GREMLIN Database
COXX2 - Protoheme IX farnesyltransferase 2
UniProt: P24009 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (273)
Sequences: 8948 (6348)
Seq/√Len: 384.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_W107_P4.2511.00
86_R107_P3.9601.00
24_D104_K3.6561.00
83_W111_L3.2461.00
21_A109_Q3.2101.00
106_Q109_Q3.1911.00
76_G118_V3.1561.00
27_S104_K2.9411.00
93_E96_K2.6951.00
226_E230_R2.6741.00
125_L128_T2.5421.00
108_S112_W2.4841.00
266_I270_M2.3911.00
129_T132_A2.2521.00
73_I121_G2.2491.00
45_M63_V2.2241.00
25_F109_Q2.2001.00
182_G185_A2.1951.00
130_V134_V2.1281.00
88_I216_I2.1111.00
34_V71_S2.1041.00
277_I280_W2.0741.00
208_T212_R2.0021.00
79_A117_L1.9761.00
132_A175_T1.9711.00
209_E212_R1.9681.00
90_H101_V1.9551.00
100_T110_A1.9491.00
65_L127_M1.9331.00
112_W116_L1.8701.00
278_M281_A1.8241.00
23_K27_S1.7991.00
42_F67_L1.7971.00
256_L260_L1.7611.00
84_Y149_M1.7311.00
86_R90_H1.7311.00
282_T286_V1.7231.00
59_N62_T1.7031.00
263_G267_L1.6921.00
86_R100_T1.6901.00
230_R234_V1.6571.00
227_V230_R1.6471.00
65_L124_M1.6361.00
280_W284_M1.5781.00
223_Y227_V1.5751.00
126_L133_A1.5691.00
115_I119_A1.5661.00
282_T285_F1.5611.00
259_L263_G1.5281.00
111_L115_I1.5181.00
25_F113_S1.5171.00
134_V138_I1.5141.00
212_R221_V1.4951.00
200_F203_L1.4851.00
200_F204_A1.4851.00
79_A114_G1.4721.00
285_F289_L1.4621.00
28_L79_A1.4621.00
29_I117_L1.4591.00
83_W110_A1.4571.00
199_H203_L1.4481.00
29_I79_A1.4421.00
72_L120_L1.4131.00
142_T165_S1.4121.00
225_F229_K1.4011.00
105_I110_A1.3971.00
174_W178_E1.3931.00
72_L121_G1.3651.00
73_I136_G1.3541.00
118_V140_V1.3441.00
141_F145_V1.3431.00
26_L31_I1.3401.00
111_L114_G1.3271.00
270_M273_R1.3241.00
256_L298_A1.3221.00
288_S292_M1.3201.00
208_T225_F1.3121.00
28_L105_I1.3111.00
186_W190_M1.3101.00
79_A113_S1.3001.00
80_I114_G1.2951.00
262_I266_I1.2941.00
255_I259_L1.2851.00
170_P173_G1.2831.00
29_I113_S1.2821.00
151_T161_V1.2721.00
29_I75_A1.2561.00
263_G266_I1.2551.00
146_L161_V1.2491.00
113_S117_L1.2311.00
251_L255_I1.2291.00
182_G186_W1.2271.00
41_T70_S1.2251.00
151_T154_R1.2241.00
283_Q286_V1.2211.00
26_L29_I1.2201.00
237_A241_P1.2191.00
267_L271_G1.2151.00
123_I127_M1.2061.00
265_L268_G1.2041.00
131_M135_I1.2011.00
289_L293_T1.1981.00
181_I185_A1.1971.00
122_L125_L1.1871.00
227_V231_Q1.1761.00
75_A117_L1.1541.00
36_S199_H1.1531.00
252_P256_L1.1441.00
230_R233_I1.1411.00
69_G124_M1.1321.00
162_G166_G1.1311.00
191_I242_L1.1231.00
268_G272_F1.1201.00
47_L174_W1.1201.00
220_P228_T1.1191.00
194_I235_W1.1191.00
83_W100_T1.1171.00
110_A114_G1.1141.00
64_L68_I1.1121.00
53_G58_G1.1061.00
243_P246_L1.1051.00
139_G168_V1.1031.00
260_L263_G1.1021.00
279_K283_Q1.0961.00
83_W114_G1.0951.00
110_A117_L1.0921.00
162_G167_A1.0811.00
290_N294_I1.0771.00
277_I281_A1.0771.00
79_A105_I1.0741.00
201_L204_A1.0661.00
121_G125_L1.0651.00
48_A174_W1.0631.00
85_D153_R1.0491.00
101_V110_A1.0481.00
120_L124_M1.0461.00
219_L223_Y1.0451.00
