GREMLIN Database
OPPD - Oligopeptide transport ATP-binding protein OppD
UniProt: P24136 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 358 (298)
Sequences: 26346 (18685)
Seq/√Len: 1082.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_E228_R4.2181.00
95_E178_K3.5581.00
9_E33_H3.3391.00
11_K72_E3.2981.00
12_D29_G3.1921.00
15_I56_A3.1081.00
76_E178_K2.9541.00
72_E79_D2.7721.00
40_L230_A2.7201.00
41_A226_A2.6691.00
242_T245_E2.6391.00
25_Q28_R2.5331.00
14_A70_R2.5051.00
230_A237_I2.4891.00
35_D38_E2.4681.00
228_R240_T2.4151.00
10_V13_L2.3991.00
135_R138_E2.3911.00
79_D82_P2.3281.00
241_G246_I2.3261.00
139_L174_A2.3071.00
151_R154_Q2.2831.00
16_S25_Q2.2761.00
9_E74_L2.2191.00
36_K178_K2.2161.00
302_I306_Q2.1531.00
54_S215_I2.1331.00
137_V152_V2.0571.00
141_E149_E2.0501.00
6_R9_E2.0401.00
6_R35_D1.9881.00
223_A244_D1.9801.00
14_A29_G1.9511.00
16_S23_E1.9141.00
128_S131_A1.8961.00
11_K74_L1.8941.00
154_Q158_E1.8851.00
41_A222_V1.8851.00
59_K88_M1.8331.00
111_M115_K1.8331.00
137_V149_E1.8311.00
135_R176_N1.8301.00
76_E95_E1.8221.00
293_A304_F1.8031.00
17_F52_V1.7711.00
16_S69_K1.7301.00
122_F132_A1.7241.00
28_R236_Q1.7171.00
138_E142_L1.7121.00
6_R33_H1.6741.00
18_K23_E1.6721.00
114_G152_V1.6401.00
10_V32_F1.6361.00
12_D31_N1.6291.00
88_M92_R1.6031.00
202_K205_Q1.5961.00
299_A304_F1.5941.00
146_P150_K1.5891.00
216_T222_V1.5841.00
54_S181_I1.5531.00
312_K315_D1.5341.00
118_T136_A1.5331.00
236_Q307_E1.5321.00
15_I69_K1.4951.00
133_K152_V1.4521.00
230_A240_T1.4511.00
114_G153_N1.4321.00
15_I61_I1.4281.00
42_I213_I1.4181.00
10_V57_I1.4171.00
201_M212_I1.4101.00
78_K83_L1.4091.00
133_K137_V1.4051.00
39_T205_Q1.4051.00
32_F53_T1.3951.00
104_M164_R1.3841.00
30_V53_T1.3741.00
14_A28_R1.3721.00
17_F26_A1.3661.00
198_L221_V1.3561.00
13_L63_M1.3541.00
112_K153_N1.3381.00
159_F167_V1.3201.00
91_V96_I1.3031.00
115_K118_T1.2951.00
112_K115_K1.2951.00
118_T132_A1.2941.00
36_K76_E1.2941.00
151_R159_F1.2921.00
110_T157_H1.2901.00
312_K316_T1.2881.00
301_K304_F1.2851.00
114_G118_T1.2701.00
83_L88_M1.2691.00
245_E249_D1.2591.00
202_K224_N1.2571.00
117_I140_L1.2471.00
99_I182_A1.2461.00
204_L210_T1.2421.00
34_L40_L1.2411.00
214_F225_V1.2271.00
14_A25_Q1.2151.00
11_K31_N1.2121.00
36_K209_D1.2071.00
32_F230_A1.2041.00
291_A307_E1.1981.00
288_K293_A1.1961.00
260_A274_T1.1961.00
256_W260_A1.1921.00
16_S28_R1.1891.00
74_L79_D1.1851.00
