GREMLIN Database
COX2 - Cytochrome c oxidase subunit 2
UniProt: P24011 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (311)
Sequences: 1213 (856)
Seq/√Len: 48.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
236_S239_E5.5551.00
237_A241_Q5.2861.00
159_V201_F5.0541.00
209_A234_T4.9771.00
265_L344_L4.7181.00
158_I235_M4.4311.00
163_Q237_A4.4071.00
161_T234_T4.2361.00
133_V157_L3.6981.00
161_T237_A3.4991.00
235_M239_E3.4841.00
134_N145_E3.4001.00
201_F234_T3.3611.00
131_L240_F3.3111.00
138_N143_E3.0491.00
161_T209_A3.0041.00
169_L189_T2.9871.00
263_E267_K2.7461.00
209_A236_S2.7421.00
151_I244_T2.6911.00
165_V201_F2.6441.00
293_L348_L2.4331.00
144_F157_L2.2381.00
87_F91_T2.1991.00
18_L21_C2.1771.00
188_D219_E2.0971.00
177_S219_E2.0281.00
149_Y240_F2.0231.00
184_G199_L2.0201.00
46_S103_L1.9880.99
167_F199_L1.9840.99
34_E202_D1.9700.99
209_A213_F1.9660.99
98_L102_I1.9510.99
337_S340_E1.9510.99
309_N312_N1.9470.99
315_A323_I1.9450.99
258_L343_A1.9070.99
159_V199_L1.8840.99
167_F197_F1.8230.99
214_F229_D1.8210.99
314_K342_N1.8190.99
63_Y67_R1.8080.99
258_L346_E1.7960.99
92_W96_P1.7910.99
336_L341_T1.7830.99
158_I233_K1.7290.98
155_Q247_M1.7110.98
241_Q245_K1.6820.98
169_L187_L1.6630.98
48_L51_V1.6510.98
162_D237_A1.6470.98
135_V167_F1.6260.98
34_E200_T1.6260.98
138_N172_S1.6190.98
137_A189_T1.5980.97
180_I232_V1.5680.97
94_V98_L1.5500.97
247_M250_Y1.5340.97
312_N315_A1.5150.96
143_E152_I1.5100.96
261_Q343_A1.5090.96
135_V177_S1.5060.96
183_V201_F1.4980.96
40_Y44_V1.4950.96
89_E92_W1.4920.96
295_T298_E1.4900.96
31_P36_A1.4740.96
238_K241_Q1.4730.96
313_V316_W1.4710.96
318_K338_D1.4500.95
90_I94_V1.4030.95
323_I327_N1.4010.94
130_A164_R1.4000.94
49_I103_L1.3830.94
266_F293_L1.3740.94
319_D322_S1.3650.94
316_W319_D1.3570.93
29_L182_S1.3570.93
37_D202_D1.3510.93
216_K229_D1.3480.93
261_Q340_E1.3460.93
278_E292_N1.3450.93
127_A130_A1.3160.92
239_E242_G1.3150.92
91_T95_I1.3020.92
133_V159_V1.2870.92
53_V57_V1.2850.91
20_G23_K1.2820.91
85_N89_E1.2740.91
319_D324_K1.2670.91
159_V234_T1.2610.91
109_L113_E1.2600.91
186_K219_E1.2550.90
31_P111_T1.2540.90
166_Y196_K1.2520.90
296_F299_R1.2380.90
149_Y244_T1.2350.90
177_S188_D1.2350.90
260_K263_E1.2340.90
183_V232_V1.2210.89
258_L261_Q1.2080.89
341_T345_Y1.2070.89
134_N170_K1.1890.88
310_K349_K1.1830.88
136_R145_E1.1800.88
44_V48_L1.1710.87
155_Q190_N1.1700.87
134_N168_N1.1700.87
220_L223_P1.1620.87
215_G230_F1.1540.86
94_V97_I1.1450.86
280_N294_A1.1380.86
297_G350_G1.1210.85
