GREMLIN Database
FLII - Flagellum-specific ATP synthase
UniProt: P23445 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 438 (410)
Sequences: 7211 (2688)
Seq/√Len: 132.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_D109_E7.7691.00
157_K249_N4.8031.00
190_A236_A4.5021.00
335_D348_N4.2031.00
32_S69_L3.6741.00
148_S347_V3.4241.00
41_D86_A3.2201.00
372_F409_L3.2181.00
43_C69_L2.8551.00
102_Q112_D2.8031.00
422_L425_E2.7711.00
37_S59_V2.7111.00
89_E92_R2.5981.00
188_V240_A2.5481.00
44_L54_V2.5331.00
97_T246_K2.5191.00
237_T307_Y2.5121.00
57_A69_L2.5121.00
43_C84_V2.4861.00
97_T248_Q2.4811.00
44_L85_E2.4561.00
140_E157_K2.4551.00
155_V306_F2.3981.00
361_S366_L2.3231.00
209_K213_K2.2981.00
98_G120_L2.2841.00
240_A303_I2.2811.00
92_R122_P2.2701.00
104_I239_I2.2501.00
147_R421_A2.2381.00
173_T417_T2.2151.00
218_V239_I2.2141.00
371_K374_E2.2051.00
380_Q383_E2.1691.00
32_S84_V2.1611.00
200_R204_E2.0861.00
338_L343_Q2.0661.00
316_M333_V2.0501.00
31_E66_N2.0461.00
363_K367_D2.0431.00
152_L372_F2.0231.00
123_V127_Q2.0061.00
406_Y410_I1.9871.00
24_R31_E1.9731.00
371_K401_E1.9691.00
22_V78_I1.9241.00
45_I57_A1.9151.00
241_E294_R1.9091.00
38_S41_D1.8951.00
19_Y83_I1.8781.00
210_E213_K1.8551.00
386_I403_I1.8211.00
41_D88_G1.8171.00
155_V332_I1.8071.00
343_Q414_K1.7951.00
151_S412_F1.7891.00
151_S426_S1.7711.00
23_K33_K1.7701.00
383_E387_N1.7651.00
242_Y246_K1.7511.00
166_G169_V1.7431.00
18_R86_A1.7021.00
343_Q410_I1.7011.00
216_I239_I1.6991.00
204_E208_G1.6971.00
203_I217_V1.6851.00
123_V242_Y1.6831.00
342_G370_N1.6831.00
123_V238_A1.6771.00
143_G150_D1.6681.00
341_K410_I1.6471.00
204_E207_L1.6451.00
309_V324_V1.6341.00
46_Y83_I1.6121.00
188_V239_I1.5941.00
378_T399_I1.5931.00
114_K207_L1.5871.00
368_A431_T1.5781.00
140_E297_A1.5681.00
44_L56_K1.5601.00
249_N302_T1.5101.00
102_Q115_L1.4991.00
154_T357_M1.4981.00
46_Y54_V1.4841.00
97_T242_Y1.4811.00
98_G118_K1.4581.00
162_G328_L1.4511.00
102_Q114_K1.4481.00
46_Y85_E1.4351.00
357_M369_A1.4301.00
93_V239_I1.4291.00
91_L125_T1.4251.00
22_V82_S1.4161.00
149_I332_I1.4131.00
104_I218_V1.4071.00
318_E321_A1.4011.00
416_G419_E1.3981.00
404_Q407_P1.3961.00
110_P115_L1.3941.00
192_V232_A1.3941.00
190_A254_M1.3891.00
341_K383_E1.3841.00
205_K359_N1.3841.00
32_S35_P1.3821.00
393_R404_Q1.3791.00
99_L239_I1.3531.00
401_E405_F1.3471.00
43_C57_A1.3471.00
21_K83_I1.3461.00
17_K85_E1.3441.00
98_G119_G1.3381.00
89_E122_P1.3381.00
233_A291_L1.3351.00
102_Q110_P1.3311.00
378_T381_N1.3241.00
237_T295_T1.3151.00
425_E429_A1.3081.00
37_S43_C1.3031.00
44_L87_T1.3021.00
37_S67_I1.2981.00
