GREMLIN Database
FLIK - Probable flagellar hook-length control protein
UniProt: P23451 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 487 (423)
Sequences: 226 (221)
Seq/√Len: 10.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
354_Q357_N4.1500.99
405_S408_A3.1910.96
429_Q433_F3.0620.95
351_V354_Q2.9920.94
379_N382_H2.7650.91
387_T415_H2.7380.91
420_K425_N2.6930.90
397_F408_A2.6250.89
368_G403_A2.6070.88
373_S389_K2.5980.88
375_T432_R2.5460.87
415_H436_P2.5160.86
362_M374_F2.4770.85
401_I427_A2.2740.80
424_P429_Q2.2660.80
397_F427_A2.2600.79
382_H425_N2.2530.79
406_Q410_E2.2520.79
350_T408_A2.2500.79
351_V411_L2.1870.77
401_I435_L2.1240.75
415_H434_T2.1210.75
400_K427_A2.1190.75
399_S415_H2.0960.74
399_S435_L2.0890.74
429_Q432_R2.0830.73
440_G443_P2.0290.71
393_E405_S2.0120.71
390_L433_F2.0060.70
399_S403_A1.9620.69
362_M392_N1.9580.68
415_H433_F1.9450.68
411_L415_H1.9450.68
351_V370_S1.9440.68
411_L429_Q1.9320.67
374_F427_A1.9270.67
370_S411_L1.8910.66
396_M433_F1.8750.65
429_Q442_Q1.8670.65
397_F433_F1.8620.64
374_F387_T1.8280.63
399_S422_S1.8080.62
354_Q373_S1.7800.61
375_T429_Q1.7740.60
380_P384_G1.7710.60
396_M420_K1.7690.60
381_E425_N1.7570.60
388_I423_L1.7560.60
387_T424_P1.7400.59
374_F397_F1.7330.59
373_S404_S1.7280.58
375_T442_Q1.7270.58
392_N397_F1.7250.58
351_V429_Q1.7220.58
374_F390_L1.7220.58
57_L61_L1.7210.58
411_L432_R1.7200.58
385_F437_V1.7200.58
355_V427_A1.7040.57
351_V405_S1.6900.57
440_G445_Y1.6840.56
397_F423_L1.6840.56
387_T441_D1.6770.56
375_T411_L1.6740.56
389_K420_K1.6700.56
411_L434_T1.6620.55
385_F389_K1.6600.55
422_S429_Q1.6590.55
391_T409_K1.6560.55
385_F441_D1.6550.55
376_I381_E1.6480.55
379_N420_K1.6480.55
377_R471_F1.6430.54
388_I396_M1.6350.54
387_T422_S1.6330.54
401_I444_I1.6320.54
374_F377_R1.6320.54
399_S427_A1.6190.53
405_S427_A1.6170.53
415_H430_I1.6130.53
429_Q437_V1.5900.52
399_S428_V1.5860.52
376_I442_Q1.5860.52
375_T422_S1.5790.51
379_N385_F1.5790.51
389_K393_E1.5740.51
392_N427_A1.5650.51
375_T387_T1.5610.51
400_K415_H1.5590.50
378_L419_L1.5570.50
359_W374_F1.5500.50
351_V408_A1.5460.50
387_T437_V1.5450.50
362_M375_T1.5380.49
375_T443_P1.5350.49
399_S424_P1.5180.48
386_V399_S1.5160.48
355_V373_S1.5160.48
370_S388_I1.5060.48
372_G433_F1.5020.48
374_F424_P1.5010.48
382_H422_S1.4960.47
372_G399_S1.4940.47
376_I389_K1.4790.47
379_N425_N1.4740.46
406_Q437_V1.4700.46
402_I415_H1.4610.46
375_T433_F1.4510.45
377_R437_V1.4470.45
384_G419_L1.4330.44
380_P419_L1.4330.44
399_S433_F1.4320.44
392_N400_K1.4270.44
380_P383_L1.4260.44
376_I414_Q1.4220.44
354_Q433_F1.4210.44
406_Q442_Q1.4200.44
383_L413_E1.4040.43
56_L62_K1.3980.43
393_E429_Q1.3910.42
404_S408_A1.3890.42
411_L437_V1.3870.42
