FLIG - BACSU - GREMLIN Contacts

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FLIG - Flagellar motor switch protein FliG

UniProt:	P23448	Sequences: MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTLEISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRLTSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAEVARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKTILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVKEIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGDDIIV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	338 (325)
Sequences:	1469 (882)
Seq/√Len:	48.9

ECOLI - FLIG
BACSU - FLIG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
14_K	63_E	5.355	1.00
244_I	317_V	4.343	1.00
248_D	251_A	4.123	1.00
249_N	278_I	4.099	1.00
254_R	325_E	4.005	1.00
273_E	277_E	3.980	1.00
13_Q	45_E	3.779	1.00
263_D	312_R	3.757	1.00
247_L	251_A	3.655	1.00
280_F	292_K	3.556	1.00
255_V	317_V	3.508	1.00
319_K	323_A	3.333	1.00
288_V	292_K	2.877	1.00
249_N	281_N	2.868	1.00
10_T	13_Q	2.854	1.00
273_E	276_K	2.787	1.00
224_E	235_K	2.751	1.00
53_D	56_K	2.700	1.00
18_L	22_L	2.667	1.00
29_S	32_K	2.657	1.00
117_A	122_I	2.652	1.00
122_I	149_I	2.648	1.00
130_H	164_R	2.614	1.00
266_L	301_V	2.401	1.00
202_E	237_R	2.396	1.00
212_D	215_T	2.360	1.00
35_T	38_E	2.322	1.00
269_K	299_G	2.285	1.00
25_D	88_K	2.285	1.00
253_Q	282_N	2.276	1.00
134_M	157_V	2.264	1.00
23_G	81_Y	2.196	1.00
39_I	90_L	2.183	1.00
204_V	234_I	2.166	1.00
252_I	282_N	2.162	1.00
254_R	258_D	2.142	1.00
157_V	161_V	2.025	1.00
259_V	313_I	2.011	1.00
62_E	66_N	1.989	0.99
243_D	246_T	1.939	0.99
317_V	328_I	1.907	0.99
241_F	267_S	1.883	0.99
265_L	291_F	1.847	0.99
126_I	134_M	1.835	0.99
132_Q	164_R	1.820	0.99
119_P	148_Q	1.784	0.99
269_K	298_M	1.780	0.99
78_G	82_A	1.769	0.99
277_E	292_K	1.761	0.99
247_L	252_I	1.758	0.99
265_L	298_M	1.757	0.99
258_D	319_K	1.747	0.99
249_N	282_N	1.733	0.99
223_L	234_I	1.688	0.98
160_E	164_R	1.687	0.98
308_E	312_R	1.664	0.98
265_L	295_M	1.654	0.98
163_R	226_Q	1.652	0.98
126_I	184_E	1.638	0.98
209_N	241_F	1.625	0.98
81_Y	85_V	1.582	0.97
13_Q	56_K	1.574	0.97
221_D	225_I	1.570	0.97
155_P	218_T	1.565	0.97
242_E	272_S	1.548	0.97
89_A	200_G	1.545	0.97
91_G	95_A	1.529	0.97
153_L	161_V	1.502	0.96
251_A	255_V	1.496	0.96
245_V	275_V	1.487	0.96
9_L	13_Q	1.487	0.96
63_E	67_I	1.466	0.96
77_G	82_A	1.459	0.96
162_A	204_V	1.458	0.96
14_K	17_I	1.454	0.96
28_A	89_A	1.437	0.95
150_L	161_V	1.434	0.95
256_I	259_V	1.425	0.95
