GREMLIN Database
SYE - Glutamate--tRNA ligase
UniProt: P22250 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 483 (411)
Sequences: 6363 (3566)
Seq/√Len: 175.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_E102_K4.7561.00
97_E101_E4.5571.00
168_N174_E4.3161.00
53_E57_Q4.0441.00
4_E38_K3.8741.00
110_C135_H3.1071.00
334_L371_H2.9631.00
146_F151_R2.8001.00
57_Q61_N2.6971.00
140_Q144_E2.6881.00
131_Y135_H2.6221.00
144_E148_A2.5401.00
205_Y234_W2.5121.00
229_Y239_F2.4781.00
335_D364_R2.3751.00
121_E125_R2.3581.00
111_T114_E2.3431.00
425_T428_N2.2371.00
96_Y155_I2.2351.00
137_D141_E2.2111.00
117_K121_E2.2051.00
148_A151_R2.2011.00
90_D94_V2.1951.00
97_E140_Q2.1711.00
64_K69_D2.1511.00
56_E84_R2.1481.00
230_Q236_I2.1471.00
141_E146_F2.1251.00
95_Y206_L2.1221.00
109_Y153_P2.0861.00
172_K216_E2.0811.00
91_I206_L2.0771.00
165_I179_S2.0731.00
166_A176_S2.0671.00
90_D189_K2.0661.00
166_A174_E2.0591.00
272_Y322_K2.0571.00
104_L231_A2.0511.00
120_E123_I2.0311.00
170_I238_Q2.0141.00
298_E302_E2.0101.00
31_F35_Q1.9761.00
110_C118_E1.9591.00
292_E299_Q1.9341.00
333_D336_Q1.9091.00
164_V176_S1.9061.00
84_R87_E1.8981.00
145_K149_E1.8891.00
6_R209_M1.8881.00
226_I236_I1.8831.00
326_N330_K1.8821.00
175_I219_I1.8761.00
64_K70_W1.8731.00
96_Y188_V1.8601.00
164_V178_E1.8441.00
94_V98_E1.8431.00
406_Q409_E1.8191.00
92_Y203_D1.7821.00
40_I209_M1.7751.00
9_Y21_N1.7751.00
143_Q147_I1.7701.00
17_L21_N1.7461.00
332_L336_Q1.7431.00
168_N238_Q1.7421.00
139_T142_E1.7291.00
91_I95_Y1.7211.00
415_A419_E1.7101.00
6_R38_K1.7091.00
89_N193_T1.6871.00
41_I60_L1.6781.00
118_E132_S1.6641.00
109_Y152_K1.6601.00
107_K153_P1.6571.00
163_K230_Q1.6471.00
273_L304_F1.6311.00
296_T299_Q1.6181.00
100_L107_K1.6131.00
73_S83_Y1.6121.00
424_F429_I1.5991.00
133_G136_R1.5861.00
109_Y147_I1.5721.00
395_N398_A1.5701.00
157_F231_A1.5611.00
70_W73_S1.5441.00
98_E101_E1.5281.00
211_H238_Q1.5211.00
250_R315_L1.5171.00
91_I94_V1.5151.00
114_E118_E1.4951.00
142_E145_K1.4861.00
179_S188_V1.4821.00
99_L104_L1.4741.00
95_Y232_F1.4731.00
116_E120_E1.4691.00
61_N265_E1.4661.00
416_A419_E1.4641.00
6_R40_I1.4611.00
157_F227_M1.4521.00
108_C135_H1.4411.00
159_V227_M1.4361.00
197_N225_Q1.4341.00
61_N64_K1.4321.00
240_G306_V1.4091.00
413_T417_K1.4021.00
385_D389_T1.4021.00
24_T215_G1.4001.00
399_K403_E1.3951.00
22_A66_L1.3951.00
247_N257_D1.3931.00
275_E336_Q1.3911.00
38_K71_D1.3911.00
413_T416_A1.3911.00
279_N283_L1.3741.00
107_K147_I1.3671.00
140_Q143_Q1.3661.00
65_W268_K1.3591.00
6_R208_K1.3541.00
336_Q340_L1.3391.00
327_Q331_K1.3351.00
234_W237_P1.3321.00
