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MENF - Isochorismate synthase MenF

UniProt:	P23973	Sequences: MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFFNYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFHIYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTVNRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQIKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPERLIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSSCSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVDVIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPISEYEETQIKLKPMISALGGERR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	471 (429)
Sequences:	5797 (4007)
Seq/√Len:	193.4

ECOLI - TRPE PABB MENF ENTC
BACSU - MENF TRPE PABB DHBC
HALSA - TRPE1 TRPE2 Q9HQN2
SULSO - TRPE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
335_C	361_G	4.817	1.00
382_L	406_A	4.536	1.00
97_K	368_S	4.225	1.00
205_K	209_L	3.758	1.00
294_I	309_E	3.522	1.00
284_T	360_V	3.228	1.00
293_S	352_V	3.215	1.00
234_L	433_T	3.114	1.00
447_E	450_S	3.091	1.00
341_P	360_V	3.057	1.00
218_Q	396_E	2.867	1.00
209_L	449_I	2.859	1.00
218_Q	223_Q	2.797	1.00
342_D	345_V	2.749	1.00
204_D	207_D	2.731	1.00
208_W	440_C	2.728	1.00
205_K	449_I	2.686	1.00
389_K	392_D	2.633	1.00
410_G	420_F	2.531	1.00
91_E	374_E	2.499	1.00
367_A	371_D	2.478	1.00
304_R	308_L	2.477	1.00
339_E	360_V	2.465	1.00
217_S	221_E	2.445	1.00
296_R	303_D	2.429	1.00
307_G	348_K	2.406	1.00
308_L	312_N	2.379	1.00
234_L	435_R	2.337	1.00
203_L	211_A	2.331	1.00
124_F	391_V	2.322	1.00
364_R	367_A	2.299	1.00
236_T	433_T	2.292	1.00
269_F	404_W	2.262	1.00
243_I	268_T	2.249	1.00
91_E	94_E	2.197	1.00
224_Y	227_V	2.169	1.00
210_K	213_E	2.168	1.00
215_A	227_V	2.149	1.00
313_D	316_N	2.132	1.00
283_G	362_Q	2.125	1.00
297_G	302_D	2.102	1.00
260_F	271_G	2.099	1.00
379_T	422_V	2.081	1.00
348_K	353_Q	2.034	1.00
260_F	409_I	2.033	1.00
346_L	355_L	2.011	1.00
284_T	362_Q	2.003	1.00
311_L	355_L	1.968	1.00
304_R	307_G	1.931	1.00
429_I	434_A	1.924	1.00
64_E	152_T	1.922	1.00
331_F	335_C	1.896	1.00
300_E	304_R	1.857	1.00
213_E	216_T	1.846	1.00
242_Q	245_P	1.833	1.00
393_V	397_I	1.828	1.00
118_L	144_V	1.789	1.00
307_G	346_L	1.788	1.00
287_S	327_I	1.786	1.00
276_R	419_E	1.782	1.00
270_V	429_I	1.782	1.00
213_E	448_P	1.770	1.00
202_E	400_M	1.770	1.00