311_E315_A1.1180.85
132_V166_Y1.1110.84
117_T198_F1.1110.84
100_L179_W1.1100.84
327_N330_T1.1090.84
316_W320_P1.1080.84
82_V96_P1.1080.84
338_D341_T1.1060.84
259_A350_G1.1010.84
179_W218_A1.0990.83
48_L52_V1.0900.83
68_F89_E1.0670.82
163_Q241_Q1.0670.82
100_L115_A1.0650.82
321_D330_T1.0620.81
316_W348_L1.0610.81
315_A319_D1.0540.81
325_P330_T1.0510.81
187_L197_F1.0460.80
148_D244_T1.0380.80
269_K340_E1.0290.79
321_D327_N1.0220.79
161_T201_F1.0210.79
277_V347_Y1.0090.78
320_P323_I1.0080.78
89_E93_T1.0060.78
212_M233_K1.0050.78
135_V144_F0.9980.77
62_F66_V0.9970.77
276_A290_A0.9960.77
244_T248_K0.9910.77
209_A235_M0.9850.76
324_K327_N0.9810.76
164_R200_T0.9760.75
280_N287_A0.9730.75
293_L299_R0.9730.75
104_V108_V0.9710.75
290_A293_L0.9700.75
168_N194_E0.9640.75
278_E294_A0.9640.75
294_A299_R0.9540.74
34_E234_T0.9500.73
309_N313_V0.9440.73
308_A312_N0.9410.73
177_S218_A0.9370.72
100_L106_P0.9360.72
213_F234_T0.9340.72
45_L49_I0.9300.72
130_A163_Q0.9290.72
35_V39_Q0.9240.71
19_S22_G0.9180.71
257_D261_Q0.9140.71
312_N316_W0.9130.70
90_I93_T0.9050.70
251_K295_T0.9040.70
309_N316_W0.9040.70
201_F209_A0.9000.69
150_G241_Q0.8980.69
332_T335_K0.8980.69
320_P326_G0.8960.69
18_L22_G0.8940.69
38_K113_E0.8880.68
42_L110_Y0.8840.68
311_E314_K0.8800.68
139_L214_F0.8800.68
292_N295_T0.8730.67
261_Q264_E0.8700.67
104_V107_V0.8620.66
52_V56_V0.8590.66
202_D209_A0.8550.65
341_T344_L0.8530.65
81_Q84_G0.8490.65
54_V58_S0.8480.65
249_N253_T0.8400.64
22_G25_F0.8370.64
143_E240_F0.8350.64
46_S220_L0.8340.63
59_V306_K0.8320.63
38_K41_D0.8170.62
79_P84_G0.8160.62
17_L22_G0.8140.62
95_I99_L0.8130.61
239_E256_S0.8080.61
134_N147_P0.8060.61
296_F340_E0.8040.61
255_E264_E0.8010.60
138_N190_N0.7970.60
52_V317_L0.7920.59
238_K246_E0.7900.59
141_W324_K0.7820.58
209_A212_M0.7800.58
133_V254_A0.7770.58
45_L102_I0.7760.58
308_A316_W0.7760.58
293_L324_K0.7760.58
88_L92_W0.7730.58
316_W324_K0.7720.57
92_W95_I0.7700.57
81_Q85_N0.7670.57
256_S260_K0.7640.57
29_L33_G0.7620.56
140_Y220_L0.7600.56
310_K314_K0.7490.55
252_S286_A0.7490.55
269_K336_L0.7480.55
135_V169_L0.7470.55
65_I218_A0.7470.55
208_E255_E0.7440.55
214_F231_K0.7400.54
331_G345_Y0.7400.54
55_A245_K0.7400.54
141_W316_W0.7390.54
188_D218_A0.7370.54
202_D208_E0.7360.54
209_A239_E0.7340.54
34_E38_K0.7300.53
168_N196_K0.7260.53
134_N137_A0.7260.53
41_D45_L0.7240.53
127_A164_R0.7240.53
35_V114_L0.7230.53
311_E345_Y0.7230.53
265_L340_E0.7200.52
170_K190_N0.7190.52
191_T210_G0.7170.52
240_F294_A0.7160.52
