GREMLIN Database
YLXF - FlaA locus 22.9 kDa protein
UniProt: P23454 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 204 (173)
Sequences: 578 (493)
Seq/√Len: 37.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_I93_L3.4351.00
83_I86_Q3.3751.00
111_I114_L3.3621.00
167_E186_K2.8531.00
76_T79_L2.7631.00
104_I107_L2.7561.00
118_A121_Q2.5791.00
171_I196_T2.5251.00
27_I31_I2.4401.00
51_T54_L2.3641.00
85_D89_E2.2740.99
163_L168_A2.1660.99
144_V175_L2.0670.99
168_A172_L2.0530.99
140_E143_K1.9600.98
110_K113_S1.9100.98
21_P24_F1.8960.98
172_L180_L1.8720.98
148_Y196_T1.8660.98
18_I21_P1.8620.98
161_A188_T1.7900.97
112_R115_E1.7510.97
123_K126_E1.7100.96
182_D185_A1.7010.96
101_K111_I1.6510.95
150_S153_S1.6330.95
161_A191_Q1.6140.95
22_L25_L1.6120.95
148_Y158_K1.6080.95
86_Q90_I1.5630.94
32_V36_A1.5260.93
158_K161_A1.5260.93
22_L29_G1.5140.93
148_Y181_A1.4820.92
78_A139_S1.4600.91
15_L19_I1.4550.91
146_S150_S1.4540.91
147_V180_L1.4310.90
139_S190_E1.4160.90
93_L100_S1.4050.90
33_L163_L1.4040.89
152_D186_K1.4020.89
145_I197_E1.3700.88
107_L110_K1.3640.88
108_N112_R1.3590.88
53_V58_V1.3570.88
166_Q198_K1.3530.88
53_V57_L1.3420.87
101_K104_I1.3410.87
188_T191_Q1.3400.87
54_L57_L1.3380.87
89_E92_I1.3370.87
30_G34_W1.3200.86
172_L193_A1.3190.86
167_E171_I1.3150.86
101_K145_I1.3010.86
118_A144_V1.2870.85
96_D99_T1.2840.85
144_V196_T1.2780.84
104_I159_I1.2700.84
24_F36_A1.2500.83
39_N42_K1.2460.83
20_L25_L1.2360.82
115_E119_E1.2160.81
171_I193_A1.1990.80
107_L111_I1.1560.78
79_L169_L1.1560.78
190_E194_T1.1350.77
76_T153_S1.1330.77
100_S104_I1.1140.75
149_K179_Q1.1120.75
153_S185_A1.1080.75
168_A195_Y1.1060.75
54_L61_T1.1060.75
159_I201_A1.0970.74
121_Q125_S1.0960.74
191_Q195_Y1.0950.74
187_M195_Y1.0940.74
21_P187_M1.0890.74
146_S149_K1.0880.74
55_K83_I1.0720.72
93_L96_D1.0700.72
84_K88_S1.0540.71
108_N114_L1.0440.70
23_M26_L1.0390.70
138_S174_G1.0380.70
107_L148_Y1.0120.68
82_T85_D1.0060.67
160_I187_M1.0050.67
79_L152_D0.9920.66
31_I37_G0.9920.66
197_E200_A0.9850.66
80_E187_M0.9820.66
114_L117_T0.9710.65
165_E198_K0.9700.65
28_A97_L0.9690.65
149_K181_A0.9680.64
109_Q112_R0.9650.64
177_K181_A0.9620.64
165_E194_T0.9600.64
167_E181_A0.9560.63
176_S197_E0.9520.63
143_K149_K0.9520.63
102_S166_Q0.9520.63
165_E168_A0.9450.63
86_Q105_D0.9440.62
148_Y155_K0.9420.62
164_K183_I0.9420.62
27_I30_G0.9420.62
82_T86_Q0.9350.62
152_D167_E0.9300.61
141_N144_V0.9290.61
23_M64_K0.9250.61
169_L199_I0.9230.61
114_L181_A0.9200.60
146_S177_K0.9100.60
163_L195_Y0.9020.59
100_S108_N0.9020.59
195_Y198_K0.9010.59
98_E108_N0.8990.59
164_K167_E0.8940.58
169_L180_L0.8920.58
48_A58_V0.8880.58
76_T115_E0.8840.57
60_E63_N0.8760.57
27_I37_G0.8750.57
160_I193_A0.8580.55
169_L195_Y0.8410.54
170_K195_Y0.8400.54
168_A179_Q0.8330.53
146_S179_Q0.8330.53
93_L107_L0.8270.52
159_I171_I0.8250.52
160_I197_E0.8250.52
44_I164_K0.8220.52
153_S189_P0.8200.52
165_E169_L0.8160.51
