GREMLIN Database
CCPA - Catabolite control protein A
UniProt: P25144 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 334 (324)
Sequences: 36252 (26372)
Seq/√Len: 1465.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_H242_T3.5381.00
163_E203_R3.3701.00
12_E44_R3.1751.00
265_S268_E3.0661.00
169_A273_I2.6891.00
178_H271_D2.6381.00
120_G306_L2.6371.00
277_N292_V2.6321.00
198_L202_K2.5551.00
167_Y207_E2.3811.00
156_P309_L2.3311.00
228_L261_D2.2671.00
86_I89_M2.2241.00
32_P36_K2.2141.00
40_E44_R2.1921.00
36_K40_E2.1751.00
86_I304_R2.1541.00
232_Q262_Q2.1301.00
301_V304_R2.0631.00
167_Y204_A2.0471.00
167_Y203_R2.0461.00
174_V208_A2.0271.00
87_A303_M2.0171.00
171_K204_A2.0161.00
164_Q168_D1.9931.00
23_V38_V1.9921.00
82_G299_G1.9761.00
166_I170_V1.9681.00
232_Q258_A1.9661.00
165_A275_F1.9621.00
24_V42_I1.9411.00
35_R39_L1.9301.00
227_G254_G1.9201.00
163_E199_Q1.8881.00
173_L243_A1.8771.00
171_K175_D1.8681.00
7_Y17_M1.8451.00
86_I300_A1.8341.00
166_I245_L1.8271.00
259_A270_L1.7851.00
236_S262_Q1.7771.00
308_K313_E1.7741.00
170_V201_Y1.7721.00
292_V325_R1.7711.00
85_D296_Y1.7581.00
13_A41_A1.7321.00
171_K208_A1.7081.00
167_Y171_K1.6861.00
228_L258_A1.6801.00
287_Q330_K1.6751.00
183_F247_A1.6581.00
65_G118_V1.6571.00
294_P297_D1.6461.00
231_L255_I1.6451.00
12_E41_A1.6371.00
82_G296_Y1.6341.00
182_A241_P1.6191.00
246_S255_I1.6171.00
168_D324_H1.6051.00
301_V320_V1.5961.00
277_N329_R1.5921.00
264_L269_D1.5801.00
172_L176_K1.5761.00
180_D213_N1.5751.00
146_A302_A1.5531.00
86_I90_Y1.5491.00
39_L43_E1.5341.00
258_A262_Q1.5341.00
265_S269_D1.5321.00
23_V42_I1.5261.00
180_D240_K1.5181.00
164_Q167_Y1.5181.00
199_Q203_R1.5131.00
260_Q285_R1.5121.00
161_D164_Q1.4731.00
90_Y307_T1.4701.00
174_V204_A1.4631.00
297_D301_V1.4581.00
172_L175_D1.4551.00
258_A261_D1.4441.00
9_V41_A1.4371.00
218_A233_H1.4361.00
39_L42_I1.4221.00
196_K199_Q1.4171.00
62_T119_D1.4091.00
273_I289_S1.3871.00
297_D300_A1.3851.00
202_K206_E1.3801.00
165_A324_H1.3771.00
166_I200_G1.3761.00
86_I303_M1.3721.00
170_V174_V1.3611.00
172_L328_L1.3561.00
170_V200_G1.3511.00
178_H243_A1.3361.00
259_A264_L1.3321.00
204_A207_E1.3321.00
9_V13_A1.3161.00
228_L257_H1.3141.00
180_D242_T1.3021.00
232_Q261_D1.2911.00
62_T92_Y1.2871.00
12_E45_L1.2851.00
170_V204_A1.2851.00
182_A234_L1.2821.00
22_R27_N1.2801.00
231_L244_I1.2741.00
228_L232_Q1.2711.00
7_Y11_R1.2641.00
307_T311_N1.2641.00
32_P35_R1.2611.00
31_K34_T1.2591.00
304_R308_K1.2581.00
213_N216_F1.2531.00
231_L259_A1.2511.00
200_G204_A1.2461.00
64_V87_A1.2421.00
8_D11_R1.2411.00
97_S113_M1.2401.00
