GREMLIN Database
SYY2 - Tyrosine--tRNA ligase 2
UniProt: P25151 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 413 (390)
Sequences: 4225 (2352)
Seq/√Len: 119.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
319_E323_E4.1331.00
195_V199_D3.9031.00
314_R319_E3.4231.00
357_D368_K3.4001.00
310_R326_E3.2651.00
146_N149_D3.1741.00
83_I134_E3.1421.00
381_R403_Q3.1271.00
101_K247_K3.1261.00
136_H140_K3.0531.00
211_V228_V2.8821.00
218_Q226_Q2.8581.00
273_K291_V2.7411.00
118_K121_F2.6791.00
51_K83_I2.6761.00
75_R79_E2.5481.00
235_E274_K2.4981.00
58_P93_G2.4841.00
194_V221_Y2.4451.00
318_G321_A2.4311.00
321_A324_A2.4301.00
197_E224_E2.2851.00
354_A357_D2.2781.00
43_S47_G2.2291.00
23_Y34_E2.1421.00
121_F125_G2.0651.00
289_Q293_D2.0611.00
381_R386_K2.0591.00
169_E173_A2.0451.00
378_G386_K2.0391.00
109_T112_E2.0181.00
273_K277_H2.0151.00
314_R322_A2.0131.00
365_L371_A2.0051.00
194_V198_S2.0021.00
114_Q118_K1.9791.00
376_Q390_V1.9471.00
198_S222_N1.9321.00
286_E289_Q1.9291.00
360_V368_K1.9171.00
54_L70_V1.9011.00
115_H119_T1.8941.00
366_S370_E1.8901.00
306_M330_K1.8691.00
115_H118_K1.8661.00
52_I77_F1.8641.00
358_L412_L1.8641.00
277_H291_V1.8511.00
24_M33_P1.8331.00
71_L124_F1.8291.00
291_V295_E1.8081.00
292_K297_G1.7921.00
91_F142_L1.7821.00
364_L410_L1.7751.00
87_L196_L1.7651.00
51_K85_Q1.7481.00
110_D114_Q1.7361.00
310_R322_A1.7361.00
33_P36_L1.6971.00
52_I74_L1.6961.00
359_L380_V1.6951.00
293_D298_A1.6811.00
94_K110_D1.6641.00
370_E374_M1.6621.00
307_L311_T1.6441.00
374_M379_G1.6431.00
288_K291_V1.6301.00
238_D241_E1.6251.00
236_G241_E1.6221.00
326_E330_K1.6211.00
117_A137_Y1.6191.00
24_M284_L1.6161.00
284_L288_K1.6121.00
271_L274_K1.6081.00
29_E208_H1.6051.00
392_A398_E1.6041.00
142_L145_L1.5961.00
241_E247_K1.5941.00
358_L394_A1.5821.00
70_V231_M1.5801.00
157_I213_M1.5731.00
310_R323_E1.5611.00
369_S373_R1.5571.00
112_E115_H1.5551.00
129_D132_K1.5541.00
139_S143_K1.5541.00
190_G213_M1.5451.00
108_L112_E1.5281.00
289_Q292_K1.5281.00
103_A106_K1.5091.00
374_M377_N1.5031.00
32_P228_V1.5011.00
374_M404_V1.5001.00
260_M313_V1.4991.00
298_A301_P1.4961.00
136_H196_L1.4841.00
373_R377_N1.4811.00
85_Q136_H1.4791.00
365_L374_M1.4741.00
54_L202_L1.4731.00
283_E286_E1.4671.00
44_I50_L1.4611.00
292_K295_E1.4591.00
355_M387_V1.4551.00
268_P271_L1.4511.00
85_Q134_E1.4411.00
260_M312_I1.4341.00
403_Q409_F1.4271.00
108_L116_N1.4181.00
156_K220_R1.4011.00
56_L71_L1.3971.00
56_L70_V1.3881.00
323_E327_H1.3851.00