166_A	200_G	1.421	0.95
267_S	313_I	1.416	0.95
9_L	12_K	1.405	0.95
259_V	316_I	1.393	0.94
15_A	42_L	1.366	0.94
232_E	236_K	1.362	0.94
27_S	31_Y	1.359	0.94
165_I	207_V	1.356	0.94
133_T	243_D	1.354	0.94
17_I	52_V	1.347	0.93
321_E	326_I	1.322	0.93
202_E	206_E	1.295	0.92
17_I	60_I	1.289	0.92
234_I	238_M	1.281	0.92
34_L	42_L	1.279	0.91
211_V	215_T	1.260	0.91
19_M	220_L	1.257	0.91
28_A	32_K	1.256	0.91
205_V	237_R	1.242	0.90
31_Y	85_V	1.231	0.90
279_V	291_F	1.231	0.90
200_G	230_L	1.224	0.90
19_M	42_L	1.223	0.90
162_A	234_I	1.204	0.89
20_I	49_V	1.196	0.88
132_Q	241_F	1.187	0.88
287_M	291_F	1.184	0.88
136_L	179_V	1.181	0.88
91_G	230_L	1.174	0.87
180_E	213_R	1.173	0.87
208_L	211_V	1.169	0.87
187_L	320_L	1.166	0.87
226_Q	326_I	1.165	0.87
123_L	152_E	1.152	0.86
20_I	70_A	1.142	0.86
244_I	247_L	1.137	0.86
276_K	292_K	1.136	0.86
290_T	294_E	1.134	0.86
264_L	291_F	1.133	0.86
134_M	161_V	1.132	0.86
270_V	306_V	1.127	0.85
19_M	31_Y	1.113	0.85
167_V	279_V	1.090	0.83
140_Y	285_Q	1.085	0.83
242_E	273_E	1.075	0.82
12_K	42_L	1.066	0.82
282_N	307_E	1.066	0.82
171_T	280_F	1.065	0.82
122_I	209_N	1.064	0.82
27_S	91_G	1.058	0.81
232_E	327_V	1.053	0.81
261_N	265_L	1.051	0.81
251_A	327_V	1.049	0.81
112_D	197_Q	1.048	0.81
233_E	236_K	1.040	0.80
247_L	326_I	1.032	0.80
289_E	292_K	1.031	0.80
260_E	279_V	1.015	0.79
208_L	219_I	1.012	0.78
13_Q	55_Q	1.008	0.78
264_L	306_V	0.999	0.77
12_K	41_R	0.995	0.77
9_L	56_K	0.994	0.77
99_L	333_G	0.993	0.77
276_K	280_F	0.990	0.77
252_I	257_R	0.990	0.77
295_M	298_M	0.988	0.77
20_I	52_V	0.987	0.77
136_L	243_D	0.984	0.76
124_N	127_Q	0.979	0.76
118_E	121_Q	0.977	0.76
261_N	291_F	0.970	0.75
98_I	181_R	0.964	0.75
55_Q	59_E	0.956	0.74
247_L	255_V	0.954	0.74
278_I	287_M	0.950	0.74
66_N	98_I	0.950	0.74
247_L	330_R	0.945	0.73
36_D	94_K	0.944	0.73
277_E	281_N	0.932	0.72
97_N	100_N	0.930	0.72
36_D	144_V	0.926	0.72
201_I	230_L	0.924	0.72
66_N	259_V	0.924	0.72
115_R	142_D	0.923	0.72
234_I	310_Q	0.917	0.71
209_N	267_S	0.917	0.71
268_L	295_M	0.915	0.71
111_F	140_Y	0.914	0.71
246_T	334_D	0.912	0.71
67_I	266_L	0.909	0.70
236_K	311_S	0.907	0.70
291_F	333_G	0.907	0.70
49_V	60_I	0.905	0.70
141_L	319_K	0.898	0.70
123_L	149_I	0.898	0.70
255_V	291_F	0.895	0.69
133_T	136_L	0.894	0.69
174_E	308_E	0.893	0.69
162_A	215_T	0.893	0.69
9_L	17_I	0.891	0.69
241_F	313_I	0.886	0.68
126_I	137_I	0.885	0.68
247_L	334_D	0.882	0.68
256_I	287_M	0.882	0.68
57_K	171_T	0.879	0.68
126_I	295_M	0.878	0.68
257_R	293_E	0.874	0.67