302_D	305_R	1.765	1.00
226_K	441_G	1.764	1.00
334_S	375_K	1.755	1.00
217_S	220_K	1.754	1.00
449_I	453_E	1.731	1.00
290_L	356_F	1.728	1.00
67_I	150_T	1.710	1.00
298_V	302_D	1.706	1.00
263_E	268_T	1.700	1.00
205_K	452_Y	1.683	1.00
215_A	229_L	1.647	1.00
297_G	306_I	1.605	1.00
299_N	302_D	1.600	1.00
427_G	434_A	1.597	1.00
231_R	455_T	1.580	1.00
288_S	347_Y	1.578	1.00
347_Y	356_F	1.575	1.00
404_W	423_A	1.572	1.00
122_F	126_P	1.555	1.00
453_E	457_I	1.551	1.00
212_I	448_P	1.549	1.00
199_A	235_L	1.547	1.00
125_D	395_R	1.545	1.00
305_R	309_E	1.543	1.00
306_I	309_E	1.539	1.00
281_D	417_N	1.538	1.00
229_L	440_C	1.530	1.00
43_F	151_M	1.519	1.00
237_F	429_I	1.491	1.00
232_E	435_R	1.482	1.00
332_V	336_S	1.465	1.00
218_Q	393_V	1.453	1.00
230_A	437_F	1.445	1.00
373_I	412_I	1.435	1.00
209_L	213_E	1.419	1.00
133_Q	136_H	1.416	1.00
218_Q	389_K	1.399	1.00
170_A	173_V	1.390	1.00
285_V	335_C	1.383	1.00
331_F	361_G	1.371	1.00
450_S	453_E	1.357	1.00
94_E	97_K	1.354	1.00
177_L	181_A	1.354	1.00
413_D	417_N	1.348	1.00
229_L	442_I	1.346	1.00
261_A	268_T	1.341	1.00
212_I	442_I	1.334	1.00
246_V	427_G	1.334	1.00
207_D	399_P	1.332	1.00
142_F	420_F	1.328	1.00
173_V	177_L	1.327	1.00
214_T	217_S	1.323	1.00
227_V	394_I	1.321	1.00
438_A	459_L	1.318	1.00
213_E	217_S	1.316	1.00
214_T	396_E	1.314	1.00
271_G	421_A	1.310	1.00
243_I	429_I	1.309	1.00
205_K	453_E	1.306	1.00
125_D	401_S	1.306	1.00
286_M	360_V	1.305	1.00
133_Q	401_S	1.298	1.00
260_F	269_F	1.295	1.00
207_D	210_K	1.294	1.00
224_Y	390_A	1.291	1.00
288_S	342_D	1.290	1.00
280_R	363_L	1.287	1.00
209_L	448_P	1.282	1.00
452_Y	456_Q	1.281	1.00
370_F	412_I	1.275	1.00
280_R	372_L	1.267	1.00
170_A	174_L	1.253	1.00
373_I	420_F	1.248	1.00
453_E	456_Q	1.244	1.00
404_W	428_L	1.236	1.00
246_V	429_I	1.233	1.00
246_V	270_V	1.228	1.00
228_V	439_G	1.228	1.00
341_P	358_P	1.226	1.00
176_G	180_F	1.223	1.00
427_G	462_M	1.217	1.00
45_N	248_K	1.214	1.00
173_V	176_G	1.208	1.00
409_I	423_A	1.207	1.00
301_E	305_R	1.206	1.00
210_K	214_T	1.206	1.00
285_V	331_F	1.202	1.00
235_L	434_A	1.202	1.00
258_Y	276_R	1.184	1.00
214_T	218_Q	1.183	1.00
321_D	343_G	1.179	1.00
128_E	395_R	1.174	1.00
150_T	161_N	1.168	1.00
95_R	98_K	1.165	1.00
440_C	455_T	1.164	1.00
305_R	308_L	1.159	1.00
77_Q	84_E	1.159	1.00
317_L	344_P	1.159	1.00
389_K	396_E	1.158	1.00
