GREMLIN Database
FLIY - Flagellar motor switch phosphatase FliY
UniProt: P24073 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 378 (367)
Sequences: 517 (428)
Seq/√Len: 22.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_Q198_G7.3011.00
122_D125_G4.4111.00
131_G134_H4.0161.00
197_V201_I3.9901.00
35_E38_R3.7251.00
133_I150_A3.6201.00
12_D18_T3.6111.00
55_A148_S3.3111.00
82_A190_K3.1751.00
309_E336_G3.1751.00
309_E340_D2.8190.99
243_K249_E2.7920.99
159_K220_S2.7190.99
339_V362_V2.6950.99
341_I362_V2.6500.99
242_P245_P2.6270.99
243_K246_V2.6070.99
51_S155_T2.5580.98
299_L345_Q2.4510.98
49_F345_Q2.3610.97
245_P248_P2.2600.96
92_V221_L2.1820.96
248_P251_R2.1410.95
115_A138_V2.1260.95
111_A138_V2.1040.95
251_R257_Q2.0380.94
72_T319_E2.0250.94
340_D366_D2.0240.94
248_P253_E1.9880.93
9_D52_S1.9870.93
244_E249_E1.9740.93
309_E312_R1.9700.93
245_P251_R1.9280.92
68_T203_S1.9220.92
79_I197_V1.8970.91
323_L327_S1.8950.91
246_V251_R1.8880.91
298_M302_I1.8870.91
213_F283_F1.8750.91
253_E258_Q1.8550.90
118_M141_A1.8550.90
243_K247_T1.8350.90
243_K250_P1.8330.89
231_E238_T1.8320.89
39_D42_G1.8130.89
37_E215_K1.7930.88
154_S336_G1.7820.88
262_K265_G1.7780.88
42_G54_T1.7780.88
295_N335_A1.7480.87
336_G340_D1.7210.86
89_A103_L1.7160.86
247_T257_Q1.7120.86
113_I160_K1.7030.86
301_D358_E1.6880.85
252_I258_Q1.6820.85
252_I255_K1.6790.85
60_L201_I1.6780.85
245_P250_P1.6560.84
195_L299_L1.6500.84
40_A221_L1.6460.84
280_F356_I1.6280.83
104_L148_S1.6260.83
306_I343_V1.6240.83
251_R255_K1.6150.82
335_A339_V1.6010.82
247_T251_R1.5930.82
244_E250_P1.5690.81
44_I217_L1.5420.79
9_D158_S1.5290.79
189_V214_A1.5270.79
162_D170_L1.5190.78
106_V299_L1.5090.78
39_D54_T1.4930.77
88_V135_L1.4870.77
333_K356_I1.4830.77
78_K81_D1.4670.76
283_F329_I1.4620.75
42_G46_N1.4460.75
309_E366_D1.4390.74
111_A115_A1.4380.74
213_F336_G1.4300.74
336_G366_D1.4280.74
134_H366_D1.4190.73
12_D133_I1.4080.73
246_V256_Q1.4010.72
22_L160_K1.3990.72
134_H213_F1.3950.72
95_T164_S1.3830.71
55_A195_L1.3800.71
246_V250_P1.3780.71
39_D142_M1.3730.71
250_P253_E1.3680.70
369_S373_R1.3590.70
334_L359_N1.3580.70
246_V254_P1.3500.69
347_I368_L1.3330.68
307_T328_I1.3300.68
187_M364_V1.3210.68
348_V372_E1.3200.68
66_I142_M1.3170.67
243_K253_E1.3080.67
42_G47_I1.3060.67
201_I356_I1.3010.66
157_F221_L1.2940.66
262_K266_T1.2910.66
251_R254_P1.2820.65
145_M193_F1.2720.65
43_E47_I1.2700.65
47_I54_T1.2690.64
62_Q191_V1.2660.64
283_F336_G1.2550.64
39_D47_I1.2410.63
46_N54_T1.2380.62
242_P247_T1.2340.62
209_Y325_A1.2330.62
253_E256_Q1.2300.62
309_E362_V1.2300.62
256_Q319_E1.2090.61
297_D302_I1.2070.60
111_A294_H1.2070.60
299_L302_I1.1790.59
54_T193_F1.1780.59
249_E253_E1.1780.59
49_F139_Q1.1740.58
66_I143_N1.1680.58
54_T163_I1.1670.58
254_P257_Q1.1650.58
288_A292_P1.1590.57
317_V325_A1.1590.57
244_E251_R1.1500.57
58_T182_I1.1470.56
265_G268_K1.1460.56
219_S222_M1.1420.56
92_V111_A1.1390.56
