_I	182_N	0.505	0.50
13_I	292_C	0.505	0.50
141_P	148_V	0.504	0.50
17_F	20_S	0.503	0.50
30_S	62_S	0.503	0.50
151_L	273_H	0.502	0.50
137_I	320_S	0.502	0.50
283_E	315_T	0.502	0.50
150_I	211_N	0.501	0.50
15_N	147_A	0.501	0.50
152_V	158_V	0.501	0.50
298_S	306_I	0.500	0.50
60_S	136_Q	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1stzA	3	0.9417	100	0.272	Contact Map
2o0mA	1	0.5714	98.1	0.91	Contact Map
2p8tA	1	0.516	97.9	0.914	Contact Map
2jt1A	1	0.2041	97.5	0.921	Contact Map
4ou0A	1	0.1895	97.4	0.923	Contact Map
1on2A	2	0.379	97.3	0.925	Contact Map
1i1gA	5	0.3965	97.3	0.925	Contact Map
1oyiA	1	0.1778	97	0.928	Contact Map
2x4hA	3	0.3528	96.9	0.928	Contact Map
1okrA	2	0.2682	96.9	0.928	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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