GREMLIN Database
OPPB - Oligopeptide transport system permease protein OppB
UniProt: P24138 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (274)
Sequences: 26225 (17206)
Seq/√Len: 1039.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_K61_V3.0361.00
57_K65_S2.9951.00
28_Q62_Q2.8701.00
195_M222_A2.7641.00
68_K72_M2.5821.00
64_V68_K2.5471.00
51_A56_D2.4441.00
128_D192_R2.4041.00
198_V203_Y2.3881.00
115_F131_V2.3501.00
96_V254_I2.3451.00
208_K214_R2.3431.00
103_E176_S2.3251.00
43_P47_A2.3051.00
216_A220_R2.2801.00
259_A263_N2.2561.00
198_V201_S2.2391.00
212_L216_A2.2011.00
213_S216_A2.1331.00
204_I222_A2.0891.00
215_P219_V2.0681.00
107_L180_A2.0551.00
235_G291_V2.0001.00
89_L260_H1.9341.00
60_F64_V1.8851.00
85_S88_D1.8701.00
118_I122_Y1.8681.00
204_I217_V1.8411.00
110_A114_L1.8401.00
122_Y125_K1.8331.00
45_I48_N1.8321.00
202_D205_R1.8241.00
122_Y214_R1.8211.00
33_G50_N1.7991.00
117_V195_M1.7981.00
126_W130_T1.7541.00
46_E50_N1.7531.00
122_Y127_Q1.7341.00
33_G36_S1.7201.00
48_N52_H1.7061.00
199_L222_A1.7041.00
120_A195_M1.6831.00
82_K89_L1.6731.00
24_F94_F1.6731.00
121_L214_R1.6611.00
16_L282_V1.6541.00
187_I237_M1.6341.00
198_V226_A1.6341.00
71_A74_D1.6341.00
87_N91_S1.6161.00
3_K7_R1.5971.00
203_Y225_N1.5961.00
75_F275_G1.5681.00
69_S74_D1.5621.00
47_A50_N1.5611.00
61_V65_S1.5591.00
78_S84_Q1.5571.00
86_V275_G1.5541.00
127_Q131_V1.5531.00
111_L114_L1.5521.00
99_T103_E1.5341.00
118_I127_Q1.5231.00
176_S180_A1.5151.00
121_L218_T1.5151.00
111_L184_M1.5071.00
84_Q88_D1.4991.00
17_F21_T1.4661.00
108_A183_P1.4661.00
109_L234_M1.4361.00
47_A51_A1.4181.00
92_S95_P1.4151.00
264_S272_V1.4021.00
13_I286_L1.4011.00
131_V188_A1.3811.00
261_F276_V1.3771.00
206_T210_K1.3771.00
65_S68_K1.3611.00
112_G191_S1.3561.00
112_G187_I1.3481.00
135_T188_A1.3371.00
10_V14_I1.3351.00
198_V204_I1.3301.00
198_V222_A1.3221.00
105_I234_M1.3171.00
231_V298_I1.3001.00
232_T295_Y1.2981.00
10_V293_V1.2981.00
194_S197_E1.2941.00
75_F87_N1.2811.00
239_A284_L1.2801.00
116_G120_A1.2781.00
145_I149_V1.2771.00
190_L233_Y1.2741.00
197_E201_S1.2721.00
96_V99_T1.2721.00
295_Y299_D1.2711.00
58_P61_V1.2701.00
294_L297_I1.2641.00
150_L178_A1.2511.00
79_F263_N1.2501.00
73_W85_S1.2501.00
180_A184_M1.2441.00
19_I281_S1.2421.00
192_R196_I1.2391.00
115_F188_A1.2331.00
54_G57_K1.2321.00
65_S69_S1.2301.00
84_Q92_S1.2291.00
49_L52_H1.2281.00
20_V66_Y1.2241.00
57_K60_F1.2181.00
70_V75_F1.2101.00
84_Q89_L1.1961.00
124_N128_D1.1861.00
120_A199_L1.1831.00
126_W129_Y1.1821.00
173_F177_I1.1801.00
119_A131_V1.1791.00
133_I136_I1.1631.00
270_Y274_M1.1441.00
61_V64_V1.1361.00
138_G185_A1.1331.00
49_L53_Y1.1261.00
207_A221_H1.1151.00
116_G191_S1.1121.00
207_A217_V1.1101.00
117_V218_T1.1091.00
195_M226_A1.1061.00
178_A182_M1.1021.00
21_T25_F1.0921.00
207_A212_L1.0841.00
210_K221_H1.0801.00
191_S230_V1.0801.00
69_S72_M1.0801.00
67_L70_V1.0761.00
77_P85_S1.0741.00
27_M92_S1.0671.00
262_V266_T1.0571.00