87_E	92_E	0.872	0.67
176_I	258_D	0.865	0.67
239_F	310_Q	0.860	0.66
260_E	274_E	0.856	0.66
160_E	178_E	0.854	0.66
46_I	82_A	0.852	0.65
254_R	320_L	0.851	0.65
38_E	130_H	0.851	0.65
43_T	102_L	0.847	0.65
208_L	269_K	0.841	0.64
27_S	205_V	0.837	0.64
201_I	237_R	0.836	0.64
42_L	324_G	0.836	0.64
211_V	219_I	0.835	0.64
280_F	283_M	0.828	0.63
44_L	48_G	0.828	0.63
21_S	294_E	0.828	0.63
111_F	200_G	0.827	0.63
122_I	237_R	0.827	0.63
166_A	230_L	0.825	0.63
85_V	112_D	0.824	0.63
15_A	309_A	0.823	0.63
114_A	141_L	0.820	0.62
208_L	303_L	0.820	0.62
228_P	307_E	0.820	0.62
109_K	112_D	0.815	0.62
252_I	294_E	0.813	0.62
276_K	295_M	0.811	0.62
256_I	316_I	0.811	0.62
114_A	278_I	0.808	0.61
220_L	235_K	0.806	0.61
244_I	314_V	0.806	0.61
39_I	310_Q	0.805	0.61
25_D	61_I	0.805	0.61
288_V	294_E	0.804	0.61
114_A	301_V	0.804	0.61
180_E	194_D	0.804	0.61
283_M	295_M	0.801	0.61
244_I	252_I	0.800	0.61
111_F	186_K	0.799	0.60
272_S	303_L	0.796	0.60
122_I	133_T	0.794	0.60
158_Q	218_T	0.793	0.60
110_P	167_V	0.792	0.60
156_E	181_R	0.791	0.60
163_R	237_R	0.791	0.60
27_S	89_A	0.788	0.59
24_L	88_K	0.788	0.59
252_I	278_I	0.785	0.59
10_T	98_I	0.784	0.59
9_L	206_E	0.784	0.59
206_E	220_L	0.779	0.58
143_P	168_M	0.778	0.58
9_L	292_K	0.775	0.58
104_S	108_V	0.774	0.58
150_L	291_F	0.773	0.58
149_I	187_L	0.769	0.57
140_Y	187_L	0.765	0.57
258_D	323_A	0.765	0.57
208_L	293_E	0.757	0.56
133_T	235_K	0.756	0.56
39_I	227_D	0.753	0.56
267_S	309_A	0.752	0.56
280_F	295_M	0.752	0.56
171_T	198_T	0.750	0.56
25_D	29_S	0.745	0.55
272_S	290_T	0.743	0.55
61_I	99_L	0.741	0.55
279_V	295_M	0.738	0.54
285_Q	289_E	0.733	0.54
249_N	328_I	0.733	0.54
163_R	227_D	0.733	0.54
188_S	317_V	0.732	0.54
60_I	275_V	0.730	0.54
201_I	289_E	0.724	0.53
88_K	280_F	0.724	0.53
217_K	221_D	0.722	0.53
100_N	103_T	0.720	0.53
147_G	209_N	0.719	0.52
224_E	298_M	0.719	0.52
36_D	116_K	0.719	0.52
265_L	329_A	0.719	0.52
27_S	200_G	0.717	0.52
20_I	73_Y	0.714	0.52
91_G	200_G	0.710	0.52
138_L	151_S	0.707	0.51
182_I	186_K	0.707	0.51
233_E	237_R	0.706	0.51
164_R	239_F	0.706	0.51
258_D	261_N	0.704	0.51
13_Q	262_D	0.704	0.51
27_S	115_R	0.703	0.51
252_I	272_S	0.701	0.51
95_A	199_G	0.698	0.50
30_V	144_V	0.698	0.50
139_S	271_A	0.698	0.50
253_Q	257_R	0.697	0.50
46_I	85_V	0.695	0.50
122_I	265_L	0.694	0.50
63_E	243_D	0.694	0.50
216_E	330_R	0.693	0.50
254_R	323_A	0.691	0.50
14_K	60_I	0.691	0.50
175_I	178_E	0.689	0.49
295_M	306_V	0.688	0.49
235_K	321_E	0.687	0.49
293_E	297_F	0.684	0.49
43_T	100_N	0.683	0.49
