ARGC - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

ARGC - N-acetyl-gamma-glutamyl-phosphate reductase

UniProt:	P23715	Sequences: MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEGYPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLRIKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAPLAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQALNEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRPKGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNEETGLTITPIYP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	345 (297)
Sequences:	7200 (3656)
Seq/√Len:	212.1

ECOLI - ARGC USG DHAS
BACSU - ARGC DHAS
HALSA - Q9HPX0
SULSO - ARGC Q97WN3 Q97ZL8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
258_L	305_V	3.666	1.00
159_A	163_Q	3.571	1.00
4_G	68_I	3.274	1.00
2_K	27_E	3.182	1.00
150_F	178_T	3.124	1.00
168_D	250_T	2.974	1.00
146_N	325_N	2.915	1.00
135_Q	269_S	2.695	1.00
273_R	293_D	2.688	1.00
40_V	53_D	2.523	1.00
260_D	264_E	2.441	1.00
254_T	257_D	2.433	1.00
70_I	326_F	2.432	1.00
171_F	248_R	2.424	1.00
183_A	192_H	2.401	1.00
93_T	329_M	2.393	1.00
26_A	326_F	2.353	1.00
200_F	235_V	2.334	1.00
154_V	174_V	2.272	1.00
40_V	55_Q	2.177	1.00
153_A	243_A	2.155	1.00
157_G	245_M	2.145	1.00
180_V	196_L	2.121	1.00
23_H	327_N	2.111	1.00
19_I	323_V	2.060	1.00
137_Q	219_N	2.045	1.00
34_S	58_P	2.037	1.00
15_E	18_R	2.028	1.00
72_F	326_F	2.006	1.00
144_I	329_M	1.966	1.00
316_K	324_Q	1.954	1.00
273_R	291_F	1.936	1.00
157_G	307_I	1.929	1.00
163_Q	265_F	1.926	1.00
154_V	243_A	1.906	1.00
153_A	311_I	1.870	1.00
274_V	277_K	1.861	1.00
104_K	125_E	1.849	1.00
42_S	53_D	1.843	1.00
175_D	244_T	1.836	1.00
150_F	176_A	1.832	1.00
81_S	100_D	1.828	1.00
16_L	72_F	1.821	1.00
259_H	263_S	1.818	1.00
257_D	260_D	1.815	1.00
281_P	295_A	1.783	1.00
164_K	261_L	1.772	1.00
155_L	217_A	1.761	1.00
2_K	29_C	1.754	1.00
168_D	248_R	1.741	1.00
59_I	83_L	1.734	1.00
161_L	249_L	1.673	1.00
158_L	172_V	1.668	1.00
17_V	28_E	1.655	1.00
237_M	283_T	1.622	1.00
255_A	259_H	1.615	1.00
125_E	142_K	1.611	1.00
3_I	70_I	1.607	1.00
8_A	31_L	1.600	1.00
134_N	137_Q	1.560	1.00
20_L	26_A	1.554	1.00
176_A	243_A	1.554	1.00
185_R	189_M	1.539	1.00
157_G	309_S	1.535	1.00
270_Y	291_F	1.513	1.00
131_A	328_L	1.502	1.00
173_I	246_Y	1.499	1.00
271_F	290_N	1.491	1.00
135_Q	328_L	1.483	1.00
315_M	320_G	1.483	1.00
3_I	26_A	1.472	1.00
86_K	89_D	1.470	1.00
93_T	142_K	1.463	1.00
82_E	86_K	1.433	1.00
245_M	309_S	1.432	1.00
161_L	305_V	1.410	1.00
161_L	262_Y	1.388	1.00
12_G	319_A	1.385	1.00
249_L	305_V	1.380	1.00
70_I	330_N	1.373	1.00
39_N	43_E	1.372	1.00
2_K	69_D	1.369	1.00
133_L	159_A	1.351	1.00
60_D	63_T	1.350	1.00
15_E	239_R	1.348	1.00
6_V	73_L	1.347	1.00
78_G	100_D	1.342	1.00
88_A	143_L	1.340	1.00
164_K	257_D	1.339	1.00
255_A	296_V	1.336	1.00
262_Y	307_I	1.323	1.00
255_A	298_L	1.315	1.00