93_V235_T1.2941.00
186_L243_F1.2931.00
75_A78_I1.2911.00
25_V78_I1.2881.00
105_D224_Q1.2871.00
149_I178_I1.2861.00
258_T262_M1.2831.00
186_L248_Q1.2821.00
224_Q228_M1.2811.00
119_G122_P1.2721.00
292_L327_I1.2701.00
411_Q414_K1.2691.00
358_S366_L1.2671.00
144_V155_V1.2651.00
191_L199_V1.2601.00
250_V303_I1.2591.00
94_K122_P1.2581.00
382_S399_I1.2411.00
337_A340_N1.2401.00
288_L324_V1.2351.00
264_Q287_I1.2331.00
208_G211_G1.2331.00
55_I73_L1.2331.00
370_N373_R1.2241.00
123_V245_D1.2211.00
23_K66_N1.2211.00
134_K299_E1.2181.00
138_I156_G1.2181.00
187_N248_Q1.2101.00
173_T418_D1.2091.00
362_T423_L1.2081.00
21_K33_K1.2051.00
153_L332_I1.2010.99
56_K109_E1.1940.99
47_A55_I1.1930.99
207_L212_L1.1920.99
247_G300_H1.1920.99
31_E63_Q1.1780.99
103_V203_I1.1760.99
30_I57_A1.1750.99
408_Q411_Q1.1680.99
33_K66_N1.1650.99
161_I306_F1.1550.99
47_A53_K1.1440.99
141_K360_I1.1360.99
237_T303_I1.1280.99
366_L370_N1.1250.99
257_V324_V1.1230.99
356_V360_I1.1210.99
100_I216_I1.1130.99
79_A82_S1.1110.99
371_K375_L1.1110.99
268_G276_T1.1100.99
185_D249_N1.1070.99
96_G99_L1.1000.99
106_A235_T1.0980.99
343_Q413_L1.0890.99
142_M186_L1.0850.99
155_V304_T1.0830.99
292_L324_V1.0780.99
351_K380_Q1.0770.99
183_E249_N1.0740.99
146_V149_I1.0580.99
63_Q68_L1.0550.99
94_K119_G1.0500.99
190_A252_F1.0450.99
196_G221_T1.0440.99
348_N351_K1.0410.99
32_S43_C1.0380.99
102_Q111_L1.0340.98
127_Q245_D1.0300.98
146_V174_L1.0270.98
314_D317_N1.0250.98
179_A215_S1.0190.98
338_L414_K1.0180.98
166_G336_R1.0170.98
362_T365_H1.0130.98
112_D115_L1.0100.98
404_Q408_Q1.0070.98
314_D336_R1.0040.98
73_L228_M1.0010.98
143_G423_L0.9970.98
192_V254_M0.9960.98
144_V306_F0.9960.98
71_P75_A0.9950.98
46_Y82_S0.9900.98
136_P139_R0.9870.98
311_V318_E0.9860.98
340_N351_K0.9790.98
321_A333_V0.9770.98
45_I82_S0.9760.98
179_A253_M0.9750.98
288_L327_I0.9750.98
311_V321_A0.9740.98
421_A429_A0.9680.98
257_V292_L0.9650.98
236_A252_F0.9650.98
102_Q117_P0.9590.98
134_K298_N0.9500.97
155_V161_I0.9500.97
382_S386_I0.9460.97
211_G215_S0.9450.97
244_R250_V0.9450.97
109_E116_L0.9410.97
365_H427_I0.9410.97
99_L216_I0.9390.97
144_V150_D0.9360.97
106_A111_L0.9350.97
234_Y287_I0.9350.97
106_A228_M0.9300.97
337_A380_Q0.9290.97
216_I243_F0.9280.97
246_K250_V0.9250.97
195_R198_E0.9220.97
185_D248_Q0.9210.97
229_R266_E0.9180.97
365_H423_L0.9160.97
47_A54_V0.9130.97
262_M312_D0.9090.97
161_I330_G0.9060.97
148_S413_L0.9020.96
396_S400_D0.9020.96
99_L104_I0.9010.96
288_L323_T0.9000.96
121_S242_Y0.9000.96
166_G322_D0.8990.96
166_G314_D0.8970.96
93_V96_G0.8920.96
192_V233_A0.8910.96
194_E198_E0.8910.96
