GREMLIN Database
MENH - Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
UniProt: P23974 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (255)
Sequences: 62063 (51720)
Seq/√Len: 3238.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_D51_R4.7731.00
94_K118_A4.2761.00
58_L80_D3.5211.00
43_L264_G3.0081.00
82_A108_F2.9031.00
259_Q262_L2.8181.00
224_E249_P2.7311.00
94_K117_S2.7061.00
246_E266_I2.6531.00
123_S226_D2.5651.00
92_K117_S2.5461.00
219_L270_F2.4501.00
122_E263_F2.4131.00
248_V266_I2.3031.00
13_R64_D2.2461.00
17_A37_K2.1731.00
82_A86_D2.1561.00
82_A115_R2.1081.00
108_F112_Y2.0941.00
82_A112_Y2.0811.00
85_F93_V2.0561.00
224_E247_I2.0341.00
95_L105_A2.0131.00
15_A62_E1.9441.00
86_D115_R1.9251.00
102_G124_T1.9151.00
16_V84_I1.8611.00
107_S111_T1.8581.00
49_D268_S1.8541.00
46_M264_G1.8371.00
251_A259_Q1.8311.00
94_K271_L1.8111.00
26_A53_I1.8091.00
237_H243_S1.8031.00
18_D53_I1.7941.00
79_S111_T1.7931.00
26_A90_L1.7851.00
19_E54_K1.7451.00
109_A119_L1.7191.00
231_A247_I1.7151.00
26_A51_R1.6731.00
219_L246_E1.6561.00
15_A37_K1.6551.00
266_I269_E1.6401.00
94_K120_V1.6211.00
50_S94_K1.6091.00
31_H57_C1.5931.00
75_T111_T1.5811.00
25_E94_K1.5811.00
31_H60_H1.5701.00
25_E117_S1.5651.00
57_C104_L1.5641.00
35_G39_S1.5631.00
218_V240_L1.5461.00
235_E239_M1.5441.00
105_A119_L1.5221.00
78_V107_S1.5041.00
30_L81_L1.5031.00
55_I81_L1.4971.00
30_L57_C1.4831.00
112_Y115_R1.4711.00
108_F116_V1.4701.00
15_A56_D1.4431.00
73_S76_R1.4211.00
265_K269_E1.4041.00
81_L108_F1.3881.00
196_L199_M1.3761.00
37_K56_D1.3661.00
46_M268_S1.3361.00
30_L105_A1.3261.00
120_V267_V1.3241.00
107_S110_M1.3081.00
34_T60_H1.3031.00
222_C233_N1.3021.00
53_I84_I1.3001.00
86_D112_Y1.2841.00
48_P268_S1.2821.00
108_F115_R1.2821.00
262_L266_I1.2751.00
106_Y121_L1.2731.00
19_E44_D1.2721.00
210_R213_E1.2711.00
98_Y256_H1.2621.00
20_G51_R1.2601.00
96_I122_E1.2561.00
12_V58_L1.2301.00
29_C96_I1.2271.00
14_Y80_D1.2261.00
29_C52_L1.2211.00
99_S253_H1.2201.00
173_A176_I1.2181.00
121_L124_T1.2181.00
37_K62_E1.2081.00
262_L265_K1.2031.00
44_D54_K1.2011.00
27_V50_S1.1811.00
231_A234_Q1.1761.00
237_H245_I1.1691.00
84_I88_L1.1541.00
120_V219_L1.1511.00
192_L195_S1.1451.00
90_L93_V1.1271.00
110_M210_R1.1241.00
28_V85_F1.1181.00
32_G99_S1.1121.00
234_Q238_K1.1061.00
195_S198_G1.1001.00
222_C247_I1.0871.00
93_V116_V1.0871.00
221_I248_V1.0771.00
46_M261_R1.0721.00
212_E239_M1.0691.00
240_L243_S1.0691.00
219_L244_R1.0691.00
30_L95_L1.0641.00
222_C245_I1.0511.00
224_E250_K1.0441.00
263_F267_V1.0421.00
248_V251_A1.0421.00
21_P51_R1.0391.00
188_N191_G1.0311.00
34_T99_S1.0261.00
222_C231_A1.0241.00
37_K54_K1.0161.00
96_I267_V1.0151.00
75_T107_S1.0141.00
244_R266_I1.0091.00
16_V88_L1.0031.00
235_E238_K1.0011.00