154_V	214_I	1.297	1.00
245_M	307_I	1.296	1.00
290_N	315_M	1.291	1.00
154_V	245_M	1.286	1.00
136_L	219_N	1.271	1.00
263_S	276_P	1.271	1.00
73_L	84_T	1.270	1.00
260_D	263_S	1.269	1.00
259_H	277_K	1.263	1.00
64_I	87_L	1.259	1.00
85_P	89_D	1.258	1.00
197_N	238_T	1.257	1.00
4_G	71_M	1.248	1.00
130_L	155_L	1.246	1.00
66_H	90_A	1.246	1.00
83_L	86_K	1.241	1.00
248_R	304_R	1.218	1.00
71_M	92_I	1.215	1.00
204_K	209_Q	1.201	1.00
183_A	187_A	1.198	1.00
252_D	298_L	1.184	1.00
256_D	260_D	1.179	1.00
235_V	283_T	1.155	1.00
174_V	245_M	1.145	1.00
136_L	139_Q	1.144	1.00
175_D	246_Y	1.142	1.00
290_N	320_G	1.139	1.00
171_F	304_R	1.138	1.00
36_G	39_N	1.133	1.00
292_C	311_I	1.132	1.00
242_M	310_V	1.123	1.00
251_C	257_D	1.122	1.00
17_V	41_Y	1.117	1.00
40_V	43_E	1.117	1.00
247_T	305_V	1.106	1.00
157_G	262_Y	1.097	1.00
127_V	141_A	1.096	1.00
249_L	298_L	1.093	1.00
181_S	238_T	1.086	1.00
153_A	176_A	1.081	1.00
242_M	283_T	1.077	1.00
315_M	323_V	1.075	1.00
177_K	235_V	1.074	1.00
172_V	247_T	1.072	1.00
259_H	276_P	1.069	1.00
29_C	57_K	1.067	1.00
86_K	90_A	1.060	1.00
9_T	56_L	1.060	1.00
138_I	328_L	1.042	1.00
187_A	192_H	1.040	1.00
220_E	224_G	1.036	1.00
227_P	302_T	1.027	1.00
158_L	247_T	1.020	1.00
93_T	144_I	1.019	1.00
247_T	307_I	1.017	1.00
165_K	253_L	1.008	1.00
301_R	304_R	1.005	1.00
292_C	309_S	1.004	1.00
103_I	212_P	1.004	1.00
215_E	301_R	1.002	1.00
282_Q	285_E	1.001	1.00
188_S	192_H	0.994	1.00
177_K	246_Y	0.993	1.00
259_H	296_V	0.986	1.00
68_I	71_M	0.984	1.00
29_C	68_I	0.983	1.00
84_T	94_V	0.976	1.00
240_G	313_N	0.973	1.00
161_L	258_L	0.967	1.00
156_L	292_C	0.963	1.00
199_N	282_Q	0.958	1.00
132_E	316_K	0.957	1.00
192_H	201_K	0.949	1.00
12_G	318_A	0.947	1.00
265_F	269_S	0.947	1.00
21_S	44_G	0.946	1.00
200_F	283_T	0.932	0.99
215_E	227_P	0.930	0.99
285_E	293_D	0.925	0.99
28_E	54_Q	0.924	0.99
132_E	324_Q	0.923	0.99
242_M	308_V	0.921	0.99
157_G	160_P	0.920	0.99
134_N	217_A	0.919	0.99
126_A	143_L	0.917	0.99
37_E	58_P	0.916	0.99
233_H	244_T	0.915	0.99
72_F	322_A	0.915	0.99
19_I	320_G	0.908	0.99
9_T	33_S	0.908	0.99
162_A	167_L	0.907	0.99
95_I	326_F	0.899	0.99
150_F	210_H	0.897	0.99
193_F	196_L	0.895	0.99
208_H	212_P	0.890	0.99
63_T	66_H	0.890	0.99
280_Y	308_V	0.888	0.99
164_K	264_E	0.888	0.99
125_E	141_A	0.886	0.99
229_T	246_Y	0.885	0.99
84_T	143_L	0.884	0.99
18_R	22_H	0.882	0.99
166_L	250_T	0.879	0.99
61_M	86_K	0.876	0.99
4_G	30_I	0.876	0.99
271_F	274_V	0.868	0.99
264_E	267_Q	0.866	0.99
246_Y	306_T	0.863	0.99
326_F	330_N	0.863	0.99
289_S	293_D	0.862	0.99
79_V	82_E	0.861	0.99
71_M	87_L	0.861	0.99
158_L	245_M	0.858	0.99
194_S	282_Q	0.852	0.99
2_K	26_A	0.851	0.99
153_A	309_S	0.850	0.99
249_L	253_L	0.838	0.99
70_I	93_T	0.838	0.99
6_V	59_I	0.832	0.99
103_I	216_Q	0.830	0.99
259_H	274_V	0.824	0.99
57_K	63_T	0.823	0.99
58_P	61_M	0.821	0.99
26_A	330_N	0.820	0.99
64_I	68_I	0.817	0.99
