GREMLIN Database
FLIG - Flagellar motor switch protein FliG
UniProt: P23448 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (325)
Sequences: 1469 (882)
Seq/√Len: 48.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_K63_E5.3551.00
244_I317_V4.3431.00
248_D251_A4.1231.00
249_N278_I4.0991.00
254_R325_E4.0051.00
273_E277_E3.9801.00
13_Q45_E3.7791.00
263_D312_R3.7571.00
247_L251_A3.6551.00
280_F292_K3.5561.00
255_V317_V3.5081.00
319_K323_A3.3331.00
288_V292_K2.8771.00
249_N281_N2.8681.00
10_T13_Q2.8541.00
273_E276_K2.7871.00
224_E235_K2.7511.00
53_D56_K2.7001.00
18_L22_L2.6671.00
29_S32_K2.6571.00
117_A122_I2.6521.00
122_I149_I2.6481.00
130_H164_R2.6141.00
266_L301_V2.4011.00
202_E237_R2.3961.00
212_D215_T2.3601.00
35_T38_E2.3221.00
269_K299_G2.2851.00
25_D88_K2.2851.00
253_Q282_N2.2761.00
134_M157_V2.2641.00
23_G81_Y2.1961.00
39_I90_L2.1831.00
204_V234_I2.1661.00
252_I282_N2.1621.00
254_R258_D2.1421.00
157_V161_V2.0251.00
259_V313_I2.0111.00
62_E66_N1.9890.99
243_D246_T1.9390.99
317_V328_I1.9070.99
241_F267_S1.8830.99
265_L291_F1.8470.99
126_I134_M1.8350.99
132_Q164_R1.8200.99
119_P148_Q1.7840.99
269_K298_M1.7800.99
78_G82_A1.7690.99
277_E292_K1.7610.99
247_L252_I1.7580.99
265_L298_M1.7570.99
258_D319_K1.7470.99
249_N282_N1.7330.99
223_L234_I1.6880.98
160_E164_R1.6870.98
308_E312_R1.6640.98
265_L295_M1.6540.98
163_R226_Q1.6520.98
126_I184_E1.6380.98
209_N241_F1.6250.98
81_Y85_V1.5820.97
13_Q56_K1.5740.97
221_D225_I1.5700.97
155_P218_T1.5650.97
242_E272_S1.5480.97
89_A200_G1.5450.97
91_G95_A1.5290.97
153_L161_V1.5020.96
251_A255_V1.4960.96
245_V275_V1.4870.96
9_L13_Q1.4870.96
63_E67_I1.4660.96
77_G82_A1.4590.96
162_A204_V1.4580.96
14_K17_I1.4540.96
28_A89_A1.4370.95
150_L161_V1.4340.95
256_I259_V1.4250.95
166_A200_G1.4210.95
267_S313_I1.4160.95
9_L12_K1.4050.95
259_V316_I1.3930.94
15_A42_L1.3660.94
232_E236_K1.3620.94
27_S31_Y1.3590.94
165_I207_V1.3560.94
133_T243_D1.3540.94
17_I52_V1.3470.93
321_E326_I1.3220.93
202_E206_E1.2950.92
17_I60_I1.2890.92
234_I238_M1.2810.92
34_L42_L1.2790.91
211_V215_T1.2600.91
19_M220_L1.2570.91
28_A32_K1.2560.91
205_V237_R1.2420.90
31_Y85_V1.2310.90
279_V291_F1.2310.90
200_G230_L1.2240.90
19_M42_L1.2230.90
162_A234_I1.2040.89
20_I49_V1.1960.88
132_Q241_F1.1870.88
287_M291_F1.1840.88
136_L179_V1.1810.88
91_G230_L1.1740.87
180_E213_R1.1730.87
208_L211_V1.1690.87
187_L320_L1.1660.87
226_Q326_I1.1650.87
123_L152_E1.1520.86
20_I70_A1.1420.86
244_I247_L1.1370.86
276_K292_K1.1360.86
290_T294_E1.1340.86
264_L291_F1.1330.86
134_M161_V1.1320.86
270_V306_V1.1270.85
19_M31_Y1.1130.85