201_E	231_R	1.156	1.00
231_R	456_Q	1.154	1.00
321_D	344_P	1.144	1.00
144_V	414_S	1.140	1.00
38_L	46_Y	1.132	1.00
307_G	353_Q	1.131	1.00
200_A	236_T	1.131	1.00
137_F	428_L	1.128	1.00
122_F	412_I	1.128	1.00
207_D	211_A	1.128	1.00
411_W	419_E	1.124	1.00
308_L	311_L	1.123	1.00
244_E	261_A	1.121	1.00
206_D	210_K	1.121	1.00
280_R	285_V	1.115	1.00
169_D	173_V	1.114	1.00
92_Q	140_G	1.113	1.00
286_M	358_P	1.112	1.00
171_E	175_E	1.111	1.00
220_K	444_E	1.103	1.00
291_A	381_A	1.094	1.00
288_S	358_P	1.089	1.00
324_V	343_G	1.088	1.00
291_A	320_H	1.088	1.00
436_L	459_L	1.086	1.00
382_L	424_I	1.083	1.00
283_G	365_E	1.081	1.00
236_T	432_S	1.081	1.00
160_V	177_L	1.080	1.00
436_L	463_I	1.078	1.00
175_E	179_A	1.074	1.00
167_G	171_E	1.070	1.00
73_E	146_A	1.068	1.00
43_F	184_F	1.066	1.00
254_Q	272_A	1.066	1.00
66_T	153_A	1.061	1.00
114_V	117_V	1.057	1.00
97_K	101_F	1.055	1.00
460_K	464_S	1.053	1.00
69_G	119_F	1.050	1.00
54_N	57_F	1.048	1.00
79_N	82_N	1.043	1.00
363_L	372_L	1.042	1.00
302_D	306_I	1.038	1.00
223_Q	389_K	1.037	1.00
122_F	140_G	1.037	1.00
121_G	404_W	1.037	1.00
294_I	306_I	1.031	1.00
54_N	58_W	1.017	1.00
277_L	287_S	1.013	1.00
149_L	158_L	1.011	1.00
147_L	176_G	1.007	1.00
247_L	251_L	1.005	1.00
203_L	399_P	1.004	1.00
243_I	261_A	1.000	1.00
331_F	376_L	0.999	1.00
75_V	141_D	0.998	1.00
271_G	409_I	0.997	1.00
323_V	381_A	0.995	1.00
125_D	128_E	0.994	1.00
40_P	151_M	0.991	0.99
295_K	306_I	0.991	0.99
73_E	144_V	0.989	0.99
56_F	59_S	0.988	0.99
199_A	463_I	0.988	0.99
254_Q	351_S	0.988	0.99
237_F	246_V	0.987	0.99
78_T	83_S	0.986	0.99
408_P	420_F	0.986	0.99
151_M	158_L	0.986	0.99
291_A	323_V	0.979	0.99
224_Y	393_V	0.978	0.99
131_G	388_E	0.977	0.99
174_L	177_L	0.977	0.99
200_A	234_L	0.976	0.99
91_E	129_E	0.975	0.99
141_D	264_Q	0.974	0.99
170_A	184_F	0.974	0.99
311_L	346_L	0.974	0.99
268_T	429_I	0.972	0.99
216_T	444_E	0.971	0.99
77_Q	141_D	0.970	0.99
295_K	457_I	0.962	0.99
267_K	430_E	0.956	0.99
92_Q	129_E	0.953	0.99
55_R	58_W	0.952	0.99
122_F	373_I	0.945	0.99
320_H	323_V	0.944	0.99
48_A	263_E	0.944	0.99
266_G	430_E	0.944	0.99
147_L	162_R	0.942	0.99
122_F	142_F	0.934	0.99
231_R	452_Y	0.932	0.99
237_F	434_A	0.931	0.99
175_E	178_K	0.929	0.99
294_I	316_N	0.929	0.99
316_N	450_S	0.927	0.99
173_V	181_A	0.927	0.99
173_V	180_F	0.925	0.99
464_S	467_G	0.924	0.99
280_R	283_G	0.924	0.99
