PRSA - BACSU - GREMLIN Contacts

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PRSA - Foldase protein PrsA

UniProt:	P24327	Sequences: MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTNMKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLKEQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKGEKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYHIIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFNTSSTSNSTSSSSSNSK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	292 (254)
Sequences:	5495 (4710)
Seq/√Len:	295.5

ECOLI - SURA PPID
BACSU - PRSA YACD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
147_K	151_E	4.062	1.00
154_E	158_K	3.863	1.00
156_K	161_E	3.645	1.00
140_S	223_T	3.246	1.00
146_D	149_T	3.034	1.00
129_Y	133_L	2.969	1.00
189_G	196_S	2.866	1.00
203_K	206_E	2.752	1.00
138_R	181_D	2.743	1.00
204_T	224_E	2.571	1.00
193_E	197_K	2.554	1.00
127_K	131_E	2.424	1.00
125_D	244_K	2.382	1.00
136_K	226_R	2.340	1.00
152_E	156_K	2.340	1.00
237_K	241_L	2.276	1.00
202_L	208_S	2.262	1.00
128_E	132_G	2.260	1.00
126_I	229_Y	2.241	1.00
162_K	165_D	2.229	1.00
154_E	219_I	2.119	1.00
140_S	221_K	2.107	1.00
153_V	170_Y	2.083	1.00
34_G	61_K	2.062	1.00
138_R	224_E	1.982	1.00
141_H	218_H	1.976	1.00
77_K	80_E	1.973	1.00
32_D	65_K	1.954	1.00
155_K	159_K	1.948	1.00
38_K	42_Y	1.923	1.00
154_E	209_D	1.895	1.00
138_R	223_T	1.888	1.00
184_W	224_E	1.873	1.00
153_V	166_L	1.794	1.00
184_W	226_R	1.777	1.00
156_K	170_Y	1.771	1.00
229_Y	233_K	1.744	1.00
165_D	169_E	1.713	1.00
185_F	191_M	1.695	1.00
137_I	200_F	1.671	1.00
131_E	134_K	1.667	1.00
122_T	125_D	1.651	1.00
149_T	170_Y	1.642	1.00
154_E	210_P	1.635	1.00
213_T	218_H	1.617	1.00
157_L	166_L	1.587	1.00
202_L	206_E	1.580	1.00
29_A	54_L	1.579	1.00
233_K	237_K	1.515	1.00
137_I	225_E	1.502	1.00
234_K	237_K	1.492	1.00
98_K	102_K	1.483	1.00
187_K	200_F	1.480	1.00
32_D	262_A	1.473	1.00
70_S	73_E	1.439	1.00
138_R	184_W	1.427	1.00
44_N	60_E	1.424	1.00
149_T	152_E	1.419	1.00
253_E	257_K	1.410	1.00
213_T	216_G	1.405	1.00
212_K	217_Y	1.397	1.00
241_L	245_L	1.394	1.00
148_K	152_E	1.378	1.00
207_V	221_K	1.377	1.00
202_L	222_K	1.368	1.00
106_K	109_L	1.355	1.00
107_Y	111_T	1.349	1.00
124_A	128_E	1.343	1.00
256_Q	260_K	1.335	1.00
59_Q	259_M	1.332	1.00
127_K	229_Y	1.330	1.00
236_L	240_V	1.318	1.00
230_D	233_K	1.318	1.00
144_V	153_V	1.312	1.00
249_A	253_E	1.303	1.00
28_I	41_L	1.302	1.00
30_K	35_D	1.276	1.00
192_D	215_Y	1.276	1.00
155_K	158_K	1.273	1.00
