GREMLIN Database
YWAF - Uncharacterized protein YwaF
UniProt: P25149 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (218)
Sequences: 597 (524)
Seq/√Len: 35.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_F231_L4.8781.00
31_L148_L4.5611.00
106_F154_A4.3501.00
25_L121_L3.9591.00
87_S116_S3.8781.00
174_N218_E3.3341.00
183_I187_L3.2741.00
28_I144_G3.1001.00
184_D189_A2.6911.00
107_V165_S2.6101.00
125_D193_Y2.5931.00
87_S146_V2.5691.00
116_S146_V2.5561.00
22_V26_A2.5471.00
66_Y70_M2.4221.00
30_L122_A2.2500.99
177_G194_L2.1680.99
96_I100_T2.0800.99
129_F133_H2.0760.99
63_Q88_D1.9770.98
98_L139_F1.9670.98
82_L191_Y1.9650.98
162_G165_S1.9010.98
112_V173_V1.8750.97
87_S143_H1.8370.97
17_F21_H1.8270.97
66_Y135_R1.7710.96
108_F112_V1.7070.96
120_A193_Y1.6220.94
86_L177_G1.5950.94
18_S21_H1.5850.93
68_I179_C1.5720.93
183_I189_A1.5540.93
217_A220_I1.5530.93
132_P137_I1.5390.92
69_W129_F1.5350.92
93_L105_L1.5200.92
96_I105_L1.4920.91
58_L227_I1.4860.91
95_A180_I1.4500.90
185_R214_I1.4410.89
53_S99_V1.4320.89
173_V192_M1.4240.89
69_W133_H1.4090.88
163_Q167_W1.3980.88
109_L149_S1.3560.86
29_S84_L1.3350.85
20_E130_S1.3300.85
197_K213_Y1.3250.85
163_Q226_F1.3150.85
88_D138_L1.3140.85
228_L232_Y1.3130.84
69_W113_G1.3110.84
57_F61_G1.3100.84
24_T27_I1.3000.84
61_G68_I1.2970.84
30_L41_E1.2960.84
133_H150_C1.2950.84
219_A228_L1.2780.83
20_E23_V1.2710.82
107_V168_V1.2320.80
36_F39_Q1.2280.80
87_S164_R1.2270.80
116_S120_A1.2210.80
30_L61_G1.2070.79
67_Q85_Q1.1960.78
63_Q138_L1.1940.78
123_T203_L1.1910.78
91_V142_S1.1810.78
139_F146_V1.1750.77
205_D209_P1.1640.76
34_L42_V1.1640.76
69_W135_R1.1550.76
90_S139_F1.1520.76
78_V207_L1.1480.75
193_Y199_G1.1440.75
86_L116_S1.1370.75
119_Q123_T1.1350.75
27_I50_F1.1340.75
120_A139_F1.1320.74
49_R57_F1.1300.74
81_S113_G1.1280.74
62_S142_S1.1140.73
63_Q67_Q1.1070.73
108_F118_I1.0890.71
113_G146_V1.0880.71
34_L141_I1.0730.70
96_I186_W1.0710.70
19_T30_L1.0710.70
66_Y142_S1.0620.70
207_L216_S1.0450.68
23_V27_I1.0430.68
35_L215_V1.0430.68
33_I38_F1.0420.68
98_L136_Y1.0410.68
58_L145_S1.0330.67
26_A178_V1.0290.67
85_Q125_D1.0290.67
50_F54_L1.0270.67
215_V219_A1.0260.67
170_V210_W1.0090.66
207_L211_P1.0020.65
87_S117_S0.9940.64
97_M153_M0.9910.64
125_D199_G0.9900.64
18_S129_F0.9820.63
191_Y198_P0.9780.63
41_E219_A0.9720.63
195_T213_Y0.9700.62
85_Q150_C0.9640.62
