GREMLIN Database
COX3 - Cytochrome c oxidase subunit 3
UniProt: P24012 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 207 (183)
Sequences: 5341 (2656)
Seq/√Len: 196.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_L112_G4.0061.00
83_T106_T3.4401.00
104_G163_M3.2251.00
95_S98_K3.1251.00
99_M166_N3.1151.00
177_P181_V3.0061.00
86_Y102_W2.9461.00
39_V42_A2.6601.00
96_F100_Q2.5871.00
107_I156_L2.5021.00
51_L136_A2.4821.00
69_L116_L2.3361.00
90_H98_K2.2231.00
121_F145_V2.1421.00
69_L119_Y2.1241.00
115_G119_Y2.0671.00
158_W182_A2.0131.00
160_S164_I2.0051.00
144_L200_V1.9691.00
71_F75_M1.9511.00
114_L153_A1.9461.00
118_I122_K1.9161.00
97_G101_L1.8761.00
100_Q167_A1.8541.00
119_Y123_H1.8111.00
83_T105_I1.7851.00
40_L147_T1.7251.00
144_L196_I1.7241.00
76_L116_L1.7101.00
47_T140_A1.6911.00
87_A99_M1.6911.00
96_F169_R1.6771.00
159_I182_A1.6741.00
84_S183_S1.6731.00
84_S159_I1.6301.00
34_L184_L1.6041.00
162_L182_A1.5721.00
100_Q166_N1.5711.00
187_H190_D1.5651.00
100_Q163_M1.5581.00
87_A103_L1.5341.00
81_S187_H1.5301.00
107_I160_S1.4891.00
104_G108_L1.4751.00
73_A116_L1.4711.00
114_L156_L1.4411.00
68_T72_I1.4351.00
114_L149_G1.4071.00
179_F183_S1.3951.00
75_M79_T1.3881.00
110_G156_L1.3601.00
82_L86_Y1.3561.00
66_D123_H1.3471.00
101_L105_I1.3421.00
49_L199_V1.3401.00
83_T109_L1.2931.00
86_Y90_H1.2901.00
115_G118_I1.2761.00
96_F166_N1.2411.00
111_A156_L1.2051.00
101_L104_G1.2051.00
94_F173_L1.2051.00
69_L73_A1.2041.00
91_M99_M1.1991.00
92_K180_Y1.1721.00
98_K102_W1.1321.00
156_L160_S1.1261.00
23_G27_F1.1231.00
87_A179_F1.1161.00
153_A157_M1.1051.00
150_A154_F1.1011.00
98_K101_L1.0961.00
85_V88_M1.0931.00
37_E120_E1.0911.00
140_A144_L1.0901.00
22_E25_N1.0861.00
87_A166_N1.0751.00
198_T202_L1.0751.00
46_A50_A1.0651.00
90_H102_W1.0521.00
52_R55_N1.0511.00
85_V89_Y1.0501.00
72_I116_L1.0491.00
120_E201_Y1.0471.00
91_M179_F1.0371.00
108_L112_G1.0331.00
79_T82_L1.0331.00
185_Y189_I1.0291.00
89_Y93_N1.0281.00
44_L147_T1.0221.00
24_K28_L1.0181.00
164_I168_K1.0081.00
95_S101_L1.0001.00
107_I159_I0.9991.00
76_L109_L0.9951.00
165_R178_K0.9931.00
33_F185_Y0.9871.00
102_W105_I0.9861.00
39_V43_S0.9830.99
157_M161_T0.9790.99
20_T24_K0.9760.99
141_F149_G0.9730.99
165_R170_G0.9730.99
91_M176_A0.9640.99
134_S138_G0.9630.99
21_L24_K0.9600.99
48_F52_R0.9490.99
60_P63_E0.9450.99
88_M92_K0.9440.99
17_E21_L0.9380.99
30_F34_L0.9360.99
83_T102_W0.9120.99
44_L144_L0.9110.99
141_F145_V0.9060.99
154_F158_W0.9030.99
58_D135_S0.8870.99
59_P138_G0.8840.99
124_Y141_F0.8820.99
86_Y98_K0.8820.99
70_V117_E0.8820.99
111_A115_G0.8790.99
51_L140_A0.8790.99
73_A196_I0.8770.99
101_L167_A0.8760.99
143_T147_T0.8740.99
171_L178_K0.8680.99
117_E198_T0.8670.99
90_H95_S0.8650.99
130_F138_G0.8580.99
87_A102_W0.8370.98
39_V49_L0.8310.98
164_I167_A0.8270.98
107_I163_M0.8200.98
154_F185_Y0.8170.98
186_W193_W0.8120.98
131_T138_G0.8100.98
33_F37_E0.8070.98
121_F142_Y0.8030.98
130_F134_S0.8020.98
99_M103_L0.7990.98
77_L141_F0.7970.98
44_L143_T0.7930.98
22_E26_K0.7930.98