236_Q291_A1.1771.00
130_E134_K1.1761.00
12_D70_R1.1711.00
290_D296_S1.1701.00
134_K138_E1.1681.00
111_M119_E1.1671.00
40_L240_T1.1661.00
133_K153_N1.1651.00
11_K33_H1.1611.00
301_K305_E1.1611.00
34_L179_L1.1491.00
244_D248_Y1.1461.00
182_A212_I1.1451.00
241_G245_E1.1361.00
55_Q60_L1.1221.00
118_T122_F1.1211.00
131_A134_K1.1201.00
40_L228_R1.1121.00
142_L203_D1.0971.00
121_L174_A1.0961.00
146_P151_R1.0961.00
229_V243_V1.0931.00
117_I174_A1.0871.00
256_W298_Y1.0871.00
39_T212_I1.0791.00
118_T133_K1.0751.00
58_M98_M1.0731.00
125_E135_R1.0681.00
114_G133_K1.0571.00
42_I230_A1.0561.00
59_K62_P1.0471.00
38_E227_D1.0431.00
28_R291_A1.0431.00
296_S303_D1.0421.00
132_A136_A1.0331.00
289_G293_A1.0301.00
96_I179_L1.0251.00
56_A63_M1.0241.00
139_L142_L1.0111.00
180_L212_I1.0091.00
289_G292_F1.0041.00
138_E141_E0.9991.00
194_Q218_D0.9971.00
127_I132_A0.9911.00
116_Q171_M0.9911.00
97_G172_A0.9901.00
53_T232_M0.9881.00
124_H127_I0.9861.00
313_V317_H0.9821.00
150_K154_Q0.9801.00
58_M181_I0.9751.00
299_A303_D0.9721.00
39_T226_A0.9641.00
180_L210_T0.9571.00
94_K125_E0.9551.00
35_D211_S0.9481.00
205_Q227_D0.9441.00
108_N111_M0.9311.00
42_I53_T0.9301.00
118_T152_V0.9281.00
202_K225_V0.9281.00
205_Q212_I0.9171.00
137_V141_E0.9141.00
27_I56_A0.9101.00
56_A61_I0.9081.00
10_V73_I0.9081.00
292_F296_S0.9071.00
43_V222_V0.9021.00
293_A299_A0.9011.00
35_D228_R0.8981.00
246_I255_T0.8931.00
140_L152_V0.8921.00
245_E248_Y0.8911.00
34_L213_I0.8891.00
314_S317_H0.8851.00
13_L56_A0.8831.00
111_M116_Q0.8831.00
34_L211_S0.8691.00
83_L91_V0.8681.00
7_L75_F0.8631.00
73_I81_V0.8611.00
290_D293_A0.8601.00
237_I240_T0.8591.00
302_I305_E0.8581.00
179_L213_I0.8551.00
39_T202_K0.8521.00
129_K132_A0.8521.00
182_A201_M0.8471.00
136_A152_V0.8451.00
120_V171_M0.8441.00
286_P291_A0.8441.00
282_D285_N0.8431.00
264_T267_S0.8421.00
144_G203_D0.8411.00
48_S232_M0.8381.00
6_R36_K0.8361.00
285_N288_K0.8321.00
113_V167_V0.8321.00
56_A73_I0.8311.00
80_L91_V0.8301.00
139_L170_A0.8281.00
55_Q61_I0.8261.00
296_S300_M0.8261.00
135_R139_L0.8201.00
134_K141_E0.8201.00
131_A135_R0.8191.00
17_F61_I0.8171.00
283_L286_P0.8151.00
255_T259_L0.8091.00
128_S132_A0.8011.00
251_R313_V0.7991.00
80_L96_I0.7981.00
117_I136_A0.7941.00
278_G281_P0.7921.00
99_I169_I0.7881.00
194_Q221_V0.7871.00
287_P293_A0.7841.00
306_Q309_P0.7831.00
15_I52_V0.7821.00
40_L213_I0.7801.00
79_D83_L0.7791.00
