GREMLIN Database
BSAP - Aminopeptidase YwaD
UniProt: P25152 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 455 (400)
Sequences: 4119 (3119)
Seq/√Len: 155.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_S82_K4.1251.00
77_A81_R3.9371.00
399_W404_E3.5971.00
77_A89_V3.5511.00
144_A149_A3.4891.00
80_M290_A3.3881.00
151_I173_V3.3051.00
239_I283_D3.2341.00
128_P147_K3.1221.00
247_V426_V3.1121.00
272_E275_R2.7661.00
126_T216_T2.6791.00
91_R226_T2.6641.00
89_V228_Q2.6571.00
132_A151_I2.6281.00
148_I172_A2.6271.00
318_V429_A2.5341.00
51_T75_L2.4641.00
127_A171_K2.4291.00
248_T319_N2.4201.00
233_I287_R2.3931.00
67_A71_K2.3781.00
305_V379_A2.3271.00
73_A230_I2.2631.00
303_H307_H2.2411.00
124_G218_K2.2181.00
86_D235_K2.2041.00
124_G216_T2.2001.00
69_E292_G2.1891.00
74_L77_A2.1721.00
90_Q308_L2.1431.00
416_Q420_D2.1281.00
237_K283_D2.1101.00
92_F292_G2.0911.00
70_K74_L2.0701.00
270_M290_A2.0681.00
267_T290_A2.0611.00
146_G171_K2.0601.00
163_K167_A2.0581.00
76_I251_Y2.0451.00
149_A170_A2.0201.00
244_I287_R2.0141.00
235_K241_H2.0091.00
244_I285_E1.9981.00
269_V325_V1.9871.00
242_P315_R1.9431.00
243_D284_K1.9241.00
129_L150_L1.9231.00
313_L381_I1.9181.00
69_E251_Y1.9141.00
231_I289_I1.8891.00
74_L78_S1.8531.00
53_S407_I1.8481.00
44_K47_H1.8251.00
52_I264_G1.8201.00
128_P214_E1.7991.00
301_S375_P1.7841.00
174_I201_I1.7781.00
164_N167_A1.7701.00
126_T214_E1.7451.00
164_N168_A1.7301.00
64_A293_A1.7151.00
76_I290_A1.7151.00
269_V419_G1.7051.00
93_N226_T1.6941.00
240_K243_D1.6931.00
130_Y144_A1.6531.00
203_K207_E1.6481.00
172_A217_L1.6411.00
96_D99_E1.6411.00
45_A416_Q1.6291.00
227_S292_G1.6251.00
248_T291_F1.6181.00
291_F319_N1.6061.00
80_M232_G1.5921.00
174_I199_V1.5781.00
49_Y412_K1.5651.00
140_F164_N1.5491.00
78_S82_K1.5471.00
207_E211_Q1.5441.00
305_V375_P1.5421.00
294_E401_H1.5271.00
73_A251_Y1.5261.00
136_Y139_D1.5261.00
77_A87_V1.5201.00
353_T428_E1.5061.00
47_H272_E1.4791.00
185_M189_L1.4721.00
277_L286_I1.4681.00
201_I205_D1.4561.00
249_A267_T1.4481.00
295_E401_H1.4331.00
427_Y431_K1.4311.00
258_P406_S1.4281.00
127_A148_I1.4171.00
233_I285_E1.4121.00
322_L422_V1.4021.00
233_I244_I1.4021.00
262_D401_H1.3981.00
113_A116_G1.3911.00
184_P187_P1.3901.00
262_D294_E1.3841.00
73_A89_V1.3841.00
49_Y53_S1.3821.00
135_G140_F1.3801.00
132_A142_A1.3761.00
117_S120_T1.3761.00
154_G161_K1.3761.00
253_S259_G1.3751.00
83_L232_G1.3681.00
80_M274_A1.3651.00
294_E400_Y1.3531.00
280_V427_Y1.3491.00
184_P189_L1.3491.00
143_D147_K1.3401.00
275_R279_S1.3401.00
205_D208_A1.3401.00