349_K433_F1.3810.42
387_T429_Q1.3730.42
374_F396_M1.3720.42
370_S374_F1.3640.41
406_Q411_L1.3630.41
432_R437_V1.3590.41
73_E82_L1.3460.40
388_I411_L1.3400.40
427_A435_L1.3380.40
377_R411_L1.3360.40
396_M427_A1.3330.40
450_D454_Q1.3300.40
377_R442_Q1.3280.40
361_Q414_Q1.3270.40
408_A440_G1.3160.39
360_K408_A1.3060.39
436_P441_D1.3050.39
385_F404_S1.2950.38
378_L384_G1.2860.38
376_I415_H1.2840.38
381_E387_T1.2700.37
377_R387_T1.2670.37
403_A415_H1.2640.37
395_G431_D1.2550.36
377_R396_M1.2470.36
372_G427_A1.2410.36
396_M403_A1.2380.36
333_T431_D1.2250.35
415_H422_S1.2250.35
406_Q421_Q1.2210.35
386_V415_H1.2200.35
379_N401_I1.2160.35
373_S387_T1.2150.35
372_G401_I1.2110.34
425_N432_R1.2080.34
148_L193_A1.2080.34
406_Q429_Q1.2020.34
374_F392_N1.1990.34
362_M422_S1.1950.34
389_K423_L1.1950.34
397_F429_Q1.1920.34
373_S385_F1.1900.34
406_Q432_R1.1830.33
387_T425_N1.1830.33
387_T402_I1.1820.33
374_F429_Q1.1780.33
393_E406_Q1.1740.33
408_A429_Q1.1740.33
363_K437_V1.1730.33
364_Y471_F1.1730.33
382_H395_G1.1660.33
331_V420_K1.1640.32
415_H429_Q1.1620.32
393_E415_H1.1580.32
410_E442_Q1.1520.32
362_M404_S1.1510.32
364_Y372_G1.1510.32
411_L421_Q1.1480.32
393_E411_L1.1480.32
388_I391_T1.1450.32
399_S426_M1.1380.31
376_I387_T1.1230.31
406_Q424_P1.1200.31
361_Q390_L1.1130.30
374_F388_I1.1050.30
472_G477_E1.1050.30
470_D473_D1.1050.30
387_T420_K1.1030.30
403_A421_Q1.1020.30
387_T400_K1.0900.29
354_Q437_V1.0860.29
379_N433_F1.0860.29
442_Q445_Y1.0850.29
375_T406_Q1.0830.29
354_Q379_N1.0820.29
411_L442_Q1.0820.29
437_V442_Q1.0790.29
416_L425_N1.0790.29
399_S429_Q1.0760.29
373_S396_M1.0670.29
387_T427_A1.0670.29
440_G446_G1.0620.28
406_Q422_S1.0590.28
62_K74_D1.0590.28
393_E432_R1.0560.28
422_S425_N1.0550.28
386_V403_A1.0550.28
355_V364_Y1.0540.28
381_E420_K1.0520.28
364_Y385_F1.0450.28
402_I409_K1.0440.28
396_M424_P1.0420.28
361_Q381_E1.0340.27
383_L419_L1.0310.27
415_H437_V1.0250.27
410_E437_V1.0210.27
395_G399_S1.0200.27
405_S424_P1.0190.27
408_A411_L1.0180.27
378_L435_L1.0150.27
387_T439_S1.0140.27
361_Q398_Q1.0140.27
375_T404_S1.0120.26
397_F424_P1.0100.26
403_A422_S1.0100.26
399_S406_Q1.0100.26
357_N413_E1.0080.26
60_A63_K1.0050.26
357_N408_A1.0040.26
377_R427_A1.0030.26
375_T427_A0.9880.26
362_M387_T0.9880.26
125_E208_E0.9870.26
385_F420_K0.9870.26
399_S425_N0.9850.25
388_I420_K0.9830.25
422_S433_F0.9830.25
403_A408_A0.9830.25
378_L413_E0.9820.25
362_M421_Q0.9810.25
405_S416_L0.9810.25
396_M429_Q0.9780.25
374_F400_K0.9750.25
432_R440_G0.9740.25
366_P385_F0.9710.25
431_D455_Q0.9710.25
371_T400_K0.9670.25
385_F415_H0.9600.25
403_A416_L0.9520.24
403_A417_P0.9500.24
390_L453_K0.9470.24
414_Q452_Q0.9440.24
420_K432_R0.9440.24
411_L443_P0.9420.24