122_Q127_E1.3281.00
52_I55_G1.3281.00
149_E177_F1.3241.00
371_H374_L1.3211.00
375_S379_E1.3041.00
7_V28_N1.3031.00
141_E147_I1.3031.00
107_K155_I1.3011.00
72_E83_Y1.2971.00
95_Y202_I1.2971.00
93_K97_E1.2901.00
328_Y346_Q1.2841.00
96_Y100_L1.2821.00
292_E303_I1.2711.00
319_H322_K1.2691.00
404_E407_V1.2641.00
304_F308_R1.2591.00
26_L68_I1.2581.00
282_G300_F1.2551.00
266_Q269_E1.2531.00
327_Q330_K1.2511.00
100_L155_I1.2441.00
148_A177_F1.2431.00
114_E117_K1.2421.00
205_Y235_D1.2411.00
102_K233_G1.2261.00
40_I73_S1.2141.00
213_L240_G1.2121.00
201_A228_I1.2091.00
60_L64_K1.2081.00
138_L147_I1.2011.00
105_A155_I1.1941.00
112_E116_E1.1891.00
170_I306_V1.1791.00
197_N221_N1.1691.00
114_E132_S1.1691.00
98_E233_G1.1641.00
54_G57_Q1.1621.00
278_F297_K1.1591.00
114_E134_K1.1581.00
356_S359_E1.1571.00
226_I230_Q1.1551.00
135_H138_L1.1491.00
342_L360_Q1.1451.00
294_L324_V1.1361.00
85_Q199_A1.1361.00
29_Y33_R1.1341.00
423_E428_N1.1261.00
146_F149_E1.1251.00
31_F211_H1.1241.00
167_F219_I1.1201.00
100_L139_T1.1201.00
172_K228_I1.1181.00
110_C131_Y1.1161.00
218_H221_N1.1131.00
57_Q60_L1.1071.00
338_V364_R1.1021.00
334_L337_V1.1001.00
95_Y234_W1.1001.00
339_E360_Q1.0981.00
107_K143_Q1.0931.00
114_E135_H1.0931.00
366_L387_F1.0891.00
133_G158_R1.0861.00
5_V31_F1.0841.00
122_Q126_G1.0841.00
29_Y39_F1.0781.00
117_K120_E1.0771.00
266_Q270_L1.0761.00
38_K72_E1.0761.00
157_F228_I1.0731.00
368_S371_H1.0721.00
100_L105_A1.0661.00
249_S257_D1.0661.00
218_H225_Q1.0661.00
411_L414_F1.0641.00
362_W366_L1.0601.00
105_A187_I1.0561.00
44_E200_V1.0541.00
24_T28_N1.0531.00
120_E124_A1.0511.00
60_L70_W1.0350.99
370_Y380_I1.0350.99
101_E104_L1.0250.99
39_F68_I1.0230.99
85_Q203_D1.0200.99
137_D146_F1.0160.99
329_V373_Q1.0120.99
335_D339_E1.0090.99
123_I126_G1.0070.99
88_R92_Y1.0050.99
132_S135_H1.0030.99
297_K301_I0.9990.99
90_D93_K0.9980.99
399_K404_E0.9980.99
336_Q339_E0.9940.99
92_Y199_A0.9870.99
197_N218_H0.9860.99
95_Y98_E0.9840.99
142_E146_F0.9820.99
405_E408_P0.9800.99
48_K193_T0.9770.99
417_K420_E0.9750.99
144_E147_I0.9720.99
334_L368_S0.9700.99
61_N268_K0.9700.99
131_Y134_K0.9700.99
342_L346_Q0.9660.99
48_K86_S0.9660.99
143_Q192_G0.9650.99
322_K375_S0.9620.99
427_D431_A0.9600.99
31_F213_L0.9600.99
53_E56_E0.9570.99
299_Q303_I0.9530.99
56_E184_D0.9480.99
299_Q302_E0.9480.99
16_H58_S0.9470.99
16_H54_G0.9450.99
136_R158_R0.9430.99
138_L143_Q0.9370.99
102_K231_A0.9360.99
292_E295_F0.9350.99
269_E347_K0.9340.99
306_V309_L0.9340.99
409_E412_S0.9310.99
412_S416_A0.9310.99
5_V211_H0.9310.99
94_V101_E0.9310.99
403_E406_Q0.9260.99
108_C115_L0.9240.99
