GREMLIN Database
MENE - 2-succinylbenzoate--CoA ligase
UniProt: P23971 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 486 (469)
Sequences: 71654 (51696)
Seq/√Len: 2387.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_T163_Q3.8321.00
406_H444_Y3.1501.00
336_I369_G3.0801.00
39_K75_L2.8921.00
318_E339_K2.8631.00
350_R353_A2.8511.00
98_D151_Y2.7951.00
57_A101_S2.7581.00
54_D102_G2.7561.00
165_T345_K2.7401.00
35_F75_L2.7141.00
370_Y378_Y2.7101.00
50_V78_V2.6621.00
23_I212_T2.5931.00
335_E364_K2.5091.00
187_R212_T2.4431.00
388_I393_N2.3961.00
20_I28_T2.3741.00
100_G349_N2.3481.00
411_E466_R2.3441.00
16_T19_R2.3071.00
404_L412_A2.3041.00
320_K327_V2.2761.00
55_T81_V2.2681.00
44_Q48_H2.2551.00
10_M35_F2.2441.00
322_E326_Q2.1871.00
403_L428_A2.1841.00
337_M364_K2.1801.00
37_A68_Y2.1771.00
333_H368_L2.1531.00
94_F158_K2.1291.00
12_R16_T2.1201.00
372_D378_Y2.1061.00
69_A105_L2.0991.00
98_D350_R2.0921.00
35_F39_K2.0621.00
473_L476_Q2.0611.00
226_H230_R2.0471.00
405_S448_R2.0421.00
24_Y64_A2.0301.00
385_D474_R2.0301.00
353_A356_A2.0221.00
427_H459_F2.0211.00
73_C78_V2.0071.00
142_Q145_A1.9661.00
309_S378_Y1.9411.00
186_D258_R1.9391.00
370_Y380_L1.9101.00
320_K337_M1.9031.00
351_E355_E1.8981.00
372_D376_F1.8831.00
41_M68_Y1.8691.00
269_L273_E1.8521.00
186_D234_T1.8511.00
23_I28_T1.8341.00
52_K145_A1.8181.00
18_E32_A1.8121.00
51_R54_D1.8091.00
93_L97_E1.8031.00
46_A76_L1.7511.00
398_E453_K1.7451.00
53_G145_A1.7411.00
410_A433_H1.7301.00
371_L377_L1.7141.00
476_Q479_D1.7131.00
38_S75_L1.7061.00
23_I231_H1.6981.00
400_E414_V1.6831.00
32_A36_A1.6711.00
11_Q15_L1.6701.00
404_L411_E1.6681.00
333_H380_L1.6671.00
214_V233_V1.6521.00
67_V203_L1.6451.00
415_S429_Y1.6441.00
61_Q107_D1.6321.00
165_T168_N1.6311.00
330_P371_L1.6081.00
30_T33_E1.5951.00
232_E256_S1.5901.00
414_V428_A1.5591.00
57_A83_L1.5561.00
146_T345_K1.5501.00
429_Y477_L1.5471.00
431_V464_L1.5411.00
123_D126_E1.5401.00
430_L460_V1.5311.00
74_F147_A1.5261.00
55_T79_K1.5261.00
12_R15_L1.5211.00
238_A243_L1.5161.00
352_S356_A1.5151.00
29_V68_Y1.5081.00
151_Y161_G1.5041.00
177_A209_Y1.5021.00
39_K43_E1.4991.00
432_L460_V1.4971.00
295_I338_V1.4841.00
223_D226_H1.4821.00
408_A440_E1.4801.00
444_Y448_R1.4791.00
402_V448_R1.4771.00
17_P32_A1.4641.00
10_M75_L1.4571.00
20_I23_I1.4501.00
418_E424_K1.4481.00
389_S394_I1.4471.00
206_S211_M1.4441.00
144_D167_G1.4431.00
281_P299_S1.4411.00
56_A73_C1.4411.00
149_L348_F1.4261.00
