GREMLIN Database
SPEA - Arginine decarboxylase
UniProt: P21885 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 490 (470)
Sequences: 2189 (1462)
Seq/√Len: 67.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
419_E429_R7.2491.00
182_V192_V4.2361.00
83_T238_N4.2201.00
107_K160_D4.2031.00
407_A450_I3.8381.00
234_S265_L3.7671.00
81_D240_R3.6511.00
6_T10_T3.5841.00
177_D180_S3.3981.00
70_A85_F3.3121.00
424_K460_F3.2651.00
152_K187_S3.2361.00
224_V236_I3.2351.00
151_A181_I3.1761.00
68_K72_D3.1281.00
405_L450_I3.1181.00
74_A83_T3.0751.00
230_S234_S3.0061.00
148_L184_L2.9531.00
153_R157_E2.9471.00
5_E69_Q2.9341.00
427_S456_I2.9241.00
86_S93_A2.7941.00
75_A80_A2.7931.00
427_S453_E2.7641.00
97_M193_L2.7391.00
453_E457_S2.7011.00
106_D162_K2.6561.00
156_T188_F2.5541.00
22_Q30_K2.4341.00
445_F451_I2.3701.00
179_K183_E2.3361.00
418_T432_A2.3291.00
109_I161_A2.3111.00
110_I118_I2.2951.00
99_M256_L2.2671.00
351_V361_C2.2601.00
298_L379_L2.2521.00
84_F250_Q2.2431.00
155_L190_V2.2121.00
422_P425_E2.1971.00
196_E212_A2.1711.00
107_K128_V2.1131.00
90_T235_S2.1121.00
172_F355_D2.0801.00
107_K158_H2.0701.00
164_L185_A2.0611.00
97_M219_I2.0491.00
346_S381_E2.0361.00
109_I132_I2.0351.00
152_K156_T2.0291.00
11_G66_I2.0151.00
324_K360_L2.0141.00
213_M220_A1.9911.00
294_T372_A1.9871.00
12_L267_A1.9781.00
90_T221_A1.9471.00
193_L221_A1.9471.00
8_L266_L1.9341.00
346_S385_Q1.9241.00
5_E10_T1.9211.00
339_V382_I1.9191.00
200_V227_L1.9091.00
108_I163_G1.8601.00
222_T238_N1.8581.00
344_R350_E1.8381.00
23_F375_L1.8251.00
86_S92_G1.8211.00
327_I379_L1.8191.00
129_P410_P1.8161.00
70_A270_D1.8071.00
275_R283_L1.8021.00
102_C127_A1.7901.00
219_I249_V1.7861.00
367_D371_D1.7811.00
69_Q72_D1.7801.00
421_I426_A1.7781.00
351_V359_I1.7711.00
102_C106_D1.7601.00
74_A78_F1.7481.00
74_A236_I1.7471.00
326_I360_L1.7341.00
135_E150_S1.7321.00
76_E277_A1.7281.00
118_I165_L1.7101.00
191_P243_L1.6920.99
304_I379_L1.6770.99
82_H250_Q1.6610.99
185_A192_V1.6580.99
81_D241_E1.6320.99
297_R380_T1.6290.99
294_T376_V1.6260.99
100_A249_V1.6210.99
290_L369_Q1.6180.99
92_G256_L1.6000.99
369_Q373_D1.5930.99
293_Q369_Q1.5900.99
231_L264_L1.5790.99
270_D273_R1.5730.99
73_L273_R1.5600.99
274_K278_T1.5260.99
9_Y271_V1.5260.99
291_A363_F1.5130.99
104_P126_G1.5100.99
155_L188_F1.5050.99
96_T253_L1.5040.99
301_I383_A1.4910.99
355_D358_N1.4650.99
13_K17_S1.4590.98
363_F372_A1.4570.98
21_V349_I1.4570.98
292_N322_P1.4420.98
168_N176_A1.4370.98
186_H218_D1.4320.98
97_M221_A1.4240.98
93_A253_L1.4200.98
82_H246_K1.4200.98
46_A264_L1.4160.98
334_L339_V1.4130.98
107_K130_I1.4030.98
239_M246_K1.4030.98
189_D243_L1.4010.98
42_I46_A1.3940.98
135_E147_T1.3920.98
110_I122_I1.3910.98
193_L219_I1.3830.98
51_L57_L1.3720.98
178_L192_V1.3680.98
