GREMLIN Database
PRSA - Foldase protein PrsA
UniProt: P24327 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (254)
Sequences: 5495 (4710)
Seq/√Len: 295.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_K151_E4.0621.00
154_E158_K3.8631.00
156_K161_E3.6451.00
140_S223_T3.2461.00
146_D149_T3.0341.00
129_Y133_L2.9691.00
189_G196_S2.8661.00
203_K206_E2.7521.00
138_R181_D2.7431.00
204_T224_E2.5711.00
193_E197_K2.5541.00
127_K131_E2.4241.00
125_D244_K2.3821.00
136_K226_R2.3401.00
152_E156_K2.3401.00
237_K241_L2.2761.00
202_L208_S2.2621.00
128_E132_G2.2601.00
126_I229_Y2.2411.00
162_K165_D2.2291.00
154_E219_I2.1191.00
140_S221_K2.1071.00
153_V170_Y2.0831.00
34_G61_K2.0621.00
138_R224_E1.9821.00
141_H218_H1.9761.00
77_K80_E1.9731.00
32_D65_K1.9541.00
155_K159_K1.9481.00
38_K42_Y1.9231.00
154_E209_D1.8951.00
138_R223_T1.8881.00
184_W224_E1.8731.00
153_V166_L1.7941.00
184_W226_R1.7771.00
156_K170_Y1.7711.00
229_Y233_K1.7441.00
165_D169_E1.7131.00
185_F191_M1.6951.00
137_I200_F1.6711.00
131_E134_K1.6671.00
122_T125_D1.6511.00
149_T170_Y1.6421.00
154_E210_P1.6351.00
213_T218_H1.6171.00
157_L166_L1.5871.00
202_L206_E1.5801.00
29_A54_L1.5791.00
233_K237_K1.5151.00
137_I225_E1.5021.00
234_K237_K1.4921.00
98_K102_K1.4831.00
187_K200_F1.4801.00
32_D262_A1.4731.00
70_S73_E1.4391.00
138_R184_W1.4271.00
44_N60_E1.4241.00
149_T152_E1.4191.00
253_E257_K1.4101.00
213_T216_G1.4051.00
212_K217_Y1.3971.00
241_L245_L1.3941.00
148_K152_E1.3781.00
207_V221_K1.3771.00
202_L222_K1.3681.00
106_K109_L1.3551.00
107_Y111_T1.3491.00
124_A128_E1.3431.00
256_Q260_K1.3351.00
59_Q259_M1.3321.00
127_K229_Y1.3301.00
236_L240_V1.3181.00
230_D233_K1.3181.00
144_V153_V1.3121.00
249_A253_E1.3031.00
28_I41_L1.3021.00
30_K35_D1.2761.00
192_D215_Y1.2761.00
155_K158_K1.2731.00
126_I237_K1.2661.00
151_E155_K1.2641.00
250_A253_E1.2581.00
36_V57_L1.2511.00
27_V35_D1.2461.00
229_Y232_M1.2391.00
26_E38_K1.2321.00
146_D172_T1.2121.00
61_K64_D1.2091.00
147_K217_Y1.2051.00
17_L20_C1.1871.00
88_Q91_A1.1811.00
99_D102_K1.1801.00
129_Y132_G1.1751.00
257_K261_K1.1511.00
156_K169_E1.1511.00
148_K151_E1.1391.00
157_L207_V1.1281.00
75_D79_K1.1271.00
136_K184_W1.1231.00
98_K101_L1.1211.00
44_N57_L1.1191.00
42_Y50_G1.1091.00
204_T222_K1.1091.00
40_E61_K1.1031.00
99_D103_E1.0871.00
37_T40_E1.0841.00
55_T59_Q1.0821.00
139_A185_F1.0621.00
137_I199_A1.0611.00
128_E131_E1.0551.00
129_Y236_L1.0541.00
101_L109_L1.0531.00
149_T172_T1.0491.00
152_E170_Y1.0441.00
232_M235_E1.0421.00
161_E165_D1.0291.00
233_K236_L1.0271.00
64_D67_Y1.0271.00
75_D102_K1.0241.00
25_K39_G1.0121.00
157_L219_I1.0101.00
233_K244_K1.0091.00
147_K212_K1.0041.00
254_A257_K0.9991.00
161_E166_L0.9971.00
154_E157_L0.9821.00
44_N47_K0.9811.00
101_L106_K0.9791.00
