GREMLIN Database
TENI - Thiazole tautomerase
UniProt: P25053 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (193)
Sequences: 5437 (4103)
Seq/√Len: 295.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_L70_F2.8421.00
128_C176_M2.8411.00
72_T95_L2.5661.00
186_L190_R2.5331.00
50_F53_G2.3721.00
38_S41_D2.2901.00
46_L71_S2.2791.00
92_F95_L2.2481.00
23_I57_R2.1851.00
39_A64_R2.1551.00
162_L173_I2.1171.00
184_E187_E2.0851.00
109_Q113_E2.0531.00
159_P191_R2.0451.00
111_E148_S1.9781.00
24_Q186_L1.9321.00
124_F161_R1.9051.00
92_F97_I1.9011.00
144_K171_D1.8291.00
80_S106_E1.8241.00
163_R195_K1.8221.00
53_G74_H1.7761.00
78_L88_I1.7451.00
5_A180_F1.7441.00
144_K151_V1.7281.00
87_Q90_A1.7111.00
123_V140_L1.6841.00
124_F164_D1.6511.00
43_L47_D1.6461.00
23_I55_D1.6341.00
52_G59_L1.6181.00
5_A179_I1.6091.00
187_E191_R1.5971.00
122_H134_G1.5921.00
20_I24_Q1.5741.00
20_I54_I1.5631.00
25_N186_L1.5571.00
121_G154_I1.5411.00
5_A27_V1.5071.00
102_H106_E1.5051.00
104_L108_V1.4991.00
178_G192_Y1.4951.00
108_V111_E1.4691.00
98_G117_Y1.4661.00
14_E18_R1.4661.00
111_E149_I1.4641.00
34_E37_K1.4581.00
25_N189_A1.4361.00
15_E20_I1.4161.00
43_L71_S1.4131.00
158_T161_R1.3681.00
7_T30_I1.3591.00
108_V146_R1.3531.00
24_Q55_D1.3501.00
84_S87_Q1.3411.00
182_S188_A1.3261.00
42_I64_R1.3261.00
79_P82_S1.3051.00
50_F74_H1.2991.00
29_F60_V1.2901.00
86_K113_E1.2811.00
159_P192_Y1.2771.00
65_V76_V1.2691.00
85_P99_R1.2631.00
135_R139_L1.2501.00
27_V30_I1.2501.00
103_S106_E1.2501.00
50_F59_L1.2441.00
43_L67_I1.2211.00
23_I52_G1.2181.00
28_D193_S1.2131.00
99_R115_A1.2061.00
32_I45_L1.2051.00
44_K48_L1.2011.00
142_D146_R1.2011.00
76_V97_I1.1981.00
107_A147_I1.1811.00
107_A143_I1.1731.00
32_I59_L1.1641.00
31_H62_N1.1591.00
164_D167_Q1.1501.00
104_L146_R1.1471.00
104_L142_D1.1471.00
48_L51_E1.1371.00
188_A191_R1.1371.00
32_I42_I1.1331.00
187_E190_R1.1141.00
125_E134_G1.1111.00
44_K47_D1.1051.00
178_G188_A1.1011.00
41_D44_K1.1011.00
17_A20_I1.0981.00
108_V112_K1.0961.00
162_L195_K1.0961.00
9_D34_E1.0931.00
138_S142_D1.0811.00
15_E19_I1.0791.00
141_S145_Q1.0761.00
120_F151_V1.0741.00
19_I49_I1.0731.00
8_D11_K1.0721.00
127_D177_S1.0551.00
152_I172_G1.0501.00
50_F71_S1.0491.00
179_I189_A1.0491.00
138_S141_S1.0381.00
139_L142_D1.0381.00
64_R67_I1.0381.00
15_E18_R1.0301.00
69_L91_R1.0251.00
34_E45_L1.0151.00
190_R194_R1.0141.00
52_G55_D0.9981.00
28_D57_R0.9911.00
78_L99_R0.9851.00
140_L153_A0.9771.00
141_S168_A0.9601.00
88_I92_F0.9591.00
104_L143_I0.9581.00
21_I186_L0.9571.00
37_K41_D0.9501.00
32_I46_L0.9491.00
51_E54_I0.9471.00
123_V153_A0.9461.00
6_I176_M0.9451.00
85_P115_A0.9421.00
37_K42_I0.9391.00
140_L144_K0.9371.00
136_G139_L0.9361.00
109_Q112_K0.9291.00
165_V170_A0.9221.00
21_I24_Q0.9181.00
137_V168_A0.9091.00
77_Q117_Y0.9091.00
6_I154_I0.9051.00
80_S99_R0.9021.00
46_L61_M0.8981.00
191_R195_K0.8961.00
158_T177_S0.8951.00
85_P97_I0.8951.00
101_V107_A0.8871.00
39_A70_F0.8871.00
189_A193_S0.8851.00
39_A66_D0.8761.00
40_A44_K0.8741.00
41_D45_L0.8691.00
162_L166_K0.8641.00
177_S181_S0.8531.00
105_E108_V0.8501.00
60_V96_H0.8491.00
67_I71_S0.8471.00
66_D70_F0.8401.00
175_V179_I0.8311.00