126_I	237_K	1.266	1.00
151_E	155_K	1.264	1.00
250_A	253_E	1.258	1.00
36_V	57_L	1.251	1.00
27_V	35_D	1.246	1.00
229_Y	232_M	1.239	1.00
26_E	38_K	1.232	1.00
146_D	172_T	1.212	1.00
61_K	64_D	1.209	1.00
147_K	217_Y	1.205	1.00
17_L	20_C	1.187	1.00
88_Q	91_A	1.181	1.00
99_D	102_K	1.180	1.00
129_Y	132_G	1.175	1.00
257_K	261_K	1.151	1.00
156_K	169_E	1.151	1.00
148_K	151_E	1.139	1.00
157_L	207_V	1.128	1.00
75_D	79_K	1.127	1.00
136_K	184_W	1.123	1.00
98_K	101_L	1.121	1.00
44_N	57_L	1.119	1.00
42_Y	50_G	1.109	1.00
204_T	222_K	1.109	1.00
40_E	61_K	1.103	1.00
99_D	103_E	1.087	1.00
37_T	40_E	1.084	1.00
55_T	59_Q	1.082	1.00
139_A	185_F	1.062	1.00
137_I	199_A	1.061	1.00
128_E	131_E	1.055	1.00
129_Y	236_L	1.054	1.00
101_L	109_L	1.053	1.00
149_T	172_T	1.049	1.00
152_E	170_Y	1.044	1.00
232_M	235_E	1.042	1.00
161_E	165_D	1.029	1.00
233_K	236_L	1.027	1.00
64_D	67_Y	1.027	1.00
75_D	102_K	1.024	1.00
25_K	39_G	1.012	1.00
157_L	219_I	1.010	1.00
233_K	244_K	1.009	1.00
147_K	212_K	1.004	1.00
254_A	257_K	0.999	1.00
161_E	166_L	0.997	1.00
154_E	157_L	0.982	1.00
44_N	47_K	0.981	1.00
101_L	106_K	0.979	1.00
141_H	195_F	0.976	1.00
222_K	225_E	0.975	1.00
166_L	170_Y	0.974	1.00
143_L	216_G	0.971	1.00
236_L	239_E	0.963	1.00
113_K	116_K	0.959	1.00
104_Q	108_E	0.959	1.00
215_Y	218_H	0.956	1.00
41_L	54_L	0.956	1.00
123_D	127_K	0.955	1.00
211_V	220_I	0.954	1.00
171_S	180_G	0.954	1.00
186_A	189_G	0.944	1.00
192_D	214_Q	0.941	1.00
140_S	164_E	0.939	1.00
124_A	127_K	0.937	1.00
139_A	191_M	0.937	1.00
197_K	201_K	0.934	1.00
210_P	217_Y	0.933	1.00
29_A	58_V	0.931	1.00
165_D	168_K	0.929	1.00
101_L	105_V	0.925	1.00
152_E	155_K	0.918	1.00
102_K	106_K	0.916	1.00
253_E	256_Q	0.914	1.00
61_K	65_K	0.913	1.00
123_D	237_K	0.907	1.00
204_T	225_E	0.907	1.00
154_E	207_V	0.895	1.00
164_E	179_G	0.890	1.00
243_Q	249_A	0.888	1.00
51_A	55_T	0.885	1.00
126_I	233_K	0.885	1.00
98_K	109_L	0.881	1.00
42_Y	46_K	0.879	1.00
257_K	260_K	0.878	1.00
90_T	94_K	0.876	1.00
244_K	249_A	0.875	1.00
130_W	134_K	0.874	1.00
186_A	190_Q	0.872	1.00
123_D	233_K	0.868	1.00
142_I	167_A	0.868	1.00
125_D	128_E	0.868	1.00
127_K	130_W	0.866	1.00
31_T	34_G	0.866	1.00
195_F	218_H	0.857	1.00
244_K	250_A	0.856	1.00
150_A	219_I	0.855	1.00
199_A	220_I	0.852	1.00
232_M	236_L	0.849	1.00
103_E	106_K	0.849	1.00
145_A	172_T	0.848	1.00
12_T	15_L	0.847	1.00
139_A	199_A	0.837	1.00
198_A	211_V	0.836	1.00
34_G	65_K	0.830	1.00
91_A	95_Q	0.829	1.00
73_E	76_N	0.828	1.00
