GREMLIN Database
SYY1 - Tyrosine--tRNA ligase 1
UniProt: P22326 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (386)
Sequences: 3938 (2124)
Seq/√Len: 108.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
311_R315_E4.0741.00
180_N184_D3.8231.00
359_D370_K3.3311.00
306_S311_R3.3001.00
132_N135_D3.2711.00
302_E318_I3.2001.00
83_K237_E3.1261.00
383_Y410_R3.0001.00
122_A126_D2.9611.00
65_H120_V2.8551.00
207_I217_A2.8341.00
266_V284_A2.8021.00
200_I219_G2.7761.00
40_P75_G2.5561.00
226_T267_K2.5421.00
9_S20_E2.4941.00
57_R61_L2.4721.00
33_R65_H2.4541.00
310_G313_A2.4081.00
100_Q103_K2.4001.00
179_L210_S2.3761.00
313_A316_Q2.2561.00
285_E289_T2.2291.00
25_K29_E2.1831.00
356_S359_D2.1741.00
19_D22_G2.1691.00
182_Y215_A2.1451.00
380_G388_R2.1421.00
183_R211_E2.1171.00
112_F119_A2.0941.00
266_V270_K2.0791.00
156_S160_E2.0611.00
348_E420_T2.0061.00
91_T94_I1.9701.00
179_L183_R1.9621.00
306_S314_L1.9531.00
36_S52_P1.9461.00
367_S373_A1.9441.00
383_Y388_R1.9161.00
53_I106_L1.9101.00
279_E282_A1.9061.00
34_L59_F1.8951.00
96_S100_Q1.8881.00
97_E101_K1.8821.00
362_V370_K1.8791.00
368_P372_Q1.8741.00
378_Q392_I1.8601.00
103_K107_S1.8541.00
73_A128_I1.8481.00
97_E100_Q1.8151.00
270_K284_A1.8101.00
298_K322_Q1.8071.00
22_G27_L1.7931.00
22_G26_Q1.7741.00
361_L382_V1.7651.00
360_V419_V1.7631.00
34_L56_L1.7421.00
92_A96_S1.7261.00
302_E314_L1.7251.00
282_A286_K1.7201.00
143_N209_K1.7181.00
10_F277_K1.7161.00
26_Q32_I1.7061.00
33_R67_I1.6961.00
227_K231_T1.6811.00
76_L92_A1.6631.00
128_I131_M1.6631.00
69_L181_L1.6441.00
318_I322_Q1.6161.00
284_A288_E1.6141.00
302_E315_E1.6111.00
281_E284_A1.6051.00
282_A285_E1.5981.00
372_Q376_D1.5951.00
99_S123_N1.5901.00
366_L417_F1.5841.00
360_V396_L1.5841.00
277_K281_E1.5831.00
371_R375_E1.5831.00
94_I97_E1.5751.00
175_S202_A1.5721.00
376_D381_A1.5631.00
144_F202_A1.5621.00
125_F129_G1.5351.00
276_S279_E1.5231.00
90_N94_I1.5191.00
18_T219_G1.5111.00
299_R303_E1.4951.00
52_P222_I1.4951.00
290_A293_K1.4891.00
85_A88_T1.4871.00
67_I122_A1.4871.00
253_F304_V1.4801.00
295_E298_K1.4721.00
264_D267_K1.4631.00
36_S191_I1.4621.00
38_F53_I1.4611.00
205_E208_R1.4491.00
354_E395_T1.4491.00
38_F45_L1.4481.00
182_Y211_E1.4351.00
254_Y318_I1.4321.00
253_F305_T1.4271.00
23_L26_Q1.4241.00
72_G123_N1.4231.00
376_D411_R1.4191.00
122_A181_L1.4061.00
410_R416_Y1.3971.00
376_D379_N1.3971.00
375_E379_N1.3961.00
231_T237_E1.3871.00
315_E319_N1.3871.00