90_D137_Y1.3811.00
21_Q24_M1.3761.00
261_Y326_E1.3681.00
354_A368_K1.3641.00
44_I48_T1.3491.00
321_A325_A1.3491.00
352_T393_K1.3461.00
360_V365_L1.3301.00
302_R306_M1.3301.00
216_H219_E1.3241.00
44_I47_G1.3241.00
282_L307_L1.3171.00
303_D306_M1.3151.00
90_D139_S1.3111.00
288_K292_K1.3101.00
56_L63_V1.3051.00
370_E373_R1.3031.00
286_E307_L1.3011.00
273_K294_L1.2911.00
197_E222_N1.2891.00
42_K46_T1.2781.00
320_K324_A1.2680.99
355_M392_A1.2640.99
118_K122_E1.2440.99
158_T177_P1.2440.99
43_S46_T1.2370.99
380_V404_V1.2290.99
251_I264_T1.2270.99
74_L77_F1.2270.99
293_D303_D1.2260.99
282_L311_T1.2200.99
322_A329_F1.2120.99
77_F200_I1.2080.99
86_L124_F1.2010.99
389_D392_A1.1970.99
256_H259_D1.1940.99
147_L150_V1.1700.99
356_I368_K1.1590.99
61_P115_H1.1570.99
357_D361_K1.1540.99
378_G388_T1.1520.99
327_H331_T1.1520.99
65_L264_T1.1510.99
197_E223_K1.1400.99
342_I401_I1.1400.99
194_V218_Q1.1360.99
147_L188_M1.1350.99
382_I400_M1.1350.99
395_E398_E1.1250.99
306_M326_E1.1230.99
236_G249_N1.1220.99
260_M264_T1.1210.99
353_I358_L1.1020.99
161_R164_E1.1000.99
327_H330_K1.0990.99
282_L286_E1.0960.99
362_L410_L1.0880.98
323_E326_E1.0860.98
165_R212_L1.0820.98
142_L188_M1.0810.98
285_E288_K1.0770.98
122_E254_N1.0760.98
311_T314_R1.0730.98
166_D170_E1.0730.98
353_I361_K1.0690.98
355_M375_I1.0650.98
142_L191_Y1.0630.98
310_R314_R1.0610.98
262_G266_S1.0580.98
195_V198_S1.0580.98
394_A400_M1.0530.98
273_K288_K1.0460.98
194_V222_N1.0460.98
356_I375_I1.0450.98
322_A326_E1.0380.98
287_K291_V1.0330.98
277_H284_L1.0310.98
383_D400_M1.0250.98
72_N315_M1.0230.98
45_S50_L1.0210.98
73_K231_M1.0150.98
42_K45_S1.0130.98
373_R379_G1.0110.97
137_Y140_K1.0070.97
257_P317_H1.0010.97
71_L127_V1.0010.97
33_P37_K0.9990.97
20_L42_K0.9950.97
320_K323_E0.9870.97
404_V408_K0.9860.97
306_M310_R0.9840.97
345_V410_L0.9830.97
85_Q196_L0.9830.97
243_M263_K0.9800.97
67_H70_V0.9750.97
276_I308_L0.9680.97
129_D133_V0.9640.97
44_I49_P0.9640.97
389_D394_A0.9600.97
194_V217_F0.9570.96
51_K134_E0.9500.96
151_I188_M0.9490.96
162_L183_F0.9440.96
149_D153_L0.9420.96
355_M380_V0.9380.96
29_E205_T0.9370.96
27_A229_I0.9350.96
83_I132_K0.9350.96
75_R281_D0.9350.96
200_I229_I0.9350.96
260_M316_Y0.9300.96
331_T335_E0.9290.96
125_G133_V0.9210.96
150_V187_L0.9200.96
147_L184_F0.9180.96
87_L136_H0.9180.96
387_V392_A0.9150.95
258_N328_S0.9140.95
255_E321_A0.9120.95
72_N281_D0.9120.95
366_S408_K0.9100.95
23_Y229_I0.9050.95
17_E37_K0.9050.95
251_I263_K0.9010.95
