GREMLIN Database
MENF - Isochorismate synthase MenF
UniProt: P23973 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 471 (429)
Sequences: 5797 (4007)
Seq/√Len: 193.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
335_C361_G4.8171.00
382_L406_A4.5361.00
97_K368_S4.2251.00
205_K209_L3.7581.00
294_I309_E3.5221.00
284_T360_V3.2281.00
293_S352_V3.2151.00
234_L433_T3.1141.00
447_E450_S3.0911.00
341_P360_V3.0571.00
218_Q396_E2.8671.00
209_L449_I2.8591.00
218_Q223_Q2.7971.00
342_D345_V2.7491.00
204_D207_D2.7311.00
208_W440_C2.7281.00
205_K449_I2.6861.00
389_K392_D2.6331.00
410_G420_F2.5311.00
91_E374_E2.4991.00
367_A371_D2.4781.00
304_R308_L2.4771.00
339_E360_V2.4651.00
217_S221_E2.4451.00
296_R303_D2.4291.00
307_G348_K2.4061.00
308_L312_N2.3791.00
234_L435_R2.3371.00
203_L211_A2.3311.00
124_F391_V2.3221.00
364_R367_A2.2991.00
236_T433_T2.2921.00
269_F404_W2.2621.00
243_I268_T2.2491.00
91_E94_E2.1971.00
224_Y227_V2.1691.00
210_K213_E2.1681.00
215_A227_V2.1491.00
313_D316_N2.1321.00
283_G362_Q2.1251.00
297_G302_D2.1021.00
260_F271_G2.0991.00
379_T422_V2.0811.00
348_K353_Q2.0341.00
260_F409_I2.0331.00
346_L355_L2.0111.00
284_T362_Q2.0031.00
311_L355_L1.9681.00
304_R307_G1.9311.00
429_I434_A1.9241.00
64_E152_T1.9221.00
331_F335_C1.8961.00
300_E304_R1.8571.00
213_E216_T1.8461.00
242_Q245_P1.8331.00
393_V397_I1.8281.00
118_L144_V1.7891.00
307_G346_L1.7881.00
287_S327_I1.7861.00
276_R419_E1.7821.00
270_V429_I1.7821.00
213_E448_P1.7701.00
202_E400_M1.7701.00
302_D305_R1.7651.00
226_K441_G1.7641.00
334_S375_K1.7551.00
217_S220_K1.7541.00
449_I453_E1.7311.00
290_L356_F1.7281.00
67_I150_T1.7101.00
298_V302_D1.7061.00
263_E268_T1.7001.00
205_K452_Y1.6831.00
215_A229_L1.6471.00
297_G306_I1.6051.00
299_N302_D1.6001.00
427_G434_A1.5971.00
231_R455_T1.5801.00
288_S347_Y1.5781.00
347_Y356_F1.5751.00
404_W423_A1.5721.00
122_F126_P1.5551.00
453_E457_I1.5511.00
212_I448_P1.5491.00
199_A235_L1.5471.00
125_D395_R1.5451.00
305_R309_E1.5431.00
306_I309_E1.5391.00
281_D417_N1.5381.00
229_L440_C1.5301.00
43_F151_M1.5191.00
237_F429_I1.4911.00
232_E435_R1.4821.00
332_V336_S1.4651.00
218_Q393_V1.4531.00
230_A437_F1.4451.00
373_I412_I1.4351.00
209_L213_E1.4191.00
133_Q136_H1.4161.00
218_Q389_K1.3991.00
170_A173_V1.3901.00
285_V335_C1.3831.00
331_F361_G1.3711.00
450_S453_E1.3571.00
94_E97_K1.3541.00
177_L181_A1.3541.00
413_D417_N1.3481.00
229_L442_I1.3461.00
261_A268_T1.3411.00
212_I442_I1.3341.00
246_V427_G1.3341.00
207_D399_P1.3321.00
142_F420_F1.3281.00
173_V177_L1.3271.00
214_T217_S1.3231.00
227_V394_I1.3211.00
438_A459_L1.3181.00
213_E217_S1.3161.00
214_T396_E1.3141.00
271_G421_A1.3101.00
243_I429_I1.3091.00
205_K453_E1.3061.00
125_D401_S1.3061.00
