GREMLIN Database
DCDA - Diaminopimelate decarboxylase
UniProt: P23630 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 439 (387)
Sequences: 8134 (4934)
Seq/√Len: 250.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_I297_G3.8961.00
137_A192_Q3.7421.00
151_D200_Q3.6671.00
46_K80_E3.3921.00
42_R80_E3.0631.00
93_Y119_M3.0601.00
117_L139_L3.0321.00
25_L33_L3.0201.00
60_Q286_E3.0001.00
118_R142_L2.9271.00
122_E146_T2.8051.00
114_R141_D2.7961.00
202_L241_K2.7561.00
319_V376_V2.7381.00
29_Y414_A2.6641.00
45_A82_L2.5781.00
149_S200_Q2.5691.00
38_V410_E2.4931.00
311_E317_Q2.4581.00
140_E196_S2.4441.00
321_V356_I2.4041.00
187_E231_E2.3991.00
200_Q241_K2.3931.00
119_M123_H2.3921.00
42_R79_E2.3301.00
133_F189_A2.3071.00
303_L381_L2.2611.00
114_R138_L2.2551.00
118_R146_T2.1961.00
151_D202_L2.1551.00
341_A385_F2.1491.00
353_T372_D2.1461.00
48_F294_S2.1331.00
96_V123_H2.1291.00
47_S263_T2.1141.00
223_E272_A2.0621.00
302_T323_G2.0481.00
140_E198_H2.0201.00
133_F185_Q2.0031.00
317_Q352_K2.0011.00
26_A31_T1.9981.00
117_L128_I1.9841.00
319_V354_V1.9671.00
33_L303_L1.9671.00
304_Y321_V1.9291.00
403_R421_E1.9181.00
84_L100_F1.9111.00
84_L95_A1.9071.00
86_V92_L1.9051.00
78_E100_F1.8871.00
118_R122_E1.8311.00
305_T381_L1.8061.00
219_V268_K1.7961.00
42_R76_L1.7691.00
117_L142_L1.7501.00
352_K375_E1.7441.00
219_V271_E1.7421.00
42_R46_K1.7411.00
40_L44_R1.7211.00
351_D372_D1.7161.00
49_K53_I1.7121.00
41_I296_V1.7121.00
206_C225_I1.6911.00
89_G93_Y1.6861.00
45_A80_E1.6841.00
63_Y67_A1.6671.00
45_A77_A1.6631.00
44_R298_D1.6601.00
121_L142_L1.6541.00
67_A296_V1.6411.00
121_L150_I1.6351.00
97_A424_E1.6291.00
301_T383_A1.6261.00
58_K286_E1.6221.00
77_A295_L1.6011.00
134_Y378_E1.5831.00
96_V102_A1.5781.00
304_Y382_L1.5491.00
140_E197_E1.5461.00
41_I77_A1.5351.00
28_K414_A1.5331.00
303_L383_A1.5261.00
408_F417_V1.5261.00
153_L242_V1.5221.00
261_H264_E1.5081.00
25_L414_A1.5021.00
187_E236_Y1.5001.00
127_C242_V1.4911.00
40_L43_E1.4891.00
130_V139_L1.4891.00
93_Y97_A1.4731.00
101_P104_R1.4661.00
44_R47_S1.4601.00
65_S84_L1.4351.00
46_K50_Q1.4291.00
38_V42_R1.4281.00
407_V414_A1.4251.00
410_E415_H1.4251.00
407_V416_L1.4221.00
302_T387_T1.4211.00
69_S400_R1.4161.00
77_A82_L1.4131.00
29_Y416_L1.4111.00
179_F189_A1.4021.00
187_E191_E1.3891.00
89_G116_E1.3891.00
112_K135_E1.3761.00
39_A43_E1.3671.00
263_T267_E1.3671.00
133_F188_R1.3641.00
251_I386_C1.3621.00
309_Q319_V1.3431.00
397_N403_R1.3401.00