232_Q236_S1.2331.00
65_G113_M1.2271.00
134_A138_R1.2241.00
37_K41_A1.2231.00
97_S109_L1.2211.00
122_V302_A1.2181.00
6_I17_M1.2141.00
168_D171_K1.2031.00
221_D226_S1.2011.00
163_E167_Y1.1991.00
87_A94_I1.1971.00
256_I272_I1.1891.00
83_I303_M1.1831.00
179_T242_T1.1811.00
9_V45_L1.1801.00
41_A44_R1.1791.00
238_D241_P1.1731.00
163_E196_K1.1721.00
41_A45_L1.1721.00
66_V83_I1.1721.00
233_H237_L1.1661.00
83_I122_V1.1561.00
254_G258_A1.1511.00
171_K207_E1.1471.00
34_T37_K1.1321.00
111_N135_E1.1311.00
201_Y205_L1.1211.00
6_I20_V1.1201.00
296_Y300_A1.1191.00
249_D290_T1.1131.00
225_D229_E1.1061.00
176_K328_L1.1061.00
90_Y304_R1.1041.00
249_D274_G1.0991.00
63_T93_N1.0991.00
23_V30_V1.0981.00
66_V94_I1.0971.00
181_I205_L1.0951.00
40_E43_E1.0941.00
299_G303_M1.0921.00
183_F198_L1.0861.00
184_V255_I1.0811.00
244_I255_I1.0791.00
169_A245_L1.0771.00
203_R207_E1.0711.00
163_E200_G1.0701.00
84_E88_T1.0651.00
36_K39_L1.0541.00
301_V305_L1.0521.00
204_A208_A1.0441.00
230_A233_H1.0361.00
223_T226_S1.0321.00
42_I45_L1.0251.00
50_N56_L1.0241.00
26_G35_R1.0231.00
107_L111_N1.0221.00
175_D208_A1.0211.00
63_T95_I1.0211.00
174_V210_L1.0131.00
227_G231_L1.0061.00
300_A304_R1.0041.00
88_T105_K1.0011.00
199_Q202_K1.0011.00
305_L320_V1.0001.00
90_Y311_N0.9991.00
52_V55_G0.9981.00
246_S251_M0.9941.00
218_A230_A0.9941.00
201_Y245_L0.9891.00
188_M219_E0.9891.00
50_N53_A0.9871.00
229_E233_H0.9861.00
246_S252_A0.9781.00
180_D239_K0.9771.00
13_A20_V0.9771.00
205_L210_L0.9751.00
306_L310_M0.9741.00
92_Y307_T0.9721.00
301_V322_L0.9631.00
224_Y257_H0.9621.00
226_S229_E0.9531.00
172_L289_S0.9491.00
231_L235_M0.9431.00
164_Q323_P0.9431.00
195_S199_Q0.9371.00
169_A291_V0.9321.00
89_M300_A0.9291.00
160_I294_P0.9201.00
256_I284_V0.9171.00
176_K271_D0.9151.00
186_G222_Y0.9071.00
170_V205_L0.9071.00
122_V306_L0.9061.00
81_R85_D0.9001.00
85_D300_A0.8991.00
294_P322_L0.8961.00
111_N115_G0.8961.00
181_I243_A0.8951.00
325_R328_L0.8871.00
49_P54_R0.8861.00
64_V122_V0.8851.00
180_D216_F0.8851.00
83_I299_G0.8771.00
249_D277_N0.8751.00
292_V327_E0.8701.00
105_K108_H0.8681.00
202_K212_F0.8651.00
256_I266_I0.8581.00
26_G39_L0.8581.00
164_Q324_H0.8561.00
53_A56_L0.8551.00
260_Q287_Q0.8551.00
174_V179_T0.8521.00
66_V80_A0.8481.00
259_A272_I0.8481.00
235_M258_A0.8441.00
274_G290_T0.8431.00
23_V39_L0.8431.00
161_D321_E0.8401.00
229_E232_Q0.8371.00
75_F295_T0.8341.00
160_I324_H0.8331.00
182_A244_I0.8321.00
158_V305_L0.8271.00
157_S319_I0.8241.00
19_T22_R0.8241.00
159_A321_E0.8221.00
161_D323_P0.8221.00
162_Y197_K0.8191.00
244_I270_L0.8181.00
276_D293_Q0.8161.00