122_E220_K1.3351.00
250_H262_D1.3331.00
140_F165_A1.3311.00
117_S198_V1.3301.00
334_E337_V1.3241.00
91_R228_Q1.3231.00
78_S81_R1.3161.00
70_K228_Q1.3111.00
251_Y290_A1.2931.00
129_L215_A1.2921.00
249_A270_M1.2921.00
282_S286_I1.2921.00
51_T79_S1.2911.00
83_L271_L1.2891.00
304_Y316_S1.2831.00
287_R304_Y1.2811.00
79_S275_R1.2641.00
148_I215_A1.2601.00
86_D233_I1.2591.00
55_L267_T1.2451.00
302_S306_D1.2431.00
313_L379_A1.2431.00
165_A170_A1.2421.00
80_M271_L1.2351.00
144_A170_A1.2281.00
49_Y407_I1.2221.00
90_Q303_H1.2191.00
120_T124_G1.2191.00
250_H294_E1.1931.00
132_A149_A1.1821.00
48_A419_G1.1821.00
72_S251_Y1.1771.00
319_N383_S1.1691.00
246_Y289_I1.1691.00
140_F168_A1.1661.00
349_E352_R1.1601.00
88_K233_I1.1541.00
320_F426_V1.1541.00
263_N321_N1.1531.00
89_V230_I1.1441.00
166_E195_G1.1421.00
37_S41_L1.1201.00
85_L288_F1.1171.00
241_H285_E1.1151.00
63_I66_T1.1131.00
52_I268_S1.1101.00
250_H323_D1.1071.00
309_S312_E1.1020.99
63_I296_L1.1020.99
406_S409_H1.0990.99
286_I430_V1.0960.99
178_N181_S1.0950.99
51_T271_L1.0920.99
277_L288_F1.0910.99
293_A299_L1.0830.99
274_A288_F1.0790.99
333_S337_V1.0720.99
162_A173_V1.0670.99
73_A228_Q1.0670.99
47_H275_R1.0660.99
208_A212_Q1.0650.99
236_P285_E1.0640.99
304_Y310_E1.0630.99
79_S83_L1.0600.99
161_K165_A1.0590.99
129_L174_I1.0400.99
229_N300_G1.0400.99
114_A117_S1.0390.99
101_T218_K1.0350.99
334_E338_N1.0330.99
152_S210_T1.0330.99
90_Q307_H1.0270.99
85_L234_K1.0270.99
51_T272_E1.0260.99
262_D400_Y1.0250.99
303_H306_D1.0240.99
186_T189_L1.0210.99
234_K282_S1.0190.99
97_R100_G1.0150.99
90_Q229_N1.0070.99
129_L209_L1.0060.99
131_N213_K1.0040.99
60_G67_A1.0040.99
236_P284_K1.0010.99
346_Y350_S0.9970.99
261_N324_M0.9950.99
43_F276_V0.9930.99
83_L278_K0.9910.99
295_E400_Y0.9880.99
68_A71_K0.9870.99
137_Q168_A0.9860.99
341_D345_N0.9850.99
186_T190_S0.9830.99
85_L232_G0.9810.99
291_F376_F0.9800.99
107_R208_A0.9780.99
158_Y175_I0.9770.99
273_M426_V0.9730.99
142_A149_A0.9720.99
189_L193_K0.9680.99
247_V270_M0.9660.99
85_L274_A0.9620.99
132_A173_V0.9550.99
332_A337_V0.9440.98
208_A211_Q0.9410.98
187_P190_S0.9400.98
377_H383_S0.9390.98
248_T289_I0.9390.98
231_I287_R0.9310.98
273_M423_T0.9260.98
282_S285_E0.9260.98
174_I215_A0.9190.98
116_G119_P0.9180.98
199_V219_L0.9180.98
399_W409_H0.9180.98
98_L222_F0.9170.98
250_H295_E0.9130.98
131_N152_S0.9110.98
138_K141_T0.9070.98
121_E124_G0.9060.98
250_H401_H0.9050.98
240_K283_D0.9030.98
113_A118_A0.9010.98
219_L223_T0.9010.98
60_G256_F0.8990.98
261_N327_T0.8960.98
50_S53_S0.8960.98
