GREMLIN Database
FLIH - Probable flagellar assembly protein FliH
UniProt: P23449 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (174)
Sequences: 1671 (1369)
Seq/√Len: 103.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_L44_A3.9921.00
36_E40_L3.3881.00
42_E46_A3.3771.00
55_L59_E2.9221.00
169_A173_T2.8581.00
59_E63_Q2.8281.00
44_A48_G2.7821.00
56_G60_A2.6241.00
47_E51_Q2.6151.00
97_A101_A2.5961.00
51_Q55_L2.5421.00
46_A50_E2.5411.00
42_E45_K2.4631.00
41_I45_K2.3971.00
43_E47_E2.2771.00
36_E44_A2.2191.00
32_D36_E2.2041.00
34_A37_K2.1111.00
53_V57_K2.0531.00
39_K43_E2.0451.00
33_W37_K2.0081.00
38_Q42_E1.9681.00
50_E54_A1.9061.00
100_L194_L1.8131.00
106_Q121_Q1.7461.00
49_F53_V1.7381.00
58_A62_K1.7371.00
28_Q32_D1.7221.00
140_Y172_G1.7171.00
29_E33_W1.6881.00
37_K41_I1.6531.00
135_Y175_Y1.6461.00
54_A58_A1.6111.00
184_D189_T1.6081.00
71_A78_S1.5441.00
45_K49_F1.5431.00
141_Y145_F1.5371.00
54_A57_K1.5191.00
30_K33_W1.4741.00
61_M65_A1.4721.00
57_K61_M1.4721.00
136_V163_I1.4551.00
139_Y171_K1.4491.00
41_I47_E1.4121.00
38_Q41_I1.4091.00
27_E31_N1.4071.00
49_F59_E1.3971.00
34_A38_Q1.3931.00
103_K106_Q1.3861.00
170_Q188_D1.3510.99
64_Y67_L1.3470.99
35_A39_K1.3440.99
55_L58_A1.3410.99
141_Y165_A1.3180.99
84_D88_D1.3150.99
137_D169_A1.2850.99
177_E182_R1.2820.99
173_T186_S1.2600.99
26_I29_E1.2590.99
173_T184_D1.2570.99
102_K108_K1.2470.99
45_K51_Q1.1890.99
52_G56_G1.1860.99
50_E53_V1.1820.99
25_Q29_E1.1720.98
41_I51_Q1.1460.98
30_K36_E1.1460.98
137_D171_K1.1440.98
108_K111_D1.1260.98
30_K34_A1.1220.98
37_K40_L1.1140.98
138_P165_A1.1120.98
36_E39_K1.1000.98
46_A49_F1.0940.98
65_A69_G1.0910.98
45_K55_L1.0840.97
90_N120_Q1.0820.97
33_W40_L1.0690.97
101_A105_W1.0660.97
141_Y163_I1.0630.97
170_Q173_T1.0620.97
140_Y171_K1.0600.97
60_A64_Y1.0590.97
104_V194_L1.0460.97
37_K44_A1.0440.97
43_E46_A1.0400.97
126_V181_G1.0300.97
30_K40_L1.0240.96
26_I30_K1.0010.96
135_Y166_D1.0000.96
31_N35_A0.9870.96
57_K60_A0.9860.96
169_A186_S0.9840.96
25_Q28_Q0.9620.95
49_F55_L0.9580.95
67_L70_Q0.9530.95
26_I33_W0.9510.95
142_E146_Q0.9470.94
107_Q114_A0.9390.94
107_Q111_D0.9320.94
102_K195_K0.9320.94
48_G52_G0.9300.94
103_K190_Q0.9230.94
72_N76_E0.9130.93
105_W108_K0.9050.93
130_D179_P0.8970.93
63_Q66_E0.8950.93
40_L48_G0.8900.92
121_Q190_Q0.8840.92
53_V56_G0.8800.92
134_I176_I0.8780.92
67_L71_A0.8730.92
67_L75_T0.8720.92
137_D140_Y0.8680.91
193_Q196_D0.8660.91
53_V63_Q0.8630.91
41_I44_A0.8570.91
58_A61_M0.8380.90
81_A84_D0.8320.90
137_D173_T0.8250.89
142_E145_F0.8240.89
57_K63_Q0.8210.89
136_V141_Y0.8200.89
116_L120_Q0.8130.89
33_W36_E0.8110.88
76_E80_K0.8020.88
193_Q197_K0.7770.86
135_Y164_Y0.7690.86
90_N191_L0.7680.86
144_I163_I0.7630.85
135_Y177_E0.7600.85
35_A38_Q0.7590.85
133_S174_C0.7530.84
107_Q117_L0.7500.84
137_D141_Y0.7490.84
86_L89_A0.7430.84
62_K65_A0.7410.84
99_A102_K0.7370.83
123_I181_G0.7320.83