355_V358_A0.9410.24
355_V379_N0.9400.24
392_N429_Q0.9400.24
362_M385_F0.9400.24
393_E423_L0.9390.24
397_F415_H0.9380.24
100_Q141_A0.9380.24
377_R404_S0.9350.24
381_E408_A0.9350.24
373_S427_A0.9320.24
401_I423_L0.9270.23
424_P432_R0.9250.23
360_K388_I0.9230.23
404_S471_F0.9210.23
393_E420_K0.9170.23
422_S428_V0.9170.23
356_I401_I0.9160.23
443_P446_G0.9160.23
361_Q429_Q0.9150.23
349_K354_Q0.9130.23
363_K366_P0.9130.23
387_T432_R0.9130.23
363_K433_F0.9110.23
347_E363_K0.9070.23
375_T440_G0.9060.23
377_R421_Q0.9040.23
370_S390_L0.9040.23
393_E422_S0.9040.23
355_V433_F0.9020.23
47_K68_L0.8960.22
355_V401_I0.8960.22
105_L471_F0.8950.22
388_I441_D0.8940.22
404_S427_A0.8920.22
373_S401_I0.8910.22
374_F438_Q0.8910.22
443_P454_Q0.8890.22
353_D357_N0.8860.22
400_K406_Q0.8860.22
357_N360_K0.8850.22
373_S426_M0.8830.22
393_E437_V0.8810.22
374_F420_K0.8800.22
374_F433_F0.8790.22
390_L396_M0.8750.22
379_N388_I0.8740.22
152_K157_Q0.8730.22
397_F411_L0.8680.21
428_V440_G0.8680.21
376_I435_L0.8670.21
422_S432_R0.8640.21
374_F437_V0.8630.21
362_M415_H0.8600.21
433_F442_Q0.8580.21
375_T379_N0.8560.21
422_S437_V0.8560.21
388_I447_Q0.8550.21
376_I425_N0.8540.21
74_D78_Q0.8530.21
389_K411_L0.8530.21
405_S439_S0.8520.21
355_V374_F0.8510.21
406_Q415_H0.8490.21
373_S403_A0.8480.21
58_A61_L0.8470.21
354_Q385_F0.8470.21
400_K412_L0.8470.21
376_I393_E0.8460.21
427_A434_T0.8420.21
71_S78_Q0.8410.21
427_A433_F0.8400.21
375_T441_D0.8400.21
415_H425_N0.8360.20
355_V385_F0.8360.20
362_M397_F0.8350.20
378_L383_L0.8350.20
358_A412_L0.8330.20
385_F422_S0.8330.20
411_L440_G0.8320.20
375_T424_P0.8290.20
373_S392_N0.8280.20
400_K425_N0.8280.20
374_F385_F0.8270.20
377_R433_F0.8240.20
416_L446_G0.8230.20
377_R434_T0.8200.20
411_L424_P0.8160.20
364_Y375_T0.8150.20
375_T423_L0.8100.20
388_I408_A0.8080.20
55_Q65_G0.8080.20
387_T423_L0.8070.20
379_N415_H0.8050.20
231_S241_E0.8040.19
373_S379_N0.7950.19
310_Q388_I0.7910.19
432_R446_G0.7880.19
395_G412_L0.7860.19
400_K422_S0.7850.19
418_Q443_P0.7840.19
379_N394_N0.7840.19
398_Q434_T0.7830.19
354_Q362_M0.7810.19
375_T396_M0.7790.19
410_E429_Q0.7790.19
379_N412_L0.7780.19
392_N411_L0.7780.19
424_P433_F0.7750.19
377_R432_R0.7750.19
386_V433_F0.7730.19
375_T397_F0.7710.19
363_K374_F0.7710.19
354_Q432_R0.7690.18
432_R442_Q0.7690.18
445_Y448_L0.7670.18
393_E396_M0.7660.18
362_M438_Q0.7620.18
359_W427_A0.7620.18
103_Q143_D0.7600.18
420_K444_I0.7580.18
375_T393_E0.7580.18
361_Q432_R0.7580.18
193_A461_Q0.7540.18
420_K434_T0.7540.18
362_M386_V0.7530.18
387_T421_Q0.7520.18
57_L62_K0.7490.18
406_Q443_P0.7450.18
388_I401_I0.7440.18
359_W423_L0.7380.18
379_N422_S0.7370.18
400_K410_E0.7360.18
375_T408_A0.7350.18
375_T382_H0.7350.18
