MEND - BACSU - GREMLIN Contacts

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MEND - 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

UniProt:	P23970	Sequences: MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHPDISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVLTADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQKRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAEAEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLKDDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIHCNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQHLVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAPVTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGTPTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDMLNEAVREVKKQWEL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	580 (532)
Sequences:	14267 (9114)
Seq/√Len:	395.1

ECOLI - ILVB OXC ILVI ILVG GCL POXB MEND
BACSU - MEND ILVX ILVB IOLD YDAP
HALSA - MEND
SULSO - Q7LXT8 Q97ZB3 Q97UP3 Q97U16 Q980V7 Q97V62 Q97XR3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
516_H	519_A	4.960	1.00
389_I	535_K	3.749	1.00
483_N	551_E	3.735	1.00
58_G	88_A	3.580	1.00
243_K	264_K	3.568	1.00
526_S	540_P	3.423	1.00
237_N	342_E	3.281	1.00
23_T	70_R	3.131	1.00
530_S	533_E	3.087	1.00
210_S	347_G	2.943	1.00
527_C	553_K	2.932	1.00
393_L	539_A	2.839	1.00
237_N	338_S	2.760	1.00
67_A	447_T	2.705	1.00
335_C	340_F	2.662	1.00
226_C	238_I	2.566	1.00
524_T	546_G	2.550	1.00
526_S	548_H	2.550	1.00
263_D	419_D	2.495	1.00
389_I	392_H	2.491	1.00
24_D	47_S	2.466	1.00
529_A	533_E	2.431	1.00
212_V	314_I	2.367	1.00
292_F	337_A	2.366	1.00
18_A	45_D	2.352	1.00
440_A	453_L	2.330	1.00
526_S	537_A	2.323	1.00
286_P	289_V	2.224	1.00
524_T	540_P	2.198	1.00
513_D	516_H	2.197	1.00
76_C	85_F	2.194	1.00
316_I	340_F	2.154	1.00
527_C	551_E	2.152	1.00
392_H	535_K	2.143	1.00
71_P	160_Q	2.139	1.00
11_G	39_L	2.105	1.00
291_R	294_P	2.070	1.00
461_Y	521_Y	2.069	1.00
100_I	156_A	2.064	1.00
51_Q	57_A	2.037	1.00
89_V	101_V	2.034	1.00
517_A	520_L	2.016	1.00
83_A	87_P	1.995	1.00
215_M	288_V	1.982	1.00
215_M	312_Q	1.976	1.00
215_M	331_H	1.964	1.00
224_I	242_S	1.961	1.00
103_T	168_H	1.940	1.00
515_K	525_Y	1.931	1.00
216_L	290_I	1.918	1.00
528_P	537_A	1.902	1.00
15_D	19_L	1.887	1.00
244_A	345_M	1.886	1.00
151_L	169_V	1.870	1.00
244_A	349_T	1.868	1.00
71_P	100_I	1.836	1.00
206_R	343_E	1.827	1.00
120_N	123_F	1.823	1.00
395_P	398_S	1.817	1.00
242_S	249_I	1.811	1.00
539_A	543_D	1.807	1.00
260_G	263_D	1.803	1.00