82_V86_L0.7290.83
40_L43_E0.7240.82
119_V174_C0.7190.82
69_G73_S0.7190.82
41_I48_G0.7170.81
148_K163_I0.7130.81
108_K114_A0.7100.81
28_Q31_N0.7100.81
59_E62_K0.7100.81
132_I176_I0.7080.81
124_N134_I0.7080.81
111_D114_A0.6940.79
187_V194_L0.6940.79
81_A181_G0.6920.79
51_Q54_A0.6890.79
161_L190_Q0.6850.78
53_V59_E0.6790.78
143_T146_Q0.6750.77
175_Y182_R0.6720.77
32_D40_L0.6700.77
197_K200_T0.6700.77
77_M84_D0.6690.77
65_A68_I0.6620.76
138_P173_T0.6600.76
30_K37_K0.6600.76
100_L104_V0.6590.76
102_K188_D0.6540.75
29_E36_E0.6480.75
28_Q36_E0.6440.74
122_V183_V0.6440.74
73_S76_E0.6430.74
135_Y182_R0.6420.74
46_A69_G0.6390.74
181_G185_A0.6390.74
80_K84_D0.6370.73
37_K47_E0.6360.73
188_D192_M0.6340.73
36_E41_I0.6340.73
78_S89_A0.6330.73
195_K198_L0.6330.73
27_E34_A0.6300.72
31_N34_A0.6290.72
133_S177_E0.6250.72
185_A189_T0.6240.72
78_S86_L0.6240.72
122_V126_V0.6230.72
104_V190_Q0.6200.71
26_I32_D0.6190.71
94_V179_P0.6190.71
71_A74_I0.6150.71
115_F118_L0.6130.70
134_I163_I0.6090.70
147_Q164_Y0.6060.70
56_G74_I0.5990.69
115_F174_C0.5980.69
43_E77_M0.5970.68
175_Y186_S0.5930.68
174_C189_T0.5920.68
27_E30_K0.5920.68
63_Q67_L0.5910.68
80_K83_E0.5890.67
96_L100_L0.5860.67
184_D190_Q0.5860.67
45_K53_V0.5850.67
86_L127_K0.5840.67
166_D198_L0.5790.66
131_D162_G0.5790.66
66_E70_Q0.5780.66
117_L121_Q0.5760.66
174_C185_A0.5740.65
31_N61_M0.5730.65
77_M80_K0.5720.65
103_K107_Q0.5720.65
189_T193_Q0.5710.65
181_G195_K0.5680.65
55_L62_K0.5660.64
166_D175_Y0.5650.64
69_G76_E0.5630.64
33_W44_A0.5590.63
97_A191_L0.5550.63
174_C190_Q0.5540.63
102_K105_W0.5540.63
78_S181_G0.5510.62
97_A158_E0.5490.62
143_T171_K0.5450.61
61_M68_I0.5400.61
133_S162_G0.5390.61
35_A58_A0.5370.60
101_A104_V0.5370.60
46_A58_A0.5360.60
39_K44_A0.5310.59
152_Q160_R0.5310.59
173_T188_D0.5280.59
90_N94_V0.5270.59
133_S164_Y0.5270.59
115_F171_K0.5250.59
129_Y179_P0.5240.58
89_A136_V0.5220.58
177_E183_V0.5210.58
186_S189_T0.5210.58
182_R191_L0.5200.58
176_I194_L0.5180.58
105_W114_A0.5170.57
34_A41_I0.5160.57
173_T189_T0.5160.57
185_A198_L0.5160.57
62_K66_E0.5130.57
111_D117_L0.5120.57
50_E58_A0.5110.57
186_S190_Q0.5110.57
89_A120_Q0.5100.56
92_E177_E0.5100.56
173_T185_A0.5080.56
54_A109_S0.5070.56
47_E50_E0.5070.56
25_Q30_K0.5060.56
103_K151_I0.5060.56
100_L122_V0.5050.56
128_E181_G0.5040.56
68_I72_N0.5030.55
128_E179_P0.5010.55
49_F52_G0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dm9A 2 0.5481 99.8 0.514 Contact Map
3v6iA 1 0.8654 99.7 0.591 Contact Map
4efaE 1 0.9375 99.6 0.621 Contact Map
3lg8A 1 0.4808 97.9 0.798 Contact Map
2wssS 1 0.6827 92.2 0.872 Contact Map
2lc0A 1 0.5192 90.4 0.878 Contact Map
4efaG 1 0.4327 50.3 0.914 Contact Map
1l2pA 1 0.2933 29.6 0.924 Contact Map
3v6iB 1 0.4375 28.2 0.925 Contact Map
2kk7A 1 0.2115 23.8 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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