202_K205_D0.8960.98
88_K231_I0.8950.98
352_R356_E0.8910.98
129_L172_A0.8910.98
103_S216_T0.8890.98
319_N376_F0.8870.98
261_N399_W0.8830.98
135_G139_D0.8800.97
45_A49_Y0.8760.97
36_N40_E0.8740.97
234_K288_F0.8740.97
32_V36_N0.8730.97
236_P282_S0.8730.97
272_E276_V0.8730.97
144_A168_A0.8720.97
247_V288_F0.8650.97
302_S375_P0.8640.97
50_S54_Q0.8630.97
165_A169_G0.8580.97
80_M288_F0.8570.97
155_D159_Y0.8570.97
234_K278_K0.8560.97
51_T83_L0.8520.97
134_L152_S0.8500.97
206_G210_T0.8490.97
355_A362_S0.8480.97
388_W418_A0.8470.97
355_A421_L0.8460.97
131_N210_T0.8440.97
109_I112_Q0.8420.97
31_A34_I0.8390.97
49_Y411_S0.8380.97
46_K50_S0.8350.97
64_A296_L0.8340.97
67_A70_K0.8340.97
246_Y319_N0.8340.97
74_L89_V0.8340.97
153_R158_Y0.8330.96
135_G151_I0.8310.96
294_E371_S0.8300.96
301_S372_D0.8260.96
162_A198_V0.8230.96
370_S400_Y0.8180.96
305_V376_F0.8140.96
373_H385_N0.8130.96
361_D364_S0.8130.96
47_H50_S0.8120.96
250_H372_D0.8120.96
185_M188_N0.8090.96
349_E353_T0.8070.96
345_N348_W0.8060.96
35_S38_E0.8030.96
135_G165_A0.8030.96
360_F363_L0.7990.96
294_E321_N0.7980.96
294_E298_L0.7980.96
351_S355_A0.7970.95
359_G363_L0.7960.95
277_L423_T0.7930.95
316_S381_I0.7920.95
106_G111_L0.7900.95
259_G405_D0.7880.95
69_E76_I0.7880.95
291_F301_S0.7870.95
148_I217_L0.7870.95
217_L221_A0.7860.95
59_I71_K0.7850.95
240_K433_E0.7850.95
355_A358_I0.7830.95
245_V429_A0.7810.95
312_E315_R0.7800.95
335_L338_N0.7790.95
350_S354_A0.7780.95
399_W402_T0.7780.95
162_A189_L0.7740.95
261_N397_E0.7710.95
407_I412_K0.7680.94
40_E424_A0.7650.94
54_Q71_K0.7630.94
140_F144_A0.7610.94
51_T275_R0.7600.94
287_R311_K0.7600.94
55_L264_G0.7570.94
309_S379_A0.7560.94
250_H321_N0.7550.94
153_R177_N0.7540.94
345_N349_E0.7540.94
262_D372_D0.7510.94
190_S193_K0.7510.94
54_Q57_E0.7500.94
133_G139_D0.7500.94
34_I37_S0.7470.94
295_E301_S0.7460.94
185_M190_S0.7440.94
39_R423_T0.7440.94
262_D321_N0.7420.93
295_E298_L0.7400.93
105_A212_Q0.7390.93
250_H400_Y0.7390.93
90_Q304_Y0.7370.93
265_S410_I0.7360.93
249_A263_N0.7340.93
113_A117_S0.7330.93
76_I267_T0.7320.93
262_D323_D0.7320.93
80_M85_L0.7320.93
235_K239_I0.7310.93
63_I68_A0.7290.93
184_P190_S0.7290.93
246_Y316_S0.7240.93
324_M400_Y0.7240.93
210_T213_K0.7230.93
155_D158_Y0.7220.92
244_I316_S0.7210.92
218_K221_A0.7190.92
350_S353_T0.7190.92
298_L371_S0.7180.92
45_A413_E0.7160.92
348_W351_S0.7120.92
52_I56_S0.7110.92
293_A296_L0.7100.92
401_H405_D0.7100.92
344_S348_W0.7100.92
277_L426_V0.7090.92
294_E323_D0.7090.92
146_G170_A0.7080.92
354_A357_K0.7070.92