243_L260_I1.4251.00
273_E277_E1.4251.00
189_L233_V1.4161.00
13_A35_F1.4151.00
20_I212_T1.4091.00
321_I369_G1.4071.00
163_Q348_F1.4051.00
306_K374_E1.4031.00
178_L315_F1.4011.00
329_E332_E1.4001.00
99_S151_Y1.3931.00
19_R185_Q1.3921.00
467_N473_L1.3901.00
288_M363_L1.3841.00
437_S440_E1.3821.00
369_G379_V1.3801.00
241_T265_G1.3781.00
442_T458_F1.3761.00
29_V64_A1.3761.00
96_L101_S1.3701.00
168_N292_C1.3691.00
220_S223_D1.3611.00
163_Q346_S1.3551.00
368_L383_R1.3461.00
187_R214_V1.3381.00
430_L458_F1.3351.00
183_T186_D1.3341.00
57_A96_L1.3331.00
24_Y27_Q1.3281.00
333_H370_Y1.3261.00
339_K362_W1.3211.00
81_V99_S1.3211.00
143_M167_G1.3191.00
322_E328_C1.3191.00
186_D235_M1.3191.00
21_A34_L1.3151.00
296_V319_I1.3131.00
227_S231_H1.3121.00
344_M358_F1.3071.00
56_A78_V1.3061.00
357_S363_L1.3031.00
319_I338_V1.3011.00
443_D447_E1.2991.00
216_H227_S1.2901.00
312_K376_F1.2851.00
429_Y461_L1.2841.00
44_Q127_L1.2811.00
55_T149_L1.2761.00
387_I396_P1.2731.00
419_D425_V1.2711.00
306_K376_F1.2711.00
411_E431_V1.2681.00
71_H207_V1.2651.00
50_V54_D1.2651.00
53_G345_K1.2621.00
41_M72_A1.2541.00
98_D349_N1.2531.00
427_H457_K1.2521.00
262_L267_A1.2511.00
320_K362_W1.2511.00
167_G341_P1.2471.00
442_T446_K1.2431.00
417_A427_H1.2331.00
55_T348_F1.2281.00
94_F98_D1.2211.00
79_K146_T1.2171.00
98_D158_K1.2161.00
187_R233_V1.2081.00
335_E383_R1.2071.00
37_A40_R1.2051.00
397_A401_S1.1971.00
25_E217_Q1.1871.00
444_Y447_E1.1871.00
163_Q345_K1.1871.00
58_I69_A1.1831.00
336_I379_V1.1741.00
298_L376_F1.1731.00
50_V56_A1.1721.00
429_Y478_K1.1651.00
416_G424_K1.1651.00
385_D397_A1.1631.00
35_F136_E1.1611.00
198_S237_S1.1591.00
392_E452_Y1.1591.00
89_T93_L1.1561.00
236_I257_I1.1511.00
149_L161_G1.1501.00
425_V456_A1.1501.00
337_M362_W1.1471.00
34_L71_H1.1401.00
248_E274_E1.1391.00
446_K451_K1.1381.00
36_A40_R1.1341.00
72_A76_L1.1291.00
313_P319_I1.1291.00
141_M145_A1.1271.00
438_A460_V1.1271.00
28_T231_H1.1181.00
27_Q64_A1.1161.00
328_C332_E1.1101.00
228_I256_S1.1081.00
10_M39_K1.1061.00
432_L436_V1.1031.00
89_T113_K1.1021.00
235_M259_C1.1021.00
244_A271_L1.0991.00
97_E158_K1.0971.00
428_A458_F1.0961.00
164_Q168_N1.0961.00
59_L92_R1.0951.00
21_A31_F1.0951.00
247_L274_E1.0861.00
29_V37_A1.0811.00
37_A65_E1.0761.00
152_T162_V1.0751.00
323_R383_R1.0751.00
33_E36_A1.0711.00
48_H120_Q1.0701.00
44_Q47_A1.0681.00
446_K454_I1.0671.00
144_D165_T1.0671.00
425_V457_K1.0661.00
439_G443_D1.0661.00