259_V	272_A	0.923	0.99
44_F	53_G	0.922	0.99
395_R	401_S	0.921	0.99
277_L	376_L	0.919	0.99
72_K	145_P	0.918	0.99
173_V	184_F	0.915	0.99
276_R	286_M	0.915	0.99
114_V	119_F	0.913	0.99
228_V	382_L	0.913	0.99
269_F	409_I	0.912	0.99
134_W	400_M	0.911	0.99
294_I	457_I	0.911	0.99
285_V	372_L	0.911	0.99
178_K	182_A	0.910	0.99
48_A	51_Y	0.908	0.99
137_F	267_K	0.908	0.99
452_Y	455_T	0.906	0.99
206_D	209_L	0.899	0.99
174_L	178_K	0.896	0.99
228_V	406_A	0.894	0.99
362_Q	365_E	0.892	0.99
282_G	417_N	0.887	0.99
101_F	368_S	0.881	0.99
216_T	220_K	0.881	0.99
215_A	442_I	0.878	0.99
280_R	369_I	0.876	0.99
71_G	147_L	0.875	0.99
379_T	421_A	0.874	0.99
211_A	215_A	0.874	0.99
197_I	236_T	0.872	0.99
313_D	450_S	0.872	0.99
215_A	224_Y	0.871	0.99
440_C	450_S	0.866	0.99
349_T	356_F	0.859	0.99
135_D	435_R	0.858	0.99
233_L	463_I	0.857	0.99
94_E	98_K	0.857	0.99
176_G	181_A	0.853	0.98
79_N	84_E	0.849	0.98
130_R	377_H	0.843	0.98
285_V	361_G	0.840	0.98
228_V	383_G	0.839	0.98
70_L	147_L	0.832	0.98
260_F	421_A	0.831	0.98
327_I	379_T	0.829	0.98
181_A	185_M	0.828	0.98
148_M	161_N	0.827	0.98
79_N	139_E	0.827	0.98
170_A	180_F	0.826	0.98
227_V	393_V	0.824	0.98
76_F	95_R	0.823	0.98
74_A	99_T	0.822	0.98
97_K	371_D	0.822	0.98
342_D	358_P	0.815	0.98
211_A	399_P	0.813	0.98
65_L	150_T	0.809	0.98
97_K	374_E	0.803	0.98
233_L	456_Q	0.802	0.98
369_I	418_G	0.801	0.98
67_I	148_M	0.801	0.98
119_F	262_I	0.800	0.98
427_G	436_L	0.796	0.98
209_L	212_I	0.795	0.98
277_L	291_A	0.790	0.98
320_H	381_A	0.788	0.97
133_Q	232_E	0.786	0.97
279_K	286_M	0.786	0.97
96_F	142_F	0.785	0.97
213_E	220_K	0.783	0.97
135_D	401_S	0.782	0.97
277_L	320_H	0.778	0.97
309_E	312_N	0.777	0.97
55_R	59_S	0.775	0.97
256_T	259_V	0.775	0.97
169_D	172_A	0.774	0.97
160_V	181_A	0.773	0.97
215_A	397_I	0.772	0.97
78_T	140_G	0.772	0.97
320_H	406_A	0.770	0.97
180_F	184_F	0.770	0.97
253_D	464_S	0.768	0.97
212_I	216_T	0.768	0.97
126_P	140_G	0.765	0.97
202_E	234_L	0.760	0.97
170_A	181_A	0.759	0.97
287_S	376_L	0.757	0.97
306_I	353_Q	0.756	0.97
218_Q	392_D	0.756	0.97
247_L	270_V	0.754	0.97
325_G	328_H	0.752	0.97
429_I	432_S	0.750	0.97
264_Q	267_K	0.749	0.97
269_F	423_A	0.748	0.97
318_L	322_I	0.742	0.96
262_I	409_I	0.741	0.96
346_L	353_Q	0.741	0.96
39_D	42_S	0.740	0.96
120_G	142_F	0.739	0.96
287_S	331_F	0.739	0.96
131_G	333_S	0.738	0.96