86_S193_T0.9230.99
110_C134_K0.9230.99
163_K179_S0.9200.99
93_K188_V0.9180.99
101_E140_Q0.9170.99
96_Y105_A0.9160.99
404_E408_P0.9140.99
4_E208_K0.9140.99
6_R72_E0.9130.99
94_V97_E0.9130.99
24_T213_L0.9110.99
40_I83_Y0.9110.99
369_L387_F0.9090.99
408_P412_S0.9080.99
145_K148_A0.9040.99
416_A420_E0.9030.99
34_N305_D0.8960.98
273_L276_A0.8950.98
379_E382_E0.8950.98
89_N93_K0.8940.98
400_A404_E0.8890.98
121_E124_A0.8890.98
361_E365_K0.8870.98
6_R73_S0.8830.98
332_L340_L0.8820.98
394_Y398_A0.8810.98
88_R91_I0.8800.98
407_V411_L0.8800.98
306_V333_D0.8790.98
362_W365_K0.8750.98
166_A221_N0.8710.98
405_E409_E0.8690.98
62_Y265_E0.8690.98
340_L343_P0.8660.98
338_V342_L0.8650.98
295_F300_F0.8650.98
122_Q125_R0.8650.98
9_Y17_L0.8630.98
348_A381_V0.8620.98
229_Y232_F0.8620.98
370_Y384_T0.8620.98
118_E127_E0.8610.98
109_Y151_R0.8530.98
403_E407_V0.8530.98
143_Q146_F0.8470.98
428_N431_A0.8450.98
376_Y379_E0.8430.98
167_F226_I0.8430.98
341_T380_I0.8410.98
365_K368_S0.8360.98
328_Y331_K0.8350.98
366_L384_T0.8250.97
275_E304_F0.8200.97
147_I151_R0.8200.97
33_R69_D0.8170.97
318_M322_K0.8150.97
348_A382_E0.8050.97
426_P430_K0.8050.97
399_K402_L0.8050.97
427_D430_K0.8030.97
33_R71_D0.8030.97
157_F187_I0.7980.97
24_T27_F0.7960.97
113_E116_E0.7940.97
141_E144_E0.7910.97
322_K376_Y0.7890.97
329_V332_L0.7810.96
320_K347_K0.7800.96
137_D147_I0.7790.96
98_E104_L0.7790.96
383_L386_L0.7780.96
91_I98_E0.7760.96
294_L328_Y0.7730.96
272_Y277_L0.7720.96
202_I232_F0.7710.96
230_Q233_G0.7690.96
278_F300_F0.7680.96
90_D143_Q0.7670.96
360_Q364_R0.7650.96
393_E396_Q0.7640.96
407_V410_V0.7630.96
172_K217_D0.7620.96
32_A37_G0.7610.96
23_R242_M0.7610.96
21_N217_D0.7580.96
93_K140_Q0.7580.96
400_A403_E0.7570.96
177_F191_D0.7560.96
334_L338_V0.7540.96
257_D260_I0.7530.96
314_A378_A0.7530.96
123_I129_P0.7530.96
267_Y277_L0.7510.96
379_E383_L0.7500.96
97_E100_L0.7450.95
63_L68_I0.7440.95
110_C115_L0.7400.95
272_Y321_L0.7370.95
34_N301_I0.7360.95
165_I227_M0.7360.95
324_V328_Y0.7310.95
40_I72_E0.7290.95
138_L142_E0.7280.95
106_Y184_D0.7280.95
155_I188_V0.7270.95
338_V367_I0.7250.95
9_Y59_Q0.7250.95
147_I150_G0.7250.95
220_S223_P0.7220.94
109_Y143_Q0.7210.94
109_Y131_Y0.7200.94
5_V35_Q0.7190.94
275_E308_R0.7160.94
273_L325_N0.7130.94
343_P374_L0.7120.94
24_T253_L0.7120.94
248_E319_H0.7070.94
221_N225_Q0.7070.94
87_E185_F0.7050.94
118_E122_Q0.7040.94
398_A401_V0.7040.94
118_E134_K0.7040.94
7_V31_F0.6990.93
275_E340_L0.6990.93
414_F418_L0.6970.93
391_E394_Y0.6930.93
412_S415_A0.6930.93
410_V413_T0.6930.93
96_Y198_F0.6920.93
394_Y397_E0.6900.93