31_W35_G0.7890.98
163_M167_A0.7800.97
35_G39_V0.7710.97
148_H151_H0.7600.97
19_V22_E0.7580.97
88_M180_Y0.7570.97
104_G167_A0.7560.97
90_H93_N0.7500.97
29_G33_F0.7490.97
48_F51_L0.7400.96
195_F199_V0.7380.96
71_F197_F0.7340.96
64_M130_F0.7320.96
28_L32_L0.7230.96
61_T135_S0.7210.96
97_G100_Q0.7140.96
134_S142_Y0.7140.96
88_M183_S0.7070.95
20_T23_G0.7040.95
112_G116_L0.7040.95
64_M124_Y0.7040.95
117_E141_F0.7020.95
27_F180_Y0.7010.95
70_V73_A0.7000.95
120_E190_D0.6950.95
67_V197_F0.6930.95
53_N203_M0.6920.95
17_E20_T0.6910.95
50_A54_S0.6890.95
80_S109_L0.6880.95
161_T164_I0.6860.95
42_A46_A0.6840.95
81_S202_L0.6830.95
143_T146_G0.6800.94
103_L163_M0.6790.94
51_L56_A0.6780.94
18_K22_E0.6750.94
23_G175_T0.6540.93
191_V198_T0.6540.93
120_E189_I0.6530.93
30_F181_V0.6520.93
68_T71_F0.6500.93
26_K177_P0.6480.93
37_E201_Y0.6470.93
38_T188_F0.6470.93
80_S106_T0.6400.92
122_K129_G0.6370.92
57_G63_E0.6360.92
114_L118_I0.6350.92
103_L179_F0.6310.92
58_D138_G0.6270.92
117_E149_G0.6250.92
130_F135_S0.6240.91
162_L179_F0.6240.91
166_N169_R0.6210.91
97_G115_G0.6190.91
92_K176_A0.6120.91
73_A120_E0.6120.91
104_G164_I0.6110.91
36_G43_S0.6080.90
80_S190_D0.6080.90
78_L82_L0.6040.90
111_A153_A0.6010.90
88_M179_F0.5990.90
48_F62_T0.5990.90
30_F33_F0.5940.89
77_L201_Y0.5890.89
79_T109_L0.5850.89
55_N58_D0.5840.89
152_V189_I0.5780.88
132_I138_G0.5770.88
117_E138_G0.5760.88
199_V203_M0.5760.88
188_F192_V0.5760.88
54_S194_V0.5750.88
29_G45_F0.5750.88
103_L166_N0.5740.88
45_F195_F0.5700.87
97_G108_L0.5690.87
55_N59_P0.5680.87
55_N60_P0.5670.87
147_T152_V0.5650.87
44_L184_L0.5640.87
35_G38_T0.5610.86
38_T192_V0.5610.86
107_I110_G0.5610.86
84_S87_A0.5590.86
67_V71_F0.5570.86
81_S190_D0.5550.86
166_N171_L0.5530.86
99_M179_F0.5530.86
191_V195_F0.5450.85
155_G188_F0.5450.85
60_P91_M0.5430.85
135_S138_G0.5400.84
17_E28_L0.5390.84
50_A53_N0.5390.84
162_L178_K0.5370.84
135_S139_S0.5360.84
155_G186_W0.5340.84
169_R174_Y0.5310.83
104_G111_A0.5310.83
30_F158_W0.5290.83
45_F137_L0.5270.83
169_R173_L0.5250.83
17_E23_G0.5240.83
155_G187_H0.5240.83
48_F200_V0.5190.82
77_L120_E0.5170.82
21_L25_N0.5160.82
64_M138_G0.5160.82
73_A117_E0.5150.81
94_F97_G0.5150.81
49_L185_Y0.5150.81
178_K181_V0.5150.81
76_L80_S0.5140.81
81_S85_V0.5140.81
109_L112_G0.5140.81
132_I139_S0.5130.81
120_E137_L0.5120.81
22_E81_S0.5120.81
80_S189_I0.5090.81
121_F196_I0.5080.81
67_V70_V0.5060.80
38_T42_A0.5040.80
78_L171_L0.5040.80
119_Y122_K0.5020.80
100_Q104_G0.5020.80
149_G192_V0.5000.80
89_Y92_K0.5000.80
33_F77_L0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftC 1 0.8937 100 0.163 Contact Map
1v54C 1 0.971 100 0.163 Contact Map
1qleC 1 0.9662 100 0.167 Contact Map
1m56C 2 0.9662 100 0.167 Contact Map
2yevA 1 0.9614 100 0.177 Contact Map
4ryoA 1 0.6667 12.6 0.952 Contact Map
2jafA 3 0.8357 8.9 0.955 Contact Map
3qbgA 3 0.8792 7.5 0.956 Contact Map
4fbzA 3 0.8357 7.4 0.956 Contact Map
1xioA 2 0.7778 6.5 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0077 seconds.