201_E	455_T	0.738	0.96
393_V	396_E	0.736	0.96
178_K	181_A	0.736	0.96
209_L	447_E	0.735	0.96
389_K	393_V	0.734	0.96
326_M	380_P	0.734	0.96
127_C	391_V	0.732	0.96
260_F	426_S	0.730	0.96
280_R	418_G	0.726	0.96
345_V	358_P	0.725	0.96
211_A	229_L	0.725	0.96
463_I	467_G	0.723	0.96
388_E	391_V	0.722	0.96
44_F	48_A	0.721	0.96
350_K	461_P	0.719	0.96
123_S	139_E	0.719	0.96
113_A	281_D	0.718	0.96
128_E	139_E	0.717	0.96
179_A	183_E	0.714	0.96
276_R	288_S	0.711	0.95
127_C	395_R	0.708	0.95
74_A	144_V	0.705	0.95
269_F	426_S	0.704	0.95
301_E	304_R	0.701	0.95
138_S	267_K	0.699	0.95
327_I	406_A	0.699	0.95
126_P	129_E	0.696	0.95
136_H	430_E	0.695	0.95
64_E	154_E	0.693	0.95
277_L	327_I	0.692	0.95
337_E	362_Q	0.691	0.95
115_G	415_Q	0.690	0.95
232_E	400_M	0.687	0.94
122_F	410_G	0.687	0.94
228_V	271_G	0.686	0.94
74_A	85_R	0.684	0.94
130_R	374_E	0.682	0.94
44_F	68_V	0.680	0.94
230_A	439_G	0.678	0.94
368_S	371_D	0.678	0.94
278_I	418_G	0.677	0.94
230_A	455_T	0.677	0.94
203_L	231_R	0.672	0.94
42_S	46_Y	0.671	0.94
232_E	437_F	0.670	0.94
320_H	327_I	0.669	0.94
93_W	126_P	0.669	0.94
42_S	45_N	0.666	0.94
99_T	102_H	0.666	0.94
278_I	372_L	0.666	0.94
295_K	453_E	0.665	0.93
37_S	45_N	0.664	0.93
392_D	396_E	0.663	0.93
256_T	351_S	0.662	0.93
43_F	149_L	0.660	0.93
181_A	184_F	0.659	0.93
373_I	418_G	0.657	0.93
285_V	363_L	0.656	0.93
122_F	420_F	0.656	0.93
295_K	298_V	0.656	0.93
227_V	390_A	0.656	0.93
228_V	421_A	0.656	0.93
219_I	444_E	0.655	0.93
82_N	89_V	0.655	0.93
225_D	329_N	0.654	0.93
38_L	42_S	0.651	0.93
339_E	362_Q	0.649	0.93
307_G	311_L	0.649	0.93
198_A	467_G	0.649	0.93
317_L	343_G	0.648	0.93
209_L	452_Y	0.648	0.93
430_E	433_T	0.644	0.92
141_D	267_K	0.644	0.92
137_F	404_W	0.642	0.92
412_I	418_G	0.641	0.92
288_S	345_V	0.641	0.92
400_M	437_F	0.639	0.92
254_Q	461_P	0.639	0.92
246_V	434_A	0.638	0.92
202_E	231_R	0.637	0.92
318_L	445_D	0.636	0.92
320_H	357_T	0.636	0.92
325_G	330_A	0.636	0.92
406_A	421_A	0.634	0.92
320_H	324_V	0.634	0.92
212_I	440_C	0.630	0.92
399_P	437_F	0.629	0.91
90_F	94_E	0.629	0.91
278_I	376_L	0.629	0.91
334_S	372_L	0.629	0.91
203_L	207_D	0.629	0.91
277_L	323_V	0.627	0.91
228_V	260_F	0.627	0.91
354_H	441_G	0.626	0.91
73_E	78_T	0.626	0.91
98_K	101_F	0.626	0.91
295_K	450_S	0.625	0.91
72_K	75_V	0.625	0.91
73_E	118_L	0.624	0.91
174_L	181_A	0.621	0.91