204_A207_K1.0451.00
131_M175_T1.0381.00
22_W26_L1.0361.00
61_N65_L1.0311.00
272_F275_K1.0301.00
264_W267_L1.0301.00
167_A193_F1.0261.00
217_P222_V1.0231.00
152_K155_Y1.0181.00
72_L117_L1.0141.00
224_G228_T1.0141.00
203_L207_K1.0131.00
286_V290_N1.0011.00
60_I64_L0.9941.00
190_M194_I0.9911.00
219_L222_V0.9831.00
54_L58_G0.9751.00
205_I227_V0.9721.00
254_V258_L0.9661.00
287_Y291_Y0.9621.00
88_I153_R0.9621.00
61_N64_L0.9571.00
269_L272_F0.9511.00
142_T164_V0.9471.00
207_K211_Y0.9371.00
208_T221_V0.9371.00
158_N218_M0.9331.00
41_T66_T0.9331.00
119_A123_I0.9331.00
77_S144_V0.9321.00
164_V189_F0.9291.00
248_S251_L0.9281.00
97_V104_K0.9261.00
157_I160_V0.9171.00
137_F141_F0.9161.00
266_I269_L0.9151.00
250_G253_I0.9121.00
233_I237_A0.9101.00
87_D91_L0.9091.00
286_V289_L0.9061.00
131_M134_V0.9021.00
107_P111_L0.8981.00
289_L296_F0.8981.00
132_A172_I0.8911.00
235_W239_L0.8881.00
181_I186_W0.8881.00
270_M274_S0.8841.00
110_A113_S0.8781.00
278_M285_F0.8731.00
290_N293_T0.8691.00
280_W287_Y0.8661.00
204_A220_P0.8631.00
262_I265_L0.8621.00
125_L136_G0.8591.00
203_L206_K0.8581.00
105_I113_S0.8581.00
99_P103_G0.8531.00
91_L214_A0.8501.00
44_G48_A0.8491.00
168_V172_I0.8471.00
285_F288_S0.8471.00
114_G118_V0.8441.00
256_L259_L0.8381.00
100_T105_I0.8381.00
38_L42_F0.8321.00
270_M275_K0.8311.00
236_V239_L0.8301.00
283_Q287_Y0.8291.00
138_I141_F0.8261.00
21_A24_D0.8211.00
75_A113_S0.8191.00
125_L133_A0.8171.00
151_T155_Y0.8141.00
280_W283_Q0.8141.00
167_A196_Q0.8091.00
192_L196_Q0.8051.00
92_M210_D0.8011.00
249_L299_M0.7981.00
87_D90_H0.7941.00
226_E229_K0.7911.00
73_I140_V0.7881.00
234_V238_C0.7881.00
265_L269_L0.7871.00
74_I78_C0.7801.00
21_A25_F0.7801.00
286_V292_M0.7771.00
289_L292_M0.7761.00
68_I72_L0.7711.00
205_I225_F0.7621.00
108_S111_L0.7611.00
199_H204_A0.7601.00
294_I298_A0.7571.00
167_A173_G0.7561.00
118_V121_G0.7521.00
240_M261_N0.7521.00
292_M295_Y0.7501.00
209_E213_A0.7481.00
100_T103_G0.7471.00
126_L130_V0.7461.00
124_M127_M0.7461.00
240_M243_P0.7441.00
293_T296_F0.7421.00
105_I109_Q0.7421.00
229_K233_I0.7421.00
69_G125_L0.7411.00
282_T289_L0.7401.00
278_M282_T0.7391.00
85_D88_I0.7381.00
180_N184_V0.7361.00
191_I195_W0.7321.00
264_W268_G0.7301.00
255_I258_L0.7271.00
199_H202_A0.7241.00
281_A285_F0.7221.00
46_W300_V0.7181.00
145_V149_M0.7161.00
239_L243_P0.7151.00
247_G254_V0.7131.00
183_V187_V0.7101.00
253_I257_G0.7091.00
216_I222_V0.7021.00
183_V186_W0.7011.00
148_T152_K0.7011.00
45_M177_V0.7011.00
268_G271_G0.6980.99
123_I126_L0.6970.99
62_T128_T0.6940.99
161_V166_G0.6930.99
250_G254_V0.6920.99
156_T159_T0.6890.99
185_A189_F0.6870.99
36_S40_T0.6860.99
151_T158_N0.6850.99
166_G170_P0.6820.99
38_L67_L0.6820.99
287_Y290_N0.6820.99
155_Y161_V0.6800.99
229_K232_I0.6790.99
254_V257_G0.6780.99
66_T176_A0.6770.99
238_C242_L0.6740.99
246_L253_I0.6740.99
159_T197_I0.6710.99
25_F105_I0.6690.99
206_K282_T0.6680.99
211_Y218_M0.6670.99
49_L53_G0.6660.99
249_L252_P0.6620.99