286_M360_V1.3051.00
133_Q401_S1.2981.00
260_F269_F1.2951.00
207_D210_K1.2941.00
224_Y390_A1.2911.00
288_S342_D1.2901.00
280_R363_L1.2871.00
209_L448_P1.2821.00
452_Y456_Q1.2811.00
370_F412_I1.2751.00
280_R372_L1.2671.00
170_A174_L1.2531.00
373_I420_F1.2481.00
453_E456_Q1.2441.00
404_W428_L1.2361.00
246_V429_I1.2331.00
246_V270_V1.2281.00
228_V439_G1.2281.00
341_P358_P1.2261.00
176_G180_F1.2231.00
427_G462_M1.2171.00
45_N248_K1.2141.00
173_V176_G1.2081.00
409_I423_A1.2071.00
301_E305_R1.2061.00
210_K214_T1.2061.00
285_V331_F1.2021.00
235_L434_A1.2021.00
258_Y276_R1.1841.00
214_T218_Q1.1831.00
321_D343_G1.1791.00
128_E395_R1.1741.00
150_T161_N1.1681.00
95_R98_K1.1651.00
440_C455_T1.1641.00
305_R308_L1.1591.00
77_Q84_E1.1591.00
317_L344_P1.1591.00
389_K396_E1.1581.00
201_E231_R1.1561.00
231_R456_Q1.1541.00
321_D344_P1.1441.00
144_V414_S1.1401.00
38_L46_Y1.1321.00
307_G353_Q1.1311.00
200_A236_T1.1311.00
137_F428_L1.1281.00
122_F412_I1.1281.00
207_D211_A1.1281.00
411_W419_E1.1241.00
308_L311_L1.1231.00
244_E261_A1.1211.00
206_D210_K1.1211.00
280_R285_V1.1151.00
169_D173_V1.1141.00
92_Q140_G1.1131.00
286_M358_P1.1121.00
171_E175_E1.1111.00
220_K444_E1.1031.00
291_A381_A1.0941.00
288_S358_P1.0891.00
324_V343_G1.0881.00
291_A320_H1.0881.00
436_L459_L1.0861.00
382_L424_I1.0831.00
283_G365_E1.0811.00
236_T432_S1.0811.00
160_V177_L1.0801.00
436_L463_I1.0781.00
175_E179_A1.0741.00
167_G171_E1.0701.00
73_E146_A1.0681.00
43_F184_F1.0661.00
254_Q272_A1.0661.00
66_T153_A1.0611.00
114_V117_V1.0571.00
97_K101_F1.0551.00
460_K464_S1.0531.00
69_G119_F1.0501.00
54_N57_F1.0481.00
79_N82_N1.0431.00
363_L372_L1.0421.00
302_D306_I1.0381.00
223_Q389_K1.0371.00
122_F140_G1.0371.00
121_G404_W1.0371.00
294_I306_I1.0311.00
54_N58_W1.0171.00
277_L287_S1.0131.00
149_L158_L1.0111.00
147_L176_G1.0071.00
247_L251_L1.0051.00
203_L399_P1.0041.00
243_I261_A1.0001.00
331_F376_L0.9991.00
75_V141_D0.9981.00
271_G409_I0.9971.00
323_V381_A0.9951.00
125_D128_E0.9941.00
40_P151_M0.9910.99
295_K306_I0.9910.99
73_E144_V0.9890.99
56_F59_S0.9880.99
199_A463_I0.9880.99
254_Q351_S0.9880.99
237_F246_V0.9870.99
78_T83_S0.9860.99
408_P420_F0.9860.99
151_M158_L0.9860.99
291_A323_V0.9790.99
224_Y393_V0.9780.99
131_G388_E0.9770.99
174_L177_L0.9770.99
200_A234_L0.9760.99
91_E129_E0.9750.99
141_D264_Q0.9740.99
170_A184_F0.9740.99
311_L346_L0.9740.99
268_T429_I0.9720.99
216_T444_E0.9710.99
77_Q141_D0.9700.99
295_K457_I0.9620.99
267_K430_E0.9560.99
92_Q129_E0.9530.99
55_R58_W0.9520.99
122_F373_I0.9450.99
320_H323_V0.9440.99
48_A263_E0.9440.99
266_G430_E0.9440.99
147_L162_R0.9420.99
122_F142_F0.9340.99
231_R452_Y0.9320.99
237_F434_A0.9310.99
175_E178_K0.9290.99
294_I316_N0.9290.99
316_N450_S0.9270.99
