GSPA - BACSU - GREMLIN Contacts

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GSPA - General stress protein A

UniProt:	P25148	Sequences: MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVIDGGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDESIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSGIMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQTYIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKWNTIGNPAINQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	286 (254)
Sequences:	3610 (2348)
Seq/√Len:	147.3

ECOLI - RFAI RFAJ
BACSU - GSPA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
89_A	159_S	5.389	1.00
11_S	24_M	4.791	1.00
105_K	167_E	4.290	1.00
114_A	161_I	4.015	1.00
39_K	67_E	3.308	1.00
41_Y	69_L	3.151	1.00
15_D	51_N	3.094	1.00
108_I	163_I	3.066	1.00
118_E	244_A	2.817	1.00
159_S	194_H	2.517	1.00
164_I	169_W	2.483	1.00
173_N	176_E	2.439	1.00
31_N	270_Y	2.426	1.00
166_F	170_R	2.414	1.00
157_F	199_L	2.391	1.00
168_S	171_K	2.379	1.00
135_A	157_F	2.313	1.00
97_D	175_T	2.302	1.00
28_L	40_L	2.235	1.00
213_R	244_A	2.174	1.00
30_T	273_Y	2.171	1.00
24_M	114_A	2.148	1.00
159_S	195_D	2.097	1.00
128_I	134_A	2.009	1.00
158_N	215_N	1.981	1.00
20_H	267_Y	1.977	1.00
8_H	41_Y	1.975	1.00
25_F	40_L	1.958	1.00
117_L	266_E	1.946	1.00
167_E	171_K	1.938	1.00
15_D	48_K	1.917	1.00
116_V	245_I	1.876	1.00
10_V	95_I	1.872	1.00
89_A	194_H	1.832	1.00
10_V	107_M	1.762	1.00
26_V	30_T	1.750	1.00
172_Q	206_Q	1.749	1.00
168_S	172_Q	1.718	1.00
176_E	180_N	1.713	1.00
214_W	244_A	1.710	1.00
110_I	114_A	1.701	1.00
13_A	21_L	1.694	1.00
134_A	208_Y	1.687	1.00
181_F	201_A	1.672	1.00
130_P	165_D	1.670	1.00
8_H	39_K	1.670	1.00
128_I	131_Y	1.658	1.00
106_R	165_D	1.642	1.00
129_A	208_Y	1.604	1.00
49_P	53_K	1.600	1.00
132_T	172_Q	1.573	1.00
131_Y	208_Y	1.567	1.00
24_M	28_L	1.523	1.00
121_S	125_D	1.500	1.00
269_H	273_Y	1.482	1.00
144_R	147_E	1.477	1.00
85_I	194_H	1.468	1.00
117_L	246_V	1.461	1.00
157_F	207_W	1.441	1.00
110_I	161_I	1.437	1.00
181_F	185_H	1.431	1.00
161_I	245_I	1.426	1.00
110_I	116_V	1.403	1.00
7_M	10_V	1.382	1.00
243_P	246_V	1.368	1.00
14_D	88_A	1.354	1.00
156_Y	197_D	1.353	1.00
36_R	125_D	1.343	1.00
89_A	195_D	1.335	1.00
178_V	198_A	1.321	1.00
165_D	168_S	1.318	1.00
36_R	121_S	1.311	1.00
157_F	200_N	1.308	1.00
120_I	245_I	1.299	1.00
122_K	244_A	1.274	1.00
23_G	115_L	1.272	1.00
28_L	120_I	1.259	1.00
265_D	269_H	1.258	1.00
110_I	245_I	1.257	1.00