66_M194_L1.0641.00
222_S249_E1.0631.00
23_I214_V1.0551.00
50_V103_F1.0501.00
42_A75_L1.0481.00
34_L68_Y1.0451.00
214_V231_H1.0431.00
390_G422_W1.0411.00
83_L92_R1.0401.00
41_M105_L1.0401.00
386_L395_Y1.0331.00
440_E443_D1.0301.00
274_E278_K1.0291.00
187_R234_T1.0281.00
445_C454_I1.0271.00
310_A379_V1.0271.00
438_A458_F1.0261.00
353_A357_S1.0231.00
317_C342_N1.0221.00
168_N343_V1.0201.00
268_P271_L1.0171.00
214_V227_S1.0141.00
410_A431_V1.0121.00
192_L198_S1.0021.00
417_A457_K1.0021.00
402_V405_S0.9991.00
406_H441_L0.9951.00
188_W206_S0.9951.00
461_L480_A0.9931.00
186_D211_M0.9931.00
461_L464_L0.9891.00
339_K360_N0.9871.00
338_V365_T0.9861.00
91_E453_K0.9861.00
298_L309_S0.9841.00
54_D78_V0.9761.00
464_L472_L0.9761.00
400_E474_R0.9691.00
90_H448_R0.9691.00
450_A453_K0.9661.00
245_S421_K0.9631.00
38_S72_A0.9601.00
153_S469_S0.9571.00
475_N479_D0.9551.00
19_R212_T0.9531.00
270_P274_E0.9521.00
44_Q131_A0.9511.00
55_T100_G0.9491.00
340_G343_V0.9481.00
29_V34_L0.9471.00
413_G464_L0.9461.00
309_S376_F0.9461.00
296_V377_L0.9461.00
41_M69_A0.9461.00
476_Q480_A0.9441.00
387_I426_P0.9421.00
162_V344_M0.9421.00
114_E118_I0.9391.00
87_L95_Q0.9391.00
94_F151_Y0.9381.00
94_F97_E0.9351.00
22_L67_V0.9311.00
171_F341_P0.9261.00
171_F316_S0.9251.00
150_M289_T0.9241.00
48_H103_F0.9221.00
90_H94_F0.9201.00
443_D446_K0.9181.00
319_I377_L0.9181.00
60_L63_R0.9161.00
45_L73_C0.9141.00
20_I30_T0.9131.00
402_V445_C0.9121.00
27_Q37_A0.9101.00
321_I328_C0.9101.00
243_L275_C0.9081.00
84_N195_F0.9061.00
267_A272_L0.9031.00
9_L13_A0.9031.00
70_V80_A0.9021.00
107_D110_F0.8971.00
57_A104_L0.8961.00
172_S293_S0.8941.00
244_A268_P0.8931.00
64_A68_Y0.8921.00
90_H93_L0.8901.00
274_E277_E0.8891.00
189_L216_H0.8891.00
438_A442_T0.8881.00
405_S444_Y0.8871.00
306_K372_D0.8861.00
43_E46_A0.8861.00
368_L381_D0.8851.00
34_L38_S0.8801.00
319_I336_I0.8791.00
219_F242_M0.8781.00
406_H440_E0.8751.00
389_S416_G0.8731.00
259_C283_F0.8711.00
173_A208_I0.8711.00
206_S213_V0.8671.00
46_A51_R0.8661.00
46_A137_I0.8651.00
261_L285_S0.8621.00
440_E444_Y0.8591.00
43_E137_I0.8581.00
229_N253_C0.8571.00
58_I80_A0.8541.00
23_I187_R0.8541.00
164_Q292_C0.8481.00
65_E68_Y0.8471.00
197_I288_M0.8461.00
322_E332_E0.8411.00
61_Q109_S0.8401.00
70_V200_L0.8381.00
45_L105_L0.8371.00
11_Q14_Q0.8371.00
418_E421_K0.8371.00
359_Q364_K0.8361.00
10_M14_Q0.8341.00
42_A76_L0.8281.00
325_G337_M0.8241.00
147_A166_F0.8231.00
33_E37_A0.8231.00