19_M	276_K	0.683	0.49
264_L	284_S	0.682	0.49
254_R	261_N	0.682	0.49
138_L	146_A	0.679	0.48
99_L	184_E	0.676	0.48
209_N	302_R	0.674	0.48
154_N	276_K	0.673	0.48
83_R	103_T	0.671	0.48
257_R	264_L	0.668	0.47
79_L	82_A	0.666	0.47
257_R	282_N	0.665	0.47
34_L	269_K	0.663	0.47
275_V	317_V	0.662	0.47
40_E	113_F	0.661	0.47
62_E	211_V	0.661	0.47
14_K	59_E	0.660	0.46
41_R	45_E	0.659	0.46
165_I	325_E	0.657	0.46
34_L	136_L	0.656	0.46
93_D	281_N	0.656	0.46
122_I	137_I	0.656	0.46
210_G	243_D	0.654	0.46
49_V	138_L	0.652	0.46
28_A	220_L	0.652	0.46
18_L	164_R	0.651	0.46
244_I	255_V	0.649	0.45
52_V	316_I	0.646	0.45
67_I	225_I	0.643	0.45
162_A	208_L	0.642	0.45
31_Y	235_K	0.641	0.45
110_P	180_E	0.641	0.45
20_I	147_G	0.640	0.44
271_A	302_R	0.640	0.44
68_A	171_T	0.639	0.44
97_N	128_Q	0.638	0.44
85_V	146_A	0.637	0.44
311_S	321_E	0.637	0.44
11_G	67_I	0.634	0.44
213_R	216_E	0.634	0.44
71_Q	81_Y	0.632	0.44
126_I	178_E	0.630	0.43
90_L	205_V	0.629	0.43
264_L	287_M	0.626	0.43
173_P	318_R	0.625	0.43
125_F	190_A	0.622	0.43
33_H	112_D	0.620	0.42
98_I	177_N	0.618	0.42
266_L	309_A	0.617	0.42
216_E	243_D	0.617	0.42
94_K	314_V	0.616	0.42
89_A	95_A	0.614	0.42
183_L	231_A	0.613	0.42
36_D	240_V	0.612	0.42
294_E	297_F	0.610	0.42
294_E	332_G	0.610	0.42
140_Y	293_E	0.608	0.41
165_I	179_V	0.606	0.41
18_L	72_D	0.605	0.41
108_V	112_D	0.605	0.41
120_E	235_K	0.604	0.41
137_I	179_V	0.604	0.41
95_A	166_A	0.603	0.41
295_M	299_G	0.603	0.41
244_I	285_Q	0.603	0.41
136_L	233_E	0.603	0.41
14_K	97_N	0.602	0.41
127_Q	154_N	0.602	0.41
207_V	270_V	0.601	0.41
221_D	296_E	0.600	0.41
196_T	255_V	0.599	0.40
42_L	133_T	0.599	0.40
132_Q	320_L	0.596	0.40
63_E	161_V	0.595	0.40
80_S	145_Q	0.595	0.40
166_A	201_I	0.595	0.40
215_T	314_V	0.593	0.40
88_K	206_E	0.591	0.40
179_V	205_V	0.591	0.40
215_T	279_V	0.591	0.40
38_E	238_M	0.587	0.39
36_D	91_G	0.587	0.39
60_I	83_R	0.586	0.39
142_D	145_Q	0.584	0.39
158_Q	161_V	0.584	0.39
255_V	326_I	0.584	0.39
77_G	186_K	0.583	0.39
137_I	228_P	0.583	0.39
206_E	234_I	0.583	0.39
286_R	306_V	0.583	0.39
89_A	230_L	0.582	0.39
280_F	291_F	0.582	0.39
255_V	259_V	0.582	0.39
146_A	207_V	0.579	0.38
158_Q	288_V	0.579	0.38
92_E	96_E	0.578	0.38
259_V	279_V	0.578	0.38
125_F	220_L	0.571	0.38
78_G	208_L	0.569	0.38
145_Q	289_E	0.569	0.38
78_G	137_I	0.569	0.38
109_K	182_I	0.569	0.38
59_E	334_D	0.567	0.37
10_T	277_E	0.567	0.37
160_E	328_I	0.566	0.37
9_L	20_I	0.566	0.37
302_R	327_V	0.566	0.37
27_S	95_A	0.564	0.37
251_A	326_I	0.564	0.37
