GREMLIN Database
FLIM - Flagellar motor switch protein FliM
UniProt: P23453 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 332 (311)
Sequences: 1937 (1306)
Seq/√Len: 74.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_A295_L5.8951.00
297_V307_G5.4211.00
130_D137_G5.3981.00
265_E268_T4.9371.00
306_L322_D4.9291.00
147_T150_E4.1981.00
67_L161_A3.8321.00
8_Q12_D3.8021.00
77_T208_G3.5951.00
297_V318_V3.5761.00
271_L276_F3.2781.00
296_T306_L3.2071.00
307_G318_V3.1561.00
294_P321_L3.1271.00
125_A154_I3.0971.00
133_M153_I2.9671.00
264_A297_V2.7501.00
296_T303_P2.6881.00
70_H164_N2.6841.00
21_G25_A2.6231.00
279_L283_D2.6221.00
271_L279_L2.5261.00
12_D18_I2.4551.00
267_G287_L2.4021.00
50_K53_I2.3161.00
265_E296_T2.0431.00
265_E298_L1.9641.00
93_E96_R1.9451.00
273_I276_F1.9281.00
220_H224_E1.9141.00
155_S159_E1.9131.00
130_D135_G1.8491.00
21_G24_D1.8101.00
128_M157_L1.7751.00
202_S213_V1.7751.00
23_M28_L1.7551.00
106_L115_R1.7521.00
110_H178_E1.7351.00
97_S200_V1.7251.00
263_V301_D1.7171.00
274_E278_S1.6911.00
166_K176_E1.6771.00
308_Q321_L1.6731.00
23_M26_E1.6651.00
289_K296_T1.6621.00
198_V217_C1.6471.00
261_P300_G1.6361.00
23_M27_E1.6301.00
133_M149_I1.6060.99
107_F162_L1.6030.99
294_P308_Q1.5780.99
58_R181_E1.5700.99
24_D28_L1.5330.99
303_P324_D1.5330.99
104_L117_M1.4940.99
262_V299_V1.4880.99
41_D45_A1.4430.99
244_K247_E1.4390.99
8_Q11_I1.4370.99
207_I211_S1.4300.99
105_N158_F1.4240.99
263_V298_L1.4190.99
172_I230_L1.4090.99
16_S19_S1.4000.99
48_F53_I1.3950.98
91_Y198_V1.3820.98
136_I139_S1.3770.98
262_V305_F1.3750.98
109_V162_L1.3690.98
92_E96_R1.3690.98
116_I216_L1.3500.98
295_L318_V1.3430.98
10_E14_L1.3410.98
110_H176_E1.3360.98
272_T275_E1.3330.98
17_A21_G1.3310.98
19_S22_E1.3150.98
103_I146_L1.3140.98
20_T23_M1.3120.98
311_R314_R1.3060.98
93_E97_S1.3030.98
24_D27_E1.2990.98
94_F217_C1.2910.97
98_I102_T1.2890.97
312_V317_A1.2850.97
12_D99_P1.2770.97
127_T131_R1.2530.97
116_I218_I1.2460.97
18_I21_G1.2460.97
83_V203_L1.2440.97
55_S230_L1.2440.97
307_G311_R1.2430.97
272_T326_R1.2420.97
118_M216_L1.2400.97
65_R76_R1.2390.97
90_P93_E1.2360.97
118_M178_E1.2140.96
273_I285_I1.2130.96
8_Q15_L1.2080.96
179_M182_F1.2020.96
7_S15_L1.2020.96
233_H320_I1.1790.96
105_N179_M1.1680.95
9_N21_G1.1640.95
25_A28_L1.1630.95
243_P248_T1.1610.95
108_D115_R1.1530.95
124_I205_T1.1520.95
107_F116_I1.1510.95
6_L10_E1.1510.95
86_V179_M1.1460.95
264_A280_E1.1440.95
121_N212_G1.1360.95
5_V18_I1.1290.95
22_E27_E1.1270.94
