TENA - BACSU - GREMLIN Contacts

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TENA - Aminopyrimidine aminohydrolase

UniProt:	P25052	Sequences: MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQDSYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKAFKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWIGTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGWSDSAIKEVEECGASRHNG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	236 (212)
Sequences:	1995 (1540)
Seq/√Len:	105.8

BACSU - TENA
SULSO - Q97VM4 Q97WL0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
26_G	213_Y	4.158	1.00
210_G	214_R	3.603	1.00
10_A	195_K	3.517	1.00
58_G	128_I	3.224	1.00
157_Q	161_G	3.102	1.00
124_N	190_V	3.045	1.00
115_H	201_S	3.007	1.00
26_G	29_D	2.662	1.00
140_Y	169_R	2.647	1.00
4_S	180_D	2.638	1.00
16_E	20_V	2.568	1.00
28_G	146_L	2.452	1.00
22_P	26_G	2.349	1.00
200_I	203_Y	2.323	1.00
127_E	193_K	2.264	1.00
124_N	127_E	2.263	1.00
92_L	158_K	2.243	1.00
96_S	99_E	2.188	1.00
57_F	61_Y	2.130	1.00
67_T	181_E	2.114	1.00
173_E	177_N	2.089	1.00
129_L	179_F	2.075	1.00
64_D	67_T	2.045	1.00
166_D	170_Q	2.031	1.00
207_Q	210_G	1.974	1.00
25_Q	29_D	1.967	1.00
20_V	25_Q	1.942	1.00
6_E	191_R	1.908	1.00
187_T	190_V	1.894	1.00
6_E	195_K	1.891	1.00
18_S	138_L	1.866	1.00
76_Q	80_E	1.863	1.00
110_Y	114_S	1.846	1.00
123_G	127_E	1.827	1.00
50_H	113_T	1.813	1.00
42_L	103_F	1.729	1.00
34_I	38_K	1.707	1.00
106_S	211_M	1.687	1.00
134_P	201_S	1.617	1.00
39_Y	106_S	1.600	1.00
98_E	102_A	1.597	1.00
74_H	136_Y	1.586	1.00
158_K	161_G	1.573	1.00
140_Y	172_V	1.546	1.00
3_F	183_A	1.544	1.00
147_L	164_G	1.533	1.00
33_P	36_R	1.527	1.00
188_E	191_R	1.523	1.00
119_S	197_N	1.438	1.00
46_Y	105_P	1.426	1.00
133_L	137_W	1.424	1.00
11_A	199_V	1.420	1.00
12_A	16_E	1.401	1.00
205_E	208_F	1.401	1.00
111_S	204_Y	1.395	1.00
137_W	176_I	1.387	1.00
143_G	146_L	1.377	1.00
59_A	75_A	1.365	1.00
186_S	194_M	1.361	1.00
13_E	199_V	1.355	1.00
97_E	101_K	1.329	0.99
127_E	197_N	1.306	0.99
143_G	164_G	1.305	0.99
47_Y	51_F	1.298	0.99
5_E	180_D	1.286	0.99
114_S	118_R	1.285	0.99
10_A	199_V	1.269	0.99
6_E	188_E	1.266	0.99
136_Y	175_Q	1.241	0.99
126_A	190_V	1.230	0.99
144_E	169_R	1.219	0.99
57_F	120_V	1.213	0.99
11_A	195_K	1.211	0.99
118_R	122_S	1.195	0.99
136_Y	172_V	1.188	0.99
145_K	149_C	1.187	0.99
53_K	68_T	1.170	0.99
138_L	202_S	1.161	0.98
143_G	159_W	1.132	0.98
85_L	162_T	1.132	0.98
133_L	179_F	1.131	0.98
47_Y	116_M	1.127	0.98
5_E	176_I	1.126	0.98
120_V	128_I	1.119	0.98
135_C	163_Y	1.112	0.98
177_N	181_E	1.096	0.98
168_F	172_V	1.092	0.98
125_F	182_L	1.087	0.98
32_L	156_Y	1.085	0.98
7_C	195_K	1.080	0.98
194_M	197_N	1.078	0.98
26_G	36_R	1.077	0.98
195_K	199_V	1.048	0.97
72_A	76_Q	1.044	0.97
109_A	211_M	1.043	0.97