38_F52_P1.3801.00
367_S376_D1.3651.00
7_D10_F1.3631.00
313_A317_A1.3601.00
90_N98_W1.3521.00
356_S370_K1.3391.00
261_D264_D1.3290.99
275_L299_R1.3280.99
372_Q375_E1.3150.99
312_E316_Q1.3130.99
145_G162_G1.3110.99
47_I257_W1.3100.99
21_E25_K1.3080.99
275_L303_E1.2910.99
357_L389_Q1.2840.99
294_R298_K1.2810.99
362_V367_S1.2780.99
67_I120_V1.2690.99
266_V287_T1.2630.99
286_K295_E1.2630.99
72_G125_F1.2540.99
59_F189_L1.2510.99
179_L207_I1.2340.99
245_K250_P1.2320.99
279_E299_R1.2240.99
382_V411_R1.2140.99
56_L59_F1.2120.99
68_A106_L1.2080.99
241_I257_W1.2070.99
285_E288_E1.1960.99
100_Q104_N1.1920.99
353_Q363_Q1.1920.99
357_L394_Y1.1850.99
314_L321_S1.1840.99
133_V136_F1.1810.99
358_V370_K1.1700.99
179_L211_E1.1660.99
286_K290_A1.1630.99
182_Y214_G1.1620.99
148_Y151_A1.1580.99
298_K318_I1.1540.99
227_K239_G1.1480.98
43_D97_E1.1440.98
358_V377_I1.1400.98
104_N244_D1.1370.98
303_E306_S1.1360.98
152_K201_T1.1350.98
275_L279_E1.1340.98
26_Q29_E1.1290.98
380_G390_T1.1260.98
384_I407_T1.1220.98
253_F257_W1.1210.98
315_E318_I1.1160.98
111_D114_A1.1140.98
266_V281_E1.1140.98
123_N126_D1.1020.98
302_E306_S1.0950.98
347_M417_F1.0940.98
319_N322_Q1.0900.98
278_E281_E1.0900.98
250_P309_H1.0860.98
133_V173_L1.0860.98
14_I17_M1.0800.98
128_I173_L1.0740.98
26_Q30_E1.0700.98
364_S417_F1.0690.98
359_D363_Q1.0690.98
281_E285_E1.0680.98
153_D157_S1.0670.98
180_N183_R1.0660.98
54_L307_L1.0570.97
16_Q19_D1.0460.97
128_I176_Y1.0430.97
157_S161_S1.0390.97
357_L377_I1.0370.97
270_K277_K1.0350.97
280_I284_A1.0250.97
55_T222_I1.0230.97
27_L32_I1.0160.97
255_Q259_N1.0140.97
350_D353_Q1.0130.97
355_L363_Q1.0070.97
375_E381_A1.0030.96
9_S24_N1.0000.96
7_D58_R0.9980.96
23_L27_L0.9960.96
355_L360_V0.9950.96
49_H52_P0.9910.96
298_K302_E0.9890.96
20_E24_N0.9850.96
251_Y320_I0.9850.96
16_Q221_T0.9850.96
396_L407_T0.9810.96
211_E215_A0.9800.96
314_L318_I0.9740.96
54_L274_F0.9720.96
136_F172_I0.9720.96
15_Q194_S0.9680.96
245_K313_A0.9680.96
233_F256_F0.9600.95
319_N323_A0.9600.95
67_I181_L0.9530.95
269_L300_L0.9470.95
133_V169_S0.9400.95
269_L283_Y0.9390.95
391_E394_Y0.9360.95
189_L220_L0.9350.95
149_M168_F0.9340.95
312_E315_E0.9320.95
253_F308_V0.9270.94
179_L206_L0.9260.94
411_R415_K0.9250.94
316_Q319_N0.9240.94
51_L225_V0.9220.94
357_L382_V0.9150.94
92_A129_G0.9140.94
58_R62_A0.9130.94
270_K280_I0.9130.94
131_M176_Y0.9110.94
249_S252_E0.9090.94
368_P415_K0.9040.94
143_N210_S0.9000.94
