GREMLIN Database
MENB - 1,4-dihydroxy-2-naphthoyl-CoA synthase
UniProt: P23966 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 271 (248)
Sequences: 30094 (19722)
Seq/√Len: 1252.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_I175_Q3.1831.00
189_T199_E2.9641.00
132_A187_V2.9191.00
134_D192_P2.8331.00
110_A127_C2.8121.00
199_E202_K2.6781.00
23_K201_I2.6351.00
48_A100_L2.4801.00
51_R105_P2.3941.00
135_N193_L2.3251.00
174_R206_E2.2841.00
32_H67_K2.2451.00
17_T22_A2.2211.00
180_E183_D2.1801.00
14_L27_N2.0941.00
23_K62_A2.0781.00
168_E174_R2.0711.00
177_N180_E2.0631.00
228_G231_G2.0201.00
144_K210_K1.9911.00
170_W218_L1.9841.00
44_I100_L1.9501.00
165_K184_M1.9441.00
111_M200_T1.9391.00
20_G57_G1.9301.00
15_Y22_A1.9081.00
25_T64_A1.8991.00
111_M197_E1.8831.00
17_T53_D1.8791.00
32_H68_A1.8421.00
25_T62_A1.8281.00
254_D258_E1.8231.00
27_N64_A1.8221.00
201_I205_E1.7651.00
117_I139_G1.7591.00
131_I191_V1.7561.00
167_R223_N1.7451.00
22_A50_A1.7201.00
134_D179_Q1.7131.00
168_E188_N1.6941.00
195_Q198_E1.6811.00
38_K42_E1.6781.00
251_E260_R1.6501.00
22_A56_V1.6381.00
163_H167_R1.6331.00
180_E184_M1.6101.00
59_I104_I1.6071.00
128_D219_K1.5851.00
49_D53_D1.5781.00
12_E42_E1.5711.00
168_E189_T1.5321.00
179_Q183_D1.5291.00
131_I203_W1.5211.00
132_A138_F1.5171.00
51_R100_L1.4961.00
50_A59_I1.4911.00
191_V199_E1.4841.00
12_E36_T1.4811.00
41_A93_N1.4781.00
133_A193_L1.4661.00
18_Y201_I1.4481.00
99_R103_V1.4441.00
195_Q199_E1.4341.00
112_V124_H1.4321.00
124_H130_T1.4211.00
24_I46_A1.4201.00
130_T164_K1.4131.00
130_T160_I1.4101.00
167_R171_Y1.3951.00
14_L64_A1.3951.00
134_D193_L1.3931.00
44_I48_A1.3921.00
99_R230_A1.3771.00
113_S133_A1.3681.00
19_N205_E1.3641.00
121_H140_Q1.3541.00
58_V204_C1.3521.00
217_F242_L1.3491.00
15_Y50_A1.3381.00
167_R222_F1.3351.00
113_S135_N1.3301.00
165_K168_E1.3281.00
182_L190_V1.3261.00
47_F104_I1.3241.00
169_I176_Y1.3171.00
102_R156_Y1.3151.00
174_R180_E1.2931.00
112_V116_A1.2751.00
18_Y23_K1.2681.00
18_Y205_E1.2581.00
68_A115_Y1.2521.00
115_Y137_I1.2491.00
101_I108_V1.2451.00
44_I96_D1.2391.00
164_K188_N1.2381.00
67_K113_S1.2371.00
62_A113_S1.2321.00
139_G175_Q1.2191.00
37_P77_V1.2181.00
23_K197_E1.2161.00
210_K215_L1.1991.00
62_A197_E1.1971.00
51_R104_I1.1931.00
165_K180_E1.1821.00
16_E25_T1.1731.00
122_V153_G1.1711.00
17_T55_N1.1711.00
220_A224_A1.1641.00
36_T39_T1.1571.00
197_E201_I1.1571.00
28_R31_V1.1501.00
42_E46_A1.1321.00
196_L200_T1.1321.00
249_A253_R1.1271.00
26_I39_T1.1211.00
133_A196_L1.1191.00
224_A235_F1.1141.00
16_E23_K1.1141.00
143_P173_C1.0961.00
197_E200_T1.0911.00
94_V151_G1.0901.00
176_Y184_M1.0841.00
178_A190_V1.0791.00
14_L25_T1.0791.00
26_I70_C1.0791.00