72_A75_Q1.3201.00
233_R239_V1.3171.00
29_Y33_L1.2981.00
223_E227_K1.2971.00
35_V303_L1.2871.00
29_Y407_V1.2841.00
33_L405_A1.2831.00
62_A83_S1.2681.00
226_F230_D1.2671.00
270_I274_K1.2621.00
60_Q104_R1.2581.00
309_Q378_E1.2571.00
93_Y423_Y1.2551.00
353_T370_D1.2541.00
128_I139_L1.2531.00
31_T322_D1.2491.00
188_R191_E1.2461.00
309_Q317_Q1.2431.00
219_V272_A1.2411.00
181_L231_E1.2401.00
111_N320_A1.2371.00
33_L407_V1.2361.00
120_A128_I1.2331.00
229_L243_L1.2321.00
185_Q188_R1.2261.00
62_A288_W1.2241.00
130_V152_V1.2231.00
241_K286_E1.2211.00
223_E275_E1.2141.00
106_H244_N1.2081.00
405_A420_R1.2021.00
219_V223_E1.2021.00
267_E271_E1.1921.00
316_R370_D1.1911.00
317_Q354_V1.1881.00
130_V136_I1.1861.00
83_S104_R1.1811.00
180_D185_Q1.1791.00
75_Q79_E1.1761.00
114_R142_L1.1711.00
304_Y323_G1.1641.00
190_I201_L1.1621.00
45_A49_K1.1611.00
43_E47_S1.1531.00
114_R118_R1.1491.00
133_F137_A1.1481.00
316_R355_S1.1451.00
89_G119_M1.1421.00
102_A105_I1.1391.00
216_A220_L1.1371.00
38_V76_L1.1351.00
48_F249_F1.1351.00
321_V382_L1.1171.00
52_F266_V1.1151.00
206_C245_L1.0951.00
356_I382_L1.0941.00
114_R378_E1.0911.00
111_N307_G1.0781.00
41_I299_A1.0761.00
306_V376_V1.0751.00
340_A368_I1.0731.00
69_S393_S1.0731.00
245_L289_I1.0731.00
78_E104_R1.0721.00
40_L298_D1.0661.00
127_C151_D1.0651.00
40_L299_A1.0641.00
345_R348_E1.0621.00
133_F179_F1.0621.00
193_V201_L1.0601.00
355_S369_W1.0601.00
121_L139_L1.0591.00
26_A381_L1.0481.00
215_T268_K1.0461.00
95_A105_I1.0441.00
65_S74_I1.0421.00
419_K425_D1.0411.00
76_L80_E1.0201.00
138_L307_G1.0201.00
366_M369_W1.0181.00
354_V373_L1.0171.00
36_Y300_G1.0111.00
30_G33_L1.0071.00
252_R255_E1.0061.00
124_R148_H1.0051.00
268_K271_E1.0021.00
273_V287_I0.9981.00
65_S95_A0.9961.00
156_I228_K0.9861.00
136_I193_V0.9851.00
318_Y357_A0.9841.00
271_E275_E0.9821.00
42_R410_E0.9811.00
34_Y395_A0.9581.00
102_A125_I0.9541.00
137_A141_D0.9521.00
355_S366_M0.9501.00
298_D386_C0.9481.00
44_R294_S0.9461.00
68_F406_V0.9451.00
93_Y123_H0.9411.00
305_T322_D0.9411.00
321_V367_L0.9371.00
220_L224_K0.9331.00
249_F260_L0.9291.00
119_M122_E0.9291.00
206_C221_A0.9271.00
152_V199_I0.9271.00
243_L287_I0.9261.00
192_Q196_S0.9251.00
191_E236_Y0.9241.00
39_A410_E0.9231.00
107_F116_E0.9171.00
93_Y424_E0.9161.00
326_N360_C0.9111.00
121_L128_I0.9091.00
309_Q354_V0.9091.00
52_F82_L0.9021.00
94_T400_R0.9021.00
208_I221_A0.8981.00
222_A269_I0.8921.00
46_K49_K0.8921.00
242_V288_W0.8911.00
60_Q288_W0.8861.00