104_I	166_F	1.255	1.00
99_I	104_I	1.251	1.00
8_H	124_W	1.248	1.00
114_A	245_I	1.245	1.00
52_K	68_F	1.234	1.00
39_K	65_P	1.233	1.00
8_H	104_I	1.233	1.00
21_L	112_C	1.232	1.00
132_T	206_Q	1.229	1.00
29_L	64_V	1.224	1.00
217_Q	249_C	1.223	1.00
177_K	202_I	1.211	1.00
11_S	21_L	1.207	1.00
27_S	116_V	1.204	1.00
25_F	29_L	1.197	1.00
27_S	115_L	1.169	1.00
44_D	52_K	1.168	1.00
32_M	119_D	1.168	1.00
156_Y	200_N	1.164	1.00
92_R	109_Y	1.140	1.00
53_K	57_E	1.140	1.00
11_S	114_A	1.136	0.99
97_D	176_E	1.132	0.99
52_K	56_E	1.130	0.99
194_H	197_D	1.128	0.99
252_E	256_N	1.127	0.99
178_V	202_I	1.122	0.99
7_M	124_W	1.121	0.99
123_L	210_L	1.114	0.99
13_A	112_C	1.109	0.99
44_D	68_F	1.106	0.99
29_L	40_L	1.100	0.99
177_K	180_N	1.097	0.99
180_N	184_E	1.095	0.99
159_S	199_L	1.083	0.99
44_D	47_I	1.072	0.99
12_C	92_R	1.072	0.99
270_Y	273_Y	1.071	0.99
108_I	124_W	1.066	0.99
7_M	108_I	1.065	0.99
85_I	89_A	1.048	0.99
33_D	38_V	1.041	0.99
74_N	77_E	1.038	0.99
109_Y	162_M	1.033	0.99
136_V	161_I	1.029	0.99
158_N	196_Q	1.026	0.99
9_I	40_L	1.023	0.99
266_E	270_Y	1.023	0.99
17_Y	112_C	1.013	0.99
18_A	51_N	0.994	0.99
23_G	271_M	0.994	0.99
92_R	195_D	0.994	0.99
118_E	122_K	0.993	0.99
20_H	255_W	0.993	0.99
106_R	163_I	0.991	0.99
100_K	103_S	0.983	0.99
128_I	165_D	0.981	0.98
100_K	170_R	0.975	0.98
169_W	174_I	0.973	0.98
53_K	56_E	0.970	0.98
27_S	31_N	0.964	0.98
126_L	208_Y	0.958	0.98
15_D	18_A	0.954	0.98
131_Y	134_A	0.954	0.98
131_Y	206_Q	0.946	0.98
268_F	271_M	0.928	0.98
239_T	243_P	0.927	0.98
174_I	178_V	0.924	0.98
193_L	197_D	0.924	0.98
96_P	175_T	0.917	0.98
41_Y	67_E	0.917	0.98
43_I	95_I	0.912	0.98
90_Y	194_H	0.905	0.97
47_I	51_N	0.903	0.97
128_I	163_I	0.898	0.97
99_I	107_M	0.894	0.97
181_F	202_I	0.881	0.97
60_L	63_G	0.879	0.97
198_A	202_I	0.877	0.97
12_C	43_I	0.874	0.97
134_A	163_I	0.873	0.97
235_Q	239_T	0.871	0.97
111_D	160_G	0.864	0.97
49_P	52_K	0.862	0.97
21_L	25_F	0.858	0.96
132_T	168_S	0.853	0.96
113_D	247_H	0.850	0.96
143_E	147_E	0.838	0.96
41_Y	44_D	0.837	0.96
181_F	198_A	0.835	0.96
105_K	165_D	0.834	0.96
106_R	128_I	0.829	0.96
76_Y	94_S	0.827	0.96
180_N	183_N	0.816	0.95
135_A	207_W	0.815	0.95
100_K	104_I	0.812	0.95
94_S	179_I	0.809	0.95
175_T	179_I	0.805	0.95
95_I	107_M	0.798	0.95
6_I	36_R	0.797	0.95
50_D	54_R	0.786	0.94
32_M	38_V	0.778	0.94
26_V	273_Y	0.777	0.94
138_D	196_Q	0.775	0.94
54_R	57_E	0.775	0.94
59_T	62_F	0.771	0.94
213_R	242_N	0.768	0.94
20_H	253_K	0.763	0.93
66_I	71_V	0.761	0.93
