GREMLIN Database
ARGC - N-acetyl-gamma-glutamyl-phosphate reductase
UniProt: P23715 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 345 (297)
Sequences: 7200 (3656)
Seq/√Len: 212.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_L305_V3.6661.00
159_A163_Q3.5711.00
4_G68_I3.2741.00
2_K27_E3.1821.00
150_F178_T3.1241.00
168_D250_T2.9741.00
146_N325_N2.9151.00
135_Q269_S2.6951.00
273_R293_D2.6881.00
40_V53_D2.5231.00
260_D264_E2.4411.00
254_T257_D2.4331.00
70_I326_F2.4321.00
171_F248_R2.4241.00
183_A192_H2.4011.00
93_T329_M2.3931.00
26_A326_F2.3531.00
200_F235_V2.3341.00
154_V174_V2.2721.00
40_V55_Q2.1771.00
153_A243_A2.1551.00
157_G245_M2.1451.00
180_V196_L2.1211.00
23_H327_N2.1111.00
19_I323_V2.0601.00
137_Q219_N2.0451.00
34_S58_P2.0371.00
15_E18_R2.0281.00
72_F326_F2.0061.00
144_I329_M1.9661.00
316_K324_Q1.9541.00
273_R291_F1.9361.00
157_G307_I1.9291.00
163_Q265_F1.9261.00
154_V243_A1.9061.00
153_A311_I1.8701.00
274_V277_K1.8611.00
104_K125_E1.8491.00
42_S53_D1.8431.00
175_D244_T1.8361.00
150_F176_A1.8321.00
81_S100_D1.8281.00
16_L72_F1.8211.00
259_H263_S1.8181.00
257_D260_D1.8151.00
281_P295_A1.7831.00
164_K261_L1.7721.00
155_L217_A1.7611.00
2_K29_C1.7541.00
168_D248_R1.7411.00
59_I83_L1.7341.00
161_L249_L1.6731.00
158_L172_V1.6681.00
17_V28_E1.6551.00
237_M283_T1.6221.00
255_A259_H1.6151.00
125_E142_K1.6111.00
3_I70_I1.6071.00
8_A31_L1.6001.00
134_N137_Q1.5601.00
20_L26_A1.5541.00
176_A243_A1.5541.00
185_R189_M1.5391.00
157_G309_S1.5351.00
270_Y291_F1.5131.00
131_A328_L1.5021.00
173_I246_Y1.4991.00
271_F290_N1.4911.00
135_Q328_L1.4831.00
315_M320_G1.4831.00
3_I26_A1.4721.00
86_K89_D1.4701.00
93_T142_K1.4631.00
82_E86_K1.4331.00
245_M309_S1.4321.00
161_L305_V1.4101.00
161_L262_Y1.3881.00
12_G319_A1.3851.00
249_L305_V1.3801.00
70_I330_N1.3731.00
39_N43_E1.3721.00
2_K69_D1.3691.00
133_L159_A1.3511.00
60_D63_T1.3501.00
15_E239_R1.3481.00
6_V73_L1.3471.00
78_G100_D1.3421.00
88_A143_L1.3401.00
164_K257_D1.3391.00
255_A296_V1.3361.00
262_Y307_I1.3231.00
255_A298_L1.3151.00
154_V214_I1.2971.00
245_M307_I1.2961.00
290_N315_M1.2911.00
154_V245_M1.2861.00
136_L219_N1.2711.00
263_S276_P1.2711.00
73_L84_T1.2701.00
260_D263_S1.2691.00
259_H277_K1.2631.00
64_I87_L1.2591.00
85_P89_D1.2581.00
197_N238_T1.2571.00
4_G71_M1.2481.00
130_L155_L1.2461.00
66_H90_A1.2461.00
83_L86_K1.2411.00
248_R304_R1.2181.00