298_E301_I0.6880.93
418_L424_F0.6870.93
48_K51_N0.6860.93
292_E296_T0.6850.93
305_D308_R0.6840.93
322_K347_K0.6820.93
201_A229_Y0.6810.93
109_Y130_R0.6810.93
58_S265_E0.6810.93
245_I293_E0.6810.93
185_F224_K0.6810.93
229_Y234_W0.6800.93
260_I270_L0.6790.92
345_L371_H0.6790.92
122_Q129_P0.6780.92
398_A402_L0.6770.92
370_Y383_L0.6740.92
115_L131_Y0.6720.92
397_E400_A0.6720.92
171_V240_G0.6720.92
110_C114_E0.6710.92
130_R133_G0.6690.92
63_L215_G0.6690.92
157_F185_F0.6690.92
233_G236_I0.6670.92
113_E117_K0.6660.92
283_L300_F0.6650.92
228_I232_F0.6650.92
345_L374_L0.6640.92
251_K257_D0.6630.92
422_E425_T0.6630.92
170_I240_G0.6630.92
49_K52_I0.6630.92
321_L348_A0.6620.92
92_Y202_I0.6620.92
167_F223_P0.6610.91
259_S263_F0.6600.91
17_L24_T0.6590.91
28_N31_F0.6560.91
216_E244_L0.6560.91
344_H348_A0.6550.91
51_N55_G0.6530.91
60_L73_S0.6520.91
241_H249_S0.6510.91
183_G224_K0.6510.91
295_F299_Q0.6500.91
411_L415_A0.6500.91
205_Y208_K0.6490.91
165_I226_I0.6470.91
409_E413_T0.6470.91
193_T217_D0.6450.90
323_W327_Q0.6440.90
138_L146_F0.6430.90
202_I206_L0.6430.90
158_R161_E0.6420.90
40_I74_V0.6410.90
172_K219_I0.6400.90
221_N228_I0.6400.90
202_I234_W0.6400.90
275_E332_L0.6390.90
361_E364_R0.6390.90
368_S372_E0.6380.90
284_L314_A0.6380.90
406_Q410_V0.6350.90
122_Q165_I0.6350.90
406_Q412_S0.6310.89
95_Y198_F0.6310.89
25_A68_I0.6280.89
227_M230_Q0.6260.89
202_I228_I0.6250.89
398_A403_E0.6220.89
247_N259_S0.6210.89
247_N251_K0.6190.89
279_N300_F0.6190.89
107_K152_K0.6180.89
137_D158_R0.6130.88
199_A205_Y0.6120.88
59_Q62_Y0.6120.88
177_F223_P0.6110.88
139_T145_K0.6100.88
370_Y373_Q0.6100.88
85_Q92_Y0.6100.88
51_N54_G0.6070.88
69_D73_S0.6060.88
17_L22_A0.6060.88
422_E428_N0.6040.87
362_W387_F0.6010.87
235_D238_Q0.6010.87
267_Y276_A0.6000.87
88_R203_D0.6000.87
229_Y237_P0.5990.87
115_L154_S0.5980.87
93_K192_G0.5970.87
260_I263_F0.5960.87
60_L74_V0.5960.87
247_N258_E0.5950.87
166_A223_P0.5950.87
137_D140_Q0.5950.87
399_K406_Q0.5940.87
359_E362_W0.5930.86
259_S270_L0.5930.86
281_I284_L0.5910.86
270_L378_A0.5900.86
167_F177_F0.5900.86
381_V384_T0.5890.86
396_Q401_V0.5880.86
387_F392_I0.5880.86
26_L30_L0.5860.86
95_Y201_A0.5850.86
86_S89_N0.5840.86
17_L58_S0.5840.86
65_W274_P0.5830.85
166_A220_S0.5830.85
171_V309_L0.5820.85
424_F428_N0.5820.85
374_L383_L0.5810.85
40_I71_D0.5810.85
167_F222_T0.5800.85
205_Y232_F0.5790.85
348_A385_D0.5770.85
199_A203_D0.5770.85
402_L407_V0.5770.85
337_V367_I0.5760.85
121_E127_E0.5760.85
258_E263_F0.5750.85
74_V83_Y0.5750.85
133_G161_E0.5750.85
418_L429_I0.5740.85
326_N345_L0.5740.85
233_G237_P0.5740.85