61_M73_I0.8301.00
157_M165_V0.8291.00
4_H31_H0.8261.00
22_T179_I0.8211.00
163_R167_Q0.8211.00
49_I59_L0.8211.00
27_V179_I0.8211.00
123_V137_V0.8201.00
99_R113_E0.8141.00
4_H152_I0.8141.00
74_H96_H0.8091.00
23_I30_I0.8071.00
39_A83_F0.8061.00
120_F143_I0.8051.00
16_L48_L0.7970.99
60_V75_R0.7960.99
107_A118_V0.7940.99
158_T178_G0.7930.99
159_P188_A0.7830.99
101_V110_A0.7820.99
27_V189_A0.7780.99
66_D69_L0.7770.99
120_F139_L0.7720.99
63_G79_P0.7660.99
7_T19_I0.7640.99
191_R194_R0.7610.99
179_I188_A0.7600.99
42_I67_I0.7580.99
142_D145_Q0.7570.99
137_V165_V0.7540.99
42_I62_N0.7480.99
175_V192_Y0.7390.99
137_V164_D0.7370.99
22_T25_N0.7340.99
83_F91_R0.7340.99
9_D36_S0.7240.99
18_R21_I0.7230.99
5_A22_T0.7180.99
5_A30_I0.7140.99
89_R116_D0.7040.99
111_E147_I0.7010.99
3_L193_S0.6950.99
161_R165_V0.6940.99
119_L154_I0.6930.99
105_E109_Q0.6900.99
151_V171_D0.6870.98
63_G82_S0.6840.98
118_V151_V0.6820.98
46_L73_I0.6800.98
78_L97_I0.6770.98
76_V88_I0.6740.98
108_V147_I0.6720.98
10_S36_S0.6690.98
111_E114_D0.6690.98
47_D50_F0.6680.98
20_I55_D0.6670.98
96_H117_Y0.6650.98
70_F87_Q0.6620.98
16_L45_L0.6610.98
6_I174_A0.6590.98
17_A21_I0.6510.98
9_D45_L0.6500.98
21_I25_N0.6400.98
35_R129_K0.6380.98
28_D172_G0.6350.97
153_A170_A0.6350.97
83_F87_Q0.6350.97
50_F73_I0.6340.97
118_V147_I0.6330.97
185_P188_A0.6280.97
31_H119_L0.6280.97
102_H132_L0.6260.97
59_L74_H0.6180.97
126_T177_S0.6160.97
131_G134_G0.6160.97
11_K181_S0.6140.97
114_D149_I0.6110.97
28_D58_K0.6090.97
29_F58_K0.6080.97
47_D71_S0.6070.97
89_R92_F0.6060.97
89_R97_I0.6060.97
60_V95_L0.6050.97
120_F135_R0.6030.97
144_K168_A0.6030.97
84_S109_Q0.6010.97
14_E17_A0.6010.97
110_A114_D0.5980.96
152_I171_D0.5980.96
157_M161_R0.5970.96
30_I52_G0.5960.96
159_P162_L0.5950.96
35_R79_P0.5950.96
102_H135_R0.5900.96
39_A42_I0.5900.96
14_E20_I0.5880.96
140_L170_A0.5780.96
8_D180_F0.5770.96
140_L168_A0.5740.95
7_T15_E0.5710.95
33_R129_K0.5700.95
188_A192_Y0.5660.95
165_V173_I0.5630.95
32_I49_I0.5620.95
67_I70_F0.5610.95
122_H132_L0.5580.95
78_L85_P0.5570.95
12_P18_R0.5560.95
36_S130_K0.5550.95
101_V106_E0.5550.95
79_P129_K0.5530.94
35_R63_G0.5490.94
122_H154_I0.5490.94
123_V136_G0.5440.94
39_A67_I0.5380.94
85_P113_E0.5360.94
89_R95_L0.5350.93
84_S113_E0.5340.93
8_D34_E0.5320.93
21_I185_P0.5310.93
100_S121_G0.5300.93
37_K45_L0.5270.93
9_D37_K0.5260.93
17_A48_L0.5250.93
86_K90_A0.5200.93
123_V165_V0.5180.92
152_I174_A0.5150.92
34_E42_I0.5130.92
46_L59_L0.5110.92
127_D130_K0.5100.92
49_I52_G0.5100.92
118_V149_I0.5090.92
166_K170_A0.5090.92
78_L83_F0.5070.92
4_H29_F0.5060.91
141_S167_Q0.5040.91
35_R62_N0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nl6A 4 0.9902 100 0.317 Contact Map
3ceuA 1 0.922 100 0.403 Contact Map
1yadA 2 0.9415 100 0.415 Contact Map
3o63A 2 0.9415 100 0.426 Contact Map
1twdA 2 0.9512 100 0.43 Contact Map
1xi3A 2 0.9561 100 0.46 Contact Map
2tpsA 1 0.9902 100 0.464 Contact Map
4wuiA 1 0.922 100 0.466 Contact Map
2yw3A 4 0.9024 100 0.481 Contact Map
2bdqA 2 0.8439 100 0.509 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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