41_L	45_M	0.828	1.00
92_L	96_Y	0.825	1.00
126_I	236_L	0.815	1.00
143_L	218_H	0.809	1.00
239_E	243_Q	0.806	1.00
181_D	184_W	0.806	1.00
162_K	166_L	0.805	1.00
62_V	258_V	0.802	1.00
16_A	19_A	0.802	1.00
29_A	36_V	0.798	0.99
153_V	156_K	0.794	0.99
45_M	50_G	0.793	0.99
195_F	220_I	0.793	0.99
167_A	179_G	0.792	0.99
150_A	154_E	0.792	0.99
69_V	74_I	0.790	0.99
196_S	200_F	0.789	0.99
103_E	107_Y	0.784	0.99
101_L	104_Q	0.781	0.99
73_E	109_L	0.778	0.99
76_N	79_K	0.774	0.99
205_G	223_T	0.773	0.99
256_Q	259_M	0.771	0.99
229_Y	236_L	0.768	0.99
92_L	95_Q	0.766	0.99
207_V	210_P	0.764	0.99
234_K	238_S	0.764	0.99
106_K	110_L	0.762	0.99
230_D	234_K	0.759	0.99
123_D	126_I	0.755	0.99
203_K	222_K	0.753	0.99
238_S	242_E	0.752	0.99
71_D	75_D	0.752	0.99
137_I	222_K	0.749	0.99
145_A	149_T	0.749	0.99
191_M	195_F	0.748	0.99
30_K	33_A	0.745	0.99
87_D	91_A	0.741	0.99
153_V	157_L	0.741	0.99
181_D	223_T	0.737	0.99
53_V	57_L	0.736	0.99
140_S	181_D	0.736	0.99
251_V	254_A	0.736	0.99
91_A	94_K	0.733	0.99
164_E	221_K	0.731	0.99
240_V	244_K	0.729	0.99
107_Y	110_L	0.723	0.99
232_M	244_K	0.721	0.99
151_E	209_D	0.720	0.99
93_E	97_G	0.719	0.99
252_Q	256_Q	0.718	0.99
41_L	53_V	0.718	0.99
144_V	150_A	0.716	0.99
105_V	109_L	0.715	0.99
9_I	16_A	0.715	0.99
13_S	16_A	0.715	0.99
10_T	17_L	0.714	0.99
15_L	18_S	0.711	0.99
79_K	83_T	0.704	0.99
141_H	213_T	0.703	0.99
156_K	166_L	0.701	0.99
254_A	258_V	0.698	0.99
87_D	90_T	0.695	0.99
156_K	159_K	0.695	0.99
41_L	57_L	0.694	0.99
60_E	64_D	0.691	0.99
142_I	163_F	0.691	0.99
54_L	58_V	0.689	0.99
28_I	37_T	0.688	0.99
38_K	50_G	0.687	0.98
72_K	75_D	0.687	0.98
121_V	240_V	0.687	0.98
158_K	207_V	0.685	0.98
154_E	208_S	0.684	0.98
130_W	232_M	0.680	0.98
56_Q	60_E	0.679	0.98
89_Y	93_E	0.679	0.98
112_Q	116_K	0.676	0.98
89_Y	98_K	0.672	0.98
194_T	197_K	0.672	0.98
100_Y	103_E	0.672	0.98
187_K	196_S	0.671	0.98
98_K	106_K	0.649	0.98
173_D	176_A	0.649	0.98
163_F	180_G	0.648	0.98
101_L	107_Y	0.645	0.98
39_G	42_Y	0.644	0.98
199_A	222_K	0.643	0.98
146_D	150_A	0.641	0.98
48_T	52_S	0.640	0.98
171_S	175_S	0.639	0.98
71_D	102_K	0.639	0.98
64_D	107_Y	0.636	0.98
72_K	76_N	0.636	0.98
10_T	13_S	0.635	0.97
121_V	125_D	0.635	0.97
81_Y	84_Q	0.635	0.97
167_A	176_A	0.635	0.97
258_V	262_A	0.633	0.97
198_A	201_K	0.633	0.97
206_E	221_K	0.627	0.97
191_M	196_S	0.627	0.97
139_A	195_F	0.627	0.97
9_I	12_T	0.624	0.97
151_E	154_E	0.623	0.97
173_D	180_G	0.623	0.97
71_D	106_K	0.621	0.97
80_E	83_T	0.619	0.97
171_S	179_G	0.616	0.97