62_S145_S0.9630.62
27_I30_L0.9500.61
23_V38_F0.9490.61
29_S41_E0.9490.61
21_H63_Q0.9480.61
24_T28_I0.9440.60
56_V95_A0.9430.60
54_L58_L0.9430.60
62_S138_L0.9420.60
110_F154_A0.9390.60
90_S93_L0.9360.60
59_L151_L0.9360.60
19_T23_V0.9360.60
86_L173_V0.9320.59
30_L118_I0.9270.59
102_S175_V0.9240.59
33_I61_G0.9150.58
201_S205_D0.9130.58
197_K205_D0.9110.58
39_Q42_V0.9090.57
152_L156_I0.9080.57
35_L74_D0.9050.57
154_A159_Y0.9020.57
123_T202_S0.9010.57
88_D113_G0.9000.57
20_E24_T0.8970.56
120_A169_T0.8960.56
86_L110_F0.8880.56
63_Q139_F0.8880.56
194_L202_S0.8830.55
112_V192_M0.8800.55
95_A99_V0.8760.55
43_K47_A0.8750.54
193_Y210_W0.8720.54
84_L114_I0.8640.54
31_L215_V0.8620.53
24_T136_Y0.8620.53
178_V182_L0.8610.53
115_G193_Y0.8530.53
97_M149_S0.8440.52
85_Q184_D0.8440.52
143_H190_N0.8380.51
32_A222_I0.8370.51
86_L135_R0.8370.51
51_L59_L0.8290.51
116_S176_Y0.8290.51
127_G138_L0.8280.50
14_F17_F0.8280.50
208_G211_P0.8280.50
97_M159_Y0.8270.50
83_P184_D0.8140.49
116_S232_Y0.8040.48
19_T71_V0.8030.48
184_D195_T0.8020.48
95_A175_V0.7970.48
102_S105_L0.7960.48
97_M229_Y0.7960.48
70_M84_L0.7950.48
87_S91_V0.7940.47
50_F151_L0.7900.47
171_L227_I0.7890.47
93_L109_L0.7820.46
29_S34_L0.7760.46
99_V104_K0.7690.45
52_R122_A0.7640.45
66_Y85_Q0.7610.45
167_W186_W0.7590.44
212_W216_S0.7580.44
68_I72_A0.7570.44
85_Q195_T0.7570.44
103_R168_V0.7530.44
71_V222_I0.7530.44
62_S67_Q0.7510.44
179_C215_V0.7510.44
132_P194_L0.7510.44
34_L71_V0.7500.44
83_P143_H0.7470.43
90_S112_V0.7470.43
226_F230_W0.7460.43
26_A32_A0.7450.43
66_Y191_Y0.7440.43
216_S224_S0.7430.43
164_R223_A0.7410.43
80_T88_D0.7400.43
52_R98_L0.7400.43
19_T37_L0.7400.43
108_F150_C0.7400.43
88_D192_M0.7380.43
18_S151_L0.7350.42
117_S139_F0.7350.42
197_K211_P0.7310.42
67_Q76_W0.7310.42
95_A140_F0.7290.42
38_F42_V0.7280.42
96_I227_I0.7280.42
68_I226_F0.7270.42
110_F228_L0.7220.41
100_T149_S0.7130.41
205_D208_G0.7120.41
55_F149_S0.7080.40
66_Y69_W0.7070.40
106_F231_L0.7050.40
47_A65_G0.7050.40
26_A34_L0.7040.40
35_L38_F0.7010.40
30_L68_I0.7010.40
221_T225_F0.6970.39
153_M157_G0.6950.39
40_D219_A0.6910.39
176_Y193_Y0.6840.38
114_I166_L0.6820.38
63_Q66_Y0.6800.38
177_G181_F0.6790.38
33_I102_S0.6790.38
109_L199_G0.6790.38
144_G207_L0.6760.38
78_V203_L0.6750.37
103_R107_V0.6720.37
86_L192_M0.6710.37
115_G161_M0.6690.37
211_P214_I0.6670.37
181_F184_D0.6630.37