65_S69_S0.8841.00
45_A295_L0.8821.00
350_H375_E0.8801.00
92_L120_A0.8801.00
422_T425_D0.8781.00
377_K380_D0.8771.00
72_A417_V0.8761.00
153_L203_G0.8751.00
345_R377_K0.8741.00
231_E234_D0.8731.00
220_L223_E0.8711.00
342_A376_V0.8711.00
368_I371_I0.8701.00
134_Y308_S0.8650.99
69_S74_I0.8630.99
229_L240_S0.8590.99
330_R336_A0.8580.99
138_L378_E0.8580.99
217_G220_L0.8540.99
73_M296_V0.8520.99
51_A266_V0.8510.99
96_V105_I0.8480.99
76_L79_E0.8370.99
374_P380_D0.8340.99
62_A106_H0.8320.99
41_I73_M0.8260.99
89_G423_Y0.8250.99
47_S51_A0.8250.99
27_E305_T0.8240.99
230_D276_N0.8230.99
358_G365_D0.8220.99
204_V225_I0.8180.99
419_K422_T0.8150.99
306_V319_V0.8130.99
351_D375_E0.8120.99
328_N331_P0.8110.99
143_C150_I0.8110.99
66_K361_C0.8100.99
71_V97_A0.8080.99
275_E279_R0.8070.99
74_I100_F0.8070.99
330_R334_Y0.8060.99
191_E195_Q0.8060.99
264_E267_E0.8040.99
309_Q376_V0.8020.99
201_L240_S0.7990.99
392_Y404_P0.7980.99
242_V286_E0.7980.99
128_I150_I0.7980.99
304_Y384_V0.7970.99
140_E149_S0.7960.99
362_E398_Y0.7940.99
226_F276_N0.7920.99
311_E352_K0.7900.99
301_T385_F0.7900.99
190_I232_W0.7890.99
272_A275_E0.7880.99
354_V376_V0.7880.99
330_R394_M0.7870.99
224_K227_K0.7870.99
89_G115_E0.7870.99
60_Q83_S0.7840.99
339_E385_F0.7830.99
74_I94_T0.7790.99
274_K278_S0.7770.99
243_L273_V0.7750.99
196_S199_I0.7740.99
335_Q338_Y0.7710.99
182_H185_Q0.7710.99
230_D234_D0.7690.99
90_G402_P0.7690.99
337_K371_I0.7670.99
50_Q263_T0.7650.99
192_Q195_Q0.7630.99
143_C198_H0.7630.99
35_V301_T0.7610.99
48_F291_P0.7600.99
49_K82_L0.7580.99
245_L269_I0.7530.99
331_P335_Q0.7470.98
360_C401_I0.7460.98
49_K59_A0.7450.98
309_Q377_K0.7440.98
276_N279_R0.7410.98
30_G115_E0.7400.98
38_V408_F0.7400.98
163_H214_D0.7370.98
356_I373_L0.7370.98
167_Y335_Q0.7350.98
276_N280_Y0.7350.98
326_N330_R0.7350.98
133_F192_Q0.7330.98
402_P426_I0.7300.98
68_F73_M0.7290.98
395_A404_P0.7270.98
331_P338_Y0.7260.98
219_V275_E0.7260.98
47_S50_Q0.7190.98
207_H291_P0.7180.98
328_N387_T0.7180.98
100_F104_R0.7170.98
136_I189_A0.7160.98
147_G198_H0.7140.98
39_A411_N0.7140.98
149_S198_H0.7140.98
121_L148_H0.7110.98
106_H129_V0.7110.98
176_K399_N0.7100.98
268_K272_A0.7070.98
161_E164_T0.7070.98
332_A364_G0.7070.98
25_L29_Y0.7020.98
32_P322_D0.7010.98
392_Y406_V0.7000.98
412_G415_H0.6990.98
325_M333_L0.6990.98
324_G359_K0.6940.98
137_A196_S0.6930.98
342_A345_R0.6880.97
204_V243_L0.6870.97
71_V75_Q0.6860.97
216_A219_V0.6860.97
57_L270_I0.6860.97