8_W174_V0.8221.00
35_F38_S0.8221.00
164_Q344_M0.8201.00
237_S294_Q0.8201.00
50_V76_L0.8181.00
321_I377_L0.8181.00
22_L64_A0.8171.00
354_N358_F0.8151.00
73_C80_A0.8151.00
94_F350_R0.8121.00
67_V215_L0.8081.00
197_I293_S0.8071.00
358_F364_K0.8041.00
257_I260_I0.8041.00
413_G477_L0.8011.00
352_S355_E0.8001.00
389_S456_A0.7981.00
336_I377_L0.7981.00
37_A64_A0.7981.00
57_A81_V0.7951.00
441_L458_F0.7921.00
20_I24_Y0.7901.00
187_R232_E0.7881.00
408_A433_H0.7831.00
318_E362_W0.7751.00
68_Y72_A0.7741.00
126_E129_K0.7721.00
191_A242_M0.7691.00
291_T363_L0.7691.00
291_T343_V0.7671.00
234_T258_R0.7661.00
8_W12_R0.7631.00
19_R184_E0.7621.00
9_L71_H0.7621.00
27_Q65_E0.7621.00
40_R44_Q0.7601.00
70_V74_F0.7591.00
251_N274_E0.7591.00
385_D400_E0.7591.00
339_K361_G0.7581.00
243_L262_L0.7581.00
431_V463_R0.7571.00
120_Q123_D0.7541.00
442_T454_I0.7531.00
350_R354_N0.7501.00
34_L67_V0.7501.00
222_S226_H0.7491.00
141_M166_F0.7481.00
259_C281_P0.7481.00
146_T165_T0.7481.00
239_V242_M0.7451.00
185_Q234_T0.7421.00
331_Y373_N0.7411.00
108_S123_D0.7401.00
320_K339_K0.7391.00
147_A169_H0.7371.00
244_A274_E0.7361.00
413_G472_L0.7361.00
7_N11_Q0.7351.00
244_A248_E0.7331.00
410_A432_L0.7331.00
429_Y480_A0.7321.00
369_G377_L0.7321.00
128_M131_A0.7321.00
408_A432_L0.7311.00
81_V101_S0.7231.00
73_C76_L0.7221.00
60_L66_M0.7201.00
127_L131_A0.7191.00
182_I186_D0.7181.00
198_S263_G0.7181.00
9_L35_F0.7171.00
63_R107_D0.7151.00
59_L104_L0.7151.00
291_T338_V0.7141.00
172_S292_C0.7131.00
95_Q161_G0.7131.00
270_P273_E0.7101.00
148_T164_Q0.7101.00
28_T212_T0.7091.00
364_K383_R0.7081.00
330_P373_N0.7071.00
90_H158_K0.7051.00
223_D227_S0.7041.00
80_A200_L0.7031.00
403_L412_A0.7021.00
16_T32_A0.7021.00
249_E252_R0.7011.00
445_C449_L0.7001.00
418_E423_G0.6971.00
228_I233_V0.6961.00
417_A425_V0.6951.00
291_T295_I0.6941.00
182_I235_M0.6931.00
260_I275_C0.6891.00
7_N10_M0.6881.00
18_E30_T0.6881.00
226_H229_N0.6871.00
41_M45_L0.6861.00
177_A205_K0.6861.00
106_T110_F0.6851.00
229_N256_S0.6851.00
397_A400_E0.6821.00
51_R78_V0.6821.00
319_I369_G0.6821.00
283_F299_S0.6801.00
201_S237_S0.6791.00
57_A99_S0.6791.00
285_S294_Q0.6791.00
402_V444_Y0.6791.00
418_E422_W0.6771.00
172_S201_S0.6751.00
69_A73_C0.6751.00
59_L110_F0.6731.00
56_A103_F0.6711.00
12_R210_G0.6711.00
189_L227_S0.6701.00
196_H392_E0.6691.00
237_S285_S0.6681.00
244_A270_P0.6671.00
46_A139_A0.6661.00
188_W235_M0.6661.00
216_H224_V0.6651.00
13_A17_P0.6621.00
