GREMLIN Database
GSPA - General stress protein A
UniProt: P25148 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (254)
Sequences: 3610 (2348)
Seq/√Len: 147.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_A159_S5.3891.00
11_S24_M4.7911.00
105_K167_E4.2901.00
114_A161_I4.0151.00
39_K67_E3.3081.00
41_Y69_L3.1511.00
15_D51_N3.0941.00
108_I163_I3.0661.00
118_E244_A2.8171.00
159_S194_H2.5171.00
164_I169_W2.4831.00
173_N176_E2.4391.00
31_N270_Y2.4261.00
166_F170_R2.4141.00
157_F199_L2.3911.00
168_S171_K2.3791.00
135_A157_F2.3131.00
97_D175_T2.3021.00
28_L40_L2.2351.00
213_R244_A2.1741.00
30_T273_Y2.1711.00
24_M114_A2.1481.00
159_S195_D2.0971.00
128_I134_A2.0091.00
158_N215_N1.9811.00
20_H267_Y1.9771.00
8_H41_Y1.9751.00
25_F40_L1.9581.00
117_L266_E1.9461.00
167_E171_K1.9381.00
15_D48_K1.9171.00
116_V245_I1.8761.00
10_V95_I1.8721.00
89_A194_H1.8321.00
10_V107_M1.7621.00
26_V30_T1.7501.00
172_Q206_Q1.7491.00
168_S172_Q1.7181.00
176_E180_N1.7131.00
214_W244_A1.7101.00
110_I114_A1.7011.00
13_A21_L1.6941.00
134_A208_Y1.6871.00
181_F201_A1.6721.00
130_P165_D1.6701.00
8_H39_K1.6701.00
128_I131_Y1.6581.00
106_R165_D1.6421.00
129_A208_Y1.6041.00
49_P53_K1.6001.00
132_T172_Q1.5731.00
131_Y208_Y1.5671.00
24_M28_L1.5231.00
121_S125_D1.5001.00
269_H273_Y1.4821.00
144_R147_E1.4771.00
85_I194_H1.4681.00
117_L246_V1.4611.00
157_F207_W1.4411.00
110_I161_I1.4371.00
181_F185_H1.4311.00
161_I245_I1.4261.00
110_I116_V1.4031.00
7_M10_V1.3821.00
243_P246_V1.3681.00
14_D88_A1.3541.00
156_Y197_D1.3531.00
36_R125_D1.3431.00
89_A195_D1.3351.00
178_V198_A1.3211.00
165_D168_S1.3181.00
36_R121_S1.3111.00
157_F200_N1.3081.00
120_I245_I1.2991.00
122_K244_A1.2741.00
23_G115_L1.2721.00
28_L120_I1.2591.00
265_D269_H1.2581.00
110_I245_I1.2571.00
104_I166_F1.2551.00
99_I104_I1.2511.00
8_H124_W1.2481.00
114_A245_I1.2451.00
52_K68_F1.2341.00
39_K65_P1.2331.00
8_H104_I1.2331.00
21_L112_C1.2321.00
132_T206_Q1.2291.00
29_L64_V1.2241.00
217_Q249_C1.2231.00
177_K202_I1.2111.00
11_S21_L1.2071.00
27_S116_V1.2041.00
25_F29_L1.1971.00
27_S115_L1.1691.00
44_D52_K1.1681.00
32_M119_D1.1681.00
156_Y200_N1.1641.00
92_R109_Y1.1401.00
53_K57_E1.1401.00
11_S114_A1.1360.99
97_D176_E1.1320.99
52_K56_E1.1300.99
194_H197_D1.1280.99
252_E256_N1.1270.99
178_V202_I1.1220.99
7_M124_W1.1210.99
123_L210_L1.1140.99
13_A112_C1.1090.99
44_D68_F1.1060.99
29_L40_L1.1000.99
177_K180_N1.0970.99
180_N184_E1.0950.99
159_S199_L1.0830.99
44_D47_I1.0720.99
12_C92_R1.0720.99
270_Y273_Y1.0710.99
108_I124_W1.0660.99
7_M108_I1.0650.99
85_I89_A1.0480.99
33_D38_V1.0410.99
74_N77_E1.0380.99
109_Y162_M1.0330.99
136_V161_I1.0290.99
158_N196_Q1.0260.99
9_I40_L1.0230.99
266_E270_Y1.0230.99
17_Y112_C1.0130.99
18_A51_N0.9940.99