460_F	464_L	1.800	1.00
444_C	476_P	1.799	1.00
211_D	214_E	1.786	1.00
391_Q	416_E	1.768	1.00
62_L	66_K	1.764	1.00
471_K	523_G	1.761	1.00
11_G	42_A	1.756	1.00
240_A	244_A	1.741	1.00
524_T	548_H	1.740	1.00
533_E	536_T	1.739	1.00
535_K	539_A	1.739	1.00
214_E	218_E	1.732	1.00
123_F	126_G	1.726	1.00
205_D	208_S	1.716	1.00
481_L	549_L	1.709	1.00
224_I	290_I	1.697	1.00
541_Q	550_I	1.676	1.00
399_S	443_V	1.676	1.00
7_T	15_D	1.674	1.00
239_I	243_K	1.660	1.00
403_G	455_I	1.638	1.00
529_A	553_K	1.635	1.00
360_K	364_V	1.626	1.00
388_R	392_H	1.625	1.00
224_I	247_Y	1.617	1.00
236_E	240_A	1.599	1.00
390_L	454_V	1.591	1.00
137_L	147_Y	1.587	1.00
435_G	439_S	1.586	1.00
403_G	459_S	1.577	1.00
292_F	316_I	1.561	1.00
536_T	540_P	1.553	1.00
385_N	531_W	1.551	1.00
519_A	524_T	1.551	1.00
27_V	48_V	1.547	1.00
246_Q	266_T	1.542	1.00
37_A	48_V	1.541	1.00
15_D	18_A	1.539	1.00
323_R	334_H	1.530	1.00
285_R	360_K	1.529	1.00
425_Y	443_V	1.504	1.00
393_L	535_K	1.500	1.00
68_K	446_G	1.499	1.00
362_Q	365_N	1.497	1.00
208_S	211_D	1.493	1.00
515_K	527_C	1.488	1.00
129_V	168_H	1.488	1.00
444_C	475_I	1.482	1.00
357_W	361_W	1.477	1.00
13_F	171_V	1.470	1.00
130_K	165_G	1.450	1.00
249_I	259_N	1.450	1.00
355_S	359_E	1.449	1.00
359_E	363_F	1.442	1.00
16_E	153_S	1.441	1.00
213_A	347_G	1.441	1.00
219_A	222_G	1.438	1.00
385_N	389_I	1.435	1.00
536_T	539_A	1.435	1.00
470_A	523_G	1.434	1.00
467_L	523_G	1.426	1.00
312_Q	330_A	1.422	1.00
133_T	169_V	1.422	1.00
13_F	152_A	1.418	1.00
56_S	466_G	1.415	1.00
470_A	477_L	1.413	1.00
102_L	171_V	1.413	1.00
216_L	288_V	1.412	1.00
464_L	517_A	1.403	1.00
389_I	393_L	1.396	1.00
480_I	538_Y	1.395	1.00
480_I	550_I	1.381	1.00
395_P	450_P	1.372	1.00
51_Q	60_F	1.371	1.00
108_H	174_R	1.370	1.00
398_S	450_P	1.369	1.00
386_L	552_I	1.364	1.00
240_A	345_M	1.364	1.00
85_F	101_V	1.363	1.00
20_S	156_A	1.353	1.00
399_S	447_T	1.351	1.00
71_P	156_A	1.351	1.00
47_S	473_L	1.350	1.00
138_P	178_M	1.344	1.00
89_V	99_I	1.344	1.00
445_E	475_I	1.337	1.00
452_T	542_A	1.335	1.00
24_D	445_E	1.324	1.00
100_I	159_A	1.321	1.00
241_L	245_L	1.318	1.00
213_A	344_I	1.317	1.00
444_C	450_P	1.315	1.00
423_R	449_A	1.312	1.00
480_I	552_I	1.309	1.00
219_A	288_V	1.304	1.00
394_V	452_T	1.300	1.00
20_S	153_S	1.297	1.00
58_G	85_F	1.289	1.00
209_L	347_G	1.285	1.00
288_V	314_I	1.282	1.00
238_I	341_A	1.282	1.00
204_V	340_F	1.281	1.00
241_L	345_M	1.280	1.00
450_P	542_A	1.279	1.00
223_M	286_P	1.279	1.00
82_A	103_T	1.279	1.00
478_T	541_Q	1.276	1.00
396_E	419_D	1.273	1.00