183_T258_R0.6601.00
168_N345_K0.6591.00
314_L317_C0.6591.00
190_I202_A0.6581.00
70_V204_F0.6561.00
46_A136_E0.6541.00
267_A282_V0.6521.00
369_G380_L0.6521.00
8_W170_Y0.6501.00
42_A72_A0.6501.00
43_E132_A0.6491.00
229_N255_E0.6471.00
88_S91_E0.6471.00
389_S426_P0.6461.00
413_G474_R0.6461.00
41_M44_Q0.6451.00
323_R335_E0.6451.00
51_R102_G0.6451.00
343_V363_L0.6431.00
136_E139_A0.6411.00
39_K136_E0.6401.00
24_Y217_Q0.6391.00
179_N315_F0.6381.00
327_V337_M0.6361.00
129_K132_A0.6361.00
228_I236_I0.6341.00
436_V441_L0.6331.00
110_F113_K0.6301.00
389_S422_W0.6301.00
52_K141_M0.6291.00
52_K139_A0.6291.00
396_P414_V0.6261.00
189_L228_I0.6261.00
288_M291_T0.6251.00
71_H204_F0.6251.00
410_A434_K0.6251.00
100_G348_F0.6251.00
465_P477_L0.6241.00
60_L69_A0.6231.00
47_A131_A0.6231.00
286_Y295_I0.6231.00
182_I211_M0.6231.00
430_L441_L0.6221.00
424_K478_K0.6221.00
38_S41_M0.6211.00
158_K350_R0.6191.00
191_A239_V0.6191.00
396_P474_R0.6181.00
202_A237_S0.6181.00
14_Q35_F0.6171.00
60_L105_L0.6171.00
29_V33_E0.6161.00
144_D345_K0.6151.00
174_V208_I0.6141.00
276_R281_P0.6131.00
148_T169_H0.6131.00
81_V151_Y0.6131.00
172_S294_Q0.6121.00
192_L237_S0.6111.00
98_D348_F0.6091.00
419_D422_W0.6081.00
321_I371_L0.6081.00
344_M357_S0.6081.00
46_A138_E0.6081.00
284_Q308_G0.6081.00
43_E136_E0.6071.00
429_Y459_F0.6071.00
225_L254_P0.6071.00
415_S478_K0.6061.00
409_V430_L0.6051.00
36_A133_E0.6021.00
106_T111_E0.6021.00
38_S42_A0.6011.00
201_S293_S0.6011.00
227_S230_R0.5991.00
47_A130_E0.5981.00
49_S78_V0.5971.00
108_S125_D0.5971.00
212_T231_H0.5951.00
40_R132_A0.5941.00
55_T349_N0.5941.00
173_A204_F0.5941.00
68_Y124_V0.5931.00
442_T445_C0.5921.00
60_L107_D0.5911.00
65_E107_D0.5911.00
288_M365_T0.5901.00
219_F224_V0.5891.00
40_R43_E0.5881.00
16_T210_G0.5861.00
403_L445_C0.5851.00
409_V412_A0.5841.00
22_L213_V0.5831.00
124_V128_M0.5821.00
31_F211_M0.5821.00
451_K454_I0.5821.00
8_W208_I0.5811.00
260_I280_F0.5801.00
350_R356_A0.5801.00
310_A369_G0.5791.00
148_T200_L0.5781.00
331_Y370_Y0.5771.00
224_V228_I0.5761.00
198_S261_L0.5761.00
23_I26_D0.5751.00
190_I213_V0.5751.00
384_S424_K0.5731.00
45_L103_F0.5731.00
266_P379_V0.5731.00
271_L274_E0.5721.00
149_L163_Q0.5721.00
16_T184_E0.5721.00
193_P196_H0.5711.00
459_F480_A0.5701.00
420_K423_G0.5691.00
402_V449_L0.5681.00
387_I416_G0.5681.00
267_A284_Q0.5661.00
60_L106_T0.5651.00
39_K46_A0.5651.00
20_I187_R0.5641.00
79_K348_F0.5641.00
432_L435_P0.5621.00