60_I91_T0.7150.52
135_V142_W0.7120.51
47_T51_V0.7080.51
279_P290_A0.7060.51
247_M295_T0.7010.50
161_T236_S0.6970.50
245_K248_K0.6950.50
309_N318_K0.6920.49
212_M231_K0.6920.49
130_A200_T0.6900.49
43_T46_S0.6880.49
245_K249_N0.6830.49
88_L96_P0.6810.48
336_L340_E0.6810.48
276_A287_A0.6800.48
252_S255_E0.6800.48
131_L226_A0.6770.48
146_Y153_T0.6760.48
266_F325_P0.6760.48
21_C26_L0.6740.48
187_L196_K0.6730.48
242_G264_E0.6730.48
279_P294_A0.6720.47
133_V149_Y0.6710.47
146_Y240_F0.6710.47
45_L52_V0.6660.47
79_P97_I0.6660.47
57_V322_S0.6640.47
107_V110_Y0.6630.47
157_L161_T0.6600.46
108_V112_L0.6560.46
139_L281_D0.6540.46
76_N79_P0.6530.46
346_E350_G0.6520.45
320_P327_N0.6500.45
136_R172_S0.6490.45
200_T234_T0.6470.45
227_L305_V0.6430.45
84_G103_L0.6430.45
302_V306_K0.6420.44
67_R81_Q0.6420.44
299_R308_A0.6410.44
17_L21_C0.6410.44
94_V159_V0.6410.44
279_P351_L0.6390.44
288_R293_L0.6380.44
83_E89_E0.6380.44
105_I289_T0.6380.44
111_T166_Y0.6370.44
69_R72_R0.6370.44
309_N315_A0.6360.44
85_N92_W0.6340.44
141_W154_S0.6340.44
106_P220_L0.6330.44
279_P287_A0.6320.43
130_A165_V0.6320.43
315_A324_K0.6290.43
157_L167_F0.6290.43
86_K91_T0.6290.43
101_I350_G0.6280.43
310_K316_W0.6250.43
160_P201_F0.6240.43
297_G313_V0.6230.43
96_P104_V0.6220.42
17_L20_G0.6220.42
162_D202_D0.6220.42
84_G88_L0.6210.42
215_G304_G0.6200.42
54_V137_A0.6200.42
175_K191_T0.6190.42
80_K264_E0.6190.42
30_K37_D0.6180.42
175_K192_D0.6170.42
19_S23_K0.6150.42
175_K188_D0.6150.42
292_N325_P0.6130.42
50_M58_S0.6100.41
145_E152_I0.6090.41
99_L102_I0.6080.41
59_V72_R0.6070.41
310_K346_E0.6070.41
102_I128_E0.6060.41
97_I213_F0.6050.41
215_G324_K0.6040.41
46_S50_M0.6040.41
258_L339_S0.6030.41
117_T127_A0.6030.41
31_P54_V0.6030.41
39_Q184_G0.6020.40
302_V313_V0.6020.40
187_L195_N0.5990.40
276_A294_A0.5950.40
293_L297_G0.5950.40
252_S256_S0.5930.40
140_Y301_K0.5920.39
98_L178_F0.5920.39
148_D315_A0.5920.39
145_E240_F0.5900.39
340_E343_A0.5890.39
140_Y216_K0.5880.39
68_F71_S0.5870.39
48_L246_E0.5870.39
17_L25_F0.5850.39
33_G108_V0.5850.39
151_I240_F0.5820.39
79_P247_M0.5820.39
29_L36_A0.5810.38
21_C24_P0.5800.38
177_S326_G0.5800.38
171_A265_L0.5790.38
266_F347_Y0.5790.38
313_V319_D0.5770.38
169_L197_F0.5760.38
31_P232_V0.5760.38
66_V80_K0.5720.38
299_R348_L0.5720.38
115_A132_V0.5720.38
20_G25_F0.5720.38
276_A280_N0.5720.38
20_G218_A0.5710.37
265_L300_T0.5710.37
146_Y158_I0.5690.37
111_T115_A0.5680.37
135_V185_G0.5680.37
208_E213_F0.5680.37
310_K315_A0.5670.37