181_E	185_N	1.040	0.97
200_I	204_Y	1.039	0.97
62_A	125_F	1.030	0.97
130_A	194_M	1.001	0.96
37_F	156_Y	1.000	0.96
192_A	195_K	1.000	0.96
54_V	116_M	0.991	0.96
51_F	132_L	0.987	0.96
9_S	12_A	0.978	0.96
154_P	161_G	0.976	0.96
55_Q	136_Y	0.968	0.95
88_E	92_L	0.963	0.95
86_H	163_Y	0.960	0.95
8_R	12_A	0.949	0.95
73_S	76_Q	0.947	0.95
203_Y	207_Q	0.946	0.95
8_R	11_A	0.940	0.95
74_H	77_G	0.938	0.94
90_A	95_I	0.934	0.94
136_Y	171_Q	0.929	0.94
73_S	77_G	0.920	0.94
81_A	84_A	0.918	0.94
150_D	157_Q	0.913	0.94
183_A	194_M	0.908	0.93
77_G	171_Q	0.906	0.93
38_K	42_L	0.905	0.93
48_L	163_Y	0.903	0.93
13_E	16_E	0.897	0.93
126_A	194_M	0.881	0.92
88_E	158_K	0.875	0.92
34_I	153_H	0.873	0.92
188_E	192_A	0.873	0.92
140_Y	144_E	0.871	0.92
47_Y	135_C	0.870	0.92
14_W	202_S	0.868	0.92
66_Y	181_E	0.859	0.91
57_F	121_L	0.855	0.91
110_Y	115_H	0.854	0.91
115_H	119_S	0.845	0.91
3_F	191_R	0.844	0.91
146_L	160_I	0.842	0.91
40_Y	139_Y	0.841	0.91
25_Q	149_C	0.839	0.90
86_H	135_C	0.832	0.90
83_M	87_R	0.832	0.90
22_P	213_Y	0.830	0.90
17_G	206_Y	0.813	0.89
37_F	135_C	0.813	0.89
55_Q	132_L	0.807	0.89
8_R	141_E	0.805	0.89
77_G	81_A	0.805	0.89
51_F	85_L	0.802	0.88
46_Y	104_K	0.801	0.88
3_F	7_C	0.801	0.88
36_R	39_Y	0.795	0.88
138_L	142_V	0.794	0.88
40_Y	159_W	0.793	0.88
57_F	122_S	0.789	0.88
69_G	80_E	0.784	0.87
113_T	117_Y	0.782	0.87
61_Y	123_G	0.781	0.87
138_L	209_W	0.779	0.87
68_T	79_Y	0.778	0.87
142_V	201_S	0.776	0.87
126_A	186_S	0.775	0.87
178_R	181_E	0.775	0.87
38_K	99_E	0.773	0.87
58_G	62_A	0.771	0.86
49_T	65_L	0.771	0.86
50_H	105_P	0.769	0.86
70_R	174_E	0.769	0.86
105_P	113_T	0.769	0.86
130_A	179_F	0.766	0.86
136_Y	168_F	0.761	0.86
185_N	189_E	0.756	0.85
109_A	209_W	0.743	0.84
40_Y	90_A	0.741	0.84
39_Y	211_M	0.740	0.84
22_P	25_Q	0.736	0.84
74_H	171_Q	0.732	0.83
173_E	176_I	0.731	0.83
166_D	169_R	0.731	0.83
154_P	157_Q	0.724	0.83
57_F	60_A	0.723	0.83
186_S	190_V	0.720	0.82
151_P	157_Q	0.718	0.82
56_S	75_A	0.717	0.82
190_V	193_K	0.711	0.82
49_T	101_K	0.711	0.82
15_W	141_E	0.706	0.81
16_E	145_K	0.703	0.81
86_H	159_W	0.702	0.81
24_V	28_G	0.702	0.81
15_W	138_L	0.701	0.81
115_H	197_N	0.701	0.81
51_F	54_V	0.700	0.81
186_S	191_R	0.697	0.80
44_D	208_F	0.697	0.80
191_R	195_K	0.696	0.80
69_G	73_S	0.696	0.80
17_G	20_V	0.695	0.80
24_V	138_L	0.692	0.80
4_S	176_I	0.692	0.80
86_H	143_G	0.689	0.80
9_S	173_E	0.689	0.80
119_S	131_A	0.685	0.79
14_W	199_V	0.684	0.79
73_S	174_E	0.681	0.79
21_H	210_G	0.681	0.79
14_W	206_Y	0.681	0.79
210_G	213_Y	0.681	0.79
5_E	9_S	0.680	0.79
82_E	86_H	0.680	0.79
145_K	148_H	0.679	0.79
16_E	19_F	0.677	0.78
134_P	198_F	0.670	0.78
193_K	197_N	0.663	0.77
87_R	100_R	0.662	0.77
56_S	59_A	0.662	0.77
4_S	137_W	0.661	0.77
59_A	68_T	0.661	0.77
19_F	22_P	0.660	0.77
111_S	114_S	0.657	0.76