152_S176_Y0.7030.91
116_G296_L0.7020.91
353_T357_K0.7020.91
31_A35_S0.7010.91
276_V423_T0.7000.91
56_S407_I0.6990.91
371_S400_Y0.6990.91
60_G68_A0.6980.91
386_F422_V0.6970.91
321_N372_D0.6960.91
180_E203_K0.6940.91
234_K277_L0.6940.91
178_N203_K0.6930.91
429_A432_K0.6920.91
141_T168_A0.6910.91
77_A230_I0.6890.91
227_S293_A0.6870.91
428_E432_K0.6860.90
324_M371_S0.6860.90
237_K281_P0.6860.90
260_A405_D0.6850.90
102_L217_L0.6840.90
201_I206_G0.6840.90
62_R264_G0.6840.90
116_G120_T0.6820.90
312_E316_S0.6810.90
299_L303_H0.6810.90
120_T123_Q0.6800.90
150_L213_K0.6770.90
51_T54_Q0.6760.90
348_W352_R0.6760.90
356_E360_F0.6750.90
145_K169_G0.6750.90
239_I243_D0.6720.90
355_A359_G0.6710.89
277_L282_S0.6710.89
137_Q141_T0.6690.89
75_L79_S0.6690.89
258_P261_N0.6680.89
266_G323_D0.6680.89
117_S121_E0.6660.89
410_I415_L0.6660.89
370_S374_V0.6650.89
259_G262_D0.6590.89
359_G362_S0.6580.89
320_F422_V0.6560.88
151_I175_I0.6540.88
310_E314_K0.6540.88
245_V317_E0.6520.88
278_K281_P0.6510.88
323_D371_S0.6510.88
61_P68_A0.6500.88
135_G161_K0.6500.88
250_H263_N0.6500.88
140_F149_A0.6480.88
61_P66_T0.6470.88
369_G374_V0.6450.88
262_D295_E0.6440.87
245_V426_V0.6420.87
254_V295_E0.6410.87
295_E321_N0.6390.87
201_I209_L0.6380.87
54_Q82_K0.6370.87
408_E412_K0.6370.87
33_Q37_S0.6360.87
413_E416_Q0.6350.87
184_P193_K0.6340.87
54_Q75_L0.6330.87
48_A269_V0.6320.86
326_G415_L0.6300.86
172_A197_P0.6260.86
325_V328_S0.6260.86
304_Y308_L0.6260.86
85_L278_K0.6260.86
47_H51_T0.6250.86
321_N401_H0.6240.86
69_E228_Q0.6230.86
72_S76_I0.6230.86
54_Q59_I0.6230.86
333_S336_Y0.6210.86
350_S429_A0.6210.86
56_S260_A0.6200.85
57_E211_Q0.6180.85
372_D401_H0.6170.85
274_A278_K0.6150.85
38_E41_L0.6120.85
289_I304_Y0.6120.85
51_T268_S0.6110.85
387_I390_D0.6100.85
105_A109_I0.6080.84
245_V430_V0.6080.84
251_Y267_T0.6060.84
423_T427_Y0.6050.84
62_R263_N0.6010.84
186_T193_K0.6000.84
70_K89_V0.6000.84
273_M276_V0.6000.84
384_A425_A0.6000.84
56_S59_I0.5990.83
247_V286_I0.5990.83
102_L105_A0.5960.83
338_N341_D0.5950.83
119_P122_E0.5940.83
145_K167_A0.5930.83
295_E300_G0.5930.83
136_Y140_F0.5920.83
64_A227_S0.5880.82
41_L45_A0.5870.82
69_E227_S0.5850.82
33_Q36_N0.5850.82
345_N438_T0.5840.82
318_V384_A0.5840.82
43_F420_D0.5840.82
366_T377_H0.5830.82
304_Y311_K0.5830.82
166_E196_I0.5830.82
302_S378_E0.5820.82
375_P378_E0.5810.82
231_I310_E0.5810.82
317_E435_K0.5800.81
107_R212_Q0.5790.81
150_L210_T0.5780.81
254_V401_H0.5760.81
333_S338_N0.5740.81
301_S373_H0.5740.81
55_L72_S0.5740.81
69_E72_S0.5690.80