121_S246_K0.8910.96
297_A302_T0.8860.96
316_M351_K0.8860.96
42_L56_K0.8790.96
41_D90_S0.8790.96
201_E359_N0.8780.96
154_T423_L0.8780.96
179_A189_I0.8770.96
379_Y406_Y0.8760.96
251_M306_F0.8720.96
387_N396_S0.8690.96
131_N134_K0.8640.95
357_M361_S0.8620.95
237_T252_F0.8610.95
286_A289_P0.8600.95
42_L87_T0.8600.95
106_A224_Q0.8590.95
29_M271_A0.8580.95
136_P298_N0.8560.95
368_A427_I0.8550.95
203_I207_L0.8530.95
401_E404_Q0.8520.95
361_S369_A0.8490.95
295_T305_A0.8480.95
211_G214_R0.8480.95
41_D150_D0.8480.95
242_Y245_D0.8440.95
357_M365_H0.8410.95
186_L214_R0.8410.95
175_M202_F0.8410.95
88_G91_L0.8400.95
260_V291_L0.8380.95
73_L109_E0.8330.94
149_I153_L0.8320.94
30_I45_I0.8320.94
141_K154_T0.8320.94
374_E414_K0.8290.94
316_M321_A0.8280.94
378_T382_S0.8260.94
374_E378_T0.8260.94
358_S373_R0.8250.94
151_S430_L0.8150.94
19_Y85_E0.8120.94
330_G355_R0.8120.94
58_E72_Y0.8060.93
117_P120_L0.8060.93
256_S308_T0.8050.93
136_P300_H0.8040.93
262_M280_Y0.8030.93
91_L231_K0.8020.93
136_P297_A0.8000.93
104_I117_P0.7990.93
333_V336_R0.7990.93
421_A427_I0.7960.93
156_G356_V0.7940.93
315_D322_D0.7920.93
166_G315_D0.7910.93
364_Q431_T0.7900.93
104_I107_F0.7900.93
62_F80_P0.7890.93
114_K117_P0.7860.93
367_D371_K0.7850.92
124_S127_Q0.7830.92
253_M308_T0.7810.92
179_A214_R0.7780.92
421_A426_S0.7770.92
423_L427_I0.7750.92
100_I103_V0.7720.92
140_E249_N0.7700.92
97_T243_F0.7660.92
187_N253_M0.7630.91
187_N216_I0.7620.91
152_L369_A0.7610.91
22_V30_I0.7600.91
143_G430_L0.7580.91
188_V216_I0.7560.91
284_V287_I0.7550.91
95_V238_A0.7530.91
150_D426_S0.7530.91
58_E231_K0.7490.91
29_M68_L0.7490.91
25_V125_T0.7470.91
234_Y260_V0.7450.90
72_Y228_M0.7430.90
261_A288_L0.7430.90
125_T235_T0.7430.90
157_K302_T0.7410.90
194_E259_R0.7390.90
91_L150_D0.7380.90
164_F321_A0.7370.90
260_V287_I0.7370.90
254_M291_L0.7350.90
361_S427_I0.7350.90
142_M182_T0.7340.90
235_T238_A0.7330.90
92_R124_S0.7320.90
195_R259_R0.7310.90
356_V361_S0.7300.90
376_L380_Q0.7300.90
213_K216_I0.7270.89
63_Q66_N0.7260.89
393_R403_I0.7260.89
34_G37_S0.7250.89
154_T361_S0.7240.89
102_Q116_L0.7210.89
368_A430_L0.7190.89
313_G318_E0.7150.89
43_C59_V0.7150.89
26_I388_I0.7130.88
262_M323_T0.7110.88
41_D87_T0.7110.88
333_V351_K0.7100.88
187_N190_A0.7100.88
128_S290_R0.7070.88
62_F67_I0.7070.88
375_L409_L0.7060.88
220_A224_Q0.7060.88
376_L409_L0.7050.88
58_E91_L0.7050.88
365_H369_A0.7040.88
391_Y400_D0.7020.88
384_D390_A0.7020.88
178_I251_M0.7000.87
424_E428_A0.7000.87
94_K120_L0.6970.87
230_L264_Q0.6950.87
384_D387_N0.6930.87
232_A236_A0.6930.87
322_D325_R0.6880.87
239_I243_F0.6870.86
57_A70_M0.6870.86