311_L	314_E	0.621	0.91
428_L	435_R	0.619	0.91
318_L	328_H	0.618	0.91
117_V	414_S	0.617	0.91
272_A	411_W	0.617	0.91
129_E	139_E	0.616	0.91
127_C	130_R	0.615	0.91
43_F	47_G	0.615	0.91
177_L	180_F	0.614	0.90
228_V	390_A	0.614	0.90
327_I	381_A	0.614	0.90
332_V	335_C	0.613	0.90
320_H	353_Q	0.612	0.90
176_G	179_A	0.610	0.90
283_G	363_L	0.609	0.90
290_L	424_I	0.609	0.90
48_A	53_G	0.608	0.90
340_K	343_G	0.608	0.90
291_A	443_V	0.605	0.90
272_A	462_M	0.603	0.90
216_T	445_D	0.603	0.90
310_L	346_L	0.601	0.90
271_G	379_T	0.601	0.90
168_E	172_A	0.597	0.89
128_E	401_S	0.596	0.89
379_T	382_L	0.596	0.89
58_W	63_S	0.595	0.89
317_L	321_D	0.594	0.89
238_D	432_S	0.590	0.89
381_A	440_C	0.589	0.89
90_F	98_K	0.588	0.88
295_K	302_D	0.587	0.88
463_I	466_L	0.587	0.88
50_K	53_G	0.587	0.88
228_V	379_T	0.586	0.88
311_L	317_L	0.586	0.88
246_V	466_L	0.585	0.88
382_L	462_M	0.584	0.88
169_D	177_L	0.584	0.88
124_F	383_G	0.584	0.88
160_V	180_F	0.584	0.88
328_H	385_S	0.583	0.88
233_L	459_L	0.582	0.88
323_V	327_I	0.579	0.88
314_E	317_L	0.578	0.88
327_I	421_A	0.577	0.88
291_A	440_C	0.577	0.88
260_F	379_T	0.576	0.87
78_T	129_E	0.574	0.87
41_L	244_E	0.573	0.87
288_S	349_T	0.573	0.87
312_N	317_L	0.572	0.87
381_A	437_F	0.571	0.87
226_K	323_V	0.571	0.87
215_A	393_V	0.568	0.87
382_L	422_V	0.567	0.87
172_A	175_E	0.566	0.87
265_E	268_T	0.566	0.87
244_E	248_K	0.566	0.87
228_V	327_I	0.565	0.86
40_P	54_N	0.565	0.86
41_L	248_K	0.564	0.86
322_I	330_A	0.563	0.86
294_I	353_Q	0.563	0.86
223_Q	329_N	0.562	0.86
67_I	411_W	0.561	0.86
376_L	420_F	0.561	0.86
145_P	148_M	0.561	0.86
83_S	86_Y	0.561	0.86
122_F	377_H	0.561	0.86
388_E	392_D	0.560	0.86
329_N	333_S	0.560	0.86
342_D	347_Y	0.560	0.86
323_V	440_C	0.560	0.86
379_T	406_A	0.559	0.86
271_G	382_L	0.559	0.86
147_L	160_V	0.558	0.86
78_T	81_K	0.558	0.86
57_F	60_D	0.558	0.86
253_D	351_S	0.557	0.86
461_P	465_A	0.557	0.86
75_V	143_F	0.556	0.86
297_G	303_D	0.556	0.86
51_Y	263_E	0.554	0.85
233_L	438_A	0.554	0.85
344_P	355_L	0.552	0.85
354_H	382_L	0.550	0.85
82_N	85_R	0.550	0.85
235_L	466_L	0.550	0.85
211_A	397_I	0.550	0.85
73_E	414_S	0.549	0.85
289_C	326_M	0.548	0.85
243_I	270_V	0.548	0.85
182_A	186_V	0.547	0.85
216_T	448_P	0.546	0.85
320_H	344_P	0.545	0.84
179_A	182_A	0.545	0.84
277_L	381_A	0.545	0.84
54_N	59_S	0.545	0.84
214_T	397_I	0.544	0.84
296_R	348_K	0.542	0.84