359_L402_I0.9000.95
276_I290_L0.8960.95
76_Q80_N0.8950.95
54_L67_H0.8940.95
365_L370_E0.8910.95
170_E174_M0.8880.95
24_M288_K0.8880.95
293_D297_G0.8840.95
118_K125_G0.8820.94
356_I390_V0.8800.94
198_S221_Y0.8800.94
354_A391_H0.8780.94
19_Q23_Y0.8780.94
365_L380_V0.8740.94
78_Q133_V0.8740.94
277_H287_K0.8700.94
324_A327_H0.8700.94
303_D307_L0.8670.94
99_T178_I0.8670.94
265_M302_R0.8610.94
328_S331_T0.8600.94
114_Q117_A0.8600.94
61_P67_H0.8580.94
145_L191_Y0.8570.94
382_I394_A0.8550.94
50_L82_H0.8550.94
211_V230_L0.8540.93
280_T311_T0.8510.93
110_D143_K0.8510.93
383_D398_E0.8490.93
36_L227_V0.8480.93
301_P305_K0.8450.93
310_R319_E0.8430.93
74_L86_L0.8390.93
299_V302_R0.8390.93
71_L128_L0.8360.93
307_L310_R0.8350.93
262_G333_F0.8340.93
122_E125_G0.8340.93
158_T179_S0.8320.93
52_I200_I0.8320.93
321_A329_F0.8280.92
266_S407_R0.8260.92
121_F135_L0.8240.92
328_S332_V0.8220.92
236_G248_H0.8170.92
101_K246_S0.8170.92
22_L76_Q0.8150.92
290_L307_L0.8150.92
30_V230_L0.8130.92
24_M30_V0.8130.92
290_L294_L0.8060.91
261_Y306_M0.7980.91
280_T312_I0.7950.91
276_I307_L0.7940.91
382_I402_I0.7930.91
21_Q76_Q0.7920.91
360_V371_A0.7910.91
330_K334_Q0.7900.91
76_Q79_E0.7890.90
27_A76_Q0.7870.90
259_D262_G0.7870.90
151_I184_F0.7860.90
148_E152_E0.7850.90
73_K202_L0.7840.90
377_N404_V0.7830.90
49_P82_H0.7810.90
69_V234_L0.7770.90
272_M300_H0.7770.90
60_A67_H0.7760.90
194_V226_Q0.7750.90
61_P119_T0.7740.90
262_G329_F0.7720.90
233_L241_E0.7700.89
356_I372_R0.7690.89
124_F135_L0.7660.89
161_R165_R0.7650.89
27_A278_L0.7650.89
17_E20_L0.7640.89
334_Q337_S0.7630.89
401_I411_K0.7630.89
252_G255_E0.7620.89
291_V294_L0.7610.89
277_H288_K0.7570.89
363_K366_S0.7550.88
50_L200_I0.7550.88
384_G403_Q0.7530.88
336_N339_P0.7530.88
378_G381_R0.7520.88
99_T103_A0.7500.88
31_I34_E0.7490.88
261_Y265_M0.7480.88
293_D307_L0.7480.88
271_L275_Y0.7470.88
237_L270_S0.7450.88
56_L86_L0.7450.88
42_K224_E0.7450.88
264_T279_A0.7440.88
35_E43_S0.7430.88
28_H31_I0.7420.88
58_P117_A0.7420.88
154_A191_Y0.7410.88
396_I399_N0.7410.88
67_H246_S0.7390.87
163_M172_I0.7370.87
354_A375_I0.7350.87
261_Y310_R0.7330.87
375_I390_V0.7320.87
197_E218_Q0.7300.87
142_L147_L0.7270.87
17_E46_T0.7270.87
106_K112_E0.7240.86
234_L279_A0.7230.86
326_E329_F0.7230.86
349_G396_I0.7210.86
107_Q181_H0.7180.86
157_I187_L0.7140.86
372_R390_V0.7140.86
302_R305_K0.7120.85
352_T395_E0.7050.85
281_D311_T0.7010.84
369_S372_R0.7000.84
69_V278_L0.6990.84
100_G167_D0.6990.84
149_D152_E0.6980.84