249_N297_A0.6860.86
167_S327_I0.6860.86
154_T365_H0.6860.86
110_P117_P0.6850.86
32_S57_A0.6850.86
103_V106_A0.6840.86
73_L225_P0.6840.86
199_V219_V0.6820.86
137_P359_N0.6820.86
144_V149_I0.6820.86
383_E410_I0.6810.86
230_L267_I0.6810.86
252_F295_T0.6810.86
280_Y315_D0.6800.86
153_L353_I0.6780.86
156_G355_R0.6770.86
118_K121_S0.6760.86
375_L401_E0.6760.86
363_K416_G0.6750.86
277_T323_T0.6750.86
175_M253_M0.6750.86
161_I332_I0.6710.85
47_A82_S0.6700.85
143_G183_E0.6690.85
68_L71_P0.6670.85
179_A187_N0.6660.85
103_V111_L0.6650.85
335_D351_K0.6650.85
367_D370_N0.6640.85
250_V266_E0.6630.85
122_P401_E0.6630.85
166_G279_G0.6610.84
100_I248_Q0.6610.84
37_S86_A0.6600.84
45_I84_V0.6590.84
26_I29_M0.6580.84
220_A229_R0.6580.84
241_E244_R0.6560.84
100_I212_L0.6550.84
91_L235_T0.6530.84
62_F68_L0.6530.84
98_G121_S0.6520.84
405_F408_Q0.6510.83
379_Y383_E0.6510.83
418_D429_A0.6490.83
107_F110_P0.6450.83
142_M155_V0.6440.83
105_D111_L0.6420.83
184_A214_R0.6400.82
171_K255_D0.6400.82
176_G219_V0.6390.82
187_N215_S0.6340.82
42_L91_L0.6340.82
261_A320_I0.6330.82
421_A425_E0.6330.82
151_S154_T0.6310.81
67_I84_V0.6310.81
412_F429_A0.6300.81
233_A254_M0.6300.81
237_T254_M0.6290.81
273_E283_S0.6260.81
156_G360_I0.6240.81
170_G255_D0.6240.81
208_G212_L0.6230.81
111_L116_L0.6230.81
30_I75_A0.6200.80
244_R303_I0.6200.80
273_E296_G0.6190.80
167_S325_R0.6160.80
112_D117_P0.6160.80
238_A242_Y0.6150.80
74_E77_S0.6130.80
392_K395_S0.6110.79
144_V295_T0.6100.79
225_P228_M0.6090.79
110_P116_L0.6090.79
364_Q368_A0.6080.79
149_I174_L0.6070.79
361_S365_H0.6070.79
317_N324_V0.6050.79
37_S42_L0.6050.79
17_K54_V0.6040.79
206_D211_G0.6030.78
90_S124_S0.6030.78
138_I356_V0.6030.78
425_E428_A0.6030.78
70_M267_I0.6030.78
188_V218_V0.6020.78
180_K418_D0.6010.78
100_I186_L0.6010.78
141_K356_V0.6010.78
55_I77_S0.6000.78
146_V417_T0.6000.78
189_I199_V0.5980.78
394_G401_E0.5980.78
426_S429_A0.5980.78
167_S326_G0.5970.78
362_T427_I0.5970.78
55_I74_E0.5940.77
111_L224_Q0.5940.77
153_L347_V0.5910.77
124_S238_A0.5900.77
143_G426_S0.5890.77
326_G353_I0.5880.77
229_R241_E0.5870.77
399_I403_I0.5870.77
119_G242_Y0.5870.77
169_V336_R0.5860.77
164_F328_L0.5860.77
167_S262_M0.5850.76
379_Y410_I0.5820.76
407_P410_I0.5810.76
375_L405_F0.5810.76
382_S387_N0.5810.76
109_E122_P0.5810.76
104_I235_T0.5800.76
87_T90_S0.5790.76
104_I108_G0.5780.76
375_L402_A0.5740.75
277_T399_I0.5740.75
101_G106_A0.5730.75
386_I399_I0.5730.75
349_V376_L0.5720.75
178_I306_F0.5710.75
144_V164_F0.5710.75
429_A432_S0.5700.75
205_K238_A0.5690.74
389_G394_G0.5690.74
391_Y394_G0.5690.74