363_K372_G0.7340.17
55_Q59_D0.7340.17
370_S424_P0.7310.17
351_V357_N0.7290.17
360_K429_Q0.7270.17
370_S373_S0.7260.17
365_T416_L0.7240.17
268_S435_L0.7230.17
393_E424_P0.7220.17
379_N434_T0.7210.17
54_D58_A0.7210.17
415_H424_P0.7210.17
412_L443_P0.7190.17
358_A362_M0.7180.17
392_N405_S0.7160.17
387_T434_T0.7150.17
415_H440_G0.7140.17
351_V375_T0.7130.17
375_T415_H0.7120.17
382_H401_I0.7120.17
266_A272_A0.7110.17
397_F403_A0.7100.17
431_D441_D0.7100.17
197_Y206_A0.7100.17
403_A425_N0.7090.17
385_F425_N0.7080.17
362_M429_Q0.7080.17
353_D432_R0.7060.17
410_E433_F0.7020.17
425_N429_Q0.6990.17
396_M428_V0.6960.16
445_Y449_A0.6960.16
220_L457_E0.6950.16
352_A355_V0.6900.16
381_E447_Q0.6900.16
415_H432_R0.6890.16
393_E433_F0.6870.16
385_F396_M0.6850.16
370_S429_Q0.6830.16
401_I449_A0.6820.16
372_G429_Q0.6810.16
423_L427_A0.6800.16
408_A438_Q0.6780.16
348_T374_F0.6780.16
387_T396_M0.6760.16
385_F392_N0.6750.16
84_Q88_K0.6750.16
389_K422_S0.6730.16
363_K395_G0.6720.16
387_T392_N0.6710.16
404_S438_Q0.6700.16
431_D478_V0.6670.16
414_Q438_Q0.6660.16
387_T404_S0.6660.16
379_N418_Q0.6650.16
368_G372_G0.6650.16
374_F408_A0.6650.16
396_M412_L0.6610.16
388_I442_Q0.6610.16
355_V362_M0.6600.16
408_A437_V0.6590.16
366_P409_K0.6570.15
387_T436_P0.6570.15
356_I433_F0.6560.15
361_Q368_G0.6520.15
347_E410_E0.6520.15
73_E79_N0.6520.15
56_L228_A0.6500.15
397_F438_Q0.6500.15
106_L141_A0.6480.15
381_E475_L0.6460.15
230_S271_K0.6450.15
391_T394_N0.6450.15
351_V404_S0.6440.15
380_P395_G0.6440.15
384_G395_G0.6440.15
397_F434_T0.6380.15
362_M400_K0.6370.15
401_I410_E0.6360.15
346_A420_K0.6360.15
370_S408_A0.6360.15
424_P434_T0.6340.15
413_E472_G0.6330.15
381_E439_S0.6320.15
362_M405_S0.6310.15
354_Q377_R0.6310.15
350_T440_G0.6300.15
64_I68_L0.6300.15
65_G69_N0.6290.15
47_K451_E0.6290.15
65_G73_E0.6280.15
379_N386_V0.6270.15
399_S434_T0.6270.15
404_S440_G0.6270.15
364_Y427_A0.6260.15
395_G455_Q0.6260.15
152_K413_E0.6250.15
380_P413_E0.6240.15
384_G413_E0.6240.15
430_I434_T0.6240.15
376_I434_T0.6240.15
389_K400_K0.6240.15
398_Q438_Q0.6180.15
55_Q58_A0.6180.15
385_F429_Q0.6180.15
357_N433_F0.6170.14
395_G433_F0.6150.14
348_T415_H0.6140.14
413_E419_L0.6130.14
472_G476_D0.6130.14
57_L67_W0.6130.14
422_S442_Q0.6130.14
401_I404_S0.6100.14
392_N424_P0.6090.14
385_F410_E0.6090.14
67_W72_P0.6080.14
103_Q196_I0.6080.14
363_K400_K0.6080.14
424_P427_A0.6070.14
393_E442_Q0.6070.14
410_E432_R0.6040.14
356_I370_S0.6030.14
137_A220_L0.6020.14
366_P371_T0.6010.14
391_T420_K0.6000.14
381_E432_R0.6000.14
375_T439_S0.6000.14
365_T438_Q0.5990.14
375_T389_K0.5970.14
361_Q420_K0.5960.14
379_N429_Q0.5950.14
415_H441_D0.5940.14
365_T390_L0.5930.14
55_Q67_W0.5930.14