168_F186_P0.6980.84
56_L60_A0.6970.84
54_L63_V0.6930.84
260_M317_H0.6920.84
368_K372_R0.6920.84
355_M359_L0.6900.84
241_E246_S0.6880.83
292_K298_A0.6880.83
27_A30_V0.6870.83
49_P83_I0.6860.83
374_M380_V0.6860.83
351_K396_I0.6850.83
56_L67_H0.6820.83
306_M334_Q0.6820.83
314_R320_K0.6800.83
67_H71_L0.6800.83
385_E392_A0.6790.83
161_R216_H0.6750.82
99_T167_D0.6740.82
46_T49_P0.6720.82
266_S333_F0.6710.82
65_L312_I0.6710.82
358_L400_M0.6670.81
127_V260_M0.6670.81
357_D360_V0.6650.81
25_T284_L0.6630.81
375_I380_V0.6630.81
213_M216_H0.6590.81
261_Y329_F0.6590.81
267_L275_Y0.6590.81
191_Y195_V0.6590.81
75_R78_Q0.6580.81
101_K170_E0.6560.80
122_E126_K0.6540.80
94_K113_V0.6540.80
27_A72_N0.6530.80
102_S106_K0.6520.80
290_L293_D0.6520.80
236_G263_K0.6510.80
34_E37_K0.6510.80
70_V202_L0.6480.80
285_E289_Q0.6480.80
365_L402_I0.6460.79
294_L298_A0.6460.79
238_D268_P0.6450.79
166_D169_E0.6440.79
86_L128_L0.6430.79
293_D300_H0.6430.79
68_T315_M0.6410.79
246_S249_N0.6380.78
354_A393_K0.6340.78
300_H303_D0.6330.78
52_I202_L0.6310.78
208_H230_L0.6290.78
159_V178_I0.6290.78
107_Q152_E0.6290.78
335_E338_L0.6270.77
272_M304_A0.6270.77
345_V362_L0.6270.77
125_G135_L0.6270.77
123_Q254_N0.6260.77
145_L154_A0.6250.77
212_L215_R0.6230.77
158_T161_R0.6220.77
159_V183_F0.6220.77
366_S369_S0.6220.77
267_L271_L0.6210.77
126_K255_E0.6200.77
34_E42_K0.6190.76
280_T307_L0.6190.76
20_L24_M0.6190.76
152_E156_K0.6170.76
364_L404_V0.6160.76
275_Y279_A0.6130.76
388_T392_A0.6120.76
67_H119_T0.6110.75
58_P64_H0.6110.75
299_V303_D0.6090.75
113_V116_N0.6090.75
341_D345_V0.6070.75
369_S376_Q0.6060.75
272_M291_V0.6050.75
237_L267_L0.6050.75
167_D186_P0.6050.75
294_L305_K0.6040.75
247_K250_Y0.6040.75
103_A247_K0.6020.74
45_S48_T0.6020.74
150_V154_A0.6010.74
109_T113_V0.6010.74
262_G407_R0.6010.74
359_L371_A0.6000.74
65_L263_K0.5990.74
94_K143_K0.5990.74
84_V132_K0.5980.74
108_L113_V0.5980.74
60_A248_H0.5970.74
93_G113_V0.5970.74
70_V99_T0.5960.74
67_H275_Y0.5960.74
49_P132_K0.5950.74
18_R21_Q0.5950.74
325_A329_F0.5950.74
65_L260_M0.5950.74
191_Y221_Y0.5940.73
329_F407_R0.5930.73
157_I190_G0.5920.73
75_R124_F0.5920.73
342_I409_F0.5870.73
56_L157_I0.5850.72
264_T313_V0.5820.72
331_T334_Q0.5820.72
180_L184_F0.5790.72
389_D393_K0.5770.71
65_L278_L0.5770.71
72_N76_Q0.5770.71
139_S142_L0.5770.71
385_E388_T0.5760.71
215_R226_Q0.5760.71
290_L304_A0.5750.71
100_G247_K0.5740.71
374_M408_K0.5740.71
164_E251_I0.5730.71
236_G275_Y0.5730.71