197_Q	333_G	0.562	0.37
84_Q	167_V	0.562	0.37
102_L	244_I	0.562	0.37
255_V	313_I	0.561	0.37
249_N	291_F	0.561	0.37
178_E	208_L	0.561	0.37
52_V	235_K	0.561	0.37
63_E	245_V	0.560	0.37
42_L	50_R	0.560	0.37
17_I	65_H	0.558	0.36
139_S	237_R	0.556	0.36
98_I	304_K	0.555	0.36
72_D	225_I	0.554	0.36
98_I	294_E	0.553	0.36
169_D	185_Q	0.553	0.36
219_I	222_S	0.553	0.36
47_S	223_L	0.551	0.36
205_V	209_N	0.550	0.36
117_A	238_M	0.550	0.36
66_N	146_A	0.549	0.36
303_L	332_G	0.549	0.36
264_L	313_I	0.549	0.36
43_T	221_D	0.548	0.36
153_L	174_E	0.548	0.36
77_G	80_S	0.548	0.36
31_Y	75_S	0.546	0.35
205_V	208_L	0.545	0.35
158_Q	211_V	0.542	0.35
72_D	304_K	0.541	0.35
66_N	319_K	0.540	0.35
174_E	192_T	0.539	0.35
42_L	47_S	0.539	0.35
85_V	270_V	0.538	0.35
42_L	323_A	0.538	0.35
50_R	222_S	0.537	0.35
113_F	212_D	0.536	0.34
17_I	49_V	0.536	0.34
159_A	187_L	0.535	0.34
35_T	328_I	0.535	0.34
216_E	223_L	0.532	0.34
106_L	111_F	0.532	0.34
60_I	278_I	0.531	0.34
196_T	204_V	0.531	0.34
12_K	15_A	0.530	0.34
208_L	220_L	0.528	0.34
209_N	286_R	0.528	0.34
40_E	322_E	0.527	0.34
294_E	315_S	0.526	0.34
42_L	185_Q	0.524	0.33
234_I	278_I	0.524	0.33
155_P	222_S	0.523	0.33
162_A	220_L	0.522	0.33
45_E	321_E	0.521	0.33
17_I	38_E	0.521	0.33
263_D	309_A	0.521	0.33
43_T	86_L	0.521	0.33
209_N	239_F	0.520	0.33
40_E	317_V	0.519	0.33
78_G	113_F	0.518	0.33
223_L	290_T	0.518	0.33
53_D	248_D	0.518	0.33
95_A	231_A	0.515	0.33
147_G	187_L	0.515	0.33
321_E	327_V	0.515	0.33
118_E	285_Q	0.515	0.33
162_A	223_L	0.513	0.32
192_T	252_I	0.512	0.32
20_I	46_I	0.511	0.32
263_D	313_I	0.510	0.32
166_A	227_D	0.510	0.32
138_L	149_I	0.510	0.32
90_L	138_L	0.510	0.32
206_E	246_T	0.509	0.32
186_K	212_D	0.509	0.32
270_V	303_L	0.508	0.32
186_K	318_R	0.507	0.32
78_G	284_S	0.506	0.32
23_G	38_E	0.506	0.32
165_I	204_V	0.506	0.32
137_I	231_A	0.505	0.32
246_T	332_G	0.504	0.32
122_I	152_E	0.504	0.32
77_G	86_L	0.503	0.31
141_L	163_R	0.503	0.31
27_S	39_I	0.500	0.31
271_A	310_Q	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hjlA	1	0.9497	100	0.029	Contact Map
3uswA	1	0.6243	100	0.28	Contact Map
4fhrB	1	0.6154	100	0.415	Contact Map
4fq0C	1	0.2337	99.9	0.741	Contact Map
2zy9A	2	0.4615	95.8	0.93	Contact Map
2ouxA	2	0.642	95.1	0.933	Contact Map
2yvyA	2	0.5059	92.1	0.941	Contact Map
2lwxA	1	0.2249	51.9	0.96	Contact Map
4x2uA	1	0.5148	48.7	0.961	Contact Map
4qhpA	1	0.5178	46.8	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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