515_K	519_A	1.272	1.00
292_F	341_A	1.271	1.00
441_M	470_A	1.271	1.00
18_A	44_P	1.268	1.00
241_L	341_A	1.265	1.00
476_P	546_G	1.257	1.00
147_Y	150_T	1.256	1.00
517_A	521_Y	1.256	1.00
365_N	369_R	1.246	1.00
381_S	552_I	1.245	1.00
453_L	479_V	1.234	1.00
338_S	342_E	1.231	1.00
135_S	148_I	1.231	1.00
476_P	545_P	1.228	1.00
210_S	214_E	1.225	1.00
433_I	462_H	1.224	1.00
152_A	169_V	1.224	1.00
363_F	367_R	1.223	1.00
324_D	329_S	1.218	1.00
516_H	520_L	1.217	1.00
336_N	339_V	1.209	1.00
49_H	445_E	1.202	1.00
239_I	260_G	1.199	1.00
26_V	64_L	1.199	1.00
10_I	39_L	1.197	1.00
523_G	549_L	1.197	1.00
485_D	511_G	1.195	1.00
381_S	386_L	1.193	1.00
534_F	552_I	1.191	1.00
150_T	154_R	1.191	1.00
206_R	347_G	1.186	1.00
362_Q	366_G	1.180	1.00
64_L	446_G	1.179	1.00
518_A	523_G	1.173	1.00
62_L	91_E	1.173	1.00
339_V	342_E	1.171	1.00
213_A	217_A	1.171	1.00
240_A	243_K	1.168	1.00
65_A	98_P	1.165	1.00
211_D	215_M	1.163	1.00
23_T	47_S	1.162	1.00
16_E	152_A	1.160	1.00
399_S	451_V	1.156	1.00
25_A	40_C	1.155	1.00
8_H	11_G	1.152	1.00
237_N	345_M	1.152	1.00
172_P	175_E	1.152	1.00
343_E	346_A	1.150	1.00
90_V	430_A	1.150	1.00
9_Y	148_I	1.148	1.00
203_S	343_E	1.136	1.00
230_H	238_I	1.135	1.00
22_I	73_L	1.135	1.00
518_A	549_L	1.132	1.00
366_G	370_E	1.129	1.00
109_E	174_R	1.129	1.00
224_I	241_L	1.126	1.00
239_I	259_N	1.123	1.00
237_N	240_A	1.122	1.00
251_A	267_V	1.121	1.00
67_A	443_V	1.119	1.00
526_S	550_I	1.118	1.00
537_A	550_I	1.115	1.00
468_L	472_K	1.114	1.00
12_S	180_D	1.112	1.00
133_T	154_R	1.110	1.00
62_L	97_V	1.105	1.00
396_E	420_R	1.103	1.00
158_E	167_V	1.101	1.00
212_V	331_H	1.097	1.00
8_H	179_P	1.095	1.00
359_E	362_Q	1.093	1.00
524_T	544_K	1.079	1.00
222_G	287_D	1.078	1.00
242_S	259_N	1.077	1.00
56_S	463_D	1.077	1.00
239_I	264_K	1.076	1.00
240_A	342_E	1.074	1.00
534_F	538_Y	1.073	1.00
39_L	42_A	1.072	1.00
108_H	178_M	1.072	1.00
212_V	333_I	1.070	1.00
236_E	239_I	1.069	1.00
221_K	285_R	1.068	1.00
93_H	166_P	1.068	1.00
83_A	124_L	1.065	1.00
268_I	282_R	1.062	1.00
217_A	349_T	1.061	1.00
24_D	49_H	1.055	1.00
12_S	149_R	1.055	1.00
135_S	151_L	1.053	1.00
74_L	85_F	1.053	1.00
204_V	343_E	1.051	1.00
444_C	451_V	1.049	1.00
224_I	238_I	1.045	1.00
303_L	306_K	1.044	1.00
226_C	230_H	1.044	1.00
256_N	262_H	1.044	1.00
243_K	266_T	1.044	1.00
525_Y	549_L	1.043	1.00
63_G	67_A	1.043	1.00
213_A	348_L	1.041	1.00
133_T	151_L	1.040	1.00
363_F	366_G	1.040	1.00
13_F	102_L	1.039	1.00
518_A	525_Y	1.035	1.00
329_S	332_M	1.034	1.00
250_L	268_I	1.034	1.00