33_I48_S0.6610.36
27_I31_L0.6590.36
15_H54_L0.6540.36
114_I198_P0.6500.35
64_I175_V0.6500.35
116_S124_P0.6480.35
97_M109_L0.6480.35
19_T49_R0.6440.35
91_V116_S0.6390.35
116_S142_S0.6380.35
138_L193_Y0.6370.34
89_L144_G0.6320.34
182_L186_W0.6310.34
58_L114_I0.6290.34
214_I221_T0.6290.34
78_V191_Y0.6280.34
74_D194_L0.6250.34
27_I34_L0.6250.34
19_T34_L0.6220.33
101_K231_L0.6190.33
130_S193_Y0.6180.33
66_Y82_L0.6170.33
173_V177_G0.6160.33
130_S136_Y0.6140.33
64_I68_I0.6140.33
137_I141_I0.6130.33
112_V156_I0.6120.33
26_A215_V0.6110.32
161_M211_P0.6110.32
84_L144_G0.6110.32
88_D173_V0.6100.32
28_I148_L0.6090.32
97_M151_L0.6070.32
90_S142_S0.6060.32
123_T187_L0.6020.32
214_I217_A0.6010.32
108_F172_L0.5990.32
214_I218_E0.5940.31
33_I37_L0.5920.31
18_S22_V0.5900.31
174_N177_G0.5890.31
57_F79_R0.5890.31
89_L173_V0.5890.31
97_M115_G0.5870.31
51_L164_R0.5870.31
105_L117_S0.5870.31
202_S205_D0.5860.31
110_F232_Y0.5830.30
203_L206_V0.5810.30
111_F123_T0.5810.30
73_T92_Y0.5740.30
51_L102_S0.5730.30
135_R138_L0.5720.30
21_H25_L0.5710.29
169_T226_F0.5690.29
51_L89_L0.5680.29
140_F144_G0.5680.29
139_F152_L0.5630.29
79_R183_I0.5630.29
76_W87_S0.5620.29
123_T126_L0.5570.28
70_M97_M0.5570.28
201_S204_L0.5510.28
206_V222_I0.5490.28
180_I183_I0.5480.28
172_L185_R0.5470.28
62_S151_L0.5460.28
118_I219_A0.5420.27
52_R193_Y0.5410.27
37_L178_V0.5400.27
62_S88_D0.5360.27
14_F98_L0.5340.27
176_Y221_T0.5340.27
63_Q140_F0.5330.27
74_D141_I0.5290.27
49_R58_L0.5290.27
25_L109_L0.5290.27
101_K157_G0.5200.26
25_L40_D0.5200.26
117_S146_V0.5170.26
26_A72_A0.5160.26
49_R53_S0.5160.26
119_Q201_S0.5160.26
58_L141_I0.5160.26
54_L68_I0.5140.26
126_L216_S0.5120.25
30_L34_L0.5110.25
52_R56_V0.5090.25
29_S32_A0.5080.25
78_V84_L0.5070.25
61_G171_L0.5050.25
94_S149_S0.5050.25
27_I58_L0.5040.25
92_Y191_Y0.5020.25
137_I148_L0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ksfA 1 0.1857 9.2 0.953 Contact Map
2l2tA 2 0.1857 5.2 0.958 Contact Map
2wwbC 1 0.1519 4.5 0.959 Contact Map
1fftA 1 0.5274 3.9 0.961 Contact Map
1fftB 1 0.1857 3.7 0.961 Contact Map
2rddB 1 0.1561 3.5 0.961 Contact Map
4dveA 3 0.73 2.2 0.965 Contact Map
2ww9C 1 0.0886 2.1 0.966 Contact Map
2yevB 1 0.1983 2 0.966 Contact Map
2mc7A 1 0.1266 1.8 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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