170_Q292_T1.1240.94
71_F223_L1.1190.94
40_Y45_A1.1170.94
167_E170_Q1.1150.94
166_K177_P1.1110.94
20_T27_E1.1100.94
20_T25_A1.1090.94
168_A230_L1.1050.94
106_L183_E1.1030.94
269_S287_L1.0990.94
267_G311_R1.0950.94
310_G317_A1.0930.94
189_V192_V1.0860.93
126_Y150_E1.0840.93
92_E185_N1.0840.93
147_T162_L1.0810.93
85_S213_V1.0770.93
109_V116_I1.0700.93
294_P306_L1.0680.93
175_I229_K1.0670.93
80_H206_Q1.0560.92
218_I326_R1.0540.92
273_I277_L1.0430.92
124_I212_G1.0430.92
264_A305_F1.0350.92
308_Q319_Q1.0340.92
69_T188_F1.0330.91
48_F90_P1.0280.91
48_F51_D1.0270.91
103_I132_V1.0240.91
108_D180_T1.0020.90
255_I302_K0.9960.90
9_N17_A0.9960.90
61_D65_R0.9950.90
139_S142_K0.9830.89
197_T220_H0.9770.89
21_G27_E0.9730.89
94_F215_N0.9710.89
277_L287_L0.9650.88
168_A301_D0.9630.88
19_S25_A0.9610.88
255_I258_A0.9590.88
22_E25_A0.9550.88
51_D90_P0.9520.88
72_S304_K0.9490.88
4_E17_A0.9420.87
290_S293_D0.9410.87
157_L293_D0.9360.87
20_T24_D0.9270.86
106_L150_E0.9230.86
99_P195_N0.9160.86
16_S20_T0.9140.86
169_W196_E0.9130.85
42_F45_A0.9110.85
56_L199_V0.9100.85
19_S23_M0.9090.85
63_F165_Y0.9050.85
222_V226_L0.9030.85
132_V252_E0.9020.85
18_I23_M0.9000.85
60_H169_W0.8960.84
187_Q190_Q0.8960.84
267_G299_V0.8950.84
298_L307_G0.8910.84
71_F157_L0.8900.84
60_H201_I0.8880.84
56_L138_I0.8860.84
66_L318_V0.8850.84
21_G324_D0.8760.83
52_Q224_E0.8740.83
56_L104_L0.8730.83
81_I205_T0.8730.83
56_L136_I0.8680.82
9_N13_A0.8640.82
84_S204_N0.8620.82
175_I225_P0.8620.82
286_T291_V0.8620.82
21_G42_F0.8590.82
48_F92_E0.8570.82
239_D248_T0.8560.82
165_Y179_M0.8560.82
42_F47_R0.8530.81
83_V212_G0.8530.81
111_P114_G0.8470.81
45_A50_K0.8460.81
41_D44_R0.8420.81
252_E255_I0.8360.80
170_Q207_I0.8340.80
132_V307_G0.8340.80
94_F104_L0.8290.79
116_I158_F0.8290.79
16_S23_M0.8210.79
312_V319_Q0.8170.78
149_I219_P0.8160.78
13_A56_L0.8150.78
51_D115_R0.8110.78
113_E242_E0.8100.78
24_D285_I0.8100.78
147_T198_V0.8090.78
91_Y95_I0.8090.78
218_I225_P0.8080.78
183_E191_M0.8050.77
148_E247_E0.8040.77
116_I162_L0.8030.77
295_L307_G0.8010.77
70_H160_N0.8000.77
257_T302_K0.7990.77
150_E292_T0.7980.77
312_V315_K0.7970.77
252_E256_M0.7960.77
267_G289_K0.7960.77
149_I230_L0.7960.77
258_A305_F0.7900.76
86_V199_V0.7860.76
151_T155_S0.7780.75
170_Q306_L0.7780.75
17_A301_D0.7700.74
126_Y144_D0.7700.74
112_M225_P0.7670.74
227_I230_L0.7650.74
130_D320_I0.7600.73
16_S24_D0.7600.73
7_S10_E0.7550.73
54_R57_T0.7530.73
120_V214_I0.7500.72
205_T214_I0.7490.72
