GREMLIN Database
FLIE - Flagellar hook-basal body complex protein FliE
UniProt: P24502 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 106 (93)
Sequences: 1125 (888)
Seq/√Len: 92.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_A66_K4.0181.00
51_S83_S3.5341.00
48_L87_A3.4541.00
69_N72_E3.2891.00
62_L73_V3.1301.00
42_K46_S2.9181.00
49_N53_V2.7171.00
83_S87_A2.6361.00
96_E99_Q2.6251.00
45_I87_A2.6231.00
60_N64_A2.1081.00
47_S50_E2.0781.00
85_T89_E2.0081.00
14_Q17_Q1.6211.00
59_T77_A1.6081.00
99_Q103_R1.6041.00
68_V72_E1.5821.00
100_E103_R1.5561.00
16_T20_T1.4741.00
57_N61_A1.4470.99
54_A57_N1.4370.99
72_E79_K1.3210.99
43_N96_E1.3190.99
58_M61_A1.3180.99
39_E42_K1.3090.99
57_N60_N1.2620.99
58_M76_A1.2360.98
54_A58_M1.2340.98
36_S39_E1.2240.98
53_V57_N1.1980.98
58_M68_V1.1210.97
47_S51_S1.1110.97
63_A105_Q1.0980.97
41_L44_S1.0850.96
30_D34_Q1.0640.96
55_S59_T1.0500.96
18_N22_Q1.0410.95
50_E54_A1.0000.94
15_N18_N0.9970.94
38_S42_K0.9890.94
72_E93_K0.9840.94
17_Q20_T0.9460.92
70_L81_S0.9420.92
97_A101_I0.9200.91
73_V77_A0.9130.91
45_I89_E0.8960.90
62_L68_V0.8920.90
55_S73_V0.8870.90
14_Q18_N0.8860.90
85_T88_T0.8800.89
49_N73_V0.8800.89
54_A76_A0.8570.88
19_A93_K0.8520.88
71_D88_T0.8460.87
20_T101_I0.8450.87
39_E43_N0.8370.87
71_D75_I0.8370.87
56_D105_Q0.8360.87
80_A83_S0.8200.86
55_S80_A0.8090.85
17_Q93_K0.8080.85
44_S88_T0.7840.83
28_K31_S0.7820.83
96_E100_E0.7820.83
42_K97_A0.7810.83
91_R99_Q0.7760.83
70_L82_I0.7720.82
58_M72_E0.7710.82
79_K102_M0.7650.82
33_N54_A0.7640.82
14_Q21_N0.7630.81
59_T103_R0.7620.81
40_L87_A0.7560.81
85_T101_I0.7520.81
49_N52_Q0.7500.80
84_L89_E0.7410.80
37_F41_L0.7370.79
30_D33_N0.7260.78
64_A68_V0.7240.78
26_S29_T0.7170.77
16_T19_A0.7130.77
22_Q25_N0.7100.77
38_S78_Q0.7090.76
23_V26_S0.7050.76
95_V98_Y0.7010.76
70_L99_Q0.6960.75
55_S77_A0.6900.75
67_D72_E0.6710.72
99_Q105_Q0.6710.72
38_S73_V0.6690.72
96_E105_Q0.6640.72
55_S76_A0.6630.72
43_N46_S0.6590.71
89_E92_N0.6580.71
40_L86_A0.6580.71
81_S85_T0.6530.70
83_S89_E0.6510.70
26_S30_D0.6410.69
14_Q79_K0.6370.69
44_S78_Q0.6290.68
52_Q84_L0.6290.68
59_T73_V0.6250.67
24_N43_N0.6210.67
84_L88_T0.6200.66
71_D86_A0.6200.66
56_D60_N0.6160.66
33_N36_S0.6100.65
73_V99_Q0.6070.65
81_S95_V0.6060.65
82_I86_A0.5970.64
89_E100_E0.5950.63
48_L84_L0.5910.63
40_L78_Q0.5810.61
67_D73_V0.5700.60
29_T32_S0.5700.60
26_S32_S0.5650.59
27_Q30_D0.5600.59
84_L87_A0.5590.59
63_A71_D0.5510.57
55_S83_S0.5500.57
20_T23_V0.5480.57
81_S87_A0.5420.56
55_S86_A0.5400.56
77_A101_I0.5390.56
24_N80_A0.5380.56
59_T105_Q0.5360.55
77_A81_S0.5350.55
18_N21_N0.5350.55
27_Q32_S0.5330.55
15_N20_T0.5290.54
53_V93_K0.5280.54
89_E96_E0.5190.53
21_N25_N0.5180.53
51_S101_I0.5160.53
72_E88_T0.5150.53
69_N73_V0.5080.52
27_Q50_E0.5070.51
57_N66_K0.5050.51
49_N95_V0.5010.51
62_L70_L0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rp3B 1 0.6981 8.8 0.927 Contact Map
1vw1A 5 0.9528 4.9 0.935 Contact Map
3a69A 3 0.8396 3.6 0.939 Contact Map
2ca5A 1 0.6038 3.1 0.941 Contact Map
4ut1A 1 0.9623 2.8 0.943 Contact Map
4um2A 1 0.5094 2.5 0.944 Contact Map
2g0uA 1 0.7925 2.3 0.945 Contact Map
4n78D 1 0.783 2.1 0.946 Contact Map
3l8rA 3 0.934 1.9 0.947 Contact Map
3b77A 4 0.434 1.9 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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