71_M92_I1.2151.00
204_K209_Q1.2011.00
183_A187_A1.1981.00
252_D298_L1.1841.00
256_D260_D1.1791.00
235_V283_T1.1551.00
174_V245_M1.1451.00
136_L139_Q1.1441.00
175_D246_Y1.1421.00
290_N320_G1.1391.00
171_F304_R1.1381.00
36_G39_N1.1331.00
292_C311_I1.1321.00
242_M310_V1.1231.00
251_C257_D1.1221.00
17_V41_Y1.1171.00
40_V43_E1.1171.00
247_T305_V1.1061.00
157_G262_Y1.0971.00
127_V141_A1.0961.00
249_L298_L1.0931.00
181_S238_T1.0861.00
153_A176_A1.0811.00
242_M283_T1.0771.00
315_M323_V1.0751.00
177_K235_V1.0741.00
172_V247_T1.0721.00
259_H276_P1.0691.00
29_C57_K1.0671.00
86_K90_A1.0601.00
9_T56_L1.0601.00
138_I328_L1.0421.00
187_A192_H1.0401.00
220_E224_G1.0361.00
227_P302_T1.0271.00
158_L247_T1.0201.00
93_T144_I1.0191.00
247_T307_I1.0171.00
165_K253_L1.0081.00
301_R304_R1.0051.00
292_C309_S1.0041.00
103_I212_P1.0041.00
215_E301_R1.0021.00
282_Q285_E1.0011.00
188_S192_H0.9941.00
177_K246_Y0.9931.00
259_H296_V0.9861.00
68_I71_M0.9841.00
29_C68_I0.9831.00
84_T94_V0.9761.00
240_G313_N0.9731.00
161_L258_L0.9671.00
156_L292_C0.9631.00
199_N282_Q0.9581.00
132_E316_K0.9571.00
192_H201_K0.9491.00
12_G318_A0.9471.00
265_F269_S0.9471.00
21_S44_G0.9461.00
200_F283_T0.9320.99
215_E227_P0.9300.99
285_E293_D0.9250.99
28_E54_Q0.9240.99
132_E324_Q0.9230.99
242_M308_V0.9210.99
157_G160_P0.9200.99
134_N217_A0.9190.99
126_A143_L0.9170.99
37_E58_P0.9160.99
233_H244_T0.9150.99
72_F322_A0.9150.99
19_I320_G0.9080.99
9_T33_S0.9080.99
162_A167_L0.9070.99
95_I326_F0.8990.99
150_F210_H0.8970.99
193_F196_L0.8950.99
208_H212_P0.8900.99
63_T66_H0.8900.99
280_Y308_V0.8880.99
164_K264_E0.8880.99
125_E141_A0.8860.99
229_T246_Y0.8850.99
84_T143_L0.8840.99
18_R22_H0.8820.99
166_L250_T0.8790.99
61_M86_K0.8760.99
4_G30_I0.8760.99
271_F274_V0.8680.99
264_E267_Q0.8660.99
246_Y306_T0.8630.99
326_F330_N0.8630.99
289_S293_D0.8620.99
79_V82_E0.8610.99
71_M87_L0.8610.99
158_L245_M0.8580.99
194_S282_Q0.8520.99
2_K26_A0.8510.99
153_A309_S0.8500.99
249_L253_L0.8380.99
70_I93_T0.8380.99
6_V59_I0.8320.99
103_I216_Q0.8300.99
259_H274_V0.8240.99
57_K63_T0.8230.99
58_P61_M0.8210.99
26_A330_N0.8200.99
64_I68_I0.8170.99
294_I307_I0.8140.98
75_A80_S0.8110.98
41_Y56_L0.8110.98
239_R314_L0.8110.98
62_N90_A0.8100.98
104_K220_E0.8090.98
75_A98_S0.8040.98
146_N318_A0.7980.98
19_I315_M0.7970.98
87_L94_V0.7910.98
166_L261_L0.7900.98
189_M192_H0.7870.98
200_F233_H0.7840.98