170_K174_G0.8080.51
96_D107_L0.8080.51
171_I197_E0.8050.50
62_E99_T0.8050.50
171_I201_A0.8050.50
113_S117_T0.8040.50
88_S92_I0.8010.50
79_L93_L0.8000.50
33_L86_Q0.8000.50
165_E180_L0.7960.50
111_I140_E0.7960.50
66_G89_E0.7950.50
98_E102_S0.7950.50
21_P180_L0.7890.49
19_I101_K0.7770.48
177_K180_L0.7720.47
168_A197_E0.7670.47
26_L171_I0.7650.47
147_V181_A0.7580.46
96_D168_A0.7560.46
48_A53_V0.7550.46
31_I91_S0.7530.46
98_E123_K0.7520.46
150_S178_K0.7450.45
144_V189_P0.7370.44
24_F191_Q0.7350.44
81_K104_I0.7290.44
117_T162_Q0.7270.44
144_V167_E0.7270.44
148_Y153_S0.7260.43
22_L165_E0.7170.43
74_S121_Q0.7150.42
167_E193_A0.7100.42
179_Q182_D0.7100.42
40_V47_A0.7090.42
187_M198_K0.7040.42
109_Q113_S0.6990.41
178_K185_A0.6930.41
153_S182_D0.6890.40
62_E66_G0.6860.40
111_I148_Y0.6800.39
168_A193_A0.6730.39
162_Q193_A0.6700.39
118_A164_K0.6700.39
25_L29_G0.6670.38
20_L183_I0.6630.38
116_K120_D0.6620.38
143_K146_S0.6480.37
22_L62_E0.6460.37
46_D49_A0.6450.37
125_S128_H0.6450.37
159_I173_N0.6320.35
32_V89_E0.6310.35
104_I148_Y0.6300.35
31_I35_A0.6290.35
60_E101_K0.6280.35
36_A91_S0.6230.35
44_I116_K0.6140.34
95_K99_T0.6120.34
83_I122_K0.6110.34
45_Q63_N0.6080.34
59_P175_L0.6070.33
128_H139_S0.6060.33
124_S159_I0.6050.33
140_E146_S0.6020.33
63_N123_K0.5950.33
76_T163_L0.5940.32
144_V171_I0.5930.32
105_D108_N0.5930.32
49_A58_V0.5910.32
117_T121_Q0.5850.32
18_I24_F0.5820.32
92_I195_Y0.5810.31
86_Q94_N0.5790.31
45_Q106_R0.5780.31
148_Y187_M0.5750.31
121_Q128_H0.5750.31
81_K99_T0.5740.31
79_L180_L0.5730.31
106_R141_N0.5710.31
145_I158_K0.5710.31
143_K177_K0.5690.31
165_E197_E0.5680.30
137_A181_A0.5610.30
100_S103_E0.5600.30
28_A154_G0.5570.30
145_I163_L0.5560.30
113_S183_I0.5530.29
28_A31_I0.5520.29
93_L157_A0.5500.29
81_K166_Q0.5480.29
102_S119_E0.5480.29
15_L85_D0.5470.29
22_L166_Q0.5470.29
49_A56_E0.5430.29
153_S164_K0.5380.28
76_T101_K0.5380.28
123_K154_G0.5350.28
180_L196_T0.5340.28
158_K189_P0.5340.28
50_K55_K0.5300.28
51_T113_S0.5290.28
100_S143_K0.5240.27
108_N111_I0.5240.27
147_V179_Q0.5230.27
138_S151_M0.5220.27
146_S176_S0.5210.27
160_I168_A0.5210.27
88_S106_R0.5200.27
159_I162_Q0.5200.27
27_I124_S0.5180.27
112_R148_Y0.5120.26
31_I66_G0.5090.26
114_L159_I0.5090.26
160_I171_I0.5090.26
40_V43_P0.5080.26
125_S189_P0.5070.26
42_K163_L0.5040.26
165_E172_L0.5030.26
42_K89_E0.5020.26
17_I41_L0.5020.26
170_K201_A0.5000.26
26_L63_N0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fhrB 1 0.3284 96.4 0.847 Contact Map
3uswA 1 0.299 96 0.853 Contact Map
2ouxA 2 0.5147 95.8 0.854 Contact Map
4cgkA 3 0.6176 95.2 0.861 Contact Map
4q4gX 1 0 94.4 0.866 Contact Map
4fq0C 1 0.3039 88.2 0.887 Contact Map
2zy9A 2 0.4216 86.2 0.891 Contact Map
2yvyA 2 0.4265 85.2 0.892 Contact Map
3hjlA 1 0.799 78.7 0.899 Contact Map
3kxrA 3 0.2745 72.9 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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