58_S62_F0.5670.37
165_V235_M0.5660.37
202_D234_T0.5660.37
251_K278_E0.5660.37
253_T258_L0.5650.37
138_N141_W0.5640.37
139_L173_D0.5620.37
312_N327_N0.5620.37
28_T180_I0.5620.37
166_Y198_F0.5610.37
256_S259_A0.5600.36
254_A259_A0.5600.36
32_A213_F0.5600.36
144_F230_F0.5590.36
323_I326_G0.5570.36
144_F178_F0.5570.36
293_L349_K0.5560.36
180_I183_V0.5560.36
260_K264_E0.5550.36
287_A290_A0.5550.36
310_K313_V0.5540.36
54_V182_S0.5530.36
183_V216_K0.5520.36
218_A340_E0.5520.36
83_E102_I0.5520.36
38_K110_Y0.5510.36
322_S330_T0.5450.35
53_V93_T0.5450.35
323_I330_T0.5440.35
159_V200_T0.5440.35
242_G246_E0.5430.35
158_I189_T0.5410.35
279_P292_N0.5400.35
96_P247_M0.5400.35
156_E233_K0.5390.35
287_A294_A0.5380.34
96_P170_K0.5360.34
337_S344_L0.5350.34
335_K340_E0.5350.34
165_V342_N0.5350.34
183_V340_E0.5340.34
115_A138_N0.5330.34
297_G310_K0.5320.34
52_V161_T0.5310.34
265_L341_T0.5300.34
143_E172_S0.5290.34
84_G93_T0.5280.34
281_D288_R0.5270.33
183_V209_A0.5270.33
220_L296_F0.5270.33
318_K322_S0.5270.33
171_A190_N0.5260.33
161_T202_D0.5240.33
189_T230_F0.5230.33
128_E260_K0.5230.33
56_V102_I0.5220.33
22_G40_Y0.5220.33
132_V317_L0.5220.33
263_E277_V0.5200.33
308_A313_V0.5200.33
297_G345_Y0.5190.33
317_L321_D0.5190.33
55_A266_F0.5190.33
138_N145_E0.5180.33
115_A187_L0.5180.33
24_P183_V0.5160.32
34_E201_F0.5160.32
98_L317_L0.5150.32
235_M238_K0.5150.32
189_T273_S0.5150.32
141_W146_Y0.5140.32
152_I281_D0.5140.32
141_W230_F0.5140.32
67_R72_R0.5120.32
101_I267_K0.5120.32
93_T97_I0.5110.32
234_T237_A0.5110.32
56_V60_I0.5100.32
294_A298_E0.5090.32
277_V318_K0.5080.32
92_W106_P0.5080.32
20_G169_L0.5080.32
51_V55_A0.5080.32
252_S341_T0.5080.32
253_T256_S0.5070.32
82_V92_W0.5070.32
292_N299_R0.5060.32
307_E312_N0.5060.32
72_R311_E0.5060.32
18_L24_P0.5050.31
18_L133_V0.5050.31
141_W266_F0.5050.31
17_L128_E0.5050.31
224_S227_L0.5040.31
39_Q331_G0.5040.31
133_V167_F0.5020.31
161_T183_V0.5010.31
233_K246_E0.5010.31
37_D41_D0.5010.31
60_I79_P0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yevB 1 0.8708 100 0.354 Contact Map
1fftB 1 0.6713 100 0.461 Contact Map
3hb3B 1 0.6096 100 0.497 Contact Map
2gsmB 1 0.6124 100 0.524 Contact Map
1v54B 1 0.5787 100 0.556 Contact Map
4txvB 1 0.3567 100 0.652 Contact Map
1cyxA 1 0.382 100 0.665 Contact Map
3s8fB 1 0.4073 100 0.713 Contact Map
2cuaA 1 0.3371 100 0.785 Contact Map
3ziyA 3 0.6854 100 0.793 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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