33_S	36_L	1.032	1.00
242_S	266_T	1.029	1.00
217_A	348_L	1.028	1.00
450_P	478_T	1.028	1.00
58_G	74_L	1.025	1.00
49_H	473_L	1.022	1.00
291_R	296_P	1.021	1.00
397_N	449_A	1.017	1.00
478_T	548_H	1.016	1.00
7_T	179_P	1.007	1.00
183_D	186_F	1.005	1.00
485_D	553_K	1.005	1.00
86_Y	124_L	1.004	1.00
218_E	312_Q	1.002	1.00
394_V	400_L	1.000	1.00
111_R	134_D	0.999	1.00
339_V	343_E	0.992	1.00
444_C	448_K	0.991	1.00
223_M	250_L	0.991	1.00
460_F	481_L	0.990	1.00
400_L	415_F	0.987	1.00
540_P	543_D	0.986	1.00
132_F	168_H	0.984	1.00
528_P	534_F	0.984	1.00
401_F	451_V	0.983	1.00
160_Q	164_M	0.982	1.00
544_K	548_H	0.982	1.00
528_P	533_E	0.978	1.00
259_N	264_K	0.974	1.00
481_L	514_F	0.974	1.00
203_S	339_V	0.974	1.00
436_V	453_L	0.973	1.00
240_A	349_T	0.966	1.00
13_F	36_L	0.966	1.00
76_C	101_V	0.965	1.00
401_F	453_L	0.962	1.00
467_L	549_L	0.959	1.00
437_V	460_F	0.959	1.00
237_N	341_A	0.954	1.00
360_K	363_F	0.954	1.00
235_K	239_I	0.946	1.00
86_Y	128_F	0.945	1.00
387_Y	454_V	0.940	1.00
382_F	558_S	0.939	1.00
523_G	547_L	0.939	1.00
515_K	551_E	0.938	1.00
219_A	287_D	0.938	1.00
25_A	73_L	0.937	1.00
74_L	101_V	0.935	1.00
70_R	160_Q	0.932	1.00
482_V	554_T	0.932	1.00
11_G	15_D	0.926	1.00
40_C	46_I	0.926	1.00
464_L	521_Y	0.926	1.00
207_E	210_S	0.926	1.00
541_Q	548_H	0.924	1.00
36_L	171_V	0.920	1.00
105_D	170_N	0.920	1.00
467_L	479_V	0.916	1.00
478_T	542_A	0.914	1.00
58_G	99_I	0.913	1.00
474_G	545_P	0.912	1.00
241_L	348_L	0.912	1.00
154_R	158_E	0.912	1.00
386_L	482_V	0.911	1.00
82_A	125_F	0.911	1.00
468_L	521_Y	0.907	1.00
66_K	97_V	0.907	1.00
184_E	187_G	0.904	1.00
206_R	210_S	0.903	1.00
420_R	423_R	0.903	1.00
212_V	288_V	0.902	1.00
537_A	541_Q	0.901	1.00
385_N	534_F	0.901	1.00
223_M	289_V	0.901	1.00
393_L	538_Y	0.896	1.00
308_D	311_I	0.896	1.00
83_A	90_V	0.895	1.00
218_E	288_V	0.892	1.00
444_C	546_G	0.889	1.00
460_F	549_L	0.889	1.00
214_E	217_A	0.886	1.00
533_E	537_A	0.886	1.00
358_L	362_Q	0.886	1.00
38_V	41_A	0.885	1.00
470_A	479_V	0.884	1.00
361_W	364_V	0.884	1.00
519_A	525_Y	0.879	1.00
16_E	20_S	0.878	1.00
442_G	446_G	0.873	1.00
124_L	128_F	0.871	1.00
60_F	470_A	0.871	1.00
478_T	550_I	0.870	1.00
361_W	365_N	0.870	1.00
411_V	454_V	0.868	1.00
391_Q	415_F	0.868	1.00
458_L	487_G	0.868	1.00
354_S	358_L	0.866	1.00
281_K	285_R	0.866	1.00
7_T	12_S	0.864	1.00
63_G	439_S	0.863	1.00
212_V	215_M	0.863	1.00
129_V	132_F	0.860	1.00
470_A	547_L	0.859	1.00
131_F	158_E	0.858	1.00
262_H	267_V	0.857	1.00
224_I	292_F	0.852	1.00
281_K	284_L	0.849	1.00
333_I	340_F	0.848	1.00