76_G79_A0.6580.99
156_T222_V0.6560.99
129_T135_I0.6530.99
167_A170_P0.6530.99
28_L110_A0.6520.99
65_L128_T0.6510.99
173_G177_V0.6500.99
75_A79_A0.6500.99
267_L287_Y0.6480.99
216_I219_L0.6480.99
242_L246_L0.6430.99
49_L177_V0.6420.99
59_N177_V0.6410.99
232_I236_V0.6400.99
79_A110_A0.6380.99
249_L253_I0.6350.99
288_S293_T0.6330.99
253_I260_L0.6330.99
88_I91_L0.6330.99
122_L126_L0.6330.99
219_L225_F0.6320.99
146_L151_T0.6320.99
109_Q112_W0.6290.99
92_M95_T0.6290.99
39_I46_W0.6280.99
271_G274_S0.6280.99
27_S99_P0.6210.99
265_L272_F0.6200.99
99_P104_K0.6190.99
114_G117_L0.6190.99
198_P235_W0.6170.99
83_W86_R0.6170.99
116_L123_I0.6120.99
258_L262_I0.6100.99
284_M288_S0.6050.99
45_M66_T0.6030.99
159_T200_F0.6010.98
263_G270_M0.6000.98
282_T288_S0.5990.98
135_I175_T0.5990.98
287_Y292_M0.5990.98
48_A177_V0.5970.98
158_N162_G0.5960.98
231_Q235_W0.5960.98
188_L192_L0.5950.98
231_Q234_V0.5940.98
283_Q288_S0.5920.98
249_L256_L0.5920.98
133_A137_F0.5910.98
248_S252_P0.5900.98
242_L245_F0.5870.98
235_W238_C0.5860.98
117_L121_G0.5860.98
49_L58_G0.5840.98
154_R158_N0.5800.98
122_L137_F0.5750.98
171_L189_F0.5750.98
251_L258_L0.5740.98
248_S254_V0.5690.98
122_L133_A0.5690.98
220_P223_Y0.5670.98
213_A216_I0.5660.98
267_L270_M0.5640.98
163_S167_A0.5610.98
166_G169_P0.5580.98
45_M58_G0.5580.98
46_W49_L0.5570.98
120_L123_I0.5560.98
128_T132_A0.5550.97
260_L295_Y0.5550.97
163_S166_G0.5530.97
136_G172_I0.5510.97
288_S291_Y0.5510.97
285_F298_A0.5500.97
281_A286_V0.5500.97
296_F299_M0.5490.97
148_T153_R0.5470.97
252_P255_I0.5470.97
281_A288_S0.5470.97
139_G165_S0.5460.97
76_G140_V0.5450.97
58_G63_V0.5440.97
101_V104_K0.5420.97
41_T169_P0.5400.97
194_I237_A0.5380.97
292_M296_F0.5380.97
243_P261_N0.5370.97
269_L275_K0.5360.97
80_I145_V0.5340.97
82_N85_D0.5340.97
295_Y298_A0.5340.97
80_I84_Y0.5340.97
282_T287_Y0.5330.97
157_I223_Y0.5320.97
43_T192_L0.5320.97
205_I228_T0.5310.97
127_M130_V0.5300.97
85_D216_I0.5290.97
88_I214_A0.5270.97
241_P245_F0.5260.97
142_T161_V0.5260.97
265_L291_Y0.5250.97
225_F228_T0.5240.96
196_Q200_F0.5220.96
132_A135_I0.5200.96
87_D107_P0.5190.96
118_V122_L0.5180.96
218_M222_V0.5170.96
296_F300_V0.5170.96
233_I269_L0.5160.96
76_G145_V0.5160.96
293_T297_V0.5160.96
124_M128_T0.5160.96
257_G261_N0.5140.96
76_G80_I0.5110.96
174_W177_V0.5100.96
193_F197_I0.5100.96
257_G260_L0.5090.96
284_M287_Y0.5060.96
73_I144_V0.5030.96
251_L256_L0.5020.96
77_S140_V0.5020.96
61_N127_M0.5020.96
167_A192_L0.5020.96
43_T47_L0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.8656 100 0.275 Contact Map
4tq3A 1 0.8951 100 0.353 Contact Map
2xq2A 2 0.7639 9.9 0.956 Contact Map
3ixzA 1 0.6918 9.3 0.957 Contact Map
2h88C 2 0.3869 6.9 0.959 Contact Map
1zoyC 1 0.3869 6.6 0.96 Contact Map
2cfqA 1 0.6656 5.7 0.961 Contact Map
4xnjA 1 0.6328 5.6 0.961 Contact Map
3tx3A 2 0.4557 4.7 0.962 Contact Map
2zxeA 1 0.6918 4.4 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0097 seconds.