23_G271_M0.9940.99
92_R195_D0.9940.99
118_E122_K0.9930.99
20_H255_W0.9930.99
106_R163_I0.9910.99
100_K103_S0.9830.99
128_I165_D0.9810.98
100_K170_R0.9750.98
169_W174_I0.9730.98
53_K56_E0.9700.98
27_S31_N0.9640.98
126_L208_Y0.9580.98
15_D18_A0.9540.98
131_Y134_A0.9540.98
131_Y206_Q0.9460.98
268_F271_M0.9280.98
239_T243_P0.9270.98
174_I178_V0.9240.98
193_L197_D0.9240.98
96_P175_T0.9170.98
41_Y67_E0.9170.98
43_I95_I0.9120.98
90_Y194_H0.9050.97
47_I51_N0.9030.97
128_I163_I0.8980.97
99_I107_M0.8940.97
181_F202_I0.8810.97
60_L63_G0.8790.97
198_A202_I0.8770.97
12_C43_I0.8740.97
134_A163_I0.8730.97
235_Q239_T0.8710.97
111_D160_G0.8640.97
49_P52_K0.8620.97
21_L25_F0.8580.96
132_T168_S0.8530.96
113_D247_H0.8500.96
143_E147_E0.8380.96
41_Y44_D0.8370.96
181_F198_A0.8350.96
105_K165_D0.8340.96
106_R128_I0.8290.96
76_Y94_S0.8270.96
180_N183_N0.8160.95
135_A207_W0.8150.95
100_K104_I0.8120.95
94_S179_I0.8090.95
175_T179_I0.8050.95
95_I107_M0.7980.95
6_I36_R0.7970.95
50_D54_R0.7860.94
32_M38_V0.7780.94
26_V273_Y0.7770.94
138_D196_Q0.7750.94
54_R57_E0.7750.94
59_T62_F0.7710.94
213_R242_N0.7680.94
20_H253_K0.7630.93
66_I71_V0.7610.93
115_L248_F0.7610.93
88_A91_Y0.7590.93
41_Y104_I0.7590.93
50_D53_K0.7550.93
93_I178_V0.7530.93
197_D200_N0.7510.93
132_T165_D0.7490.93
134_A210_L0.7470.93
100_K166_F0.7440.92
75_M78_H0.7350.92
266_E269_H0.7330.92
128_I208_Y0.7320.92
127_D208_Y0.7300.92
185_H190_F0.7290.92
135_A199_L0.7270.92
216_A267_Y0.7260.92
91_Y94_S0.7240.91
26_V62_F0.7220.91
143_E146_K0.7220.91
93_I199_L0.7190.91
248_F263_Y0.7190.91
19_R271_M0.7180.91
178_V203_L0.7150.91
37_E63_G0.7120.91
48_K51_N0.7090.91
115_L266_E0.7090.91
24_M116_V0.7080.91
28_L116_V0.7070.90
211_H214_W0.7060.90
133_V203_L0.7030.90
36_R119_D0.7010.90
138_D158_N0.7000.90
191_L194_H0.6980.90
181_F191_L0.6970.90
59_T64_V0.6950.90
169_W172_Q0.6950.90
158_N161_I0.6950.90
13_A20_H0.6920.90
199_L207_W0.6910.89
29_L38_V0.6890.89
169_W175_T0.6820.89
40_L116_V0.6820.89
263_Y266_E0.6810.89
118_E242_N0.6790.89
212_P239_T0.6790.89
108_I120_I0.6780.89
66_I69_L0.6770.88
30_T270_Y0.6730.88
127_D131_Y0.6710.88
59_T63_G0.6660.88
82_S85_I0.6660.88
187_D190_F0.6650.88
115_L246_V0.6630.87
195_D200_N0.6570.87
261_H264_R0.6500.86
22_G55_L0.6500.86
22_G58_T0.6490.86
235_Q238_E0.6490.86
133_V207_W0.6480.86
196_Q200_N0.6470.86
113_D160_G0.6460.86
217_Q221_M0.6460.86
195_D215_N0.6460.86
160_G215_N0.6430.86
31_N116_V0.6420.86
255_W267_Y0.6410.86
20_H271_M0.6400.86
135_A162_M0.6400.86
99_I166_F0.6370.85
191_L197_D0.6360.85
124_W140_G0.6360.85
50_D74_N0.6360.85
35_E119_D0.6340.85
47_I52_K0.6330.85
174_I203_L0.6330.85
134_A165_D0.6320.85
259_T262_P0.6310.85
127_D130_P0.6230.84
92_R159_S0.6230.84
96_P166_F0.6230.84