54_T143_N1.1390.56
146_M154_S1.1380.56
371_A375_N1.1330.56
147_G151_T1.1300.55
370_Q373_R1.1290.55
75_P299_L1.1280.55
168_V302_I1.1200.55
129_S150_A1.1120.54
44_I211_L1.1110.54
242_P251_R1.1040.54
111_A323_L1.1020.53
49_F52_S1.0940.53
230_E250_P1.0890.53
63_K191_V1.0830.52
106_V111_A1.0820.52
246_V257_Q1.0770.52
10_E14_L1.0750.52
109_S113_I1.0720.51
213_F309_E1.0720.51
238_T245_P1.0700.51
19_G364_V1.0690.51
56_L165_P1.0680.51
42_G166_P1.0680.51
238_T253_E1.0640.51
42_G163_I1.0620.51
247_T255_K1.0620.51
9_D315_R1.0580.50
27_I197_V1.0550.50
123_G141_A1.0530.50
244_E247_T1.0480.50
51_S95_T1.0480.50
242_P253_E1.0470.50
236_E262_K1.0470.50
280_F333_K1.0360.49
187_M300_L1.0320.49
44_I205_I1.0230.48
146_M309_E1.0180.48
54_T142_M1.0170.48
164_S335_A1.0160.48
139_Q302_I1.0160.48
157_F172_D1.0140.47
13_A323_L1.0110.47
3_N162_D1.0080.47
242_P246_V1.0040.47
39_D151_T1.0000.46
47_I142_M0.9970.46
213_F340_D0.9870.46
260_P268_K0.9870.46
46_N193_F0.9850.45
24_E244_E0.9810.45
8_Q13_A0.9770.45
228_E231_E0.9700.44
71_V188_L0.9700.44
243_K268_K0.9700.44
54_T145_M0.9610.44
54_T166_P0.9580.44
201_I366_D0.9530.43
51_S148_S0.9530.43
254_P259_Q0.9510.43
232_T260_P0.9480.43
77_S243_K0.9460.43
154_S322_E0.9460.43
296_L347_I0.9450.43
334_L339_V0.9440.43
51_S83_F0.9410.42
42_G50_G0.9380.42
102_N193_F0.9370.42
51_S106_V0.9330.42
69_P143_N0.9330.42
256_Q260_P0.9310.42
39_D46_N0.9300.42
90_I357_E0.9290.42
249_E257_Q0.9280.42
159_K216_D0.9280.42
9_D196_K0.9270.42
34_S37_E0.9260.41
21_T25_P0.9250.41
242_P256_Q0.9240.41
42_G143_N0.9240.41
163_I166_P0.9240.41
110_D203_S0.9240.41
46_N50_G0.9190.41
310_L352_E0.9180.41
208_L333_K0.9180.41
77_S129_S0.9160.41
138_V155_T0.9090.40
345_Q364_V0.9080.40
69_P193_F0.9080.40
12_D57_S0.9050.40
91_E135_L0.9010.40
244_E254_P0.9000.40
351_G359_N0.9000.40
244_E255_K0.8990.40
300_L314_K0.8970.40
49_F296_L0.8970.40
186_E229_E0.8950.39
49_F299_L0.8910.39
350_K366_D0.8890.39
247_T250_P0.8860.39
300_L345_Q0.8830.39
20_S368_L0.8830.39
175_E242_P0.8810.38
53_A309_E0.8800.38
45_G115_A0.8800.38
46_N163_I0.8790.38
237_V245_P0.8770.38
36_M108_Q0.8730.38
16_N24_E0.8680.38
49_F119_I0.8670.38
274_Q327_S0.8580.37
253_E257_Q0.8550.37
42_G193_F0.8510.37
338_P356_I0.8500.37
245_P255_K0.8500.37
251_R262_K0.8490.36
50_G54_T0.8470.36
248_P258_Q0.8450.36
252_I259_Q0.8450.36
208_L213_F0.8430.36
35_E368_L0.8420.36
150_A345_Q0.8410.36
263_R266_T0.8410.36
278_V316_S0.8410.36
234_Q237_V0.8390.36
215_K313_T0.8390.36
243_K251_R0.8380.36
339_V353_V0.8380.36
23_D30_V0.8360.36
119_I131_G0.8310.35
243_K257_Q0.8230.35
39_D166_P0.8230.35
151_T166_P0.8210.35
39_D163_I0.8200.35
19_G242_P0.8190.35
283_F333_K0.8150.34
163_I193_F0.8140.34
278_V294_H0.8130.34
138_V203_S0.8110.34
277_P340_D0.8090.34
27_I266_T0.8070.34
328_I347_I0.8050.34
246_V249_E0.8050.34
86_P117_L0.8040.34
55_A138_V0.8030.34
341_I351_G0.7990.33
46_N145_M0.7980.33
142_M166_P0.7980.33