75_F95_E0.7791.00
125_E132_A0.7771.00
15_I27_I0.7761.00
7_L179_L0.7731.00
127_I131_A0.7721.00
145_I163_M0.7681.00
189_L197_I0.7651.00
57_I213_I0.7631.00
107_L167_V0.7611.00
176_N210_T0.7591.00
313_V316_T0.7571.00
219_L247_F0.7571.00
247_F250_P0.7541.00
186_T221_V0.7531.00
7_L76_E0.7531.00
97_G177_P0.7531.00
36_K211_S0.7521.00
290_D303_D0.7471.00
43_V231_V0.7421.00
195_A199_E0.7401.00
122_F129_K0.7391.00
243_V247_F0.7371.00
144_G196_Q0.7351.00
277_P297_S0.7341.00
146_P149_E0.7341.00
12_D15_I0.7311.00
125_E128_S0.7271.00
280_P283_L0.7241.00
181_I213_I0.7191.00
112_K116_Q0.7171.00
107_L164_R0.7171.00
18_K21_G0.7151.00
214_F226_A0.7131.00
8_L57_I0.7131.00
78_K95_E0.7121.00
303_D307_E0.7111.00
159_F163_M0.7101.00
127_I135_R0.7071.00
145_I151_R0.7051.00
151_R163_M0.7051.00
291_A295_R0.7051.00
58_M96_I0.7031.00
39_T225_V0.7001.00
134_K137_V0.7001.00
75_F80_L0.7001.00
29_G236_Q0.6991.00
112_K155_F0.6941.00
228_R239_E0.6941.00
72_E82_P0.6901.00
155_F158_E0.6881.00
139_L173_L0.6881.00
233_Y236_Q0.6871.00
143_V170_A0.6861.00
294_L297_S0.6851.00
293_A297_S0.6841.00
106_S168_V0.6811.00
116_Q156_P0.6791.00
16_S70_R0.6771.00
14_A69_K0.6771.00
273_L276_I0.6771.00
121_L127_I0.6761.00
231_V250_P0.6751.00
120_V175_A0.6741.00
286_P289_G0.6721.00
307_E310_M0.6711.00
107_L116_Q0.6701.00
303_D308_P0.6701.00
30_V237_I0.6671.00
18_K69_K0.6651.00
55_Q98_M0.6641.00
310_M313_V0.6631.00
287_P290_D0.6621.00
173_L210_T0.6591.00
289_G296_S0.6551.00
223_A247_F0.6531.00
241_G247_F0.6531.00
75_F91_V0.6481.00
126_K129_K0.6481.00
226_A243_V0.6471.00
27_I30_V0.6471.00
253_P256_W0.6461.00
60_L100_F0.6441.00
252_H256_W0.6421.00
245_E314_S0.6401.00
199_E203_D0.6391.00
125_E129_K0.6381.00
299_A302_I0.6381.00
238_V291_A0.6381.00
202_K206_K0.6371.00
45_E48_S0.6361.00
117_I171_M0.6341.00
300_M304_F0.6311.00
80_L88_M0.6301.00
310_M317_H0.6281.00
125_E176_N0.6281.00
278_G283_L0.6261.00
56_A69_K0.6261.00
129_K133_K0.6251.00
8_L179_L0.6241.00
287_P294_L0.6241.00
226_A229_V0.6231.00
298_Y301_K0.6221.00
281_P285_N0.6211.00
254_Y258_L0.6191.00
59_K81_V0.6181.00
231_V246_I0.6181.00
102_D105_T0.6161.00
39_T227_D0.6161.00
272_E275_A0.6141.00
246_I250_P0.6131.00
290_D295_R0.6131.00
78_K91_V0.6101.00
256_W259_L0.6071.00
29_G70_R0.6051.00
311_F314_S0.6041.00
114_G136_A0.6031.00
23_E69_K0.6021.00
298_Y302_I0.6021.00
300_M303_D0.6011.00
51_S55_Q0.6001.00