232_G288_F0.5680.80
264_G268_S0.5660.80
31_A36_N0.5660.80
247_V422_V0.5650.80
306_D379_A0.5650.80
273_M277_L0.5650.80
45_A48_A0.5650.80
119_P124_G0.5650.80
277_L280_V0.5640.80
55_L76_I0.5620.79
234_K286_I0.5610.79
140_F161_K0.5590.79
46_K413_E0.5590.79
334_E363_L0.5580.79
113_A120_T0.5570.79
64_A69_E0.5560.79
150_L176_Y0.5560.79
34_I38_E0.5550.79
132_A135_G0.5530.78
357_K424_A0.5520.78
92_F307_H0.5520.78
62_R72_S0.5510.78
165_A196_I0.5510.78
372_D400_Y0.5500.78
372_D376_F0.5490.78
356_E362_S0.5490.78
265_S324_M0.5460.77
160_E163_K0.5460.77
146_G149_A0.5460.77
61_P255_P0.5460.77
380_G383_S0.5450.77
150_L174_I0.5450.77
354_A425_A0.5440.77
127_A147_K0.5440.77
320_F429_A0.5430.77
321_N371_S0.5430.77
252_D297_G0.5420.77
64_A225_Q0.5420.77
323_D401_H0.5410.77
295_E372_D0.5410.77
197_P217_L0.5390.77
294_E372_D0.5380.76
301_S321_N0.5380.76
332_A338_N0.5380.76
59_I74_L0.5380.76
138_K160_E0.5360.76
114_A118_A0.5360.76
107_R110_L0.5350.76
43_F419_G0.5350.76
340_L343_Q0.5350.76
107_R112_Q0.5350.76
54_Q78_S0.5340.76
261_N265_S0.5340.76
326_G410_I0.5330.76
54_Q79_S0.5320.76
123_Q218_K0.5310.75
41_L46_K0.5310.75
280_V423_T0.5300.75
163_K166_E0.5300.75
43_F48_A0.5300.75
342_G346_Y0.5290.75
245_V318_V0.5280.75
53_S57_E0.5270.75
344_S347_V0.5270.75
334_E339_T0.5260.75
367_Q390_D0.5250.75
229_N295_E0.5240.75
103_S106_G0.5240.75
301_S376_F0.5240.75
420_D424_A0.5240.75
414_R418_A0.5230.74
31_A38_E0.5220.74
69_E73_A0.5200.74
157_T160_E0.5190.74
237_K241_H0.5190.74
294_E297_G0.5160.73
188_N191_G0.5160.73
52_I407_I0.5150.73
87_V230_I0.5140.73
253_S264_G0.5140.73
269_V322_L0.5140.73
246_Y287_R0.5130.73
62_R253_S0.5120.73
246_Y376_F0.5110.73
107_R211_Q0.5100.73
176_Y206_G0.5090.72
42_P45_A0.5080.72
297_G372_D0.5080.72
355_A361_D0.5080.72
283_D433_E0.5070.72
263_N401_H0.5050.72
341_D348_W0.5050.72
172_A193_K0.5050.72
360_F417_Q0.5040.72
90_Q231_I0.5040.72
239_I285_E0.5040.72
298_L323_D0.5040.72
309_S313_L0.5030.72
36_N428_E0.5030.72
113_A121_E0.5000.71
310_E316_S0.5000.71
101_T220_K0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tweA 2 0.9275 100 0.323 Contact Map
2ek8A 2 0.8725 100 0.326 Contact Map
3fedA 2 0.9077 100 0.327 Contact Map
3kasA 2 0.9187 100 0.335 Contact Map
3iibA 2 0.8901 100 0.36 Contact Map
4r12A 1 0.7758 100 0.541 Contact Map
3k9tA 3 0.7758 100 0.577 Contact Map
1tkjA 1 0.5604 100 0.618 Contact Map
4mhpA 1 0.6066 100 0.631 Contact Map
3guxA 1 0.5231 100 0.631 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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