341_F344_V0.9000.94
320_I323_A0.8990.94
107_S119_A0.8960.93
57_R274_F0.8930.93
53_I109_F0.8920.93
140_V176_Y0.8890.93
200_I221_T0.8890.93
81_S163_I0.8890.93
346_S420_T0.8840.93
33_R120_V0.8840.93
252_E255_Q0.8830.93
405_Q420_T0.8830.93
43_D49_H0.8810.93
299_R302_E0.8790.93
295_E299_R0.8740.93
265_V292_E0.8730.93
13_L271_Y0.8720.92
13_L58_R0.8700.92
42_A49_H0.8660.92
241_I256_F0.8630.92
344_V408_V0.8630.92
225_V272_F0.8610.92
36_S49_H0.8600.92
273_T303_E0.8580.92
32_I64_H0.8550.92
273_T304_V0.8540.92
69_L122_A0.8540.92
389_Q394_Y0.8540.92
150_L159_I0.8530.92
361_L409_L0.8480.91
137_L173_L0.8410.91
83_K236_T0.8400.91
367_S382_V0.8390.91
283_Y287_T0.8370.91
257_W272_F0.8320.91
367_S372_Q0.8320.91
255_Q325_F0.8310.91
254_Y298_K0.8310.91
302_E311_R0.8310.91
313_A321_S0.8270.90
145_G164_S0.8230.90
259_N414_K0.8200.90
58_R61_L0.8140.90
320_I324_L0.8100.89
269_L299_R0.8100.89
396_L419_V0.8100.89
293_K297_Q0.8090.89
227_K238_G0.8070.89
179_L217_A0.8070.89
323_A327_G0.8070.89
137_L169_S0.8060.89
100_Q107_S0.8050.89
32_I189_L0.8040.89
60_Q119_A0.8030.89
31_K64_H0.8020.89
283_Y299_R0.8020.89
362_V373_A0.8010.89
10_F281_E0.8010.89
183_R210_S0.8000.89
111_D119_A0.7970.89
258_I294_R0.7950.89
103_K121_I0.7940.88
17_M20_E0.7940.88
22_G25_K0.7920.88
255_Q321_S0.7920.88
291_P294_R0.7860.88
42_A238_G0.7860.88
356_S393_N0.7830.88
53_I110_L0.7830.88
38_F68_A0.7810.88
131_M140_V0.7800.88
254_Y258_I0.7790.88
384_I409_L0.7760.87
408_V418_L0.7760.87
104_N107_S0.7760.87
55_T191_I0.7750.87
284_A287_T0.7730.87
34_L189_L0.7730.87
40_P99_S0.7720.87
242_W245_K0.7650.87
107_S121_I0.7640.86
254_Y302_E0.7630.86
148_Y152_K0.7590.86
386_G410_R0.7590.86
17_M23_L0.7540.86
43_D101_K0.7530.86
380_G383_Y0.7510.86
103_K112_F0.7480.85
96_S99_S0.7470.85
38_F49_H0.7470.85
286_K291_P0.7430.85
81_S85_A0.7430.85
153_D156_S0.7430.85
38_F42_A0.7430.85
228_A263_R0.7420.85
358_V392_I0.7410.85
13_L54_L0.7380.85
294_R297_Q0.7350.84
56_L68_A0.7350.84
286_K289_T0.7330.84
106_L121_I0.7300.84
211_E214_G0.7290.84
274_F303_E0.7290.84
358_V374_R0.7280.84
306_S312_E0.7270.84
142_K166_T0.7260.84
138_R143_N0.7230.83
155_V171_M0.7230.83
254_Y321_S0.7230.83
22_G216_K0.7170.83
356_S377_I0.7140.83
270_K281_E0.7140.83
49_H53_I0.7140.83
36_S45_L0.7110.82
377_I392_I0.7100.82
88_T94_I0.7090.82
370_K374_R0.7070.82
60_Q111_D0.7070.82
26_Q215_A0.7060.82
176_Y180_N0.7060.82
134_I138_R0.7050.82
182_Y207_I0.7050.82
141_G169_S0.7040.82