58_D63_P1.3680.98
85_F270_D1.3660.98
325_L363_F1.3630.98
227_L362_I1.3600.98
231_L268_S1.3500.97
10_T14_K1.3480.97
291_A295_R1.3380.97
196_E222_T1.3350.97
102_C163_G1.3170.97
18_R348_N1.3090.97
86_S253_L1.3060.97
108_I165_L1.3040.97
294_T325_L1.3030.97
411_R415_Y1.3030.97
287_T363_F1.3000.97
304_I327_I1.2940.97
126_G411_R1.2810.96
158_H161_A1.2730.96
119_M131_F1.2720.96
166_V194_V1.2620.96
210_L215_A1.2620.96
83_T236_I1.2590.96
285_E289_K1.2570.96
421_I429_R1.2570.96
179_K210_L1.2530.96
81_D246_K1.2410.96
70_A273_R1.2350.96
297_R300_Q1.2290.96
342_W382_I1.2210.95
99_M125_S1.2190.95
131_F446_I1.2090.95
122_I129_P1.2050.95
206_D281_R1.1970.95
140_L307_V1.1830.95
239_M249_V1.1780.94
184_L188_F1.1760.94
94_I111_P1.1740.94
180_S183_E1.1730.94
132_I151_A1.1710.94
182_V215_A1.1710.94
132_I150_S1.1710.94
180_S184_L1.1700.94
297_R376_V1.1670.94
328_S358_N1.1650.94
152_K180_S1.1620.94
77_A273_R1.1600.94
25_I362_I1.1570.94
183_E187_S1.1550.94
185_A190_V1.1460.94
236_I269_L1.1450.93
29_K367_D1.1370.93
163_G190_V1.1340.93
434_F447_P1.1300.93
182_V186_H1.1300.93
340_E354_S1.1290.93
98_V165_L1.1110.92
279_E282_Q1.1000.92
151_A159_P1.0990.92
292_N296_D1.0890.92
35_D274_K1.0850.92
303_G383_A1.0750.91
137_D144_H1.0740.91
113_N170_T1.0740.91
58_D67_I1.0740.91
374_R378_A1.0710.91
67_I71_Q1.0710.91
8_L66_I1.0670.91
276_L284_A1.0660.91
298_L304_I1.0610.91
202_I209_P1.0590.90
224_V269_L1.0590.90
200_V228_G1.0570.90
205_H288_L1.0540.90
14_K17_S1.0510.90
462_N467_L1.0500.90
178_L182_V1.0490.90
147_T150_S1.0460.90
288_L322_P1.0460.90
91_S95_M1.0460.90
152_K184_L1.0460.90
88_Q233_Q1.0440.90
34_M47_L1.0420.90
208_L323_T1.0390.90
334_L386_M1.0370.90
353_L360_L1.0310.89
87_V258_T1.0270.89
81_D242_G1.0260.89
407_A430_I1.0260.89
131_F406_L1.0230.89
286_E289_K1.0220.89
294_T298_L1.0190.89
108_I122_I1.0090.88
205_H285_E1.0060.88
203_H211_S1.0040.88
409_T412_D1.0040.88
15_H350_E1.0030.88
7_P273_R1.0020.88
53_N261_T0.9990.88
25_I52_I0.9960.88
104_P411_R0.9940.87
309_S319_S0.9910.87
103_G106_D0.9850.87
452_T455_N0.9820.87
172_F358_N0.9800.87
21_V374_R0.9760.87
20_P350_E0.9750.86
77_A277_A0.9700.86
8_L67_I0.9620.86
74_A85_F0.9610.86
210_L214_Q0.9610.86
228_G276_L0.9570.85
342_W346_S0.9560.85
336_G359_I0.9550.85
123_V410_P0.9550.85
204_F276_L0.9540.85
435_V445_F0.9510.85
459_I469_V0.9480.85
6_T274_K0.9390.84
425_E454_E0.9360.84
281_R285_E0.9340.84
93_A221_A0.9320.84
61_H87_V0.9320.84
9_Y270_D0.9300.84
87_V325_L0.9210.83
128_V409_T0.9200.83
232_T262_S0.9190.83
339_V359_I0.9180.83
380_T384_Q0.9170.83
241_E244_V0.9130.83
114_V167_I0.9130.83
283_L365_P0.9120.83
208_L259_T0.9120.83
104_P415_Y0.9100.82
80_A213_M0.9100.82
112_R449_E0.9050.82
340_E351_V0.9040.82
36_P40_Q0.9040.82
15_H20_P0.8980.82
336_G354_S0.8960.81