115_L	248_F	0.761	0.93
88_A	91_Y	0.759	0.93
41_Y	104_I	0.759	0.93
50_D	53_K	0.755	0.93
93_I	178_V	0.753	0.93
197_D	200_N	0.751	0.93
132_T	165_D	0.749	0.93
134_A	210_L	0.747	0.93
100_K	166_F	0.744	0.92
75_M	78_H	0.735	0.92
266_E	269_H	0.733	0.92
128_I	208_Y	0.732	0.92
127_D	208_Y	0.730	0.92
185_H	190_F	0.729	0.92
135_A	199_L	0.727	0.92
216_A	267_Y	0.726	0.92
91_Y	94_S	0.724	0.91
26_V	62_F	0.722	0.91
143_E	146_K	0.722	0.91
93_I	199_L	0.719	0.91
248_F	263_Y	0.719	0.91
19_R	271_M	0.718	0.91
178_V	203_L	0.715	0.91
37_E	63_G	0.712	0.91
48_K	51_N	0.709	0.91
115_L	266_E	0.709	0.91
24_M	116_V	0.708	0.91
28_L	116_V	0.707	0.90
211_H	214_W	0.706	0.90
133_V	203_L	0.703	0.90
36_R	119_D	0.701	0.90
138_D	158_N	0.700	0.90
191_L	194_H	0.698	0.90
181_F	191_L	0.697	0.90
59_T	64_V	0.695	0.90
169_W	172_Q	0.695	0.90
158_N	161_I	0.695	0.90
13_A	20_H	0.692	0.90
199_L	207_W	0.691	0.89
29_L	38_V	0.689	0.89
169_W	175_T	0.682	0.89
40_L	116_V	0.682	0.89
263_Y	266_E	0.681	0.89
118_E	242_N	0.679	0.89
212_P	239_T	0.679	0.89
108_I	120_I	0.678	0.89
66_I	69_L	0.677	0.88
30_T	270_Y	0.673	0.88
127_D	131_Y	0.671	0.88
59_T	63_G	0.666	0.88
82_S	85_I	0.666	0.88
187_D	190_F	0.665	0.88
115_L	246_V	0.663	0.87
195_D	200_N	0.657	0.87
261_H	264_R	0.650	0.86
22_G	55_L	0.650	0.86
22_G	58_T	0.649	0.86
235_Q	238_E	0.649	0.86
133_V	207_W	0.648	0.86
196_Q	200_N	0.647	0.86
113_D	160_G	0.646	0.86
217_Q	221_M	0.646	0.86
195_D	215_N	0.646	0.86
160_G	215_N	0.643	0.86
31_N	116_V	0.642	0.86
255_W	267_Y	0.641	0.86
20_H	271_M	0.640	0.86
135_A	162_M	0.640	0.86
99_I	166_F	0.637	0.85
191_L	197_D	0.636	0.85
124_W	140_G	0.636	0.85
50_D	74_N	0.636	0.85
35_E	119_D	0.634	0.85
47_I	52_K	0.633	0.85
174_I	203_L	0.633	0.85
134_A	165_D	0.632	0.85
259_T	262_P	0.631	0.85
127_D	130_P	0.623	0.84
92_R	159_S	0.623	0.84
96_P	166_F	0.623	0.84
70_E	73_T	0.621	0.84
117_L	242_N	0.621	0.84
267_Y	271_M	0.620	0.84
177_K	181_F	0.620	0.84
137_E	209_E	0.617	0.83
9_I	28_L	0.615	0.83
45_G	87_K	0.610	0.83
106_R	124_W	0.610	0.83
109_Y	195_D	0.610	0.83
13_A	44_D	0.608	0.83
27_S	270_Y	0.604	0.82
152_D	204_Y	0.603	0.82
212_P	217_Q	0.602	0.82
33_D	36_R	0.601	0.82
17_Y	86_T	0.601	0.82
124_W	170_R	0.600	0.82
123_L	214_W	0.600	0.82
210_L	214_W	0.599	0.82
23_G	26_V	0.597	0.81
33_D	119_D	0.595	0.81
31_N	118_E	0.594	0.81
93_I	195_D	0.592	0.81
11_S	28_L	0.589	0.81
49_P	56_E	0.589	0.81
57_E	118_E	0.588	0.80
215_N	247_H	0.587	0.80
24_M	29_L	0.587	0.80
28_L	38_V	0.587	0.80