141_H195_F0.9761.00
222_K225_E0.9751.00
166_L170_Y0.9741.00
143_L216_G0.9711.00
236_L239_E0.9631.00
113_K116_K0.9591.00
104_Q108_E0.9591.00
215_Y218_H0.9561.00
41_L54_L0.9561.00
123_D127_K0.9551.00
211_V220_I0.9541.00
171_S180_G0.9541.00
186_A189_G0.9441.00
192_D214_Q0.9411.00
140_S164_E0.9391.00
124_A127_K0.9371.00
139_A191_M0.9371.00
197_K201_K0.9341.00
210_P217_Y0.9331.00
29_A58_V0.9311.00
165_D168_K0.9291.00
101_L105_V0.9251.00
152_E155_K0.9181.00
102_K106_K0.9161.00
253_E256_Q0.9141.00
61_K65_K0.9131.00
123_D237_K0.9071.00
204_T225_E0.9071.00
154_E207_V0.8951.00
164_E179_G0.8901.00
243_Q249_A0.8881.00
51_A55_T0.8851.00
126_I233_K0.8851.00
98_K109_L0.8811.00
42_Y46_K0.8791.00
257_K260_K0.8781.00
90_T94_K0.8761.00
244_K249_A0.8751.00
130_W134_K0.8741.00
186_A190_Q0.8721.00
123_D233_K0.8681.00
142_I167_A0.8681.00
125_D128_E0.8681.00
127_K130_W0.8661.00
31_T34_G0.8661.00
195_F218_H0.8571.00
244_K250_A0.8561.00
150_A219_I0.8551.00
199_A220_I0.8521.00
232_M236_L0.8491.00
103_E106_K0.8491.00
145_A172_T0.8481.00
12_T15_L0.8471.00
139_A199_A0.8371.00
198_A211_V0.8361.00
34_G65_K0.8301.00
91_A95_Q0.8291.00
73_E76_N0.8281.00
41_L45_M0.8281.00
92_L96_Y0.8251.00
126_I236_L0.8151.00
143_L218_H0.8091.00
239_E243_Q0.8061.00
181_D184_W0.8061.00
162_K166_L0.8051.00
62_V258_V0.8021.00
16_A19_A0.8021.00
29_A36_V0.7980.99
153_V156_K0.7940.99
45_M50_G0.7930.99
195_F220_I0.7930.99
167_A179_G0.7920.99
150_A154_E0.7920.99
69_V74_I0.7900.99
196_S200_F0.7890.99
103_E107_Y0.7840.99
101_L104_Q0.7810.99
73_E109_L0.7780.99
76_N79_K0.7740.99
205_G223_T0.7730.99
256_Q259_M0.7710.99
229_Y236_L0.7680.99
92_L95_Q0.7660.99
207_V210_P0.7640.99
234_K238_S0.7640.99
106_K110_L0.7620.99
230_D234_K0.7590.99
123_D126_I0.7550.99
203_K222_K0.7530.99
238_S242_E0.7520.99
71_D75_D0.7520.99
137_I222_K0.7490.99
145_A149_T0.7490.99
191_M195_F0.7480.99
30_K33_A0.7450.99
87_D91_A0.7410.99
153_V157_L0.7410.99
181_D223_T0.7370.99
53_V57_L0.7360.99
140_S181_D0.7360.99
251_V254_A0.7360.99
91_A94_K0.7330.99
164_E221_K0.7310.99
240_V244_K0.7290.99
107_Y110_L0.7230.99
232_M244_K0.7210.99
151_E209_D0.7200.99
93_E97_G0.7190.99
252_Q256_Q0.7180.99
41_L53_V0.7180.99
144_V150_A0.7160.99
105_V109_L0.7150.99
9_I16_A0.7150.99
13_S16_A0.7150.99
10_T17_L0.7140.99
15_L18_S0.7110.99
79_K83_T0.7040.99
141_H213_T0.7030.99
156_K166_L0.7010.99
254_A258_V0.6980.99
87_D90_T0.6950.99
156_K159_K0.6950.99
41_L57_L0.6940.99
60_E64_D0.6910.99
142_I163_F0.6910.99
54_L58_V0.6890.99
28_I37_T0.6880.99
38_K50_G0.6870.98
72_K75_D0.6870.98
121_V240_V0.6870.98
158_K207_V0.6850.98
154_E208_S0.6840.98
130_W232_M0.6800.98
56_Q60_E0.6790.98
89_Y93_E0.6790.98
112_Q116_K0.6760.98
89_Y98_K0.6720.98
194_T197_K0.6720.98
100_Y103_E0.6720.98
