GREMLIN Database
C550 - Cytochrome c-550
UniProt: P24469 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 120 (106)
Sequences: 3277 (2611)
Seq/√Len: 253.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_D87_E3.4411.00
113_A117_S3.1041.00
48_A111_D2.9681.00
105_P108_K2.8901.00
50_A53_E2.8431.00
87_E90_T2.4211.00
107_D111_D2.1841.00
89_K93_E2.1601.00
65_G68_Y2.1051.00
76_L82_K2.0571.00
51_S111_D1.9741.00
56_Y112_M1.8691.00
108_K111_D1.8471.00
85_V89_K1.7891.00
65_G70_G1.7151.00
75_S78_G1.6351.00
68_Y71_V1.5791.00
56_Y116_V1.5541.00
86_A90_T1.5251.00
106_A110_D1.4991.00
65_G71_V1.4661.00
22_F26_K1.4361.00
107_D110_D1.4361.00
90_T94_K1.4261.00
92_I95_G1.3851.00
67_N70_G1.3591.00
97_N101_S1.3501.00
89_K110_D1.3351.00
75_S80_G1.3181.00
88_I113_A1.3111.00
68_Y72_S1.3081.00
93_E106_A1.2851.00
85_V110_D1.2781.00
67_N72_S1.2601.00
24_S27_G1.2561.00
15_L19_L1.2241.00
23_L27_G1.2181.00
23_L26_K1.1921.00
16_G20_T1.1871.00
49_N114_E1.1611.00
55_I112_M1.1371.00
98_G101_S1.1261.00
65_G72_S1.1121.00
88_I91_K1.1101.00
66_E69_E1.0991.00
85_V113_A1.0671.00
20_T25_V1.0651.00
113_A116_V1.0551.00
51_S108_K1.0481.00
91_K95_G1.0441.00
21_F25_V1.0371.00
83_K99_M1.0211.00
73_G80_G1.0201.00
26_K29_D0.9981.00
75_S79_V0.9971.00
65_G69_E0.9951.00
27_G30_D0.9911.00
67_N71_V0.9841.00
29_D32_R0.9831.00
31_S34_I0.9711.00
104_V109_L0.9661.00
17_I21_F0.9481.00
73_G76_L0.9421.00
69_E72_S0.9381.00
38_G41_K0.9371.00
46_K50_A0.9331.00
31_S35_A0.9321.00
42_S45_K0.9271.00
29_D33_E0.9221.00
28_L32_R0.9161.00
73_G79_V0.9091.00
53_E57_K0.8831.00
19_L24_S0.8600.99
41_K44_E0.8560.99
59_N62_A0.8540.99
21_F32_R0.8540.99
56_Y61_I0.8510.99
97_N100_P0.8480.99
85_V109_L0.8440.99
28_L31_S0.8410.99
21_F26_K0.8320.99
30_D34_I0.8220.99
106_A109_L0.8110.99
38_G44_E0.8110.99
86_A89_K0.8020.99
27_G31_S0.8020.99
14_V18_G0.7980.99
76_L79_V0.7970.99
26_K30_D0.7870.99
59_N104_V0.7760.99
89_K109_L0.7740.99
55_I59_N0.7730.99
20_T23_L0.7620.99
66_E72_S0.7600.99
66_E71_V0.7560.99
92_I99_M0.7520.99
91_K94_K0.7430.98
88_I92_I0.7370.98
87_E92_I0.7320.98
13_A16_G0.7220.98
45_K48_A0.7210.98
18_G21_F0.7120.98
37_G41_K0.7100.98
54_E62_A0.7030.98
27_G35_A0.7010.98
21_F24_S0.6990.98
21_F27_G0.6960.98
51_S55_I0.6900.98
96_G101_S0.6860.97
19_L23_L0.6850.97
93_E109_L0.6720.97
36_S39_E0.6650.97
83_K87_E0.6640.97
49_N118_K0.6630.97
22_F25_V0.6610.97
87_E91_K0.6610.97
76_L80_G0.6590.97
74_P79_V0.6510.97
73_G78_G0.6410.96
48_A51_S0.6400.96
36_S41_K0.6280.96
51_S54_E0.6200.95
102_G108_K0.6180.95
57_K61_I0.6140.95
20_T26_K0.6110.95
87_E95_G0.6100.95
32_R35_A0.6090.95
89_K94_K0.6030.95
47_D51_S0.5970.94
37_G40_S0.5940.94
50_A54_E0.5900.94
58_A92_I0.5810.94
23_L28_L0.5810.94
20_T24_S0.5720.93
45_K49_N0.5660.93
18_G22_F0.5640.93
36_S40_S0.5630.93
30_D33_E0.5620.92
84_D92_I0.5540.92
111_D114_E0.5510.92
47_D111_D0.5460.91
26_K31_S0.5450.91
110_D113_A0.5370.91
38_G42_S0.5340.90
92_I109_L0.5340.90
58_A104_V0.5310.90
60_C64_H0.5240.90
60_C63_C0.5240.90
39_E45_K0.5240.90
39_E44_E0.5240.90
40_S44_E0.5230.90
27_G33_E0.5220.89
85_V117_S0.5150.89
83_K97_N0.5140.89
56_Y68_Y0.5080.88
39_E42_S0.5060.88
91_K99_M0.5030.88
20_T27_G0.5010.87
13_A19_L0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mk7C 2 1 99.8 0.332 Contact Map
3wfdC 1 0.9333 99.7 0.395 Contact Map
1c75A 1 0.5917 99.7 0.421 Contact Map
3mk7B 1 0.975 99.7 0.422 Contact Map
1c2nA 1 0.5917 99.6 0.439 Contact Map
1h32B 1 0.8167 99.6 0.441 Contact Map
2l4dA 1 0.5833 99.6 0.444 Contact Map
1w2lA 1 0.625 99.6 0.445 Contact Map
2zzsA 4 0.6 99.6 0.448 Contact Map
2yk3A 4 0.6667 99.6 0.452 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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