48_L	86_H	0.655	0.76
11_A	198_F	0.655	0.76
204_Y	207_Q	0.655	0.76
48_L	51_F	0.653	0.76
130_A	197_N	0.651	0.76
19_F	141_E	0.651	0.76
167_W	170_Q	0.650	0.75
51_F	171_Q	0.650	0.75
144_E	147_L	0.648	0.75
142_V	163_Y	0.646	0.75
35_D	170_Q	0.645	0.75
63_K	181_E	0.643	0.75
112_Y	116_M	0.643	0.75
47_Y	136_Y	0.641	0.74
162_T	168_F	0.638	0.74
46_Y	103_F	0.636	0.74
67_T	178_R	0.635	0.74
13_E	17_G	0.635	0.74
53_K	60_A	0.634	0.74
133_L	176_I	0.633	0.74
6_E	10_A	0.631	0.73
8_R	137_W	0.631	0.73
44_D	82_E	0.628	0.73
63_K	193_K	0.622	0.72
84_A	87_R	0.618	0.72
36_R	213_Y	0.613	0.71
63_K	184_E	0.611	0.71
189_E	192_A	0.609	0.71
44_D	205_E	0.609	0.71
67_T	125_F	0.605	0.70
143_G	162_T	0.602	0.70
32_L	37_F	0.601	0.70
48_L	135_C	0.598	0.69
19_F	145_K	0.595	0.69
27_I	32_L	0.595	0.69
10_A	191_R	0.594	0.69
112_Y	209_W	0.594	0.69
46_Y	50_H	0.591	0.68
101_K	177_N	0.591	0.68
112_Y	135_C	0.587	0.68
140_Y	173_E	0.586	0.68
76_Q	79_Y	0.585	0.68
82_E	209_W	0.585	0.68
45_S	87_R	0.585	0.68
27_I	160_I	0.584	0.67
84_A	88_E	0.583	0.67
40_Y	143_G	0.582	0.67
50_H	117_Y	0.579	0.67
131_A	135_C	0.576	0.66
54_V	128_I	0.576	0.66
206_Y	210_G	0.575	0.66
61_Y	128_I	0.572	0.66
143_G	163_Y	0.570	0.66
70_R	74_H	0.568	0.65
88_E	91_E	0.568	0.65
182_L	186_S	0.567	0.65
56_S	62_A	0.566	0.65
14_W	203_Y	0.565	0.65
71_M	129_L	0.564	0.65
127_E	186_S	0.563	0.65
89_F	162_T	0.562	0.65
134_P	163_Y	0.560	0.64
24_V	209_W	0.555	0.64
117_Y	123_G	0.554	0.63
14_W	17_G	0.554	0.63
51_F	201_S	0.552	0.63
40_Y	51_F	0.552	0.63
139_Y	205_E	0.549	0.63
139_Y	208_F	0.545	0.62
43_Q	109_A	0.543	0.62
159_W	163_Y	0.541	0.62
137_W	198_F	0.539	0.61
33_P	196_E	0.538	0.61
86_H	134_P	0.535	0.61
45_S	78_T	0.533	0.60
149_C	192_A	0.531	0.60
26_G	31_T	0.530	0.60
40_Y	198_F	0.529	0.60
3_F	130_A	0.529	0.60
46_Y	109_A	0.529	0.60
96_S	103_F	0.527	0.60
60_A	121_L	0.525	0.59
43_Q	106_S	0.525	0.59
190_V	194_M	0.522	0.59
83_M	160_I	0.521	0.59
85_L	163_Y	0.519	0.58
24_V	82_E	0.518	0.58
149_C	153_H	0.518	0.58
48_L	82_E	0.515	0.58
89_F	158_K	0.515	0.58
106_S	109_A	0.513	0.58
15_W	19_F	0.509	0.57
53_K	57_F	0.506	0.57
6_E	9_S	0.506	0.57
127_E	190_V	0.504	0.56
150_D	153_H	0.502	0.56
15_W	18_S	0.501	0.56
116_M	138_L	0.500	0.56
177_N	185_N	0.500	0.56
70_R	178_R	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qcxA	4	0.9576	100	0.115	Contact Map
3no6A	4	0.9449	100	0.189	Contact Map
3rm5A	2	0.911	100	0.206	Contact Map
2qzcA	4	0.8814	100	0.22	Contact Map
4fn6A	4	0.9364	100	0.22	Contact Map
3mvuA	4	0.9068	100	0.229	Contact Map
3ibxA	4	0.911	100	0.229	Contact Map
2a2mA	3	0.8686	100	0.233	Contact Map
1uddA	4	0.8941	100	0.238	Contact Map
2f2gA	1	0.8898	100	0.238	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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