324_K362_I0.8940.81
410_P413_A0.8930.81
150_S153_R0.8910.81
114_V131_F0.8900.81
7_P73_L0.8900.81
184_L187_S0.8870.81
230_S272_A0.8850.81
21_V371_D0.8830.80
171_Y352_E0.8750.80
22_Q29_K0.8740.80
41_F45_N0.8740.80
94_I117_S0.8710.80
205_H208_L0.8680.79
95_M256_L0.8680.79
335_T338_D0.8670.79
383_A386_M0.8670.79
229_G275_R0.8660.79
313_G316_A0.8630.79
169_P199_G0.8620.79
299_N308_G0.8600.79
408_M416_A0.8600.79
103_G248_R0.8570.78
55_E344_R0.8550.78
259_T280_G0.8540.78
15_H54_I0.8540.78
437_V462_N0.8540.78
86_S237_L0.8540.78
327_I361_C0.8530.78
14_K18_R0.8520.78
10_T37_E0.8480.78
164_L192_V0.8460.78
340_E350_E0.8460.78
98_V108_I0.8340.77
87_V92_G0.8320.76
58_D232_T0.8280.76
224_V238_N0.8230.76
207_E285_E0.8230.76
213_M240_R0.8220.75
293_Q297_R0.8220.75
84_F239_M0.8150.75
290_L372_A0.8150.75
113_N134_P0.8140.75
11_G14_K0.8120.75
92_G257_T0.8080.74
93_A257_T0.8060.74
71_Q75_A0.7980.73
116_K470_Q0.7950.73
83_T222_T0.7950.73
230_S265_L0.7930.73
397_E400_L0.7890.72
337_H467_L0.7880.72
155_L184_L0.7870.72
220_A238_N0.7850.72
404_P410_P0.7830.72
241_E246_K0.7820.72
26_P50_D0.7780.71
122_I127_A0.7770.71
77_A204_F0.7770.71
109_I154_A0.7760.71
132_I146_I0.7730.71
219_I244_V0.7690.71
368_S371_D0.7650.70
146_I166_V0.7650.70
377_E381_E0.7650.70
94_I118_I0.7640.70
95_M120_T0.7640.70
25_I232_T0.7630.70
25_I53_N0.7610.70
408_M412_D0.7600.70
406_L409_T0.7600.70
47_L231_L0.7600.70
267_A270_D0.7560.69
203_H214_Q0.7550.69
340_E344_R0.7540.69
85_F269_L0.7530.69
250_Q253_L0.7500.69
65_G69_Q0.7490.69
106_D128_V0.7460.68
11_G57_L0.7450.68
20_P348_N0.7450.68
297_R373_D0.7420.68
329_V333_G0.7410.68
170_T233_Q0.7400.68
408_M413_A0.7400.68
19_Q348_N0.7380.67
224_V227_L0.7370.67
422_P453_E0.7360.67
52_I354_S0.7340.67
433_E474_D0.7330.67
323_T362_I0.7330.67
54_I57_L0.7320.67
85_F273_R0.7320.67
29_K324_K0.7290.66
96_T257_T0.7290.66
109_I150_S0.7270.66
282_Q286_E0.7260.66
400_L403_I0.7250.66
73_L77_A0.7250.66
88_Q92_G0.7250.66
194_V217_A0.7230.66
155_L164_L0.7220.66
49_I264_L0.7200.65
280_G283_L0.7190.65
110_I165_L0.7170.65
9_Y49_I0.7170.65
116_K120_T0.7150.65
438_Y441_G0.7120.65
22_Q25_I0.7120.65
9_Y41_F0.7110.64
38_F271_V0.7100.64
213_M222_T0.7100.64
123_V413_A0.7060.64
381_E384_Q0.7060.64
25_I54_I0.7050.64
364_T367_D0.7040.64
184_L192_V0.7030.64
24_H54_I0.7010.63
111_P167_I0.7000.63
182_V185_A0.7000.63
152_K188_F0.6990.63
293_Q373_D0.6970.63
6_T9_Y0.6970.63
155_L161_A0.6970.63
73_L277_A0.6960.63
283_L366_G0.6960.63
13_K40_Q0.6960.63
111_P114_V0.6930.62
198_H232_T0.6930.62
246_K249_V0.6920.62
430_I450_I0.6920.62
177_D316_A0.6890.62
269_L273_R0.6890.62
228_G261_T0.6860.62
337_H354_S0.6830.61
60_L263_Y0.6830.61
431_I472_P0.6810.61
53_N198_H0.6810.61
411_R414_F0.6810.61
25_I262_S0.6800.61
472_P475_S0.6800.61