6_G10_V1.0571.00
191_S195_M1.0531.00
134_L138_G1.0521.00
141_V146_M1.0461.00
117_V223_I1.0391.00
99_T172_T1.0081.00
260_H272_V1.0061.00
114_L117_V1.0051.00
276_V280_F1.0031.00
9_L13_I1.0021.00
147_A178_A0.9921.00
48_N51_A0.9901.00
287_C291_V0.9871.00
113_V191_S0.9781.00
216_A219_V0.9761.00
89_L272_V0.9731.00
194_S198_V0.9711.00
22_V26_L0.9691.00
35_F46_E0.9611.00
132_A188_A0.9601.00
36_S46_E0.9591.00
90_I279_F0.9491.00
54_G65_S0.9441.00
12_M285_L0.9421.00
293_V297_I0.9411.00
88_D92_S0.9391.00
104_A180_A0.9381.00
205_R208_K0.9371.00
128_D196_I0.9361.00
129_Y133_I0.9241.00
231_V291_V0.9231.00
100_L249_E0.9201.00
13_I293_V0.9181.00
228_L295_Y0.9151.00
18_V22_V0.9061.00
93_G260_H0.9051.00
75_F90_I0.9031.00
238_A287_C0.9021.00
99_T102_A0.9011.00
86_V272_V0.8951.00
191_S226_A0.8941.00
262_V265_I0.8891.00
184_M188_A0.8891.00
20_V283_I0.8831.00
171_Y174_L0.8791.00
23_T91_S0.8781.00
89_L92_S0.8761.00
212_L217_V0.8751.00
8_R11_Y0.8731.00
104_A108_A0.8721.00
86_V260_H0.8691.00
226_A229_P0.8631.00
17_F286_L0.8621.00
208_K217_V0.8621.00
130_T134_L0.8601.00
104_A179_L0.8591.00
129_Y132_A0.8581.00
143_S248_I0.8521.00
5_I11_Y0.8471.00
286_L290_I0.8441.00
207_A210_K0.8401.00
214_R217_V0.8371.00
173_F176_S0.8361.00
95_P99_T0.8301.00
233_Y237_M0.8291.00
177_I180_A0.8281.00
88_D91_S0.8261.00
261_F264_S0.8251.00
263_N267_N0.8081.00
116_G195_M0.8081.00
91_S95_P0.8061.00
113_V230_V0.7981.00
264_S273_I0.7981.00
120_A196_I0.7971.00
20_V278_V0.7921.00
5_I293_V0.7911.00
77_P83_G0.7911.00
124_N129_Y0.7901.00
51_A57_K0.7891.00
275_G278_V0.7861.00
127_Q130_T0.7831.00
31_P34_P0.7811.00
25_F28_Q0.7761.00
114_L118_I0.7751.00
44_E47_A0.7731.00
109_L114_L0.7721.00
154_F174_L0.7701.00
109_L187_I0.7691.00
14_I18_V0.7681.00
103_E254_I0.7671.00
4_Y296_G0.7671.00
12_M289_L0.7661.00
90_I275_G0.7651.00
172_T176_S0.7631.00
150_L174_L0.7631.00
135_T185_A0.7621.00
205_R209_A0.7621.00
143_S147_A0.7621.00
9_L289_L0.7601.00
32_G35_F0.7591.00
102_A106_L0.7571.00
260_H276_V0.7561.00
263_N266_T0.7461.00
73_W77_P0.7461.00
16_L286_L0.7431.00
78_S269_D0.7421.00
16_L20_V0.7411.00
271_T275_G0.7401.00
28_Q59_L0.7381.00
19_I23_T0.7381.00
110_A113_V0.7351.00
274_M278_V0.7351.00
212_L221_H0.7341.00
97_S101_G0.7301.00
31_P88_D0.7281.00
219_V222_A0.7271.00
115_F184_M0.7271.00
139_I185_A0.7261.00
179_L248_I0.7251.00
43_P46_E0.7231.00
296_G302_I0.7221.00
17_F67_L0.7211.00
91_S94_F0.7191.00
214_R218_T0.7181.00
44_E48_N0.7181.00
20_V282_V0.7161.00
16_L285_L0.7141.00
107_L176_S0.7131.00
25_F59_L0.7111.00
274_M277_T0.7091.00
282_V286_L0.7081.00
183_P186_F0.7071.00
104_A245_S0.7041.00
217_V222_A0.7031.00
94_F283_I0.7031.00
11_Y15_T0.7021.00
68_K71_A0.6981.00
35_F49_L0.6981.00
112_G116_G0.6971.00
128_D132_A0.6961.00
28_Q270_Y0.6951.00
15_T19_I0.6941.00
14_I17_F0.6931.00
109_L113_V0.6911.00
74_D85_S0.6881.00
26_L29_A0.6871.00
21_T59_L0.6861.00
174_L177_I0.6841.00
260_H264_S0.6831.00
201_S205_R0.6831.00