167_V279_V1.0900.83
140_Y285_Q1.0850.83
242_E273_E1.0750.82
12_K42_L1.0660.82
282_N307_E1.0660.82
171_T280_F1.0650.82
122_I209_N1.0640.82
27_S91_G1.0580.81
232_E327_V1.0530.81
261_N265_L1.0510.81
251_A327_V1.0490.81
112_D197_Q1.0480.81
233_E236_K1.0400.80
247_L326_I1.0320.80
289_E292_K1.0310.80
260_E279_V1.0150.79
208_L219_I1.0120.78
13_Q55_Q1.0080.78
264_L306_V0.9990.77
12_K41_R0.9950.77
9_L56_K0.9940.77
99_L333_G0.9930.77
276_K280_F0.9900.77
252_I257_R0.9900.77
295_M298_M0.9880.77
20_I52_V0.9870.77
136_L243_D0.9840.76
124_N127_Q0.9790.76
118_E121_Q0.9770.76
261_N291_F0.9700.75
98_I181_R0.9640.75
55_Q59_E0.9560.74
247_L255_V0.9540.74
278_I287_M0.9500.74
66_N98_I0.9500.74
247_L330_R0.9450.73
36_D94_K0.9440.73
277_E281_N0.9320.72
97_N100_N0.9300.72
36_D144_V0.9260.72
201_I230_L0.9240.72
66_N259_V0.9240.72
115_R142_D0.9230.72
234_I310_Q0.9170.71
209_N267_S0.9170.71
268_L295_M0.9150.71
111_F140_Y0.9140.71
246_T334_D0.9120.71
67_I266_L0.9090.70
236_K311_S0.9070.70
291_F333_G0.9070.70
49_V60_I0.9050.70
141_L319_K0.8980.70
123_L149_I0.8980.70
255_V291_F0.8950.69
133_T136_L0.8940.69
174_E308_E0.8930.69
162_A215_T0.8930.69
9_L17_I0.8910.69
241_F313_I0.8860.68
126_I137_I0.8850.68
247_L334_D0.8820.68
256_I287_M0.8820.68
57_K171_T0.8790.68
126_I295_M0.8780.68
257_R293_E0.8740.67
87_E92_E0.8720.67
176_I258_D0.8650.67
239_F310_Q0.8600.66
260_E274_E0.8560.66
160_E178_E0.8540.66
46_I82_A0.8520.65
254_R320_L0.8510.65
38_E130_H0.8510.65
43_T102_L0.8470.65
208_L269_K0.8410.64
27_S205_V0.8370.64
201_I237_R0.8360.64
42_L324_G0.8360.64
211_V219_I0.8350.64
280_F283_M0.8280.63
44_L48_G0.8280.63
21_S294_E0.8280.63
111_F200_G0.8270.63
122_I237_R0.8270.63
166_A230_L0.8250.63
85_V112_D0.8240.63
15_A309_A0.8230.63
114_A141_L0.8200.62
208_L303_L0.8200.62
228_P307_E0.8200.62
109_K112_D0.8150.62
252_I294_E0.8130.62
276_K295_M0.8110.62
256_I316_I0.8110.62
114_A278_I0.8080.61
220_L235_K0.8060.61
244_I314_V0.8060.61
39_I310_Q0.8050.61
25_D61_I0.8050.61
288_V294_E0.8040.61
114_A301_V0.8040.61
180_E194_D0.8040.61
283_M295_M0.8010.61
244_I252_I0.8000.61
111_F186_K0.7990.60
272_S303_L0.7960.60
122_I133_T0.7940.60
158_Q218_T0.7930.60
110_P167_V0.7920.60
156_E181_R0.7910.60
163_R237_R0.7910.60
27_S89_A0.7880.59
24_L88_K0.7880.59
252_I278_I0.7850.59
10_T98_I0.7840.59
9_L206_E0.7840.59
206_E220_L0.7790.58
143_P168_M0.7780.58
9_L292_K0.7750.58
104_S108_V0.7740.58
150_L291_F0.7730.58
149_I187_L0.7690.57
140_Y187_L0.7650.57
258_D323_A0.7650.57
208_L293_E0.7570.56
133_T235_K0.7560.56
39_I227_D0.7530.56
267_S309_A0.7520.56
280_F295_M0.7520.56
171_T198_T0.7500.56