84_F100_A0.6800.61
163_G193_L0.6790.61
137_D140_L0.6790.61
234_S268_S0.6760.61
417_N429_R0.6760.61
287_T291_A0.6760.61
109_I164_L0.6740.60
367_D372_A0.6730.60
305_Y328_S0.6730.60
172_F353_L0.6710.60
101_V191_P0.6710.60
168_N202_I0.6700.60
334_L382_I0.6660.59
431_I445_F0.6660.59
301_I304_I0.6660.59
444_I459_I0.6650.59
175_A209_P0.6620.59
148_L427_S0.6620.59
208_L288_L0.6620.59
117_S438_Y0.6620.59
151_A164_L0.6610.59
172_F360_L0.6600.59
132_I154_A0.6600.59
343_L379_L0.6590.59
161_A190_V0.6590.59
232_T263_Y0.6590.59
24_H263_Y0.6590.59
28_H50_D0.6590.59
53_N93_A0.6580.59
155_L159_P0.6580.59
176_A181_I0.6560.58
142_I170_T0.6560.58
72_D282_Q0.6550.58
398_V402_E0.6550.58
148_L152_K0.6540.58
199_G262_S0.6540.58
237_L249_V0.6540.58
126_G410_P0.6540.58
53_N263_Y0.6530.58
144_H172_F0.6530.58
166_V178_L0.6520.58
91_S259_T0.6500.58
15_H30_K0.6500.58
94_I198_H0.6490.57
95_M116_K0.6480.57
71_Q253_L0.6480.57
451_I455_N0.6480.57
140_L358_N0.6470.57
296_D300_Q0.6450.57
130_I158_H0.6450.57
9_Y13_K0.6440.57
52_I61_H0.6440.57
413_A416_A0.6440.57
123_V447_P0.6430.57
310_E313_G0.6420.57
86_S221_A0.6410.57
288_L292_N0.6410.57
52_I263_Y0.6400.56
232_T352_E0.6390.56
224_V228_G0.6390.56
95_M259_T0.6390.56
39_R44_E0.6380.56
253_L259_T0.6370.56
20_P344_R0.6360.56
80_A240_R0.6350.56
290_L294_T0.6330.56
253_L257_T0.6320.55
287_T323_T0.6300.55
253_L262_S0.6300.55
286_E290_L0.6300.55
198_H253_L0.6290.55
120_T339_V0.6260.55
64_K325_L0.6250.55
73_L76_E0.6230.54
31_G57_L0.6220.54
105_G453_E0.6200.54
168_N182_V0.6200.54
79_G203_H0.6190.54
373_D377_E0.6170.54
148_L151_A0.6170.54
208_L227_L0.6140.53
270_D276_L0.6140.53
38_F42_I0.6140.53
205_H209_P0.6140.53
168_N213_M0.6130.53
77_A270_D0.6130.53
338_D341_K0.6120.53
456_I460_F0.6120.53
224_V273_R0.6110.53
15_H18_R0.6090.53
87_V198_H0.6080.53
377_E389_Q0.6080.53
123_V259_T0.6060.52
79_G214_Q0.6060.52
52_I262_S0.6060.52
93_A198_H0.6050.52
102_C109_I0.6050.52
166_V327_I0.6050.52
435_V459_I0.6040.52
98_V121_A0.6020.52
44_E48_S0.6010.52
54_I324_K0.6000.52
24_H61_H0.5990.52
119_M446_I0.5990.52
458_Y462_N0.5990.52
27_G232_T0.5980.51
283_L287_T0.5980.51
149_E152_K0.5980.51
462_N469_V0.5980.51
377_E384_Q0.5980.51
167_I436_M0.5980.51
84_F246_K0.5970.51
148_L164_L0.5960.51
341_K345_E0.5960.51
412_D416_A0.5950.51
114_V165_L0.5940.51
116_K436_M0.5940.51
413_A447_P0.5930.51
199_G232_T0.5920.51
98_V101_V0.5920.51
159_P162_K0.5920.51
13_K49_I0.5910.51
51_L54_I0.5900.50
203_H276_L0.5900.50
24_H52_I0.5900.50
64_K258_T0.5900.50
395_Q398_V0.5890.50
121_A125_S0.5880.50
71_Q91_S0.5880.50
111_P176_A0.5870.50
78_F203_H0.5870.50
154_A159_P0.5870.50
338_D342_W0.5870.50
422_P460_F0.5850.50
58_D66_I0.5850.50
320_Y326_I0.5840.50
204_F259_T0.5830.50
457_S460_F0.5820.50
86_S257_T0.5820.50