173_V181_A0.9270.99
173_V180_F0.9250.99
464_S467_G0.9240.99
280_R283_G0.9240.99
259_V272_A0.9230.99
44_F53_G0.9220.99
395_R401_S0.9210.99
277_L376_L0.9190.99
72_K145_P0.9180.99
173_V184_F0.9150.99
276_R286_M0.9150.99
114_V119_F0.9130.99
228_V382_L0.9130.99
269_F409_I0.9120.99
134_W400_M0.9110.99
294_I457_I0.9110.99
285_V372_L0.9110.99
178_K182_A0.9100.99
48_A51_Y0.9080.99
137_F267_K0.9080.99
452_Y455_T0.9060.99
206_D209_L0.8990.99
174_L178_K0.8960.99
228_V406_A0.8940.99
362_Q365_E0.8920.99
282_G417_N0.8870.99
101_F368_S0.8810.99
216_T220_K0.8810.99
215_A442_I0.8780.99
280_R369_I0.8760.99
71_G147_L0.8750.99
379_T421_A0.8740.99
211_A215_A0.8740.99
197_I236_T0.8720.99
313_D450_S0.8720.99
215_A224_Y0.8710.99
440_C450_S0.8660.99
349_T356_F0.8590.99
135_D435_R0.8580.99
233_L463_I0.8570.99
94_E98_K0.8570.99
176_G181_A0.8530.98
79_N84_E0.8490.98
130_R377_H0.8430.98
285_V361_G0.8400.98
228_V383_G0.8390.98
70_L147_L0.8320.98
260_F421_A0.8310.98
327_I379_T0.8290.98
181_A185_M0.8280.98
148_M161_N0.8270.98
79_N139_E0.8270.98
170_A180_F0.8260.98
227_V393_V0.8240.98
76_F95_R0.8230.98
74_A99_T0.8220.98
97_K371_D0.8220.98
342_D358_P0.8150.98
211_A399_P0.8130.98
65_L150_T0.8090.98
97_K374_E0.8030.98
233_L456_Q0.8020.98
369_I418_G0.8010.98
67_I148_M0.8010.98
119_F262_I0.8000.98
427_G436_L0.7960.98
209_L212_I0.7950.98
277_L291_A0.7900.98
320_H381_A0.7880.97
133_Q232_E0.7860.97
279_K286_M0.7860.97
96_F142_F0.7850.97
213_E220_K0.7830.97
135_D401_S0.7820.97
277_L320_H0.7780.97
309_E312_N0.7770.97
55_R59_S0.7750.97
256_T259_V0.7750.97
169_D172_A0.7740.97
160_V181_A0.7730.97
215_A397_I0.7720.97
78_T140_G0.7720.97
320_H406_A0.7700.97
180_F184_F0.7700.97
253_D464_S0.7680.97
212_I216_T0.7680.97
126_P140_G0.7650.97
202_E234_L0.7600.97
170_A181_A0.7590.97
287_S376_L0.7570.97
306_I353_Q0.7560.97
218_Q392_D0.7560.97
247_L270_V0.7540.97
325_G328_H0.7520.97
429_I432_S0.7500.97
264_Q267_K0.7490.97
269_F423_A0.7480.97
318_L322_I0.7420.96
262_I409_I0.7410.96
346_L353_Q0.7410.96
39_D42_S0.7400.96
120_G142_F0.7390.96
287_S331_F0.7390.96
131_G333_S0.7380.96
201_E455_T0.7380.96
393_V396_E0.7360.96
178_K181_A0.7360.96
209_L447_E0.7350.96
389_K393_V0.7340.96
326_M380_P0.7340.96
127_C391_V0.7320.96
260_F426_S0.7300.96
280_R418_G0.7260.96
345_V358_P0.7250.96
211_A229_L0.7250.96
463_I467_G0.7230.96
388_E391_V0.7220.96
44_F48_A0.7210.96
350_K461_P0.7190.96
123_S139_E0.7190.96
113_A281_D0.7180.96
128_E139_E0.7170.96
179_A183_E0.7140.96
276_R288_S0.7110.95
127_C395_R0.7080.95
74_A144_V0.7050.95
269_F426_S0.7040.95
301_E304_R0.7010.95
138_S267_K0.6990.95
327_I406_A0.6990.95
126_P129_E0.6960.95
136_H430_E0.6950.95
64_E154_E0.6930.95
277_L327_I0.6920.95
337_E362_Q0.6910.95
115_G415_Q0.6900.95