79_I201_I0.7490.72
46_L88_Q0.7470.72
74_Q160_N0.7470.72
193_S196_E0.7470.72
64_A301_D0.7440.72
139_S216_L0.7430.72
263_V321_L0.7420.72
150_E322_D0.7280.70
120_V197_T0.7250.70
228_P244_K0.7240.70
95_I186_P0.7220.69
38_K83_V0.7210.69
188_F194_P0.7210.69
58_R264_A0.7190.69
268_T298_L0.7190.69
179_M184_V0.7140.69
11_I18_I0.7130.68
286_T289_K0.7090.68
155_S259_Q0.7070.68
117_M185_N0.7060.68
267_G288_D0.7010.67
240_R247_E0.7010.67
230_L288_D0.6990.67
144_D150_E0.6980.67
7_S14_L0.6960.67
295_L309_A0.6960.67
48_F52_Q0.6930.66
185_N189_V0.6930.66
213_V255_I0.6910.66
219_P279_L0.6910.66
19_S108_D0.6890.66
218_I265_E0.6860.65
292_T296_T0.6830.65
51_D237_Q0.6820.65
224_E230_L0.6810.65
87_D243_P0.6800.65
5_V21_G0.6780.65
135_G219_P0.6760.64
101_M220_H0.6750.64
88_Q195_N0.6730.64
5_V9_N0.6730.64
120_V125_A0.6720.64
17_A23_M0.6720.64
41_D190_Q0.6720.64
289_K293_D0.6700.64
291_V295_L0.6650.63
103_I151_T0.6640.63
273_I281_V0.6640.63
133_M294_P0.6560.62
304_K309_A0.6550.62
106_L147_T0.6550.62
43_K275_E0.6520.62
261_P325_I0.6490.61
242_E246_E0.6480.61
81_I203_L0.6480.61
19_S26_E0.6470.61
164_N168_A0.6470.61
250_S254_R0.6460.61
265_E292_T0.6440.61
49_S52_Q0.6420.60
45_A239_D0.6420.60
54_R62_N0.6410.60
26_E326_R0.6410.60
260_I277_L0.6400.60
251_L310_G0.6400.60
42_F49_S0.6390.60
163_G167_E0.6380.60
199_V275_E0.6360.60
100_N143_V0.6360.60
104_L107_F0.6350.60
18_I26_E0.6350.60
305_F323_H0.6350.60
124_I158_F0.6350.60
102_T105_N0.6330.59
163_G307_G0.6320.59
183_E225_P0.6300.59
92_E186_P0.6290.59
72_S79_I0.6280.59
283_D310_G0.6260.58
298_L311_R0.6260.58
43_K50_K0.6240.58
311_R323_H0.6200.58
46_L51_D0.6190.58
40_Y43_K0.6180.57
238_S242_E0.6160.57
248_T252_E0.6160.57
89_V192_V0.6150.57
263_V309_A0.6140.57
118_M249_K0.6120.57
251_L260_I0.6110.57
271_L275_E0.6110.57
170_Q288_D0.6100.56
114_G224_E0.6090.56
298_L303_P0.6070.56
237_Q240_R0.6050.56
265_E318_V0.6040.56
272_T278_S0.6040.56
101_M143_V0.6040.56
52_Q57_T0.6020.56
97_S275_E0.6010.55
109_V175_I0.6000.55
88_Q196_E0.5990.55
114_G128_M0.5980.55
196_E283_D0.5970.55
92_E194_P0.5960.55
214_I266_L0.5940.55
9_N67_L0.5930.54
144_D191_M0.5930.54
203_L260_I0.5930.54
274_E316_Q0.5920.54
47_R197_T0.5910.54
187_Q197_T0.5910.54
119_E304_K0.5900.54
150_E222_V0.5890.54
22_E28_L0.5850.53
125_A290_S0.5840.53
166_K301_D0.5840.53
309_A316_Q0.5810.53
112_M226_L0.5810.53
113_E133_M0.5800.53
294_P322_D0.5780.53
82_S152_K0.5770.52
147_T219_P0.5770.52
70_H153_I0.5770.52
290_S314_R0.5760.52
41_D91_Y0.5750.52