89_V	125_F	0.847	1.00
477_L	547_L	0.845	1.00
86_Y	125_F	0.845	1.00
537_A	540_P	0.844	1.00
96_R	163_P	0.844	1.00
215_M	314_I	0.844	1.00
122_H	132_F	0.843	1.00
485_D	556_R	0.842	1.00
16_E	19_L	0.842	1.00
472_K	510_T	0.841	1.00
316_I	333_I	0.840	1.00
387_Y	482_V	0.837	1.00
24_D	64_L	0.833	1.00
221_K	287_D	0.833	1.00
398_S	452_T	0.831	1.00
540_P	544_K	0.830	1.00
454_V	482_V	0.825	1.00
73_L	100_I	0.824	1.00
8_H	39_L	0.824	1.00
389_I	534_F	0.824	1.00
288_V	312_Q	0.820	1.00
277_D	281_K	0.820	1.00
87_P	432_G	0.819	1.00
234_D	237_N	0.816	1.00
209_L	343_E	0.816	1.00
393_L	542_A	0.815	1.00
263_D	396_E	0.813	1.00
502_F	505_L	0.812	1.00
35_P	177_L	0.810	1.00
320_G	334_H	0.803	1.00
343_E	347_G	0.803	1.00
122_H	134_D	0.801	1.00
280_L	284_L	0.800	1.00
67_A	425_Y	0.800	1.00
226_C	251_A	0.799	1.00
230_H	258_R	0.799	1.00
171_V	176_P	0.799	1.00
452_T	480_I	0.798	1.00
100_I	160_Q	0.796	1.00
204_V	209_L	0.792	1.00
245_L	348_L	0.792	1.00
483_N	553_K	0.792	1.00
323_R	332_M	0.790	1.00
212_V	340_F	0.788	1.00
17_F	73_L	0.788	1.00
397_N	420_R	0.787	1.00
217_A	346_A	0.787	1.00
441_M	475_I	0.786	1.00
159_A	167_V	0.786	1.00
131_F	151_L	0.785	1.00
513_D	527_C	0.785	1.00
513_D	519_A	0.785	1.00
342_E	346_A	0.784	1.00
59_F	432_G	0.783	1.00
506_F	509_P	0.780	1.00
356_E	359_E	0.779	1.00
64_L	70_R	0.778	1.00
461_Y	464_L	0.778	1.00
29_P	50_V	0.778	1.00
478_T	545_P	0.777	1.00
226_C	249_I	0.774	1.00
23_T	64_L	0.774	1.00
471_K	547_L	0.772	1.00
9_Y	138_P	0.771	1.00
532_D	536_T	0.765	1.00
25_A	75_I	0.764	1.00
75_I	102_L	0.764	1.00
407_P	459_S	0.764	1.00
33_S	75_I	0.764	1.00
105_D	111_R	0.763	1.00
301_V	304_W	0.760	1.00
130_K	167_V	0.758	1.00
364_V	368_F	0.758	1.00
89_V	128_F	0.757	1.00
387_Y	415_F	0.757	1.00
65_A	99_I	0.756	1.00
67_A	446_G	0.754	1.00
211_D	331_H	0.752	1.00
394_V	398_S	0.752	1.00
381_S	531_W	0.751	1.00
290_I	316_I	0.750	1.00
65_A	97_V	0.747	1.00
437_V	479_V	0.746	1.00
33_S	37_A	0.744	1.00
22_I	156_A	0.741	1.00
402_V	424_I	0.740	1.00
51_Q	56_S	0.739	1.00
26_V	60_F	0.739	1.00
20_S	160_Q	0.738	1.00
525_Y	551_E	0.738	1.00
222_G	247_Y	0.737	1.00
55_R	84_N	0.737	1.00
18_A	23_T	0.736	1.00
440_A	477_L	0.736	1.00
356_E	360_K	0.734	1.00
364_V	367_R	0.733	1.00
450_P	476_P	0.729	1.00
471_K	510_T	0.725	1.00
228_E	254_L	0.725	1.00
23_T	45_D	0.725	1.00
217_A	347_G	0.724	1.00
340_F	343_E	0.723	1.00
131_F	167_V	0.721	1.00
461_Y	512_L	0.721	1.00
454_V	480_I	0.719	1.00
28_C	85_F	0.719	1.00
365_N	368_F	0.718	1.00
491_S	495_Q	0.718	1.00