143_L	215_Y	0.615	0.97
13_S	20_C	0.613	0.97
81_Y	85_L	0.613	0.97
157_L	162_K	0.612	0.97
249_A	252_Q	0.611	0.97
48_T	51_A	0.610	0.97
195_F	215_Y	0.609	0.97
162_K	221_K	0.607	0.97
203_K	225_E	0.606	0.97
149_T	153_V	0.606	0.97
246_N	252_Q	0.606	0.97
197_K	200_F	0.605	0.97
118_N	121_V	0.605	0.97
142_I	219_I	0.604	0.97
6_I	9_I	0.604	0.97
164_E	167_A	0.599	0.96
202_L	209_D	0.597	0.96
39_G	43_T	0.595	0.96
73_E	113_K	0.594	0.96
44_N	53_V	0.594	0.96
150_A	210_P	0.590	0.96
76_N	80_E	0.587	0.96
16_A	20_C	0.586	0.96
27_V	37_T	0.585	0.96
62_V	262_A	0.581	0.96
144_V	172_T	0.579	0.96
194_T	214_Q	0.578	0.96
50_G	53_V	0.578	0.96
108_E	112_Q	0.578	0.96
147_K	210_P	0.575	0.96
52_S	56_Q	0.574	0.95
52_S	55_T	0.573	0.95
171_S	174_S	0.572	0.95
41_L	50_G	0.571	0.95
13_S	18_S	0.571	0.95
163_F	167_A	0.570	0.95
158_K	209_D	0.569	0.95
42_Y	45_M	0.569	0.95
66_K	261_K	0.568	0.95
235_E	238_S	0.565	0.95
55_T	259_M	0.564	0.95
62_V	66_K	0.563	0.95
141_H	182_L	0.561	0.95
11_A	19_A	0.558	0.95
186_A	196_S	0.557	0.95
208_S	211_V	0.553	0.94
245_L	250_A	0.553	0.94
240_V	243_Q	0.553	0.94
242_E	246_N	0.551	0.94
160_G	166_L	0.550	0.94
88_Q	92_L	0.549	0.94
175_S	179_G	0.547	0.94
109_L	112_Q	0.547	0.94
9_I	13_S	0.546	0.94
151_E	210_P	0.545	0.94
79_K	82_K	0.543	0.94
27_V	30_K	0.541	0.94
198_A	202_L	0.538	0.94
29_A	57_L	0.538	0.94
231_D	236_L	0.535	0.93
235_E	239_E	0.534	0.93
130_W	229_Y	0.533	0.93
44_N	56_Q	0.530	0.93
82_K	85_L	0.529	0.93
233_K	238_S	0.528	0.93
108_E	111_T	0.527	0.93
167_A	171_S	0.526	0.93
60_E	107_Y	0.525	0.93
14_I	17_L	0.523	0.93
137_I	187_K	0.521	0.93
185_F	199_A	0.519	0.92
172_T	176_A	0.515	0.92
136_K	186_A	0.515	0.92
104_Q	107_Y	0.511	0.92
77_K	81_Y	0.510	0.92
194_T	198_A	0.510	0.92
29_A	41_L	0.509	0.92
28_I	38_K	0.508	0.92
242_E	245_L	0.508	0.92
49_A	52_S	0.505	0.91
167_A	180_G	0.504	0.91
126_I	240_V	0.503	0.91
11_A	15_L	0.501	0.91
238_S	241_L	0.500	0.91
133_L	236_L	0.500	0.91
168_K	177_S	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4wo7A	2	0.8699	100	0.238	Contact Map
3nrkA	3	0.8904	100	0.331	Contact Map
1m5yA	1	0.7979	100	0.387	Contact Map
3rfwA	2	0.7603	100	0.391	Contact Map
3rgcA	2	0.7705	100	0.412	Contact Map
1yw5A	1	0.4863	99.8	0.618	Contact Map
1jnsA	1	0.3151	99.8	0.647	Contact Map
2pv1A	1	0.3116	99.8	0.653	Contact Map
3gpkA	1	0.3527	99.8	0.655	Contact Map
2m08A	1	0.3151	99.8	0.656	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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