329_I391_G0.6850.97
127_C202_L0.6810.97
64_A67_A0.6800.97
226_F277_A0.6770.97
151_D241_K0.6760.97
75_Q78_E0.6760.97
138_L141_D0.6760.97
72_A415_H0.6750.97
222_A272_A0.6740.97
186_T228_K0.6730.97
214_D217_G0.6730.97
333_L337_K0.6720.97
119_M423_Y0.6710.97
367_L384_V0.6680.97
44_R299_A0.6680.97
415_H419_K0.6670.97
252_R256_D0.6670.97
341_A346_I0.6650.97
71_V94_T0.6630.97
204_V232_W0.6630.97
143_C146_T0.6630.97
325_M330_R0.6630.97
133_F186_T0.6610.97
331_P336_A0.6590.97
154_L189_A0.6590.97
74_I84_L0.6570.97
222_A245_L0.6570.97
204_V229_L0.6560.97
113_S307_G0.6560.97
224_K228_K0.6550.97
132_N308_S0.6540.97
410_E413_E0.6530.96
135_E138_L0.6510.96
31_T305_T0.6500.96
36_Y70_S0.6490.96
111_N324_G0.6470.96
341_A344_N0.6470.96
76_L408_F0.6440.96
110_N131_D0.6420.96
138_L308_S0.6420.96
213_F250_G0.6420.96
362_E399_N0.6410.96
227_K276_N0.6410.96
78_E98_A0.6400.96
162_A220_L0.6390.96
275_E278_S0.6390.96
102_A124_R0.6380.96
160_V224_K0.6380.96
129_V153_L0.6380.96
331_P334_Y0.6360.96
61_V82_L0.6320.96
305_T379_G0.6320.96
325_M332_A0.6320.96
333_L336_A0.6310.96
392_Y403_R0.6310.96
154_L179_F0.6310.96
74_I98_A0.6300.96
172_Q175_S0.6290.96
143_C149_S0.6260.96
61_V289_I0.6250.96
156_I181_L0.6250.96
363_S399_N0.6240.95
334_Y338_Y0.6230.95
232_W238_F0.6230.95
179_F186_T0.6220.95
77_A84_L0.6200.95
107_F120_A0.6200.95
73_M417_V0.6190.95
351_D374_P0.6190.95
96_V119_M0.6180.95
124_R151_D0.6180.95
421_E425_D0.6180.95
139_L150_I0.6170.95
272_A276_N0.6160.95
334_Y362_E0.6160.95
302_T391_G0.6150.95
180_D313_P0.6140.95
323_G327_D0.6140.95
227_K230_D0.6140.95
226_F229_L0.6140.95
63_Y68_F0.6130.95
218_F265_Y0.6130.95
88_S401_I0.6120.95
330_R335_Q0.6110.95
113_S116_E0.6100.95
321_V324_G0.6090.95
142_L146_T0.6090.95
75_Q98_A0.6080.95
41_I76_L0.6080.95
192_Q197_E0.6070.95
66_K177_F0.6060.95
245_L287_I0.6030.95
44_R262_A0.6020.95
48_F295_L0.6010.94
188_R192_Q0.6010.94
31_T381_L0.5960.94
108_H244_N0.5950.94
118_R141_D0.5940.94
47_S262_A0.5940.94
140_E143_C0.5940.94
45_A61_V0.5930.94
115_E119_M0.5930.94
416_L419_K0.5910.94
201_L238_F0.5900.94
350_H373_L0.5900.94
109_G112_K0.5900.94
92_L105_I0.5890.94
36_Y406_V0.5880.94
323_G326_N0.5880.94
188_R195_Q0.5870.94
95_A100_F0.5870.94
41_I45_A0.5860.94
136_I152_V0.5860.94
140_E199_I0.5860.94
50_Q53_I0.5850.94
51_A263_T0.5840.94
59_A289_I0.5840.94
324_G327_D0.5830.94
143_C148_H0.5830.94
308_S320_A0.5820.93
193_V196_S0.5820.93
227_K231_E0.5820.93
339_E386_C0.5810.93