103_V230_A1.0691.00
213_T248_E1.0651.00
31_V76_K1.0591.00
12_E38_K1.0551.00
17_T49_D1.0521.00
37_P41_A1.0501.00
162_G165_K1.0421.00
108_V127_C1.0261.00
59_I106_K1.0211.00
46_A49_D1.0121.00
204_C208_L0.9981.00
42_E45_D0.9951.00
62_A111_M0.9941.00
105_P216_R0.9891.00
198_E202_K0.9861.00
160_I164_K0.9851.00
161_V165_K0.9821.00
70_C120_G0.9701.00
192_P195_Q0.9681.00
129_L203_W0.9631.00
59_I108_V0.9581.00
111_M196_L0.9531.00
21_I58_V0.9521.00
179_Q182_L0.9501.00
45_D49_D0.9411.00
250_K254_D0.9401.00
28_R74_D0.9291.00
121_H138_F0.9261.00
217_F220_A0.9241.00
163_H226_T0.9201.00
56_V106_K0.9181.00
60_V200_T0.9141.00
220_A239_A0.9131.00
65_G113_S0.9111.00
212_P216_R0.9111.00
235_F238_D0.9091.00
231_G234_Q0.9071.00
137_I177_N0.8941.00
143_P218_L0.8861.00
182_L187_V0.8831.00
217_F239_A0.8751.00
133_A194_E0.8741.00
40_V97_L0.8721.00
148_F243_Y0.8671.00
155_G232_I0.8611.00
23_K60_V0.8511.00
112_V138_F0.8511.00
113_S193_L0.8471.00
134_D190_V0.8431.00
154_S236_A0.8411.00
117_I175_Q0.8401.00
113_S196_L0.8351.00
201_I204_C0.8251.00
24_I59_I0.8091.00
182_L189_T0.8081.00
32_H71_S0.8081.00
44_I93_N0.8071.00
169_I184_M0.8061.00
199_E203_W0.8051.00
76_K257_K0.8021.00
17_T56_V0.8021.00
54_Q106_K0.8001.00
170_W222_F0.8001.00
112_V130_T0.7961.00
200_T204_C0.7941.00
47_F101_I0.7891.00
217_F243_Y0.7871.00
122_V142_G0.7861.00
202_K206_E0.7851.00
206_E210_K0.7811.00
129_L188_N0.7811.00
235_F239_A0.7791.00
161_V169_I0.7791.00
144_K175_Q0.7781.00
157_L161_V0.7771.00
51_R106_K0.7751.00
239_A242_L0.7741.00
209_E261_K0.7721.00
48_A52_D0.7711.00
37_P93_N0.7691.00
98_Q126_V0.7681.00
198_E201_I0.7681.00
44_I97_L0.7591.00
13_I46_A0.7531.00
189_T203_W0.7511.00
28_R36_T0.7491.00
229_L233_Q0.7471.00
61_L127_C0.7471.00
178_A187_V0.7441.00
168_E172_L0.7411.00
221_A239_A0.7411.00
12_E39_T0.7401.00
155_G158_A0.7371.00
41_A45_D0.7371.00
48_A96_D0.7361.00
207_M215_L0.7341.00
35_F39_T0.7331.00
15_Y46_A0.7301.00
247_D250_K0.7281.00
211_S248_E0.7271.00
105_P220_A0.7221.00
162_G166_A0.7181.00
125_I186_L0.7161.00
131_I189_T0.7161.00
82_G85_G0.7151.00
181_A186_L0.7131.00
118_G141_T0.7131.00
68_A113_S0.7111.00
202_K205_E0.7091.00
163_H223_N0.7061.00
50_A56_V0.7021.00
253_R257_K0.6931.00
36_T77_V0.6891.00
148_F221_A0.6891.00
142_G150_A0.6861.00
79_G254_D0.6861.00
237_G241_L0.6801.00
92_L96_D0.6791.00
172_L203_W0.6781.00
165_K182_L0.6781.00
57_G212_P0.6771.00
205_E209_E0.6751.00
138_F187_V0.6721.00
60_V111_M0.6721.00
149_D218_L0.6661.00
112_V136_A0.6651.00
32_H115_Y0.6651.00
21_I60_V0.6621.00
92_L237_G0.6621.00
104_I108_V0.6611.00
221_A235_F0.6601.00
48_A51_R0.6601.00
140_Q153_G0.6581.00
15_Y49_D0.6581.00
46_A50_A0.6571.00
117_I141_T0.6561.00
203_W206_E0.6521.00