220_G251_M0.8151.00
160_I293_Q0.8141.00
80_A84_E0.8131.00
79_L146_A0.8131.00
277_N327_E0.8101.00
264_L270_L0.8031.00
305_L308_K0.8021.00
120_G310_M0.8001.00
33_T36_K0.7951.00
61_T119_D0.7931.00
15_V38_V0.7931.00
179_T210_L0.7921.00
203_R206_E0.7901.00
69_P76_Y0.7901.00
183_F245_L0.7831.00
240_K264_L0.7831.00
294_P325_R0.7811.00
184_V246_S0.7801.00
78_E296_Y0.7781.00
198_L217_V0.7771.00
185_S198_L0.7771.00
249_D252_A0.7751.00
51_A54_R0.7751.00
205_L212_F0.7721.00
303_M307_T0.7711.00
216_F237_L0.7711.00
135_E138_R0.7701.00
281_S284_V0.7701.00
156_P305_L0.7701.00
82_G300_A0.7671.00
22_R28_P0.7661.00
83_I94_I0.7611.00
102_N105_K0.7611.00
85_D89_M0.7591.00
196_K200_G0.7591.00
226_S230_A0.7591.00
173_L273_I0.7561.00
189_A195_S0.7561.00
253_L284_V0.7531.00
63_T116_K0.7531.00
18_A22_R0.7521.00
231_L234_L0.7491.00
22_R29_N0.7491.00
231_L258_A0.7461.00
64_V303_M0.7421.00
82_G86_I0.7421.00
33_T37_K0.7421.00
137_K154_E0.7381.00
65_G121_I0.7371.00
235_M262_Q0.7371.00
172_L326_I0.7371.00
108_H111_N0.7351.00
80_A96_L0.7351.00
242_T271_D0.7331.00
114_L139_S0.7301.00
159_A319_I0.7301.00
218_A234_L0.7261.00
212_F215_Q0.7251.00
60_K119_D0.7211.00
257_H260_Q0.7211.00
237_L241_P0.7191.00
95_I118_V0.7121.00
81_R84_E0.7111.00
48_R115_G0.7101.00
237_L240_K0.7071.00
168_D291_V0.7061.00
277_N281_S0.7011.00
84_E94_I0.7011.00
280_L284_V0.6981.00
252_A274_G0.6971.00
245_L273_I0.6971.00
167_Y200_G0.6961.00
105_K109_L0.6931.00
149_V319_I0.6921.00
84_E98_N0.6911.00
104_E108_H0.6901.00
120_G144_V0.6881.00
60_K311_N0.6871.00
67_I109_L0.6861.00
136_F143_I0.6801.00
194_R222_Y0.6771.00
100_D105_K0.6771.00
145_L155_T0.6761.00
231_L254_G0.6761.00
134_A137_K0.6751.00
248_T276_D0.6751.00
257_H287_Q0.6721.00
233_H236_S0.6701.00
308_K312_K0.6701.00
259_A266_I0.6691.00
181_I242_T0.6671.00
7_Y57_A0.6651.00
23_V35_R0.6641.00
122_V146_A0.6621.00
227_G230_A0.6591.00
36_K43_E0.6571.00
220_G226_S0.6531.00
174_V205_L0.6491.00
147_A162_Y0.6481.00
257_H261_D0.6471.00
145_L150_E0.6471.00
137_K143_I0.6421.00
218_A237_L0.6381.00
9_V20_V0.6381.00
20_V23_V0.6351.00
287_Q329_R0.6351.00
29_N34_T0.6341.00
289_S326_I0.6341.00
183_F201_Y0.6291.00
73_S250_E0.6281.00
156_P317_E0.6261.00
48_R111_N0.6241.00
43_E46_G0.6241.00
37_K40_E0.6231.00
20_V42_I0.6221.00
186_G194_R0.6201.00
222_Y247_A0.6201.00
168_D172_L0.6201.00
181_I201_Y0.6191.00
182_A216_F0.6171.00
120_G302_A0.6171.00
143_I155_T0.6171.00
296_Y299_G0.6161.00
82_G295_T0.6131.00
15_V34_T0.6121.00
95_I116_K0.6121.00
79_L295_T0.6101.00
78_E295_T0.6101.00
253_L278_T0.6091.00
144_V158_V0.6071.00
22_R30_V0.6061.00