76_L95_V0.7020.81
49_H236_T0.7020.81
273_T299_R0.7000.81
322_Q326_S0.7000.81
340_G343_D0.6980.81
265_V296_A0.6980.81
51_L271_Y0.6940.81
34_L191_I0.6940.81
128_I133_V0.6930.81
107_S112_F0.6920.81
277_K280_I0.6910.80
109_F253_F0.6910.80
13_L220_L0.6910.80
357_L361_L0.6870.80
292_E296_A0.6860.80
47_I256_F0.6830.80
365_K368_P0.6820.80
23_L189_L0.6810.80
229_D261_D0.6810.80
237_E240_A0.6810.80
82_G154_T0.6800.79
144_F172_I0.6800.79
105_Q244_D0.6790.79
224_L237_E0.6770.79
89_L166_T0.6750.79
298_K326_S0.6750.79
379_N411_R0.6740.79
406_F420_T0.6730.79
52_P191_I0.6720.79
227_K256_F0.6680.78
318_I321_S0.6640.78
384_I396_L0.6640.78
146_I163_I0.6630.78
374_R392_I0.6590.77
264_D268_Y0.6580.77
145_G148_Y0.6570.77
89_L138_R0.6550.77
50_L307_L0.6550.77
371_R374_R0.6540.77
19_D26_Q0.6530.77
202_A205_E0.6520.77
31_K65_H0.6520.77
50_L272_F0.6500.76
231_T236_T0.6490.76
15_Q197_W0.6490.76
148_Y205_E0.6470.76
47_I227_K0.6470.76
165_Y169_S0.6460.76
176_Y210_S0.6440.76
95_V98_W0.6440.76
260_T268_Y0.6430.76
227_K268_Y0.6430.76
47_I304_V0.6430.76
144_F175_S0.6430.76
28_N31_K0.6430.76
253_F309_H0.6400.75
15_Q19_D0.6390.75
255_Q414_K0.6390.75
85_A237_E0.6360.75
359_D362_V0.6360.75
377_I382_V0.6340.74
146_I168_F0.6320.74
197_W221_T0.6320.74
321_S414_K0.6310.74
149_M171_M0.6290.74
47_I109_F0.6270.74
205_E209_K0.6270.74
154_T171_M0.6260.74
269_L296_A0.6260.74
259_N325_F0.6240.73
54_L58_R0.6220.73
245_K249_S0.6210.73
86_E142_K0.6210.73
225_V256_F0.6190.73
149_M165_Y0.6190.73
81_S154_T0.6190.73
201_T204_L0.6180.73
136_F173_L0.6180.73
58_R274_F0.6130.72
228_A260_T0.6120.72
40_P46_H0.6120.72
286_K299_R0.6100.72
13_L16_Q0.6100.72
283_Y296_A0.6090.72
7_D62_A0.6090.72
83_K157_S0.6080.71
57_R60_Q0.6080.71
76_L129_G0.6050.71
292_E295_E0.6050.71
390_T394_Y0.6040.71
75_G95_V0.6030.71
57_R106_L0.6020.71
265_V284_A0.6010.71
114_A119_A0.6010.71
344_V416_Y0.6000.70
257_W305_T0.5960.70
275_L283_Y0.5940.70
269_L280_I0.5940.70
47_I271_Y0.5940.70
236_T239_G0.5930.70
385_N407_T0.5920.69
361_L373_A0.5900.69
26_Q218_F0.5900.69
376_D382_V0.5880.69
287_T290_A0.5880.69
204_L217_A0.5880.69
149_M155_V0.5880.69
171_M175_S0.5870.69
47_I253_F0.5860.69
381_A386_G0.5860.69
108_R244_D0.5860.69
84_K88_T0.5850.68
10_F19_D0.5850.68
224_L244_D0.5840.68
255_Q258_I0.5840.68
198_G201_T0.5830.68
317_A321_S0.5830.68
76_L90_N0.5820.68
371_R378_Q0.5810.68
16_Q197_W0.5800.68
131_M135_D0.5780.68
228_A261_D0.5760.67
52_P81_S0.5750.67