55_I84_I0.9991.00
246_E269_E0.9891.00
78_V104_L0.9821.00
118_A217_P0.9761.00
261_R265_K0.9741.00
252_G258_E0.9731.00
85_F108_F0.9711.00
98_Y254_T0.9661.00
56_D61_G0.9651.00
21_P24_S0.9651.00
82_A111_T0.9601.00
178_Y181_R0.9561.00
39_S256_H0.9561.00
248_V262_L0.9551.00
97_G105_A0.9541.00
42_F45_E0.9501.00
50_S271_L0.9491.00
152_G155_A0.9441.00
191_G194_N0.9441.00
82_A85_F0.9421.00
179_R183_G0.9361.00
178_Y182_S0.9301.00
28_V93_V0.9281.00
93_V115_R0.9281.00
251_A255_V0.9281.00
122_E256_H0.9271.00
12_V64_D0.9241.00
234_Q245_I0.9121.00
14_Y63_T0.9111.00
194_N197_T0.8991.00
234_Q237_H0.8991.00
195_S199_M0.8941.00
144_L148_I0.8921.00
83_E87_Q0.8921.00
85_F90_L0.8901.00
71_R76_R0.8861.00
53_I88_L0.8831.00
234_Q247_I0.8821.00
190_I193_A0.8801.00
142_R146_D0.8791.00
221_I266_I0.8701.00
122_E255_V0.8691.00
76_R79_S0.8691.00
26_A50_S0.8651.00
83_E86_D0.8611.00
25_E92_K0.8601.00
27_V96_I0.8601.00
41_T54_K0.8531.00
190_I194_N0.8491.00
179_R182_S0.8481.00
97_G102_G0.8461.00
24_S51_R0.8451.00
174_E178_Y0.8451.00
25_E50_S0.8421.00
18_D21_P0.8361.00
246_E262_L0.8351.00
57_C100_M0.8331.00
44_D52_L0.8321.00
27_V52_L0.8301.00
193_A197_T0.8291.00
215_D241_P0.8271.00
30_L55_I0.8271.00
119_L218_V0.8231.00
79_S82_A0.8191.00
107_S210_R0.8191.00
109_A116_V0.8141.00
78_V111_T0.8131.00
251_A258_E0.8121.00
194_N198_G0.8061.00
192_L196_L0.8001.00
180_I183_G0.7961.00
223_G255_V0.7901.00
220_L243_S0.7881.00
28_V81_L0.7871.00
233_N245_I0.7851.00
136_E139_M0.7811.00
29_C40_W0.7801.00
264_G268_S0.7761.00
191_G195_S0.7711.00
43_L46_M0.7701.00
164_P167_S0.7681.00
26_A93_V0.7661.00
181_R185_L0.7601.00
145_A149_L0.7591.00
189_K192_L0.7581.00
95_L108_F0.7581.00
146_D149_L0.7491.00
183_G186_R0.7481.00
79_S83_E0.7471.00
77_Q100_M0.7461.00
248_V259_Q0.7461.00
144_L149_L0.7451.00
89_K92_K0.7441.00
177_R181_R0.7411.00
78_V108_F0.7401.00
173_A177_R0.7391.00
95_L116_V0.7341.00
57_C77_Q0.7341.00
37_K55_I0.7331.00
33_F100_M0.7291.00
250_K259_Q0.7281.00
174_E177_R0.7241.00
17_A41_T0.7201.00
75_T79_S0.7171.00
146_D150_R0.7171.00
98_Y123_S0.7161.00
56_D62_E0.7101.00
224_E231_A0.7081.00
38_Q41_T0.7071.00
31_H55_I0.7071.00
123_S255_V0.7051.00
50_S268_S0.7041.00
25_E118_A0.6971.00
109_A216_V0.6931.00
27_V94_K0.6911.00
15_A63_T0.6911.00
123_S223_G0.6891.00
27_V271_L0.6891.00
40_W44_D0.6841.00
156_F160_W0.6841.00
118_A270_F0.6831.00
209_S212_E0.6811.00
118_A271_L0.6801.00
53_I90_L0.6791.00
34_T100_M0.6781.00
98_Y122_E0.6731.00
43_L47_L0.6721.00
41_T45_E0.6711.00
120_V271_L0.6701.00
153_L156_F0.6671.00
265_K268_S0.6651.00
106_Y126_P0.6651.00
51_R90_L0.6641.00
148_I152_G0.6591.00
58_L77_Q0.6581.00
260_P264_G0.6571.00
187_N190_I0.6531.00
188_N192_L0.6511.00
93_V117_S0.6491.00
14_Y58_L0.6481.00
93_V108_F0.6471.00