233_L247_K0.5720.71
65_L279_A0.5680.70
65_L127_V0.5660.70
317_H321_A0.5660.70
237_L268_P0.5660.70
276_I287_K0.5650.70
20_L23_Y0.5650.70
76_Q281_D0.5650.70
67_H75_R0.5640.70
209_F212_L0.5620.69
341_D344_A0.5610.69
126_K254_N0.5590.69
162_L168_F0.5580.69
393_K408_K0.5580.69
158_T174_M0.5570.69
68_T279_A0.5570.69
156_K181_H0.5560.68
312_I316_Y0.5560.68
114_Q137_Y0.5560.68
101_K106_K0.5550.68
293_D299_V0.5540.68
234_L278_L0.5520.68
180_L187_L0.5520.68
65_L236_G0.5520.68
69_V73_K0.5500.68
284_L287_K0.5460.67
377_N380_V0.5440.67
186_P190_G0.5440.67
400_M412_L0.5430.67
396_I412_L0.5420.67
104_A181_H0.5420.67
262_G265_M0.5400.66
202_L231_M0.5380.66
385_E398_E0.5370.66
382_I392_A0.5370.66
368_K379_G0.5350.66
302_R333_F0.5350.66
113_V117_A0.5340.65
78_Q129_D0.5340.65
43_S49_P0.5340.65
360_V363_K0.5340.65
397_R400_M0.5340.65
31_I37_K0.5320.65
219_E225_K0.5320.65
30_V229_I0.5310.65
162_L180_L0.5310.65
216_H220_R0.5300.65
276_I304_A0.5290.65
352_T396_I0.5290.65
358_L402_I0.5270.64
234_L263_K0.5270.64
246_S260_M0.5270.64
94_K108_L0.5270.64
233_L254_N0.5260.64
67_H120_Y0.5260.64
106_K247_K0.5250.64
379_G384_G0.5240.64
366_S374_M0.5220.64
67_H231_M0.5210.64
384_G401_I0.5210.64
162_L186_P0.5200.63
31_I228_V0.5190.63
144_T149_D0.5190.63
125_G128_L0.5170.63
51_K197_E0.5170.63
167_D170_E0.5150.63
89_G96_G0.5150.63
159_V162_L0.5140.62
345_V355_M0.5140.62
169_E219_E0.5140.62
276_I280_T0.5130.62
372_R376_Q0.5120.62
119_T122_E0.5120.62
104_A156_K0.5120.62
32_P215_R0.5110.62
273_K287_K0.5110.62
360_V369_S0.5110.62
390_V394_A0.5100.62
243_M305_K0.5100.62
89_G92_T0.5090.62
371_A375_I0.5080.62
54_L86_L0.5080.62
64_H93_G0.5080.62
158_T186_P0.5070.61
376_Q391_H0.5060.61
344_A348_K0.5060.61
359_L364_L0.5060.61
280_T315_M0.5040.61
103_A176_K0.5030.61
23_Y28_H0.5030.61
354_A394_A0.5030.61
392_A396_I0.5020.61
393_K397_R0.5020.61
394_A397_R0.5020.61
71_L86_L0.5020.61
84_V133_V0.5010.61
190_G217_F0.5010.61
121_F130_P0.5000.60
357_D391_H0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2janA 2 0.9395 100 0.196 Contact Map
2ts1A 2 0.7385 100 0.2 Contact Map
1jilA 2 0.753 100 0.201 Contact Map
4oudA 2 0.9177 100 0.202 Contact Map
1h3fA 2 0.9031 100 0.218 Contact Map
1y42X 2 0.77 100 0.335 Contact Map
2pidA 2 0.7264 100 0.374 Contact Map
2yxnA 2 0.7482 100 0.386 Contact Map
3p0jA 1 0.9298 100 0.45 Contact Map
3vgjA 2 0.7845 100 0.474 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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