360_V407_T0.5740.67
175_S206_L0.5730.67
49_H101_K0.5730.67
91_T95_V0.5720.67
51_L55_T0.5710.67
407_T419_V0.5710.67
108_R245_K0.5710.67
354_E397_S0.5700.67
125_F128_I0.5680.66
229_D239_G0.5680.66
320_I340_G0.5680.66
191_I222_I0.5680.66
49_H222_I0.5670.66
323_A326_S0.5670.66
104_N108_R0.5670.66
359_D393_N0.5660.66
368_P371_R0.5650.66
47_I240_A0.5630.66
342_K345_P0.5620.65
25_K28_N0.5620.65
45_L68_A0.5610.65
304_V308_V0.5610.65
68_A110_L0.5600.65
387_E390_T0.5600.65
38_F106_L0.5580.65
306_S315_E0.5570.65
53_I68_A0.5570.65
236_T253_F0.5560.65
367_S409_L0.5550.64
136_F140_V0.5530.64
402_I405_Q0.5520.64
341_F346_S0.5520.64
356_S395_T0.5510.64
251_Y325_F0.5510.64
273_T307_L0.5510.64
83_K88_T0.5500.64
47_I272_F0.5500.64
257_W268_Y0.5490.64
362_V371_R0.5480.63
165_Y172_I0.5470.63
146_I149_M0.5460.63
387_E394_Y0.5460.63
291_P295_E0.5450.63
272_F307_L0.5430.63
326_S329_I0.5420.63
231_T238_G0.5420.63
376_D415_K0.5410.63
49_H268_Y0.5410.63
21_E24_N0.5390.62
151_A241_I0.5380.62
59_F191_I0.5380.62
75_G99_S0.5380.62
9_S14_I0.5340.62
46_H75_G0.5340.62
366_L411_R0.5340.62
49_H102_I0.5320.61
165_Y168_F0.5310.61
86_E166_T0.5300.61
27_L64_H0.5300.61
354_E398_G0.5290.61
323_A329_I0.5280.61
38_F144_F0.5270.61
36_S53_I0.5270.61
373_A377_I0.5260.60
36_S56_L0.5260.60
90_N95_V0.5250.60
272_F304_V0.5200.59
88_T237_E0.5190.59
256_F260_T0.5190.59
18_T204_L0.5190.59
251_Y321_S0.5180.59
41_T49_H0.5180.59
368_P376_D0.5170.59
101_K104_N0.5170.59
7_D277_K0.5160.59
154_T157_S0.5150.59
82_G237_E0.5150.59
386_G408_V0.5140.59
145_G171_M0.5120.58
96_S123_N0.5120.58
266_V280_I0.5120.58
261_D265_V0.5110.58
61_L274_F0.5110.58
75_G166_T0.5110.58
22_G218_F0.5100.58
294_R325_F0.5100.58
40_P162_G0.5100.58
273_T306_S0.5090.58
377_I381_A0.5090.58
109_F112_F0.5080.58
251_Y255_Q0.5080.58
370_K381_A0.5070.58
34_L52_P0.5070.58
130_K135_D0.5060.57
255_Q320_I0.5060.57
92_A135_D0.5050.57
36_S68_A0.5040.57
152_K202_A0.5030.57
106_L123_N0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jilA 2 0.7607 100 0.248 Contact Map
2ts1A 2 0.7512 100 0.251 Contact Map
4oudA 2 0.9621 100 0.252 Contact Map
2janA 2 0.9858 100 0.256 Contact Map
1h3fA 2 0.8768 100 0.359 Contact Map
1y42X 2 0.7488 100 0.394 Contact Map
2pidA 2 0.7275 100 0.445 Contact Map
2yxnA 2 0.7512 100 0.456 Contact Map
3p0jA 1 0.91 100 0.571 Contact Map
3hv0A 2 0.718 100 0.581 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0123 seconds.