402_V	426_S	0.718	1.00
36_L	176_P	0.718	1.00
479_V	523_G	0.718	1.00
204_V	339_V	0.717	1.00
315_V	329_S	0.716	1.00
77_T	117_Q	0.715	1.00
123_F	127_N	0.714	1.00
491_S	508_T	0.712	1.00
103_T	170_N	0.712	1.00
235_K	421_P	0.711	1.00
342_E	345_M	0.710	1.00
234_D	338_S	0.709	1.00
76_C	103_T	0.705	1.00
480_I	534_F	0.702	1.00
381_S	530_S	0.701	1.00
208_S	212_V	0.700	1.00
38_V	42_A	0.700	1.00
83_A	86_Y	0.698	1.00
131_F	155_A	0.697	1.00
149_R	153_S	0.697	1.00
471_K	522_G	0.697	1.00
131_F	154_R	0.696	1.00
366_G	369_R	0.696	1.00
345_M	349_T	0.696	1.00
403_G	436_V	0.696	1.00
224_I	249_I	0.695	1.00
97_V	435_G	0.693	1.00
233_A	422_F	0.693	1.00
138_P	149_R	0.693	1.00
470_A	475_I	0.693	1.00
271_Y	283_K	0.692	1.00
391_Q	419_D	0.692	1.00
373_Q	388_R	0.690	1.00
253_P	412_D	0.690	1.00
402_V	411_V	0.689	1.00
134_D	170_N	0.681	0.99
58_G	101_V	0.681	0.99
217_A	351_A	0.680	0.99
452_T	478_T	0.680	0.99
246_Q	265_S	0.679	0.99
260_G	419_D	0.678	0.99
401_F	443_V	0.677	0.99
158_E	163_P	0.677	0.99
437_V	455_I	0.676	0.99
245_L	266_T	0.673	0.99
259_N	267_V	0.673	0.99
14_I	44_P	0.673	0.99
215_M	218_E	0.672	0.99
138_P	180_D	0.672	0.99
208_S	333_I	0.672	0.99
251_A	262_H	0.671	0.99
486_G	491_S	0.670	0.99
386_L	480_I	0.670	0.99
90_V	128_F	0.670	0.99
437_V	466_G	0.668	0.99
108_H	172_P	0.668	0.99
223_M	283_K	0.667	0.99
460_F	514_F	0.666	0.99
125_F	168_H	0.665	0.99
151_L	154_R	0.664	0.99
528_P	550_I	0.664	0.99
453_L	459_S	0.664	0.99
225_V	291_R	0.663	0.99
36_L	75_I	0.662	0.99
183_D	187_G	0.662	0.99
461_Y	514_F	0.661	0.99
222_G	288_V	0.660	0.99
346_A	349_T	0.660	0.99
201_T	336_N	0.656	0.99
92_A	99_I	0.656	0.99
523_G	546_G	0.655	0.99
257_L	262_H	0.653	0.99
220_E	287_D	0.651	0.99
64_L	68_K	0.650	0.99
93_H	130_K	0.650	0.99
112_E	118_A	0.650	0.99
195_V	198_K	0.649	0.99
304_W	307_D	0.648	0.99
504_D	508_T	0.646	0.99
154_R	157_G	0.644	0.99
370_E	373_Q	0.641	0.99
108_H	136_A	0.641	0.99
545_P	548_H	0.641	0.99
237_N	241_L	0.640	0.99
35_P	176_P	0.640	0.99
24_D	70_R	0.640	0.99
441_M	469_A	0.638	0.99
59_F	91_E	0.638	0.99
25_A	46_I	0.637	0.99
260_G	264_K	0.637	0.99
476_P	547_L	0.636	0.99
512_L	520_L	0.636	0.99
47_S	448_K	0.635	0.99
445_E	473_L	0.634	0.99
323_R	329_S	0.633	0.99
513_D	551_E	0.632	0.99
84_N	87_P	0.631	0.99
138_P	175_E	0.631	0.99
52_I	472_K	0.630	0.99
340_F	344_I	0.630	0.99
440_A	451_V	0.630	0.99
76_C	82_A	0.630	0.99
291_R	313_Q	0.629	0.99
537_A	548_H	0.629	0.99
379_D	531_W	0.628	0.99
216_L	245_L	0.628	0.99
242_S	245_L	0.625	0.99
229_L	317_D	0.623	0.99
357_W	360_K	0.623	0.99