86_V95_A0.5780.93
276_N285_P0.5750.93
114_R305_T0.5740.93
168_I211_Q0.5740.93
115_E118_R0.5740.93
193_V199_I0.5730.93
325_M336_A0.5720.93
47_S294_S0.5720.93
310_K318_Y0.5720.93
233_R285_P0.5710.93
255_E339_E0.5710.93
260_L264_E0.5690.93
361_C399_N0.5690.93
339_E343_A0.5690.93
226_F272_A0.5680.93
52_F289_I0.5660.93
181_L186_T0.5650.92
130_V154_L0.5650.92
43_E46_K0.5640.92
154_L193_V0.5630.92
330_R333_L0.5620.92
143_C147_G0.5610.92
43_E50_Q0.5610.92
333_L338_Y0.5600.92
250_G293_R0.5590.92
225_I243_L0.5590.92
334_Y394_M0.5580.92
254_T339_E0.5580.92
343_A383_A0.5570.92
116_E401_I0.5570.92
34_Y387_T0.5550.92
61_V295_L0.5510.92
136_I199_I0.5510.92
115_E305_T0.5500.91
325_M328_N0.5500.91
216_A268_K0.5480.91
34_Y404_P0.5480.91
166_D169_T0.5460.91
223_E276_N0.5460.91
153_L205_H0.5460.91
355_S370_D0.5440.91
166_D172_Q0.5430.91
177_F363_S0.5430.91
47_S261_H0.5410.91
405_A416_L0.5400.91
202_L242_V0.5380.91
339_E344_N0.5370.90
44_R295_L0.5360.90
397_N421_E0.5360.90
329_I336_A0.5360.90
414_A417_V0.5360.90
412_G416_L0.5330.90
296_V299_A0.5320.90
53_I57_L0.5320.90
311_E375_E0.5310.90
48_F289_I0.5310.90
174_D316_R0.5300.90
264_E268_K0.5270.90
73_M76_L0.5260.90
29_Y303_L0.5260.90
207_H399_N0.5250.89
332_A336_A0.5250.89
139_L152_V0.5240.89
309_Q375_E0.5230.89
308_S378_E0.5230.89
229_L285_P0.5220.89
362_E394_M0.5210.89
416_L420_R0.5190.89
346_I349_A0.5190.89
134_Y309_Q0.5180.89
339_E342_A0.5180.89
215_T219_V0.5170.89
78_E84_L0.5160.89
66_K85_D0.5160.89
30_G405_A0.5160.89
73_M408_F0.5130.88
58_K278_S0.5130.88
208_I212_I0.5120.88
211_Q253_Y0.5120.88
326_N329_I0.5110.88
116_E359_K0.5100.88
85_D399_N0.5100.88
140_E192_Q0.5100.88
108_H129_V0.5100.88
122_E148_H0.5090.88
331_P394_M0.5080.88
260_L268_K0.5080.88
237_S379_G0.5070.88
206_C222_A0.5070.88
113_S305_T0.5060.88
232_W236_Y0.5050.88
176_K362_E0.5050.88
152_V201_L0.5040.88
213_F259_P0.5040.88
49_K61_V0.5030.87
38_V80_E0.5020.87
326_N401_I0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o0tA 2 0.9749 100 0.248 Contact Map
1twiA 4 0.9749 100 0.255 Contact Map
2qghA 2 0.8975 100 0.258 Contact Map
2j66A 2 0.8861 100 0.266 Contact Map
3vabA 2 0.9453 100 0.267 Contact Map
1knwA 2 0.9248 100 0.268 Contact Map
3n2bA 2 0.9476 100 0.276 Contact Map
3nzpA 2 0.9567 100 0.281 Contact Map
3nzqA 2 0.9886 100 0.285 Contact Map
3n2oA 2 0.9886 100 0.306 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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