25_D29_S0.7450.55
272_S290_T0.7430.55
61_I99_L0.7410.55
279_V295_M0.7380.54
285_Q289_E0.7330.54
249_N328_I0.7330.54
163_R227_D0.7330.54
188_S317_V0.7320.54
60_I275_V0.7300.54
201_I289_E0.7240.53
88_K280_F0.7240.53
217_K221_D0.7220.53
100_N103_T0.7200.53
147_G209_N0.7190.52
224_E298_M0.7190.52
36_D116_K0.7190.52
265_L329_A0.7190.52
27_S200_G0.7170.52
20_I73_Y0.7140.52
91_G200_G0.7100.52
138_L151_S0.7070.51
182_I186_K0.7070.51
233_E237_R0.7060.51
164_R239_F0.7060.51
258_D261_N0.7040.51
13_Q262_D0.7040.51
27_S115_R0.7030.51
252_I272_S0.7010.51
95_A199_G0.6980.50
30_V144_V0.6980.50
139_S271_A0.6980.50
253_Q257_R0.6970.50
46_I85_V0.6950.50
122_I265_L0.6940.50
63_E243_D0.6940.50
216_E330_R0.6930.50
254_R323_A0.6910.50
14_K60_I0.6910.50
175_I178_E0.6890.49
295_M306_V0.6880.49
235_K321_E0.6870.49
293_E297_F0.6840.49
43_T100_N0.6830.49
19_M276_K0.6830.49
264_L284_S0.6820.49
254_R261_N0.6820.49
138_L146_A0.6790.48
99_L184_E0.6760.48
209_N302_R0.6740.48
154_N276_K0.6730.48
83_R103_T0.6710.48
257_R264_L0.6680.47
79_L82_A0.6660.47
257_R282_N0.6650.47
34_L269_K0.6630.47
275_V317_V0.6620.47
40_E113_F0.6610.47
62_E211_V0.6610.47
14_K59_E0.6600.46
41_R45_E0.6590.46
165_I325_E0.6570.46
34_L136_L0.6560.46
93_D281_N0.6560.46
122_I137_I0.6560.46
210_G243_D0.6540.46
49_V138_L0.6520.46
28_A220_L0.6520.46
18_L164_R0.6510.46
244_I255_V0.6490.45
52_V316_I0.6460.45
67_I225_I0.6430.45
162_A208_L0.6420.45
31_Y235_K0.6410.45
110_P180_E0.6410.45
20_I147_G0.6400.44
271_A302_R0.6400.44
68_A171_T0.6390.44
97_N128_Q0.6380.44
85_V146_A0.6370.44
311_S321_E0.6370.44
11_G67_I0.6340.44
213_R216_E0.6340.44
71_Q81_Y0.6320.44
126_I178_E0.6300.43
90_L205_V0.6290.43
264_L287_M0.6260.43
173_P318_R0.6250.43
125_F190_A0.6220.43
33_H112_D0.6200.42
98_I177_N0.6180.42
266_L309_A0.6170.42
216_E243_D0.6170.42
94_K314_V0.6160.42
89_A95_A0.6140.42
183_L231_A0.6130.42
36_D240_V0.6120.42
294_E297_F0.6100.42
294_E332_G0.6100.42
140_Y293_E0.6080.41
165_I179_V0.6060.41
18_L72_D0.6050.41
108_V112_D0.6050.41
120_E235_K0.6040.41
137_I179_V0.6040.41
95_A166_A0.6030.41
295_M299_G0.6030.41
244_I285_Q0.6030.41
136_L233_E0.6030.41
14_K97_N0.6020.41
127_Q154_N0.6020.41
207_V270_V0.6010.41
221_D296_E0.6000.41
196_T255_V0.5990.40
42_L133_T0.5990.40
132_Q320_L0.5960.40
63_E161_V0.5950.40
80_S145_Q0.5950.40
166_A201_I0.5950.40
215_T314_V0.5930.40
88_K206_E0.5910.40
179_V205_V0.5910.40
215_T279_V0.5910.40
38_E238_M0.5870.39
36_D91_G0.5870.39
60_I83_R0.5860.39
142_D145_Q0.5840.39
158_Q161_V0.5840.39
255_V326_I0.5840.39
77_G186_K0.5830.39
137_I228_P0.5830.39
206_E234_I0.5830.39