261_P301_D0.5750.52
188_F225_P0.5740.52
184_V237_Q0.5710.52
5_V17_A0.5700.52
26_E275_E0.5690.51
185_N225_P0.5690.51
180_T297_V0.5690.51
54_R227_I0.5680.51
232_V237_Q0.5650.51
108_D214_I0.5650.51
4_E22_E0.5640.51
263_V269_S0.5630.51
275_E314_R0.5630.51
268_T296_T0.5630.51
82_S211_S0.5620.51
264_A307_G0.5620.51
18_I92_E0.5620.51
155_S213_V0.5610.50
202_S215_N0.5610.50
154_I255_I0.5610.50
68_T83_V0.5600.50
68_T71_F0.5590.50
159_E170_Q0.5590.50
253_K306_L0.5590.50
41_D47_R0.5580.50
174_D279_L0.5570.50
131_R167_E0.5570.50
106_L191_M0.5570.50
101_M128_M0.5550.50
79_I152_K0.5550.50
123_T204_N0.5540.50
257_T260_I0.5530.49
156_N181_E0.5520.49
108_D288_D0.5510.49
118_M278_S0.5510.49
266_L290_S0.5500.49
51_D54_R0.5500.49
40_Y44_R0.5490.49
111_P176_E0.5490.49
91_Y115_R0.5490.49
110_H121_N0.5480.49
270_E323_H0.5470.49
177_P297_V0.5460.49
107_F177_P0.5460.49
125_A273_I0.5440.48
293_D325_I0.5440.48
94_F187_Q0.5420.48
94_F117_M0.5420.48
46_L220_H0.5410.48
296_T321_L0.5410.48
226_L249_K0.5410.48
99_P230_L0.5390.48
75_L137_G0.5390.48
132_V158_F0.5390.48
56_L59_I0.5370.47
163_G179_M0.5360.47
188_F193_S0.5350.47
141_N292_T0.5320.47
242_E250_S0.5310.47
172_I320_I0.5310.47
275_E319_Q0.5280.46
265_E312_V0.5280.46
205_T315_K0.5270.46
264_A289_K0.5260.46
204_N211_S0.5250.46
182_F216_L0.5250.46
97_S186_P0.5250.46
267_G293_D0.5240.46
51_D142_K0.5230.46
92_E196_E0.5230.46
176_E260_I0.5220.46
287_L294_P0.5210.45
93_E183_E0.5200.45
255_I262_V0.5190.45
111_P126_Y0.5160.45
4_E7_S0.5140.45
258_A312_V0.5140.45
117_M281_V0.5130.44
47_R50_K0.5130.44
52_Q62_N0.5130.44
265_E271_L0.5130.44
260_I299_V0.5110.44
285_I292_T0.5100.44
84_S300_G0.5090.44
22_E26_E0.5080.44
103_I182_F0.5080.44
301_D320_I0.5080.44
126_Y283_D0.5070.44
93_E147_T0.5070.44
4_E21_G0.5060.44
255_I281_V0.5060.44
277_L298_L0.5060.44
277_L323_H0.5040.43
262_V278_S0.5010.43
46_L197_T0.5010.43
260_I315_K0.5010.43
247_E310_G0.5000.43
147_T185_N0.5000.43
69_T127_T0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gc8A 1 0.5542 100 0.506 Contact Map
4fhrA 1 0.5482 100 0.594 Contact Map
4hynA 1 0.5753 100 0.642 Contact Map
1xkrA 1 0.5602 100 0.642 Contact Map
4yxcB 1 0.4789 99.9 0.691 Contact Map
3qtaA 2 0.5783 99.9 0.712 Contact Map
1o6aA 2 0.253 99.8 0.737 Contact Map
3uepA 2 0.247 99.8 0.747 Contact Map
4yxbD 2 0.2319 99.8 0.753 Contact Map
4tt9A 2 0.2199 99.8 0.755 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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