232_E400_M0.6870.94
122_F410_G0.6870.94
228_V271_G0.6860.94
74_A85_R0.6840.94
130_R374_E0.6820.94
44_F68_V0.6800.94
230_A439_G0.6780.94
368_S371_D0.6780.94
278_I418_G0.6770.94
230_A455_T0.6770.94
203_L231_R0.6720.94
42_S46_Y0.6710.94
232_E437_F0.6700.94
320_H327_I0.6690.94
93_W126_P0.6690.94
42_S45_N0.6660.94
99_T102_H0.6660.94
278_I372_L0.6660.94
295_K453_E0.6650.93
37_S45_N0.6640.93
392_D396_E0.6630.93
256_T351_S0.6620.93
43_F149_L0.6600.93
181_A184_F0.6590.93
373_I418_G0.6570.93
285_V363_L0.6560.93
122_F420_F0.6560.93
295_K298_V0.6560.93
227_V390_A0.6560.93
228_V421_A0.6560.93
219_I444_E0.6550.93
82_N89_V0.6550.93
225_D329_N0.6540.93
38_L42_S0.6510.93
339_E362_Q0.6490.93
307_G311_L0.6490.93
198_A467_G0.6490.93
317_L343_G0.6480.93
209_L452_Y0.6480.93
430_E433_T0.6440.92
141_D267_K0.6440.92
137_F404_W0.6420.92
412_I418_G0.6410.92
288_S345_V0.6410.92
400_M437_F0.6390.92
254_Q461_P0.6390.92
246_V434_A0.6380.92
202_E231_R0.6370.92
318_L445_D0.6360.92
320_H357_T0.6360.92
325_G330_A0.6360.92
406_A421_A0.6340.92
320_H324_V0.6340.92
212_I440_C0.6300.92
399_P437_F0.6290.91
90_F94_E0.6290.91
278_I376_L0.6290.91
334_S372_L0.6290.91
203_L207_D0.6290.91
277_L323_V0.6270.91
228_V260_F0.6270.91
354_H441_G0.6260.91
73_E78_T0.6260.91
98_K101_F0.6260.91
295_K450_S0.6250.91
72_K75_V0.6250.91
73_E118_L0.6240.91
174_L181_A0.6210.91
311_L314_E0.6210.91
428_L435_R0.6190.91
318_L328_H0.6180.91
117_V414_S0.6170.91
272_A411_W0.6170.91
129_E139_E0.6160.91
127_C130_R0.6150.91
43_F47_G0.6150.91
177_L180_F0.6140.90
228_V390_A0.6140.90
327_I381_A0.6140.90
332_V335_C0.6130.90
320_H353_Q0.6120.90
176_G179_A0.6100.90
283_G363_L0.6090.90
290_L424_I0.6090.90
48_A53_G0.6080.90
340_K343_G0.6080.90
291_A443_V0.6050.90
272_A462_M0.6030.90
216_T445_D0.6030.90
310_L346_L0.6010.90
271_G379_T0.6010.90
168_E172_A0.5970.89
128_E401_S0.5960.89
379_T382_L0.5960.89
58_W63_S0.5950.89
317_L321_D0.5940.89
238_D432_S0.5900.89
381_A440_C0.5890.89
90_F98_K0.5880.88
295_K302_D0.5870.88
463_I466_L0.5870.88
50_K53_G0.5870.88
228_V379_T0.5860.88
311_L317_L0.5860.88
246_V466_L0.5850.88
382_L462_M0.5840.88
169_D177_L0.5840.88
124_F383_G0.5840.88
160_V180_F0.5840.88
328_H385_S0.5830.88
233_L459_L0.5820.88
323_V327_I0.5790.88
314_E317_L0.5780.88
327_I421_A0.5770.88
291_A440_C0.5770.88
260_F379_T0.5760.87
78_T129_E0.5740.87
41_L244_E0.5730.87
288_S349_T0.5730.87
312_N317_L0.5720.87
381_A437_F0.5710.87
226_K323_V0.5710.87
215_A393_V0.5680.87
382_L422_V0.5670.87
172_A175_E0.5660.87
265_E268_T0.5660.87
244_E248_K0.5660.87
228_V327_I0.5650.86
40_P54_N0.5650.86
41_L248_K0.5640.86
322_I330_A0.5630.86
294_I353_Q0.5630.86
223_Q329_N0.5620.86
67_I411_W0.5610.86
376_L420_F0.5610.86
145_P148_M0.5610.86