123_S222_C0.6441.00
110_M213_E0.6411.00
182_S185_L0.6401.00
57_C60_H0.6401.00
189_K196_L0.6401.00
116_V216_V0.6391.00
199_M202_G0.6391.00
172_L176_I0.6381.00
40_W43_L0.6381.00
226_D253_H0.6371.00
207_L210_R0.6361.00
189_K193_A0.6341.00
91_H115_R0.6321.00
176_I179_R0.6301.00
102_G121_L0.6281.00
221_I263_F0.6281.00
175_D179_R0.6261.00
180_I184_R0.6241.00
145_A148_I0.6231.00
160_W163_I0.6221.00
225_W250_K0.6211.00
96_I120_V0.6191.00
120_V270_F0.6191.00
135_R139_M0.6181.00
157_V160_W0.6081.00
157_V161_E0.6081.00
143_K147_F0.6071.00
103_R125_T0.6031.00
97_G101_G0.6001.00
134_R137_R0.6001.00
120_V221_I0.5991.00
138_I141_D0.5981.00
18_D88_L0.5981.00
182_S186_R0.5951.00
159_Y162_N0.5941.00
161_E164_P0.5941.00
43_L263_F0.5941.00
154_E158_A0.5931.00
28_V95_L0.5931.00
19_E45_E0.5901.00
244_R269_E0.5841.00
220_L233_N0.5831.00
158_A162_N0.5821.00
159_Y163_I0.5801.00
233_N237_H0.5801.00
29_C54_K0.5791.00
187_N192_L0.5781.00
221_I246_E0.5781.00
106_Y124_T0.5731.00
143_K146_D0.5721.00
133_E137_R0.5711.00
175_D178_Y0.5681.00
149_L152_G0.5681.00
74_T107_S0.5651.00
121_L220_L0.5651.00
57_C81_L0.5651.00
172_L180_I0.5611.00
118_A219_L0.5601.00
193_A196_L0.5591.00
220_L245_I0.5581.00
152_G156_F0.5581.00
130_T133_E0.5571.00
28_V55_I0.5571.00
255_V263_F0.5551.00
76_R80_D0.5551.00
79_S112_Y0.5531.00
192_L199_M0.5521.00
27_V47_L0.5521.00
166_F169_Q0.5511.00
189_K194_N0.5471.00
78_V82_A0.5451.00
17_A54_K0.5441.00
267_V271_L0.5401.00
134_R138_I0.5381.00
137_R141_D0.5381.00
17_A38_Q0.5371.00
142_R145_A0.5371.00
164_P168_S0.5361.00
33_F99_S0.5361.00
77_Q104_L0.5351.00
176_I184_R0.5331.00
147_F150_R0.5321.00
99_S254_T0.5321.00
85_F115_R0.5311.00
158_A161_E0.5311.00
165_L169_Q0.5291.00
35_G254_T0.5261.00
29_C47_L0.5251.00
144_L147_F0.5241.00
39_S98_Y0.5231.00
92_K115_R0.5171.00
177_R180_I0.5161.00
84_I87_Q0.5151.00
162_N166_F0.5151.00
30_L104_L0.5141.00
161_E166_F0.5141.00
122_E221_I0.5131.00
220_L237_H0.5121.00
206_S210_R0.5091.00
264_G269_E0.5071.00
208_W239_M0.5051.00
193_A198_G0.5051.00
32_G98_Y0.5041.00
160_W166_F0.5041.00
23_A51_R0.5041.00
151_D154_E0.5031.00
103_R106_Y0.5031.00
256_H263_F0.5031.00
38_Q62_E0.5021.00
232_I235_E0.5021.00
225_W249_P0.5021.00
209_S213_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xmzA 1 0.9599 100 0.163 Contact Map
1ehyA 1 0.9453 100 0.166 Contact Map
4inzA 1 0.9745 100 0.169 Contact Map
3om8A 4 0.9489 100 0.175 Contact Map
3oosA 1 0.9672 100 0.18 Contact Map
4psuA 1 0.9635 100 0.191 Contact Map
2xuaA 2 0.9343 100 0.196 Contact Map
2pujA 4 0.9745 100 0.202 Contact Map
3bwxA 1 0.9708 100 0.202 Contact Map
4ns4A 1 0.9234 100 0.207 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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