286_R306_V0.5830.39
89_A230_L0.5820.39
280_F291_F0.5820.39
255_V259_V0.5820.39
146_A207_V0.5790.38
158_Q288_V0.5790.38
92_E96_E0.5780.38
259_V279_V0.5780.38
125_F220_L0.5710.38
78_G208_L0.5690.38
145_Q289_E0.5690.38
78_G137_I0.5690.38
109_K182_I0.5690.38
59_E334_D0.5670.37
10_T277_E0.5670.37
160_E328_I0.5660.37
9_L20_I0.5660.37
302_R327_V0.5660.37
27_S95_A0.5640.37
251_A326_I0.5640.37
197_Q333_G0.5620.37
84_Q167_V0.5620.37
102_L244_I0.5620.37
255_V313_I0.5610.37
249_N291_F0.5610.37
178_E208_L0.5610.37
52_V235_K0.5610.37
63_E245_V0.5600.37
42_L50_R0.5600.37
17_I65_H0.5580.36
139_S237_R0.5560.36
98_I304_K0.5550.36
72_D225_I0.5540.36
98_I294_E0.5530.36
169_D185_Q0.5530.36
219_I222_S0.5530.36
47_S223_L0.5510.36
205_V209_N0.5500.36
117_A238_M0.5500.36
66_N146_A0.5490.36
303_L332_G0.5490.36
264_L313_I0.5490.36
43_T221_D0.5480.36
153_L174_E0.5480.36
77_G80_S0.5480.36
31_Y75_S0.5460.35
205_V208_L0.5450.35
158_Q211_V0.5420.35
72_D304_K0.5410.35
66_N319_K0.5400.35
174_E192_T0.5390.35
42_L47_S0.5390.35
85_V270_V0.5380.35
42_L323_A0.5380.35
50_R222_S0.5370.35
113_F212_D0.5360.34
17_I49_V0.5360.34
159_A187_L0.5350.34
35_T328_I0.5350.34
216_E223_L0.5320.34
106_L111_F0.5320.34
60_I278_I0.5310.34
196_T204_V0.5310.34
12_K15_A0.5300.34
208_L220_L0.5280.34
209_N286_R0.5280.34
40_E322_E0.5270.34
294_E315_S0.5260.34
42_L185_Q0.5240.33
234_I278_I0.5240.33
155_P222_S0.5230.33
162_A220_L0.5220.33
45_E321_E0.5210.33
17_I38_E0.5210.33
263_D309_A0.5210.33
43_T86_L0.5210.33
209_N239_F0.5200.33
40_E317_V0.5190.33
78_G113_F0.5180.33
223_L290_T0.5180.33
53_D248_D0.5180.33
95_A231_A0.5150.33
147_G187_L0.5150.33
321_E327_V0.5150.33
118_E285_Q0.5150.33
162_A223_L0.5130.32
192_T252_I0.5120.32
20_I46_I0.5110.32
263_D313_I0.5100.32
166_A227_D0.5100.32
138_L149_I0.5100.32
90_L138_L0.5100.32
206_E246_T0.5090.32
186_K212_D0.5090.32
270_V303_L0.5080.32
186_K318_R0.5070.32
78_G284_S0.5060.32
23_G38_E0.5060.32
165_I204_V0.5060.32
137_I231_A0.5050.32
246_T332_G0.5040.32
122_I152_E0.5040.32
77_G86_L0.5030.31
141_L163_R0.5030.31
27_S39_I0.5000.31
271_A310_Q0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hjlA 1 0.9497 100 0.029 Contact Map
3uswA 1 0.6243 100 0.28 Contact Map
4fhrB 1 0.6154 100 0.415 Contact Map
4fq0C 1 0.2337 99.9 0.741 Contact Map
2zy9A 2 0.4615 95.8 0.93 Contact Map
2ouxA 2 0.642 95.1 0.933 Contact Map
2yvyA 2 0.5059 92.1 0.941 Contact Map
2lwxA 1 0.2249 51.9 0.96 Contact Map
4x2uA 1 0.5148 48.7 0.961 Contact Map
4qhpA 1 0.5178 46.8 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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