317_L	355_L	0.542	0.84
271_G	406_A	0.542	0.84
93_W	96_F	0.542	0.84
222_K	328_H	0.540	0.84
322_I	328_H	0.540	0.84
459_L	463_I	0.540	0.84
225_D	322_I	0.538	0.84
325_G	329_N	0.537	0.84
127_C	381_A	0.537	0.84
163_W	414_S	0.537	0.84
97_K	370_F	0.536	0.83
101_F	308_L	0.536	0.83
226_K	443_V	0.536	0.83
196_V	238_D	0.535	0.83
49_K	52_T	0.535	0.83
48_A	52_T	0.535	0.83
142_F	410_G	0.534	0.83
351_S	461_P	0.534	0.83
327_I	422_V	0.532	0.83
81_K	129_E	0.529	0.83
195_A	238_D	0.529	0.83
92_Q	96_F	0.528	0.83
333_S	388_E	0.527	0.82
456_Q	460_K	0.527	0.82
182_A	185_M	0.527	0.82
382_L	423_A	0.527	0.82
48_A	242_Q	0.526	0.82
289_C	359_I	0.526	0.82
314_E	445_D	0.526	0.82
228_V	354_H	0.525	0.82
176_G	184_F	0.525	0.82
176_G	183_E	0.525	0.82
225_D	328_H	0.524	0.82
67_I	119_F	0.523	0.82
330_A	387_Q	0.523	0.82
316_N	381_A	0.522	0.82
68_V	149_L	0.522	0.82
82_N	86_Y	0.522	0.82
38_L	43_F	0.522	0.82
313_D	382_L	0.522	0.82
133_Q	430_E	0.522	0.82
255_Q	272_A	0.521	0.82
322_I	326_M	0.519	0.81
204_D	209_L	0.519	0.81
115_G	413_D	0.515	0.81
65_L	113_A	0.515	0.81
379_T	390_A	0.514	0.81
303_D	353_Q	0.514	0.81
271_G	327_I	0.513	0.81
208_W	229_L	0.513	0.81
84_E	87_R	0.513	0.81
297_G	300_E	0.512	0.81
371_D	375_K	0.512	0.81
121_G	377_H	0.512	0.81
77_Q	86_Y	0.512	0.81
301_E	365_E	0.511	0.81
451_E	454_E	0.510	0.80
79_N	138_S	0.510	0.80
172_A	176_G	0.508	0.80
76_F	83_S	0.508	0.80
49_K	53_G	0.508	0.80
283_G	366_S	0.506	0.80
123_S	126_P	0.504	0.80
216_T	443_V	0.504	0.80
139_E	401_S	0.504	0.80
250_L	272_A	0.504	0.80
299_N	305_R	0.503	0.79
289_C	387_Q	0.503	0.79
103_I	414_S	0.503	0.79
224_Y	437_F	0.502	0.79
117_V	124_F	0.502	0.79
215_A	394_I	0.502	0.79
225_D	325_G	0.501	0.79
254_Q	350_K	0.501	0.79
325_G	385_S	0.501	0.79
243_I	263_E	0.501	0.79
218_Q	397_I	0.501	0.79
454_E	458_K	0.501	0.79
460_K	467_G	0.500	0.79
218_Q	224_Y	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1i1qA	2	0.9384	100	0.182	Contact Map
1k0eA	1	0.8938	100	0.183	Contact Map
1qdlA	1	0.8535	100	0.184	Contact Map
4grhA	1	0.9023	100	0.188	Contact Map
3logA	1	0.9236	100	0.205	Contact Map
3h9mA	1	0.8089	100	0.23	Contact Map
3gseA	1	0.8896	100	0.253	Contact Map
2fn0A	2	0.8493	100	0.255	Contact Map
3bzmA	1	0.9002	100	0.274	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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