177_K233_H0.7820.98
168_D171_F0.7800.98
296_V305_V0.7780.98
159_A218_L0.7750.98
75_A79_V0.7740.98
175_D233_H0.7730.98
219_N226_G0.7720.98
227_P301_R0.7660.98
158_L174_V0.7640.98
203_Y208_H0.7620.98
286_V293_D0.7600.98
193_F197_N0.7600.98
256_D259_H0.7590.98
78_G81_S0.7570.98
23_H290_N0.7550.98
152_T321_Q0.7530.98
153_A310_V0.7520.97
253_L258_L0.7460.97
249_L252_D0.7460.97
165_K250_T0.7430.97
280_Y297_T0.7420.97
104_K216_Q0.7410.97
149_C182_G0.7390.97
103_I145_A0.7370.97
249_L258_L0.7360.97
133_L265_F0.7310.97
36_G56_L0.7290.97
244_T308_V0.7250.97
275_R285_E0.7250.97
244_T306_T0.7210.97
29_C67_E0.7190.97
85_P88_A0.7170.97
201_K282_Q0.7160.97
87_L98_S0.7140.97
70_I95_I0.7130.97
262_Y274_V0.7120.97
97_L321_Q0.7100.96
164_K251_C0.7100.96
159_A162_A0.7100.96
252_D303_N0.7090.96
95_I329_M0.7070.96
61_M82_E0.7040.96
280_Y295_A0.7040.96
165_K254_T0.7040.96
255_A258_L0.7020.96
211_T215_E0.7010.96
8_A13_G0.7000.96
165_K261_L0.6970.96
274_V279_Q0.6970.96
58_P63_T0.6940.96
8_A56_L0.6920.96
133_L156_L0.6900.96
97_L146_N0.6890.96
105_E125_E0.6880.96
299_D304_R0.6860.96
30_I41_Y0.6860.96
135_Q139_Q0.6860.96
220_E225_L0.6840.96
253_L261_L0.6830.96
5_I16_L0.6830.96
220_E226_G0.6800.95
93_T330_N0.6800.95
156_L265_F0.6780.95
141_A144_I0.6780.95
275_R293_D0.6780.95
134_N220_E0.6750.95
154_V210_H0.6750.95
174_V214_I0.6730.95
31_L54_Q0.6700.95
165_K257_D0.6700.95
88_A91_G0.6670.95
252_D261_L0.6660.95
210_H232_A0.6660.95
146_N209_Q0.6660.95
151_P155_L0.6650.95
5_I20_L0.6640.95
204_K207_E0.6620.95
254_T298_L0.6610.95
151_P204_K0.6580.95
196_L234_L0.6570.95
85_P94_V0.6570.95
61_M90_A0.6540.94
57_K67_E0.6520.94
162_A220_E0.6520.94
22_H315_M0.6510.94
196_L199_N0.6500.94
174_V243_A0.6490.94
258_L296_V0.6470.94
243_A309_S0.6470.94
128_Y151_P0.6450.94
229_T304_R0.6430.94
258_L298_L0.6430.94
66_H89_D0.6420.94
77_P99_G0.6410.94
256_D277_K0.6400.94
85_P101_L0.6400.94
240_G287_Y0.6400.94
163_Q264_E0.6390.94
129_G325_N0.6390.94
32_Y36_G0.6380.94
299_D302_T0.6340.93
41_Y44_G0.6320.93
130_L156_L0.6320.93
153_A241_I0.6280.93
99_G209_Q0.6270.93
153_A292_C0.6240.93
25_H28_E0.6230.93
155_L218_L0.6210.93
263_S267_Q0.6200.93
161_L247_T0.6190.93
166_L253_L0.6160.92
203_Y206_N0.6090.92
196_L201_K0.6090.92
154_V176_A0.6080.92
183_A201_K0.6080.92
137_Q140_Q0.6070.92
33_S36_G0.6060.92
173_I248_R0.6020.92
238_T287_Y0.6020.92
17_V30_I0.6010.92
202_I242_M0.6010.92