213_L306_V0.5730.85
361_E366_L0.5730.85
201_A221_N0.5720.84
317_D409_E0.5700.84
143_Q151_R0.5700.84
27_F215_G0.5690.84
48_K89_N0.5690.84
212_V222_T0.5690.84
335_D338_V0.5680.84
270_L318_M0.5670.84
272_Y276_A0.5660.84
316_F380_I0.5640.84
197_N224_K0.5640.84
221_N224_K0.5640.84
414_F417_K0.5630.83
217_D225_Q0.5600.83
391_E395_N0.5600.83
402_L406_Q0.5590.83
265_E269_E0.5580.83
69_D74_V0.5580.83
19_I277_L0.5580.83
404_E412_S0.5580.83
240_G287_S0.5560.83
240_G309_L0.5560.83
63_L244_L0.5560.83
224_K247_N0.5550.83
307_N333_D0.5550.83
110_C127_E0.5540.82
98_E234_W0.5530.82
109_Y146_F0.5530.82
275_E297_K0.5530.82
8_R11_P0.5520.82
9_Y23_R0.5510.82
279_N293_E0.5490.82
44_E207_M0.5480.82
122_Q132_S0.5470.82
407_V412_S0.5460.82
389_T392_I0.5430.81
209_M212_V0.5430.81
51_N218_H0.5420.81
129_P133_G0.5410.81
11_P15_G0.5410.81
30_L282_G0.5400.81
116_E123_I0.5390.81
279_N304_F0.5380.81
358_E361_E0.5360.80
16_H260_I0.5340.80
189_K225_Q0.5330.80
343_P347_K0.5330.80
229_Y236_I0.5330.80
408_P413_T0.5320.80
8_R13_P0.5310.80
89_N92_Y0.5310.80
327_Q332_L0.5300.80
409_E416_A0.5290.80
19_I316_F0.5290.80
355_L360_Q0.5290.80
276_A328_Y0.5290.80
26_L278_F0.5280.79
55_G58_S0.5280.79
260_I266_Q0.5270.79
357_A360_Q0.5260.79
356_S360_Q0.5250.79
122_Q130_R0.5240.79
124_A129_P0.5230.79
129_P132_S0.5230.79
7_V213_L0.5220.79
337_V341_T0.5210.79
39_F70_W0.5210.79
100_L188_V0.5200.78
130_R134_K0.5190.78
115_L118_E0.5190.78
330_K372_E0.5180.78
97_E107_K0.5170.78
222_T239_F0.5150.78
343_P346_Q0.5150.78
115_L119_R0.5140.78
425_T429_I0.5130.77
138_L141_E0.5130.77
72_E88_R0.5120.77
213_L286_W0.5120.77
7_V39_F0.5120.77
53_E84_R0.5100.77
406_Q411_L0.5100.77
198_F202_I0.5100.77
399_K407_V0.5090.77
344_H378_A0.5090.77
295_F303_I0.5090.77
71_D83_Y0.5090.77
300_F303_I0.5080.77
267_Y318_M0.5080.77
414_F419_E0.5080.77
172_K224_K0.5080.77
294_L327_Q0.5070.77
251_K260_I0.5060.77
389_T393_E0.5050.76
170_I307_N0.5050.76
83_Y207_M0.5050.76
189_K218_H0.5040.76
94_V206_L0.5040.76
363_V366_L0.5030.76
287_S290_G0.5010.76
101_E133_G0.5010.76
30_L300_F0.5010.76
21_N24_T0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ja2A 1 0.9814 100 0.225 Contact Map
4griA 1 0.9834 100 0.236 Contact Map
1j09A 1 0.9607 100 0.242 Contact Map
2cfoA 1 0.9689 100 0.256 Contact Map
3al0C 1 0.9503 100 0.262 Contact Map
3afhA 1 0.9317 100 0.265 Contact Map
2o5rA 1 0.9586 100 0.276 Contact Map
4g6zA 1 0.7867 100 0.283 Contact Map
2hz7A 1 0.8841 100 0.487 Contact Map
4h3sA 1 0.942 100 0.494 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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