294_I	307_I	0.814	0.98
75_A	80_S	0.811	0.98
41_Y	56_L	0.811	0.98
239_R	314_L	0.811	0.98
62_N	90_A	0.810	0.98
104_K	220_E	0.809	0.98
75_A	98_S	0.804	0.98
146_N	318_A	0.798	0.98
19_I	315_M	0.797	0.98
87_L	94_V	0.791	0.98
166_L	261_L	0.790	0.98
189_M	192_H	0.787	0.98
200_F	233_H	0.784	0.98
177_K	233_H	0.782	0.98
168_D	171_F	0.780	0.98
296_V	305_V	0.778	0.98
159_A	218_L	0.775	0.98
75_A	79_V	0.774	0.98
175_D	233_H	0.773	0.98
219_N	226_G	0.772	0.98
227_P	301_R	0.766	0.98
158_L	174_V	0.764	0.98
203_Y	208_H	0.762	0.98
286_V	293_D	0.760	0.98
193_F	197_N	0.760	0.98
256_D	259_H	0.759	0.98
78_G	81_S	0.757	0.98
23_H	290_N	0.755	0.98
152_T	321_Q	0.753	0.98
153_A	310_V	0.752	0.97
253_L	258_L	0.746	0.97
249_L	252_D	0.746	0.97
165_K	250_T	0.743	0.97
280_Y	297_T	0.742	0.97
104_K	216_Q	0.741	0.97
149_C	182_G	0.739	0.97
103_I	145_A	0.737	0.97
249_L	258_L	0.736	0.97
133_L	265_F	0.731	0.97
36_G	56_L	0.729	0.97
244_T	308_V	0.725	0.97
275_R	285_E	0.725	0.97
244_T	306_T	0.721	0.97
29_C	67_E	0.719	0.97
85_P	88_A	0.717	0.97
201_K	282_Q	0.716	0.97
87_L	98_S	0.714	0.97
70_I	95_I	0.713	0.97
262_Y	274_V	0.712	0.97
97_L	321_Q	0.710	0.96
164_K	251_C	0.710	0.96
159_A	162_A	0.710	0.96
252_D	303_N	0.709	0.96
95_I	329_M	0.707	0.96
61_M	82_E	0.704	0.96
280_Y	295_A	0.704	0.96
165_K	254_T	0.704	0.96
255_A	258_L	0.702	0.96
211_T	215_E	0.701	0.96
8_A	13_G	0.700	0.96
165_K	261_L	0.697	0.96
274_V	279_Q	0.697	0.96
58_P	63_T	0.694	0.96
8_A	56_L	0.692	0.96
133_L	156_L	0.690	0.96
97_L	146_N	0.689	0.96
105_E	125_E	0.688	0.96
299_D	304_R	0.686	0.96
30_I	41_Y	0.686	0.96
135_Q	139_Q	0.686	0.96
220_E	225_L	0.684	0.96
253_L	261_L	0.683	0.96
5_I	16_L	0.683	0.96
220_E	226_G	0.680	0.95
93_T	330_N	0.680	0.95
156_L	265_F	0.678	0.95
141_A	144_I	0.678	0.95
275_R	293_D	0.678	0.95
134_N	220_E	0.675	0.95
154_V	210_H	0.675	0.95
174_V	214_I	0.673	0.95
31_L	54_Q	0.670	0.95
165_K	257_D	0.670	0.95
88_A	91_G	0.667	0.95
252_D	261_L	0.666	0.95
210_H	232_A	0.666	0.95
146_N	209_Q	0.666	0.95
151_P	155_L	0.665	0.95
5_I	20_L	0.664	0.95
204_K	207_E	0.662	0.95
254_T	298_L	0.661	0.95
151_P	204_K	0.658	0.95
196_L	234_L	0.657	0.95
85_P	94_V	0.657	0.95
61_M	90_A	0.654	0.94
57_K	67_E	0.652	0.94
162_A	220_E	0.652	0.94
22_H	315_M	0.651	0.94
196_L	199_N	0.650	0.94
174_V	243_A	0.649	0.94
258_L	296_V	0.647	0.94
243_A	309_S	0.647	0.94
128_Y	151_P	0.645	0.94
229_T	304_R	0.643	0.94
258_L	298_L	0.643	0.94
66_H	89_D	0.642	0.94
77_P	99_G	0.641	0.94
256_D	277_K	0.640	0.94
85_P	101_L	0.640	0.94
240_G	287_Y	0.640	0.94
163_Q	264_E	0.639	0.94
129_G	325_N	0.639	0.94
32_Y	36_G	0.638	0.94
299_D	302_T	0.634	0.93
41_Y	44_G	0.632	0.93
130_L	156_L	0.632	0.93
153_A	241_I	0.628	0.93
99_G	209_Q	0.627	0.93
153_A	292_C	0.624	0.93
25_H	28_E	0.623	0.93
155_L	218_L	0.621	0.93
263_S	267_Q	0.620	0.93
161_L	247_T	0.619	0.93
166_L	253_L	0.616	0.92