330_E352_E0.7960.33
219_S237_V0.7960.33
238_T269_K0.7950.33
27_I256_Q0.7920.33
250_P254_P0.7920.33
118_M165_P0.7910.33
24_E247_T0.7890.33
62_Q149_A0.7870.33
20_S232_T0.7860.33
271_A325_A0.7850.32
54_T69_P0.7820.32
348_V357_E0.7780.32
194_N202_D0.7780.32
310_L337_E0.7780.32
46_N64_V0.7780.32
69_P145_M0.7770.32
242_P254_P0.7760.32
338_P362_V0.7740.32
16_N175_E0.7740.32
256_Q259_Q0.7730.32
154_S213_F0.7650.31
16_N223_N0.7650.31
213_F217_L0.7650.31
166_P193_F0.7640.31
312_R342_L0.7640.31
12_D224_S0.7630.31
335_A340_D0.7630.31
95_T362_V0.7630.31
50_G193_F0.7620.31
20_S23_D0.7600.31
43_E46_N0.7600.31
62_Q199_E0.7580.31
143_N163_I0.7560.31
46_N142_M0.7550.31
118_M121_G0.7550.31
248_P261_P0.7540.31
34_S252_I0.7500.30
236_E259_Q0.7500.30
299_L359_N0.7440.30
276_S281_S0.7420.30
51_S55_A0.7380.30
57_S115_A0.7370.30
47_I143_N0.7360.30
127_D347_I0.7340.29
309_E356_I0.7330.29
25_P248_P0.7320.29
46_N166_P0.7320.29
97_G151_T0.7310.29
260_P263_R0.7290.29
116_D197_V0.7280.29
137_A351_G0.7280.29
238_T244_E0.7250.29
242_P250_P0.7250.29
96_E131_G0.7250.29
167_R191_V0.7240.29
9_D21_T0.7230.29
97_G110_D0.7230.29
253_E259_Q0.7220.29
248_P254_P0.7190.29
340_D356_I0.7190.29
9_D61_N0.7160.28
79_I89_A0.7150.28
39_D193_F0.7100.28
24_E237_V0.7090.28
122_D126_A0.7080.28
203_S295_N0.7050.28
164_S339_V0.7020.28
349_A354_V0.7000.28
79_I103_L0.7000.28
8_Q12_D0.6980.27
154_S309_E0.6960.27
333_K355_V0.6940.27
143_N203_S0.6930.27
103_L182_I0.6930.27
5_R306_I0.6930.27
352_E358_E0.6910.27
15_L368_L0.6910.27
250_P255_K0.6900.27
199_E375_N0.6870.27
129_S263_R0.6860.27
95_T131_G0.6860.27
276_S305_S0.6850.27
46_N66_I0.6810.27
52_S57_S0.6800.27
112_A134_H0.6770.26
229_E261_P0.6750.26
54_T102_N0.6750.26
245_P258_Q0.6750.26
42_G66_I0.6690.26
112_A325_A0.6670.26
54_T66_I0.6640.26
51_S138_V0.6630.26
46_N151_T0.6630.26
280_F346_R0.6630.26
17_G375_N0.6610.26
43_E50_G0.6610.26
335_A360_F0.6610.26
231_E235_P0.6550.25
33_L38_R0.6550.25
249_E255_K0.6550.25
19_G32_D0.6530.25
25_P237_V0.6520.25
271_A314_K0.6510.25
254_P258_Q0.6510.25
334_L337_E0.6500.25
142_M163_I0.6490.25
339_V369_S0.6490.25
149_A372_E0.6450.25
52_S104_L0.6450.25
42_G151_T0.6450.25
315_R374_I0.6450.25
171_L178_G0.6440.25
7_S215_K0.6440.25
55_A161_I0.6440.25
342_L348_V0.6380.24
312_R320_I0.6370.24
342_L358_E0.6370.24
111_A362_V0.6360.24
185_D256_Q0.6360.24
83_F359_N0.6350.24
102_N166_P0.6350.24
86_P145_M0.6350.24
36_M235_P0.6290.24
176_E182_I0.6270.24
102_N143_N0.6270.24
332_D363_R0.6250.24
172_D287_E0.6250.24
115_A139_Q0.6240.24
23_D27_I0.6220.24
336_G350_K0.6210.23
112_A126_A0.6210.23
102_N207_Q0.6210.23
126_A329_I0.6190.23
136_S144_Q0.6190.23
226_S234_Q0.6170.23
66_I141_A0.6170.23
185_D258_Q0.6170.23
283_F328_I0.6160.23
146_M336_G0.6130.23
234_Q238_T0.6120.23
136_S143_N0.6120.23
77_S245_P0.6110.23
307_T336_G0.6100.23
353_V358_E0.6100.23
137_A143_N0.6100.23
47_I145_M0.6070.23
73_V122_D0.6060.23