70_E73_T0.6210.84
117_L242_N0.6210.84
267_Y271_M0.6200.84
177_K181_F0.6200.84
137_E209_E0.6170.83
9_I28_L0.6150.83
45_G87_K0.6100.83
106_R124_W0.6100.83
109_Y195_D0.6100.83
13_A44_D0.6080.83
27_S270_Y0.6040.82
152_D204_Y0.6030.82
212_P217_Q0.6020.82
33_D36_R0.6010.82
17_Y86_T0.6010.82
124_W170_R0.6000.82
123_L214_W0.6000.82
210_L214_W0.5990.82
23_G26_V0.5970.81
33_D119_D0.5950.81
31_N118_E0.5940.81
93_I195_D0.5920.81
11_S28_L0.5890.81
49_P56_E0.5890.81
57_E118_E0.5880.80
215_N247_H0.5870.80
24_M29_L0.5870.80
28_L38_V0.5870.80
191_L201_A0.5870.80
258_N272_S0.5860.80
68_F71_V0.5860.80
156_Y193_L0.5860.80
45_G91_Y0.5850.80
108_I123_L0.5830.80
23_G27_S0.5820.80
259_T272_S0.5820.80
237_N240_R0.5760.79
119_D122_K0.5730.79
130_P168_S0.5710.78
167_E170_R0.5700.78
7_M120_I0.5680.78
132_T203_L0.5680.78
137_E140_G0.5660.78
106_R167_E0.5650.78
201_A205_D0.5650.78
158_N249_C0.5640.78
108_I122_K0.5620.77
109_Y200_N0.5620.77
123_L163_I0.5600.77
131_Y165_D0.5590.77
65_P73_T0.5580.77
168_S206_Q0.5580.77
265_D270_Y0.5580.77
32_M214_W0.5580.77
174_I177_K0.5580.77
216_A263_Y0.5560.77
169_W203_L0.5530.76
107_M222_L0.5530.76
20_H112_C0.5530.76
264_R270_Y0.5520.76
196_Q215_N0.5520.76
65_P68_F0.5510.76
51_N54_R0.5500.76
95_I109_Y0.5470.75
17_Y84_H0.5470.75
86_T194_H0.5460.75
216_A243_P0.5450.75
44_D91_Y0.5440.75
106_R125_D0.5430.75
93_I182_I0.5430.75
42_V83_S0.5420.75
157_F209_E0.5410.75
162_M199_L0.5360.74
94_S97_D0.5360.74
160_G247_H0.5360.74
29_L62_F0.5350.74
124_W163_I0.5340.74
151_T197_D0.5310.73
92_R199_L0.5310.73
109_Y248_F0.5290.73
57_E60_L0.5280.73
240_R243_P0.5280.73
116_V120_I0.5270.73
182_I198_A0.5250.73
155_K209_E0.5230.72
73_T77_E0.5230.72
17_Y20_H0.5220.72
103_S171_K0.5220.72
165_D208_Y0.5220.72
261_H265_D0.5220.72
21_L44_D0.5210.72
44_D88_A0.5210.72
11_S112_C0.5190.72
118_E213_R0.5180.72
119_D244_A0.5170.71
104_I107_M0.5170.71
146_K210_L0.5140.71
84_H194_H0.5140.71
65_P72_D0.5130.71
61_K65_P0.5120.71
39_K104_I0.5120.71
216_A240_R0.5120.71
249_C252_E0.5110.70
77_E87_K0.5090.70
106_R208_Y0.5070.70
21_L107_M0.5070.70
50_D57_E0.5050.70
49_P70_E0.5040.69
138_D217_Q0.5030.69
66_I72_D0.5030.69
248_F251_G0.5020.69
9_I12_C0.5000.69
256_N260_K0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tztA 2 0.8287 100 0.245 Contact Map
1g9rA 1 0.9301 100 0.246 Contact Map
1ll2A 2 0.8392 100 0.392 Contact Map
4uegA 4 0.8322 100 0.394 Contact Map
3u2uA 2 0.8392 100 0.397 Contact Map
3iohA 2 0.7448 96 0.895 Contact Map
1o7qA 1 0.7762 95.8 0.897 Contact Map
4aylA 1 0.6923 94.7 0.904 Contact Map
2p6wA 1 0.6888 92.4 0.912 Contact Map
1xhbA 1 0.7762 77.5 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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