121_L125_E0.5981.00
293_A296_S0.5961.00
154_Q159_F0.5911.00
26_A52_V0.5911.00
279_T282_D0.5901.00
221_V225_V0.5901.00
75_F179_L0.5901.00
288_K292_F0.5891.00
201_M214_F0.5881.00
80_L83_L0.5881.00
41_A216_T0.5861.00
120_V123_K0.5841.00
109_P157_H0.5831.00
222_V226_A0.5821.00
169_I197_I0.5821.00
84_S88_M0.5791.00
130_E133_K0.5781.00
291_A294_L0.5781.00
281_P287_P0.5781.00
257_G260_A0.5771.00
284_T288_K0.5751.00
296_S299_A0.5751.00
114_G117_I0.5741.00
307_E311_F0.5741.00
12_D71_G0.5701.00
309_P312_K0.5681.00
72_E81_V0.5671.00
285_N289_G0.5671.00
121_L126_K0.5671.00
250_P255_T0.5661.00
257_G276_I0.5641.00
283_L287_P0.5631.00
303_D317_H0.5631.00
286_P290_D0.5631.00
262_M265_L0.5621.00
8_L75_F0.5601.00
292_F295_R0.5591.00
200_L203_D0.5591.00
243_V246_I0.5591.00
59_K79_D0.5581.00
89_Q123_K0.5571.00
306_Q310_M0.5571.00
222_V229_V0.5551.00
117_I120_V0.5531.00
156_P167_V0.5521.00
277_P280_P0.5521.00
121_L175_A0.5521.00
302_I308_P0.5501.00
105_T164_R0.5501.00
33_H228_R0.5491.00
198_L224_N0.5491.00
141_E146_P0.5471.00
182_A185_P0.5441.00
42_I237_I0.5431.00
149_E152_V0.5431.00
121_L135_R0.5431.00
116_Q120_V0.5421.00
63_M69_K0.5391.00
306_Q311_F0.5381.00
216_T226_A0.5371.00
120_V174_A0.5351.00
99_I172_A0.5351.00
295_R299_A0.5341.00
57_I73_I0.5301.00
13_L73_I0.5291.00
284_T287_P0.5291.00
99_I165_Q0.5281.00
249_D253_P0.5271.00
184_E217_H0.5271.00
135_R142_L0.5261.00
201_M225_V0.5251.00
212_I225_V0.5241.00
310_M314_S0.5241.00
257_G261_S0.5201.00
240_T310_M0.5191.00
297_S300_M0.5191.00
266_E269_G0.5181.00
10_V53_T0.5181.00
7_L211_S0.5181.00
53_T56_A0.5151.00
312_K317_H0.5141.00
39_T214_F0.5131.00
300_M317_H0.5131.00
20_Y23_E0.5121.00
37_G211_S0.5101.00
267_S270_E0.5101.00
243_V254_Y0.5081.00
294_L299_A0.5071.00
276_I279_T0.5071.00
63_M73_I0.5041.00
300_M306_Q0.5031.00
198_L225_V0.5021.00
205_Q210_T0.5021.00
261_S264_T0.5011.00
102_D164_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.9441 100 0.278 Contact Map
4ry2A 2 0.6676 100 0.282 Contact Map
4f4cA 1 0.6508 100 0.283 Contact Map
4ymuJ 2 0.6704 100 0.297 Contact Map
2oljA 2 0.676 100 0.298 Contact Map
1b0uA 2 0.6899 100 0.299 Contact Map
4u00A 1 0.6732 100 0.3 Contact Map
4q9hA 1 0.6872 100 0.301 Contact Map
1v43A 2 0.7682 100 0.303 Contact Map
4mkiB 2 0.7961 100 0.305 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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