79_K149_L0.5621.00
70_V203_L0.5621.00
98_D161_G0.5611.00
321_I336_I0.5601.00
273_E276_R0.5601.00
262_L282_V0.5581.00
201_S294_Q0.5581.00
438_A457_K0.5581.00
236_I260_I0.5561.00
129_K133_E0.5551.00
174_V177_A0.5541.00
195_F392_E0.5531.00
400_E428_A0.5521.00
396_P416_G0.5521.00
399_V426_P0.5511.00
58_I73_C0.5501.00
188_W211_M0.5491.00
82_L150_M0.5491.00
250_T278_K0.5491.00
125_D129_K0.5481.00
401_S405_S0.5481.00
58_I66_M0.5471.00
275_C282_V0.5471.00
43_E47_A0.5471.00
454_I458_F0.5461.00
31_F207_V0.5431.00
408_A444_Y0.5431.00
406_H409_V0.5431.00
191_A238_A0.5431.00
411_E464_L0.5421.00
55_T101_S0.5421.00
333_H383_R0.5421.00
145_A166_F0.5411.00
7_N140_Y0.5411.00
263_G285_S0.5401.00
103_F120_Q0.5381.00
389_S424_K0.5381.00
43_E133_E0.5381.00
252_R278_K0.5371.00
296_V310_A0.5361.00
41_M124_V0.5361.00
346_S351_E0.5351.00
187_R190_I0.5341.00
457_K460_V0.5331.00
189_L224_V0.5331.00
174_V178_L0.5321.00
327_V371_L0.5321.00
99_S161_G0.5321.00
157_G395_Y0.5301.00
87_L92_R0.5281.00
285_S297_T0.5281.00
190_I215_L0.5271.00
50_V102_G0.5271.00
419_D423_G0.5241.00
401_S404_L0.5241.00
37_A41_M0.5241.00
298_L301_E0.5231.00
338_V343_V0.5231.00
190_I199_G0.5221.00
245_S248_E0.5221.00
79_K82_L0.5221.00
91_E398_E0.5191.00
417_A429_Y0.5191.00
332_E370_Y0.5181.00
22_L29_V0.5171.00
173_A205_K0.5171.00
237_S263_G0.5171.00
99_S149_L0.5171.00
44_Q128_M0.5161.00
182_I205_K0.5151.00
321_I334_G0.5141.00
10_M136_E0.5141.00
83_L96_L0.5121.00
37_A128_M0.5111.00
45_L78_V0.5091.00
137_I141_M0.5091.00
240_Q265_G0.5091.00
351_E354_N0.5081.00
381_D396_P0.5071.00
272_L276_R0.5071.00
412_A445_C0.5071.00
225_L246_L0.5061.00
238_A260_I0.5061.00
81_V95_Q0.5061.00
162_V289_T0.5061.00
273_E307_L0.5051.00
262_L284_Q0.5031.00
234_T256_S0.5031.00
228_I232_E0.5031.00
61_Q110_F0.5021.00
381_D397_A0.5021.00
156_T160_K0.5011.00
202_A206_S0.5001.00
318_E360_N0.5001.00
263_G294_Q0.5001.00
475_N478_K0.5001.00
9_L38_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tsyA 2 0.7922 100 0.106 Contact Map
2vsqA 1 0.9979 100 0.107 Contact Map
1mdbA 1 0.9897 100 0.111 Contact Map
3etcA 2 0.9547 100 0.112 Contact Map
3g7sA 2 0.9095 100 0.115 Contact Map
3o83A 1 0.7901 100 0.12 Contact Map
4lgcA 1 0.7572 100 0.121 Contact Map
1pg4A 1 0.9938 100 0.123 Contact Map
3ni2A 1 0.9856 100 0.124 Contact Map
1amuA 1 0.9774 100 0.125 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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