163_I332_I0.5690.74
136_P299_E0.5680.74
383_E403_I0.5680.74
22_V25_V0.5680.74
362_T431_T0.5670.74
274_P282_P0.5670.74
97_T116_L0.5670.74
372_F430_L0.5650.74
237_T240_A0.5650.74
33_K65_E0.5640.74
147_R429_A0.5600.73
148_S349_V0.5570.73
63_Q67_I0.5550.73
163_I334_L0.5550.73
114_K212_L0.5540.72
54_V85_E0.5530.72
265_R320_I0.5530.72
403_I407_P0.5520.72
77_S81_G0.5510.72
306_F342_G0.5500.72
106_A109_E0.5500.72
139_R297_A0.5490.72
204_E209_K0.5470.72
55_I225_P0.5470.72
61_G68_L0.5460.71
260_V264_Q0.5460.71
110_P114_K0.5450.71
428_A432_S0.5440.71
85_E89_E0.5440.71
102_Q106_A0.5440.71
230_L287_I0.5430.71
165_A169_V0.5430.71
18_R36_A0.5430.71
98_G115_L0.5420.71
141_K423_L0.5420.71
416_G420_P0.5410.71
209_K217_V0.5410.71
166_G311_V0.5400.71
111_L219_V0.5400.71
94_K109_E0.5380.70
262_M390_A0.5380.70
358_S417_T0.5380.70
58_E198_E0.5370.70
172_S255_D0.5360.70
336_R340_N0.5350.70
368_A371_K0.5340.70
95_V99_L0.5330.70
126_E234_Y0.5330.70
191_L194_E0.5330.70
163_I306_F0.5320.69
313_G322_D0.5290.69
395_S403_I0.5290.69
348_N380_Q0.5290.69
32_S67_I0.5290.69
55_I78_I0.5280.69
350_L376_L0.5270.69
323_T390_A0.5270.69
25_V30_I0.5260.69
98_G117_P0.5250.68
38_S79_A0.5250.68
17_K47_A0.5220.68
395_S399_I0.5200.68
185_D214_R0.5200.68
234_Y264_Q0.5190.68
34_G179_A0.5190.68
264_Q267_I0.5180.67
257_V291_L0.5180.67
312_D317_N0.5170.67
329_D355_R0.5170.67
93_V99_L0.5170.67
326_G331_H0.5170.67
266_E280_Y0.5160.67
394_G400_D0.5160.67
159_Q355_R0.5150.67
207_L213_K0.5140.67
234_Y271_A0.5140.67
127_Q241_E0.5130.67
146_V177_M0.5130.67
103_V219_V0.5130.67
41_D91_L0.5120.67
180_K203_I0.5120.67
129_P257_V0.5080.66
126_E290_R0.5080.66
376_L406_Y0.5080.66
274_P286_A0.5070.66
180_K214_R0.5070.66
212_L217_V0.5070.66
73_L212_L0.5070.66
220_A228_M0.5060.66
116_L120_L0.5060.66
338_L341_K0.5050.65
207_L215_S0.5040.65
198_E201_E0.5040.65
187_N250_V0.5040.65
419_E423_L0.5030.65
94_K99_L0.5030.65
428_A431_T0.5030.65
190_A305_A0.5020.65
154_T353_I0.5020.65
244_R249_N0.5010.65
101_G108_G0.5010.65
375_L378_T0.5010.65
134_K205_K0.5010.65
168_G266_E0.5000.65
43_C67_I0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oaaA 2 0.9475 100 0.092 Contact Map
2qe7A 1 0.9406 100 0.095 Contact Map
1fx0A 1 0.9475 100 0.111 Contact Map
2c61A 2 0.9064 100 0.112 Contact Map
3vr4D 1 0.9543 100 0.113 Contact Map
3gqbB 1 0.9566 100 0.114 Contact Map
2ck3A 1 0.9475 100 0.116 Contact Map
2r9vA 1 0.9658 100 0.116 Contact Map
3j9tA 1 0.9429 100 0.116 Contact Map
3mfyA 1 0.7785 100 0.122 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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