379_D	530_S	0.623	0.99
266_T	358_L	0.622	0.99
155_A	169_V	0.621	0.99
390_L	480_I	0.621	0.99
386_L	534_F	0.620	0.99
337_A	342_E	0.620	0.99
63_G	442_G	0.619	0.99
64_L	72_V	0.619	0.99
238_I	242_S	0.618	0.99
505_L	508_T	0.617	0.99
157_G	161_K	0.616	0.99
221_K	357_W	0.616	0.99
9_Y	12_S	0.615	0.99
438_S	466_G	0.613	0.99
397_N	450_P	0.613	0.99
225_V	252_D	0.612	0.99
361_W	369_R	0.610	0.99
354_S	357_W	0.610	0.99
203_S	206_R	0.607	0.99
526_S	544_K	0.607	0.99
204_V	335_C	0.607	0.99
209_L	344_I	0.606	0.99
239_I	420_R	0.606	0.99
265_S	362_Q	0.606	0.99
100_I	169_V	0.606	0.99
100_I	167_V	0.605	0.99
401_F	425_Y	0.605	0.99
530_S	536_T	0.605	0.99
116_P	431_N	0.605	0.99
147_Y	151_L	0.602	0.99
272_D	275_L	0.602	0.99
94_Y	430_A	0.602	0.99
401_F	436_V	0.602	0.99
358_L	361_W	0.601	0.99
174_R	178_M	0.600	0.99
232_D	336_N	0.600	0.99
455_I	463_D	0.600	0.99
139_E	147_Y	0.598	0.99
478_T	546_G	0.598	0.99
437_V	470_A	0.598	0.99
399_S	449_A	0.596	0.99
130_K	161_K	0.596	0.99
130_K	158_E	0.594	0.99
455_I	479_V	0.594	0.99
443_V	451_V	0.594	0.99
385_N	535_K	0.593	0.99
7_T	11_G	0.592	0.98
83_A	119_I	0.591	0.98
23_T	68_K	0.590	0.98
314_I	331_H	0.590	0.98
121_Q	168_H	0.589	0.98
53_D	84_N	0.588	0.98
425_Y	435_G	0.587	0.98
135_S	172_P	0.586	0.98
512_L	517_A	0.586	0.98
60_F	445_E	0.584	0.98
225_V	294_P	0.584	0.98
399_S	425_Y	0.583	0.98
102_L	169_V	0.582	0.98
108_H	175_E	0.582	0.98
220_E	354_S	0.581	0.98
368_F	371_H	0.578	0.98
18_A	46_I	0.577	0.98
246_Q	351_A	0.575	0.98
71_P	159_A	0.575	0.98
217_A	220_E	0.575	0.98
460_F	479_V	0.575	0.98
52_I	468_L	0.574	0.98
357_W	368_F	0.574	0.98
474_G	546_G	0.572	0.98
402_V	436_V	0.572	0.98
234_D	337_A	0.572	0.98
240_A	346_A	0.571	0.98
16_E	149_R	0.571	0.98
479_V	549_L	0.571	0.98
372_L	388_R	0.568	0.98
47_S	445_E	0.568	0.98
156_A	160_Q	0.568	0.98
461_Y	465_N	0.568	0.98
491_S	556_R	0.568	0.98
102_L	152_A	0.567	0.98
244_A	348_L	0.566	0.98
57_A	74_L	0.565	0.98
67_A	399_S	0.565	0.98
368_F	372_L	0.565	0.98
62_L	439_S	0.565	0.98
98_P	159_A	0.563	0.98
201_T	205_D	0.563	0.98
251_A	258_R	0.563	0.98
254_L	428_R	0.562	0.98
108_H	137_L	0.562	0.98
239_I	266_T	0.562	0.98
28_C	487_G	0.559	0.98
31_S	77_T	0.557	0.98
384_G	558_S	0.557	0.98
85_F	103_T	0.555	0.98
220_E	356_E	0.554	0.98
468_L	512_L	0.554	0.98
490_F	494_P	0.554	0.98
317_D	322_W	0.553	0.98
209_L	333_I	0.552	0.98
407_P	482_V	0.552	0.98
133_T	167_V	0.551	0.98
206_R	346_A	0.551	0.98
103_T	121_Q	0.551	0.98
205_D	339_V	0.551	0.98
130_K	163_P	0.549	0.98
513_D	520_L	0.549	0.98