191_L	201_A	0.587	0.80
258_N	272_S	0.586	0.80
68_F	71_V	0.586	0.80
156_Y	193_L	0.586	0.80
45_G	91_Y	0.585	0.80
108_I	123_L	0.583	0.80
23_G	27_S	0.582	0.80
259_T	272_S	0.582	0.80
237_N	240_R	0.576	0.79
119_D	122_K	0.573	0.79
130_P	168_S	0.571	0.78
167_E	170_R	0.570	0.78
7_M	120_I	0.568	0.78
132_T	203_L	0.568	0.78
137_E	140_G	0.566	0.78
106_R	167_E	0.565	0.78
201_A	205_D	0.565	0.78
158_N	249_C	0.564	0.78
108_I	122_K	0.562	0.77
109_Y	200_N	0.562	0.77
123_L	163_I	0.560	0.77
131_Y	165_D	0.559	0.77
65_P	73_T	0.558	0.77
168_S	206_Q	0.558	0.77
265_D	270_Y	0.558	0.77
32_M	214_W	0.558	0.77
174_I	177_K	0.558	0.77
216_A	263_Y	0.556	0.77
169_W	203_L	0.553	0.76
107_M	222_L	0.553	0.76
20_H	112_C	0.553	0.76
264_R	270_Y	0.552	0.76
196_Q	215_N	0.552	0.76
65_P	68_F	0.551	0.76
51_N	54_R	0.550	0.76
95_I	109_Y	0.547	0.75
17_Y	84_H	0.547	0.75
86_T	194_H	0.546	0.75
216_A	243_P	0.545	0.75
44_D	91_Y	0.544	0.75
106_R	125_D	0.543	0.75
93_I	182_I	0.543	0.75
42_V	83_S	0.542	0.75
157_F	209_E	0.541	0.75
162_M	199_L	0.536	0.74
94_S	97_D	0.536	0.74
160_G	247_H	0.536	0.74
29_L	62_F	0.535	0.74
124_W	163_I	0.534	0.74
151_T	197_D	0.531	0.73
92_R	199_L	0.531	0.73
109_Y	248_F	0.529	0.73
57_E	60_L	0.528	0.73
240_R	243_P	0.528	0.73
116_V	120_I	0.527	0.73
182_I	198_A	0.525	0.73
155_K	209_E	0.523	0.72
73_T	77_E	0.523	0.72
17_Y	20_H	0.522	0.72
103_S	171_K	0.522	0.72
165_D	208_Y	0.522	0.72
261_H	265_D	0.522	0.72
21_L	44_D	0.521	0.72
44_D	88_A	0.521	0.72
11_S	112_C	0.519	0.72
118_E	213_R	0.518	0.72
119_D	244_A	0.517	0.71
104_I	107_M	0.517	0.71
146_K	210_L	0.514	0.71
84_H	194_H	0.514	0.71
65_P	72_D	0.513	0.71
61_K	65_P	0.512	0.71
39_K	104_I	0.512	0.71
216_A	240_R	0.512	0.71
249_C	252_E	0.511	0.70
77_E	87_K	0.509	0.70
106_R	208_Y	0.507	0.70
21_L	107_M	0.507	0.70
50_D	57_E	0.505	0.70
49_P	70_E	0.504	0.69
138_D	217_Q	0.503	0.69
66_I	72_D	0.503	0.69
248_F	251_G	0.502	0.69
9_I	12_C	0.500	0.69
256_N	260_K	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tztA	2	0.8287	100	0.245	Contact Map
1g9rA	1	0.9301	100	0.246	Contact Map
1ll2A	2	0.8392	100	0.392	Contact Map
4uegA	4	0.8322	100	0.394	Contact Map
3u2uA	2	0.8392	100	0.397	Contact Map
3iohA	2	0.7448	96	0.895	Contact Map
1o7qA	1	0.7762	95.8	0.897	Contact Map
4aylA	1	0.6923	94.7	0.904	Contact Map
2p6wA	1	0.6888	92.4	0.912	Contact Map
1xhbA	1	0.7762	77.5	0.93	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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