187_K196_S0.6710.98
98_K106_K0.6490.98
173_D176_A0.6490.98
163_F180_G0.6480.98
101_L107_Y0.6450.98
39_G42_Y0.6440.98
199_A222_K0.6430.98
146_D150_A0.6410.98
48_T52_S0.6400.98
171_S175_S0.6390.98
71_D102_K0.6390.98
64_D107_Y0.6360.98
72_K76_N0.6360.98
10_T13_S0.6350.97
121_V125_D0.6350.97
81_Y84_Q0.6350.97
167_A176_A0.6350.97
258_V262_A0.6330.97
198_A201_K0.6330.97
206_E221_K0.6270.97
191_M196_S0.6270.97
139_A195_F0.6270.97
9_I12_T0.6240.97
151_E154_E0.6230.97
173_D180_G0.6230.97
71_D106_K0.6210.97
80_E83_T0.6190.97
171_S179_G0.6160.97
143_L215_Y0.6150.97
13_S20_C0.6130.97
81_Y85_L0.6130.97
157_L162_K0.6120.97
249_A252_Q0.6110.97
48_T51_A0.6100.97
195_F215_Y0.6090.97
162_K221_K0.6070.97
203_K225_E0.6060.97
149_T153_V0.6060.97
246_N252_Q0.6060.97
197_K200_F0.6050.97
118_N121_V0.6050.97
142_I219_I0.6040.97
6_I9_I0.6040.97
164_E167_A0.5990.96
202_L209_D0.5970.96
39_G43_T0.5950.96
73_E113_K0.5940.96
44_N53_V0.5940.96
150_A210_P0.5900.96
76_N80_E0.5870.96
16_A20_C0.5860.96
27_V37_T0.5850.96
62_V262_A0.5810.96
144_V172_T0.5790.96
194_T214_Q0.5780.96
50_G53_V0.5780.96
108_E112_Q0.5780.96
147_K210_P0.5750.96
52_S56_Q0.5740.95
52_S55_T0.5730.95
171_S174_S0.5720.95
41_L50_G0.5710.95
13_S18_S0.5710.95
163_F167_A0.5700.95
158_K209_D0.5690.95
42_Y45_M0.5690.95
66_K261_K0.5680.95
235_E238_S0.5650.95
55_T259_M0.5640.95
62_V66_K0.5630.95
141_H182_L0.5610.95
11_A19_A0.5580.95
186_A196_S0.5570.95
208_S211_V0.5530.94
245_L250_A0.5530.94
240_V243_Q0.5530.94
242_E246_N0.5510.94
160_G166_L0.5500.94
88_Q92_L0.5490.94
175_S179_G0.5470.94
109_L112_Q0.5470.94
9_I13_S0.5460.94
151_E210_P0.5450.94
79_K82_K0.5430.94
27_V30_K0.5410.94
198_A202_L0.5380.94
29_A57_L0.5380.94
231_D236_L0.5350.93
235_E239_E0.5340.93
130_W229_Y0.5330.93
44_N56_Q0.5300.93
82_K85_L0.5290.93
233_K238_S0.5280.93
108_E111_T0.5270.93
167_A171_S0.5260.93
60_E107_Y0.5250.93
14_I17_L0.5230.93
137_I187_K0.5210.93
185_F199_A0.5190.92
172_T176_A0.5150.92
136_K186_A0.5150.92
104_Q107_Y0.5110.92
77_K81_Y0.5100.92
194_T198_A0.5100.92
29_A41_L0.5090.92
28_I38_K0.5080.92
242_E245_L0.5080.92
49_A52_S0.5050.91
167_A180_G0.5040.91
126_I240_V0.5030.91
11_A15_L0.5010.91
238_S241_L0.5000.91
133_L236_L0.5000.91
168_K177_S0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wo7A 2 0.8699 100 0.238 Contact Map
3nrkA 3 0.8904 100 0.331 Contact Map
1m5yA 1 0.7979 100 0.387 Contact Map
3rfwA 2 0.7603 100 0.391 Contact Map
3rgcA 2 0.7705 100 0.412 Contact Map
1yw5A 1 0.4863 99.8 0.618 Contact Map
1jnsA 1 0.3151 99.8 0.647 Contact Map
2pv1A 1 0.3116 99.8 0.653 Contact Map
3gpkA 1 0.3527 99.8 0.655 Contact Map
2m08A 1 0.3151 99.8 0.656 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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