538_Y	542_A	0.549	0.98
471_K	474_G	0.548	0.98
257_L	423_R	0.548	0.98
225_V	289_V	0.547	0.97
418_Q	423_R	0.546	0.97
469_A	475_I	0.546	0.97
540_P	548_H	0.545	0.97
236_E	243_K	0.545	0.97
85_F	88_A	0.545	0.97
387_Y	391_Q	0.545	0.97
30_G	77_T	0.544	0.97
464_L	520_L	0.543	0.97
91_E	95_S	0.543	0.97
524_T	545_P	0.542	0.97
377_S	532_D	0.542	0.97
58_G	89_V	0.540	0.97
49_H	469_A	0.540	0.97
16_E	156_A	0.540	0.97
526_S	536_T	0.540	0.97
28_C	51_Q	0.540	0.97
33_S	104_A	0.539	0.97
380_V	555_D	0.539	0.97
26_V	445_E	0.538	0.97
383_E	410_D	0.538	0.97
73_L	156_A	0.538	0.97
31_S	493_L	0.537	0.97
357_W	369_R	0.536	0.97
256_N	418_Q	0.536	0.97
14_I	40_C	0.536	0.97
212_V	290_I	0.536	0.97
282_R	361_W	0.535	0.97
239_I	249_I	0.535	0.97
528_P	536_T	0.534	0.97
322_W	325_P	0.534	0.97
478_T	544_K	0.533	0.97
228_E	295_M	0.532	0.97
214_E	351_A	0.532	0.97
208_S	331_H	0.532	0.97
201_T	339_V	0.532	0.97
65_A	71_P	0.531	0.97
212_V	344_I	0.531	0.97
239_I	242_S	0.530	0.97
65_A	72_V	0.530	0.97
9_Y	178_M	0.530	0.97
357_W	365_N	0.527	0.97
246_Q	354_S	0.525	0.97
279_E	284_L	0.524	0.97
41_A	503_E	0.523	0.97
466_G	469_A	0.523	0.97
75_I	78_S	0.523	0.97
122_H	126_G	0.522	0.97
490_F	493_L	0.521	0.97
107_P	110_L	0.521	0.97
519_A	526_S	0.520	0.97
455_I	459_S	0.517	0.96
66_K	95_S	0.517	0.96
531_W	535_K	0.516	0.96
397_N	421_P	0.516	0.96
402_V	405_S	0.516	0.96
403_G	453_L	0.515	0.96
313_Q	327_Q	0.514	0.96
387_Y	411_V	0.514	0.96
217_A	352_T	0.512	0.96
163_P	319_D	0.512	0.96
398_S	449_A	0.510	0.96
246_Q	358_L	0.509	0.96
149_R	152_A	0.509	0.96
157_G	160_Q	0.508	0.96
411_V	424_I	0.508	0.96
55_R	463_D	0.507	0.96
394_V	542_A	0.505	0.96
21_G	70_R	0.505	0.96
444_C	447_T	0.504	0.96
438_S	463_D	0.504	0.96
367_R	370_E	0.503	0.96
437_V	464_L	0.503	0.96
90_V	119_I	0.503	0.96
59_F	88_A	0.502	0.96
104_A	176_P	0.502	0.96
125_F	132_F	0.502	0.96
467_L	471_K	0.502	0.96
483_N	514_F	0.501	0.96
401_F	439_S	0.501	0.96
93_H	165_G	0.501	0.96
255_S	258_R	0.500	0.96
251_A	256_N	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2x7jA	4	0.9966	100	0.161	Contact Map
1ozhA	4	0.9328	100	0.179	Contact Map
1ybhA	4	0.9638	100	0.179	Contact Map
3lq1A	4	0.8862	100	0.18	Contact Map
1t9bA	2	0.9672	100	0.183	Contact Map
2panA	3	0.9603	100	0.184	Contact Map
4rjjA	5	0.9431	100	0.19	Contact Map
2uz1A	4	0.9345	100	0.191	Contact Map
2ihtA	4	0.9276	100	0.192	Contact Map
3eyaA	5	0.9052	100	0.194	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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