15_L208_L0.6040.23
23_D369_S0.6000.22
36_M126_A0.5980.22
219_S223_N0.5970.22
143_N193_F0.5950.22
42_G142_M0.5950.22
79_I162_D0.5940.22
216_D287_E0.5940.22
182_I271_A0.5920.22
243_K248_P0.5910.22
61_N341_I0.5900.22
244_E258_Q0.5860.22
248_P257_Q0.5860.22
65_D146_M0.5860.22
22_L246_V0.5850.22
200_L205_I0.5850.22
230_E258_Q0.5840.22
77_S248_P0.5840.22
156_V364_V0.5830.22
42_G102_N0.5830.22
316_S328_I0.5830.22
349_A352_E0.5820.22
134_H317_V0.5800.22
193_F207_Q0.5800.22
3_N316_S0.5770.21
37_E50_G0.5770.21
99_S368_L0.5770.21
54_T151_T0.5750.21
187_M302_I0.5750.21
244_E263_R0.5740.21
137_A359_N0.5740.21
275_V315_R0.5730.21
184_D197_V0.5720.21
226_S247_T0.5710.21
243_K254_P0.5700.21
218_I221_L0.5700.21
33_L267_A0.5700.21
209_Y357_E0.5680.21
66_I166_P0.5670.21
237_V258_Q0.5670.21
295_N333_K0.5640.21
49_F83_F0.5640.21
17_G278_V0.5630.21
46_N49_F0.5630.21
337_E352_E0.5630.21
122_D201_I0.5610.21
245_P256_Q0.5610.21
301_D352_E0.5610.21
142_M145_M0.5600.21
12_D16_N0.5580.21
75_P253_E0.5570.20
23_D81_D0.5560.20
165_P207_Q0.5560.20
194_N291_A0.5560.20
94_Y278_V0.5540.20
84_P132_E0.5540.20
19_G22_L0.5530.20
30_V225_E0.5530.20
215_K236_E0.5530.20
283_F323_L0.5510.20
169_E217_L0.5510.20
189_V225_E0.5500.20
77_S185_D0.5490.20
335_A366_D0.5490.20
116_D364_V0.5480.20
139_Q204_S0.5470.20
126_A314_K0.5470.20
224_S315_R0.5460.20
280_F283_F0.5450.20
227_A233_V0.5450.20
69_P166_P0.5450.20
232_T244_E0.5440.20
296_L299_L0.5420.20
47_I163_I0.5420.20
39_D102_N0.5420.20
295_N309_E0.5410.20
34_S233_V0.5400.20
91_E131_G0.5390.20
244_E253_E0.5380.20
50_G143_N0.5330.19
78_K265_G0.5320.19
245_P252_I0.5320.19
128_P285_P0.5320.19
43_E54_T0.5310.19
19_G219_S0.5310.19
247_T254_P0.5300.19
108_Q170_L0.5300.19
3_N17_G0.5290.19
341_I357_E0.5290.19
213_F366_D0.5280.19
226_S242_P0.5260.19
136_S163_I0.5220.19
17_G162_D0.5210.19
338_P352_E0.5160.19
253_E291_A0.5150.19
114_I203_S0.5150.19
226_S254_P0.5140.19
162_D298_M0.5130.19
320_I333_K0.5120.19
58_T169_E0.5120.19
338_P353_V0.5110.18
16_N362_V0.5100.18
9_D341_I0.5100.18
46_N143_N0.5100.18
248_P260_P0.5090.18
47_I193_F0.5090.18
218_I319_E0.5090.18
356_I366_D0.5070.18
19_G73_V0.5060.18
84_P332_D0.5060.18
17_G345_Q0.5060.18
89_A105_V0.5060.18
118_M207_Q0.5050.18
217_L283_F0.5040.18
139_Q324_S0.5040.18
47_I102_N0.5030.18
16_N297_D0.5030.18
249_E261_P0.5020.18
84_P221_L0.5000.18
352_E361_G0.5000.18
143_N147_G0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hynA 1 0.5265 100 0.744 Contact Map
3qtaA 2 0.5291 100 0.765 Contact Map
1xkrA 1 0.5106 100 0.773 Contact Map
4fhrA 1 0.4788 100 0.776 Contact Map
4gc8A 1 0.4815 100 0.778 Contact Map
4yxcB 1 0.4365 100 0.783 Contact Map
1o6aA 2 0.2275 99.9 0.818 Contact Map
1squA 2 0.4048 99.9 0.823 Contact Map
3hm4A 2 0.4048 99.9 0.83 Contact Map
3h2dA 2 0.4048 99.9 0.83 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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