222_Y251_M0.6051.00
147_A193_N0.6011.00
132_H135_E0.6011.00
173_L245_L0.6001.00
92_Y119_D0.6001.00
110_L121_I0.5991.00
114_L141_V0.5981.00
27_N30_V0.5971.00
201_Y212_F0.5961.00
144_V306_L0.5951.00
257_H285_R0.5941.00
198_L219_E0.5931.00
169_A243_A0.5921.00
275_F293_Q0.5911.00
81_R296_Y0.5901.00
259_A262_Q0.5891.00
75_F79_L0.5881.00
245_L275_F0.5881.00
256_I260_Q0.5861.00
202_K217_V0.5861.00
64_V120_G0.5821.00
167_Y170_V0.5821.00
224_Y254_G0.5811.00
20_V38_V0.5801.00
92_Y310_M0.5801.00
107_L132_H0.5791.00
248_T251_M0.5781.00
162_Y196_K0.5761.00
144_V309_L0.5751.00
260_Q265_S0.5731.00
212_F217_V0.5731.00
131_E134_A0.5721.00
312_K315_V0.5681.00
228_L254_G0.5681.00
172_L273_I0.5651.00
246_S274_G0.5651.00
180_D211_P0.5641.00
121_I141_V0.5631.00
225_D228_L0.5621.00
64_V92_Y0.5611.00
13_A23_V0.5601.00
282_L287_Q0.5561.00
305_L309_L0.5541.00
64_V310_M0.5491.00
202_K214_E0.5481.00
285_R330_K0.5481.00
185_S219_E0.5451.00
15_V20_V0.5431.00
144_V302_A0.5421.00
48_R52_V0.5421.00
180_D241_P0.5411.00
298_I322_L0.5411.00
144_V305_L0.5411.00
97_S112_T0.5411.00
197_K293_Q0.5391.00
103_M107_L0.5391.00
18_A27_N0.5381.00
87_A307_T0.5361.00
158_V301_V0.5351.00
54_R58_S0.5351.00
284_V287_Q0.5351.00
135_E139_S0.5321.00
76_Y124_M0.5321.00
235_M259_A0.5311.00
198_L212_F0.5291.00
281_S288_L0.5281.00
249_D278_T0.5281.00
309_L312_K0.5271.00
253_L280_L0.5261.00
260_Q286_P0.5261.00
87_A92_Y0.5241.00
81_R100_D0.5241.00
291_V324_H0.5231.00
255_I259_A0.5231.00
74_I250_E0.5231.00
257_H282_L0.5221.00
113_M118_V0.5221.00
277_N282_L0.5211.00
241_P264_L0.5201.00
277_N290_T0.5161.00
149_V157_S0.5161.00
289_S328_L0.5151.00
61_T93_N0.5131.00
99_S106_E0.5121.00
194_R247_A0.5111.00
160_I275_F0.5111.00
184_V230_A0.5111.00
224_Y280_L0.5091.00
145_L157_S0.5091.00
55_G58_S0.5081.00
13_A38_V0.5081.00
160_I165_A0.5081.00
220_G227_G0.5081.00
243_A271_D0.5071.00
228_L231_L0.5071.00
137_K155_T0.5071.00
281_S290_T0.5061.00
63_T119_D0.5051.00
83_I87_A0.5051.00
230_A234_L0.5041.00
185_S217_V0.5021.00
112_T115_G0.5011.00
301_V308_K0.5011.00
241_P244_I0.5011.00
26_G29_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.8204 100 0.044 Contact Map
2hsgA 1 0.979 100 0.05 Contact Map
2o20A 2 0.8234 100 0.054 Contact Map
1qpzA 2 0.988 100 0.062 Contact Map
4o5aA 2 0.7994 100 0.063 Contact Map
3kjxA 2 0.997 100 0.065 Contact Map
3e3mA 2 0.8024 100 0.068 Contact Map
3bilA 2 0.7635 100 0.069 Contact Map
3h5oA 2 0.8084 100 0.073 Contact Map
1jyeA 2 0.7994 100 0.077 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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