11_Y14_I0.6811.00
193_S196_I0.6801.00
275_G279_F0.6761.00
119_A128_D0.6761.00
149_V153_V0.6761.00
170_A173_F0.6761.00
12_M15_T0.6751.00
27_M30_A0.6751.00
45_I49_L0.6731.00
295_Y302_I0.6691.00
194_S226_A0.6661.00
70_V278_V0.6651.00
280_F284_L0.6651.00
239_A287_C0.6651.00
111_L180_A0.6581.00
290_I294_L0.6571.00
122_Y218_T0.6501.00
64_V67_L0.6481.00
103_E106_L0.6441.00
35_F50_N0.6441.00
124_N199_L0.6421.00
235_G287_C0.6421.00
215_P218_T0.6411.00
121_L219_V0.6401.00
155_S174_L0.6401.00
182_M185_A0.6391.00
13_I289_L0.6361.00
32_G88_D0.6361.00
108_A180_A0.6341.00
105_I238_A0.6321.00
31_P35_F0.6311.00
119_A132_A0.6221.00
79_F271_T0.6201.00
74_D87_N0.6201.00
98_F102_A0.6181.00
130_T133_I0.6171.00
90_I276_V0.6151.00
20_V67_L0.6121.00
14_I290_I0.6121.00
66_Y70_V0.6121.00
296_G303_K0.6101.00
70_V73_W0.6031.00
191_S194_S0.6011.00
186_F233_Y0.5961.00
284_L288_V0.5931.00
187_I233_Y0.5931.00
23_T277_T0.5911.00
212_L215_P0.5881.00
194_S229_P0.5881.00
186_F237_M0.5861.00
10_V13_I0.5841.00
32_G268_R0.5841.00
237_M240_Q0.5841.00
106_L110_A0.5841.00
13_I17_F0.5821.00
185_A188_A0.5801.00
198_V225_N0.5781.00
152_Y156_M0.5761.00
111_L115_F0.5761.00
23_T94_F0.5731.00
245_S248_I0.5731.00
195_M199_L0.5721.00
250_T259_A0.5711.00
95_P98_F0.5701.00
273_I277_T0.5701.00
125_K128_D0.5671.00
143_S146_M0.5661.00
247_I250_T0.5651.00
4_Y290_I0.5631.00
112_G188_A0.5631.00
187_I191_S0.5621.00
249_E253_G0.5621.00
121_L199_L0.5601.00
132_A135_T0.5591.00
247_I251_I0.5581.00
12_M16_L0.5571.00
101_G245_S0.5571.00
89_L93_G0.5561.00
32_G73_W0.5551.00
131_V135_T0.5501.00
7_R293_V0.5491.00
246_F250_T0.5451.00
21_T60_F0.5441.00
146_M181_S0.5421.00
31_P87_N0.5421.00
100_L176_S0.5411.00
147_A251_I0.5391.00
174_L178_A0.5391.00
183_P237_M0.5391.00
67_L71_A0.5381.00
143_S181_S0.5381.00
68_K73_W0.5371.00
25_F29_A0.5331.00
102_A238_A0.5321.00
94_F98_F0.5321.00
204_I208_K0.5321.00
183_P240_Q0.5311.00
105_I237_M0.5281.00
23_T27_M0.5281.00
261_F280_F0.5271.00
190_L194_S0.5261.00
248_I251_I0.5251.00
7_R10_V0.5241.00
120_A128_D0.5181.00
109_L230_V0.5171.00
293_V296_G0.5171.00
196_I199_L0.5151.00
151_Q155_S0.5141.00
78_S82_K0.5141.00
259_A262_V0.5121.00
250_T263_N0.5111.00
119_A192_R0.5111.00
227_L230_V0.5091.00
180_A183_P0.5081.00
237_M245_S0.5081.00
181_S184_M0.5061.00
135_T138_G0.5051.00
227_L231_V0.5041.00
103_E173_F0.5031.00
17_F287_C0.5021.00
135_T184_M0.5011.00
32_G72_M0.5011.00
186_F190_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.672 99.9 0.642 Contact Map
4tquM 1 0.8328 99.9 0.645 Contact Map
3rlfF 1 0.8457 99.9 0.666 Contact Map
2onkC 2 0.7974 99.8 0.672 Contact Map
3d31C 2 0.7846 99.8 0.673 Contact Map
4ymuD 2 0.6752 99.8 0.68 Contact Map
3rlfG 1 0.8521 99.8 0.693 Contact Map
4tquN 1 0.8296 99.8 0.694 Contact Map
4ltoA 3 0.3408 17.9 0.954 Contact Map
4cbcA 3 0.299 11.5 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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