83_S86_Y0.5610.86
122_F377_H0.5610.86
388_E392_D0.5600.86
329_N333_S0.5600.86
342_D347_Y0.5600.86
323_V440_C0.5600.86
379_T406_A0.5590.86
271_G382_L0.5590.86
147_L160_V0.5580.86
78_T81_K0.5580.86
57_F60_D0.5580.86
253_D351_S0.5570.86
461_P465_A0.5570.86
75_V143_F0.5560.86
297_G303_D0.5560.86
51_Y263_E0.5540.85
233_L438_A0.5540.85
344_P355_L0.5520.85
354_H382_L0.5500.85
82_N85_R0.5500.85
235_L466_L0.5500.85
211_A397_I0.5500.85
73_E414_S0.5490.85
289_C326_M0.5480.85
243_I270_V0.5480.85
182_A186_V0.5470.85
216_T448_P0.5460.85
320_H344_P0.5450.84
179_A182_A0.5450.84
277_L381_A0.5450.84
54_N59_S0.5450.84
214_T397_I0.5440.84
296_R348_K0.5420.84
317_L355_L0.5420.84
271_G406_A0.5420.84
93_W96_F0.5420.84
222_K328_H0.5400.84
322_I328_H0.5400.84
459_L463_I0.5400.84
225_D322_I0.5380.84
325_G329_N0.5370.84
127_C381_A0.5370.84
163_W414_S0.5370.84
97_K370_F0.5360.83
101_F308_L0.5360.83
226_K443_V0.5360.83
196_V238_D0.5350.83
49_K52_T0.5350.83
48_A52_T0.5350.83
142_F410_G0.5340.83
351_S461_P0.5340.83
327_I422_V0.5320.83
81_K129_E0.5290.83
195_A238_D0.5290.83
92_Q96_F0.5280.83
333_S388_E0.5270.82
456_Q460_K0.5270.82
182_A185_M0.5270.82
382_L423_A0.5270.82
48_A242_Q0.5260.82
289_C359_I0.5260.82
314_E445_D0.5260.82
228_V354_H0.5250.82
176_G184_F0.5250.82
176_G183_E0.5250.82
225_D328_H0.5240.82
67_I119_F0.5230.82
330_A387_Q0.5230.82
316_N381_A0.5220.82
68_V149_L0.5220.82
82_N86_Y0.5220.82
38_L43_F0.5220.82
313_D382_L0.5220.82
133_Q430_E0.5220.82
255_Q272_A0.5210.82
322_I326_M0.5190.81
204_D209_L0.5190.81
115_G413_D0.5150.81
65_L113_A0.5150.81
379_T390_A0.5140.81
303_D353_Q0.5140.81
271_G327_I0.5130.81
208_W229_L0.5130.81
84_E87_R0.5130.81
297_G300_E0.5120.81
371_D375_K0.5120.81
121_G377_H0.5120.81
77_Q86_Y0.5120.81
301_E365_E0.5110.81
451_E454_E0.5100.80
79_N138_S0.5100.80
172_A176_G0.5080.80
76_F83_S0.5080.80
49_K53_G0.5080.80
283_G366_S0.5060.80
123_S126_P0.5040.80
216_T443_V0.5040.80
139_E401_S0.5040.80
250_L272_A0.5040.80
299_N305_R0.5030.79
289_C387_Q0.5030.79
103_I414_S0.5030.79
224_Y437_F0.5020.79
117_V124_F0.5020.79
215_A394_I0.5020.79
225_D325_G0.5010.79
254_Q350_K0.5010.79
325_G385_S0.5010.79
243_I263_E0.5010.79
218_Q397_I0.5010.79
454_E458_K0.5010.79
460_K467_G0.5000.79
218_Q224_Y0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i1qA 2 0.9384 100 0.182 Contact Map
1k0eA 1 0.8938 100 0.183 Contact Map
1qdlA 1 0.8535 100 0.184 Contact Map
4grhA 1 0.9023 100 0.188 Contact Map
3logA 1 0.9236 100 0.205 Contact Map
3h9mA 1 0.8089 100 0.23 Contact Map
3gseA 1 0.8896 100 0.253 Contact Map
2fn0A 2 0.8493 100 0.255 Contact Map
3bzmA 1 0.9002 100 0.274 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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