195_E284_K0.6000.91
188_S191_T0.6000.91
190_G201_K0.6000.91
130_L321_Q0.5950.91
177_K200_F0.5950.91
293_D310_V0.5940.91
229_T306_T0.5920.91
271_F296_V0.5910.91
191_T194_S0.5900.91
174_V230_F0.5900.91
73_L94_V0.5900.91
139_Q328_L0.5890.91
180_V194_S0.5890.91
136_L140_Q0.5880.91
286_V289_S0.5880.91
272_V279_Q0.5880.91
272_V285_E0.5870.91
159_A265_F0.5870.91
147_P152_T0.5840.90
73_L80_S0.5830.90
162_A172_V0.5810.90
166_L249_L0.5760.90
202_I233_H0.5750.90
187_A191_T0.5750.90
305_V308_V0.5730.90
153_A313_N0.5690.89
239_R287_Y0.5680.89
72_F323_V0.5660.89
3_I326_F0.5640.89
219_N225_L0.5630.89
98_S322_A0.5610.89
187_A190_G0.5600.88
46_P54_Q0.5600.88
68_I92_I0.5590.88
167_L247_T0.5590.88
202_I282_Q0.5580.88
25_H43_E0.5570.88
63_T67_E0.5550.88
73_L87_L0.5540.88
240_G286_V0.5540.88
275_R279_Q0.5540.88
200_F237_M0.5530.88
157_G292_C0.5530.88
54_Q57_K0.5530.88
174_V228_I0.5520.88
321_Q325_N0.5500.88
162_A166_L0.5500.88
19_I22_H0.5490.87
239_R313_N0.5480.87
202_I308_V0.5470.87
11_Y188_S0.5470.87
9_T36_G0.5460.87
78_G98_S0.5450.87
18_R21_S0.5450.87
104_K126_A0.5430.87
14_T45_Y0.5410.87
20_L326_F0.5390.86
151_P243_A0.5380.86
81_S104_K0.5370.86
152_T311_I0.5360.86
148_G209_Q0.5360.86
173_I244_T0.5330.86
300_E303_N0.5320.86
198_D287_Y0.5320.86
7_G10_G0.5300.86
20_L323_V0.5280.85
251_C303_N0.5270.85
79_V98_S0.5270.85
154_V309_S0.5260.85
138_I329_M0.5250.85
20_L28_E0.5240.85
101_L126_A0.5240.85
6_V31_L0.5230.85
275_R295_A0.5230.85
262_Y296_V0.5210.85
72_F95_I0.5200.85
198_D238_T0.5190.84
168_D303_N0.5170.84
215_E226_G0.5140.84
133_L155_L0.5140.84
211_T228_I0.5120.84
76_P99_G0.5120.84
208_H211_T0.5120.84
179_G239_R0.5110.83
102_R182_G0.5100.83
81_S85_P0.5100.83
132_E135_Q0.5070.83
87_L92_I0.5070.83
281_P308_V0.5050.83
84_T87_L0.5040.83
64_I71_M0.5040.83
263_S274_V0.5040.83
93_T140_Q0.5020.82
80_S101_L0.5010.82
14_T41_Y0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vknA 4 0.9797 100 0.123 Contact Map
1xygA 4 0.9913 100 0.178 Contact Map
2nqtA 4 0.9681 100 0.19 Contact Map
2ozpA 4 0.9768 100 0.216 Contact Map
3dr3A 4 0.9507 100 0.249 Contact Map
2yv3A 2 0.8609 100 0.315 Contact Map
3uw3A 2 0.8725 100 0.318 Contact Map
2ep5A 4 0.8928 100 0.321 Contact Map
1ys4A 4 0.8928 100 0.325 Contact Map
4dplA 4 0.9014 100 0.327 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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