203_Y	206_N	0.609	0.92
196_L	201_K	0.609	0.92
154_V	176_A	0.608	0.92
183_A	201_K	0.608	0.92
137_Q	140_Q	0.607	0.92
33_S	36_G	0.606	0.92
173_I	248_R	0.602	0.92
238_T	287_Y	0.602	0.92
17_V	30_I	0.601	0.92
202_I	242_M	0.601	0.92
195_E	284_K	0.600	0.91
188_S	191_T	0.600	0.91
190_G	201_K	0.600	0.91
130_L	321_Q	0.595	0.91
177_K	200_F	0.595	0.91
293_D	310_V	0.594	0.91
229_T	306_T	0.592	0.91
271_F	296_V	0.591	0.91
191_T	194_S	0.590	0.91
174_V	230_F	0.590	0.91
73_L	94_V	0.590	0.91
139_Q	328_L	0.589	0.91
180_V	194_S	0.589	0.91
136_L	140_Q	0.588	0.91
286_V	289_S	0.588	0.91
272_V	279_Q	0.588	0.91
272_V	285_E	0.587	0.91
159_A	265_F	0.587	0.91
147_P	152_T	0.584	0.90
73_L	80_S	0.583	0.90
162_A	172_V	0.581	0.90
166_L	249_L	0.576	0.90
202_I	233_H	0.575	0.90
187_A	191_T	0.575	0.90
305_V	308_V	0.573	0.90
153_A	313_N	0.569	0.89
239_R	287_Y	0.568	0.89
72_F	323_V	0.566	0.89
3_I	326_F	0.564	0.89
219_N	225_L	0.563	0.89
98_S	322_A	0.561	0.89
187_A	190_G	0.560	0.88
46_P	54_Q	0.560	0.88
68_I	92_I	0.559	0.88
167_L	247_T	0.559	0.88
202_I	282_Q	0.558	0.88
25_H	43_E	0.557	0.88
63_T	67_E	0.555	0.88
73_L	87_L	0.554	0.88
240_G	286_V	0.554	0.88
275_R	279_Q	0.554	0.88
200_F	237_M	0.553	0.88
157_G	292_C	0.553	0.88
54_Q	57_K	0.553	0.88
174_V	228_I	0.552	0.88
321_Q	325_N	0.550	0.88
162_A	166_L	0.550	0.88
19_I	22_H	0.549	0.87
239_R	313_N	0.548	0.87
202_I	308_V	0.547	0.87
11_Y	188_S	0.547	0.87
9_T	36_G	0.546	0.87
78_G	98_S	0.545	0.87
18_R	21_S	0.545	0.87
104_K	126_A	0.543	0.87
14_T	45_Y	0.541	0.87
20_L	326_F	0.539	0.86
151_P	243_A	0.538	0.86
81_S	104_K	0.537	0.86
152_T	311_I	0.536	0.86
148_G	209_Q	0.536	0.86
173_I	244_T	0.533	0.86
300_E	303_N	0.532	0.86
198_D	287_Y	0.532	0.86
7_G	10_G	0.530	0.86
20_L	323_V	0.528	0.85
251_C	303_N	0.527	0.85
79_V	98_S	0.527	0.85
154_V	309_S	0.526	0.85
138_I	329_M	0.525	0.85
20_L	28_E	0.524	0.85
101_L	126_A	0.524	0.85
6_V	31_L	0.523	0.85
275_R	295_A	0.523	0.85
262_Y	296_V	0.521	0.85
72_F	95_I	0.520	0.85
198_D	238_T	0.519	0.84
168_D	303_N	0.517	0.84
215_E	226_G	0.514	0.84
133_L	155_L	0.514	0.84
211_T	228_I	0.512	0.84
76_P	99_G	0.512	0.84
208_H	211_T	0.512	0.84
179_G	239_R	0.511	0.83
102_R	182_G	0.510	0.83
81_S	85_P	0.510	0.83
132_E	135_Q	0.507	0.83
87_L	92_I	0.507	0.83
281_P	308_V	0.505	0.83
84_T	87_L	0.504	0.83
64_I	71_M	0.504	0.83
263_S	274_V	0.504	0.83
93_T	140_Q	0.502	0.82
80_S	101_L	0.501	0.82
14_T	41_Y	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vknA	4	0.9797	100	0.123	Contact Map
1xygA	4	0.9913	100	0.178	Contact Map
2nqtA	4	0.9681	100	0.19	Contact Map
2ozpA	4	0.9768	100	0.216	Contact Map
3dr3A	4	0.9507	100	0.249	Contact Map
2yv3A	2	0.8609	100	0.315	Contact Map
3uw3A	2	0.8725	100	0.318	Contact Map
2ep5A	4	0.8928	100	0.321	Contact Map
1ys4A	4	0.8928	100	0.325	Contact Map
4dplA	4	0.9014	100	0.327	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.