191_V196_L0.6491.00
213_T246_T0.6461.00
234_Q238_D0.6451.00
230_A234_Q0.6451.00
61_L108_V0.6421.00
73_G78_R0.6421.00
187_V190_V0.6361.00
163_H222_F0.6341.00
28_R34_A0.6341.00
38_K41_A0.6321.00
139_G173_C0.6271.00
17_T20_G0.6261.00
104_I107_P0.6251.00
53_D56_V0.6251.00
20_G55_N0.6231.00
142_G149_D0.6221.00
171_Y215_L0.6211.00
31_V74_D0.6201.00
115_Y175_Q0.6201.00
58_V208_L0.6191.00
131_I200_T0.6161.00
176_Y181_A0.6141.00
179_Q190_V0.6141.00
57_G208_L0.6131.00
132_A136_A0.6121.00
109_V204_C0.6041.00
21_I204_C0.6041.00
53_D106_K0.6011.00
251_E255_S0.6011.00
110_A130_T0.6011.00
96_D99_R0.6001.00
39_T42_E0.5991.00
21_I201_I0.5971.00
213_T243_Y0.5961.00
247_D251_E0.5961.00
96_D100_L0.5951.00
212_P215_L0.5951.00
142_G240_T0.5951.00
45_D48_A0.5931.00
155_G159_R0.5931.00
238_D242_L0.5921.00
122_V150_A0.5901.00
60_V201_I0.5891.00
58_V109_V0.5871.00
88_Q92_L0.5871.00
218_L221_A0.5791.00
124_H127_C0.5781.00
168_E180_E0.5771.00
50_A106_K0.5761.00
251_E254_D0.5741.00
31_V34_A0.5741.00
140_Q170_W0.5691.00
147_S249_A0.5691.00
254_D257_K0.5681.00
131_I196_L0.5661.00
131_I199_E0.5651.00
121_H186_L0.5651.00
161_V166_A0.5641.00
24_I61_L0.5631.00
160_I188_N0.5631.00
47_F108_V0.5611.00
12_E28_R0.5601.00
43_M97_L0.5571.00
165_K183_D0.5551.00
118_G140_Q0.5551.00
172_L207_M0.5551.00
172_L206_E0.5521.00
15_Y24_I0.5501.00
154_S232_I0.5491.00
47_F100_L0.5491.00
38_K77_V0.5481.00
122_V140_Q0.5471.00
79_G257_K0.5471.00
129_L207_M0.5461.00
219_K223_N0.5451.00
130_T187_V0.5421.00
35_F119_G0.5411.00
65_G68_A0.5391.00
75_Q145_V0.5371.00
135_N178_A0.5371.00
248_E252_G0.5361.00
110_A124_H0.5361.00
24_I50_A0.5331.00
177_N183_D0.5321.00
93_N96_D0.5321.00
40_V44_I0.5301.00
56_V59_I0.5281.00
161_V184_M0.5251.00
126_V156_Y0.5241.00
159_R228_G0.5221.00
206_E209_E0.5211.00
167_R219_K0.5211.00
168_E203_W0.5201.00
146_G211_S0.5181.00
24_I47_F0.5181.00
143_P215_L0.5181.00
102_R223_N0.5161.00
195_Q202_K0.5151.00
148_F240_T0.5151.00
174_R189_T0.5131.00
143_P210_K0.5111.00
79_G253_R0.5081.00
158_A225_D0.5081.00
121_H125_I0.5071.00
164_K167_R0.5071.00
138_F181_A0.5071.00
133_A136_A0.5021.00
25_T197_E0.5021.00
111_M204_C0.5021.00
102_R229_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2uzfA 5 0.952 100 0.097 Contact Map
4lk5A 3 0.9188 100 0.107 Contact Map
3kqfA 3 0.9483 100 0.109 Contact Map
1nzyA 4 0.9631 100 0.113 Contact Map
4jfcA 3 0.9336 100 0.114 Contact Map
4mouA 3 0.9483 100 0.114 Contact Map
4mi2A 3 0.9446 100 0.114 Contact Map
2ppyA 6 0.9668 100 0.115 Contact Map
4i4zA 6 0.9963 100 0.115 Contact Map
3g64A 6 0.9815 100 0.117 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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