375_T388_I0.5920.14
399_S430_I0.5910.14
362_M388_I0.5900.14
387_T433_F0.5880.14
427_A436_P0.5870.14
363_K402_I0.5870.14
423_L441_D0.5860.14
401_I416_L0.5820.14
386_V393_E0.5820.14
354_Q360_K0.5820.14
400_K417_P0.5820.14
62_K72_P0.5810.14
366_P391_T0.5790.14
381_E414_Q0.5790.14
355_V420_K0.5780.14
351_V387_T0.5780.14
351_V356_I0.5770.14
60_A64_I0.5760.14
408_A442_Q0.5740.14
377_R406_Q0.5700.13
377_R392_N0.5700.13
403_A434_T0.5670.13
412_L416_L0.5670.13
370_S437_V0.5670.13
348_T385_F0.5660.13
376_I411_L0.5660.13
396_M400_K0.5660.13
381_E446_G0.5660.13
380_P435_L0.5640.13
384_G435_L0.5640.13
373_S411_L0.5620.13
373_S438_Q0.5610.13
147_A271_K0.5600.13
357_N429_Q0.5560.13
398_Q442_Q0.5540.13
332_Q412_L0.5540.13
179_V187_L0.5540.13
85_T88_K0.5540.13
193_A243_K0.5530.13
240_S243_K0.5520.13
354_Q387_T0.5510.13
59_D66_E0.5500.13
79_N82_L0.5490.13
387_T393_E0.5480.13
418_Q421_Q0.5480.13
99_L412_L0.5450.13
389_K444_I0.5430.13
422_S434_T0.5430.13
354_Q365_T0.5430.13
362_M373_S0.5430.13
360_K375_T0.5420.13
363_K429_Q0.5410.13
351_V374_F0.5400.13
389_K424_P0.5400.13
54_D60_A0.5390.13
384_G399_S0.5380.13
380_P399_S0.5380.13
375_T391_T0.5380.13
416_L475_L0.5370.13
349_K414_Q0.5370.13
55_Q64_I0.5360.13
422_S431_D0.5330.13
427_A474_L0.5330.13
370_S379_N0.5320.13
408_A445_Y0.5310.13
402_I422_S0.5300.13
358_A396_M0.5300.13
425_N446_G0.5300.13
340_S373_S0.5300.13
401_I462_Q0.5290.13
375_T446_G0.5280.13
171_I180_E0.5280.13
369_R411_L0.5280.13
354_Q429_Q0.5270.12
402_I411_L0.5270.12
394_N412_L0.5260.12
421_Q432_R0.5250.12
297_S300_K0.5250.12
390_L411_L0.5250.12
379_N440_G0.5240.12
46_G49_T0.5240.12
109_V113_M0.5230.12
71_S131_A0.5200.12
412_L440_G0.5190.12
382_H455_Q0.5190.12
362_M401_I0.5160.12
419_L430_I0.5150.12
387_T406_Q0.5140.12
126_K195_A0.5140.12
396_M431_D0.5130.12
252_M257_Q0.5130.12
446_G477_E0.5130.12
404_S439_S0.5120.12
397_F445_Y0.5110.12
374_F417_P0.5110.12
394_N416_L0.5090.12
421_Q429_Q0.5080.12
362_M427_A0.5080.12
383_L435_L0.5080.12
382_H394_N0.5080.12
377_R385_F0.5050.12
471_F477_E0.5050.12
422_S439_S0.5050.12
374_F405_S0.5030.12
363_K422_S0.5020.12
409_K415_H0.5010.12
120_L143_D0.5010.12
387_T431_D0.5000.12
104_N110_E0.5000.12
391_T405_S0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rrlA 1 0.345 99.8 0.731 Contact Map
3bidA 2 0.1253 6.4 0.968 Contact Map
3ci9A 5 0.0986 4.2 0.971 Contact Map
3nr7A 2 0.1663 3.2 0.972 Contact Map
3encA 2 0.1499 2 0.975 Contact Map
4tpsB 1 0.1704 1.8 0.976 Contact Map
1sfcB 1 0.1417 1.6 0.976 Contact Map
5buzC 1 0.0678 1.4 0.977 Contact Map
5a63B 1 0 1.4 0.977 Contact Map
2jssB 1 0.0534 1.4 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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