169_P201_H0.5810.49
112_R438_Y0.5810.49
436_M470_Q0.5810.49
52_I60_L0.5810.49
116_K172_F0.5800.49
87_V257_T0.5780.49
146_I151_A0.5760.49
70_A74_A0.5760.49
105_G128_V0.5760.49
153_R457_S0.5740.49
293_Q376_V0.5740.49
381_E385_Q0.5710.48
254_S258_T0.5710.48
78_F236_I0.5700.48
325_L375_L0.5700.48
54_I262_S0.5690.48
156_T249_V0.5690.48
96_T198_H0.5690.48
378_A382_I0.5680.48
234_S264_L0.5670.48
199_G202_I0.5660.48
120_T255_M0.5640.47
396_T400_L0.5630.47
68_K379_L0.5630.47
148_L180_S0.5630.47
151_A154_A0.5630.47
299_N306_C0.5630.47
123_V414_F0.5620.47
345_E457_S0.5620.47
129_P406_L0.5610.47
170_T174_V0.5600.47
280_G323_T0.5590.47
123_V251_S0.5580.47
429_R432_A0.5570.47
222_T261_T0.5540.46
25_I29_K0.5540.46
334_L338_D0.5540.46
24_H470_Q0.5530.46
96_T122_I0.5520.46
289_K369_Q0.5510.46
57_L269_L0.5500.46
107_K161_A0.5490.46
348_N435_V0.5490.46
207_E292_N0.5480.46
72_D389_Q0.5470.45
52_I56_P0.5470.45
15_H51_L0.5470.45
222_T236_I0.5470.45
289_K293_Q0.5460.45
25_I51_L0.5460.45
454_E457_S0.5460.45
60_L258_T0.5460.45
37_E274_K0.5460.45
175_A319_S0.5450.45
175_A202_I0.5440.45
87_V182_V0.5440.45
370_N378_A0.5440.45
100_A252_I0.5440.45
212_A217_A0.5430.45
297_R377_E0.5430.45
286_E460_F0.5430.45
59_D259_T0.5420.45
16_A48_S0.5420.45
58_D350_E0.5420.45
71_Q250_Q0.5420.45
121_A295_R0.5420.45
194_V212_A0.5410.45
398_V401_P0.5410.45
232_T264_L0.5390.44
299_N305_Y0.5370.44
60_L352_E0.5370.44
148_L177_D0.5350.44
19_Q374_R0.5340.44
88_Q167_I0.5330.44
91_S239_M0.5320.44
290_L376_V0.5320.44
122_I410_P0.5320.44
53_N60_L0.5310.44
183_E345_E0.5300.43
64_K445_F0.5300.43
307_V320_Y0.5300.43
25_I352_E0.5300.43
294_T363_F0.5300.43
54_I353_L0.5290.43
42_I49_I0.5290.43
207_E289_K0.5290.43
68_K369_Q0.5280.43
464_D476_T0.5280.43
100_A193_L0.5280.43
328_S331_S0.5280.43
56_P88_Q0.5270.43
202_I211_S0.5260.43
171_Y263_Y0.5260.43
460_F463_L0.5250.43
319_S322_P0.5250.43
26_P352_E0.5240.43
233_Q265_L0.5240.43
87_V95_M0.5240.43
405_L452_T0.5240.43
73_L270_D0.5240.43
96_T237_L0.5230.43
323_T363_F0.5220.42
52_I198_H0.5220.42
369_Q460_F0.5220.42
98_V102_C0.5220.42
232_T266_L0.5220.42
445_F459_I0.5220.42
52_I266_L0.5220.42
375_L382_I0.5210.42
97_M163_G0.5200.42
27_G50_D0.5200.42
175_A375_L0.5200.42
163_G191_P0.5200.42
53_N352_E0.5200.42
330_K357_Y0.5190.42
272_A323_T0.5190.42
245_S249_V0.5180.42
307_V328_S0.5180.42
64_K341_K0.5180.42
134_P151_A0.5180.42
377_E421_I0.5180.42
67_I266_L0.5170.42
378_A381_E0.5170.42
52_I261_T0.5170.42
153_R402_E0.5160.42
394_Q397_E0.5150.42
74_A269_L0.5150.42
183_E186_H0.5140.42
92_G253_L0.5140.42
166_V181_I0.5140.42
25_I353_L0.5140.42
58_D62_A0.5130.41
338_D388_E0.5130.41
216_G442_I0.5130.41
116_K355_D0.5120.41
129_P332_L0.5120.41
274_K277_A0.5120.41
197_A226_K0.5120.41
94_I166_V0.5100.41
52_I58_D0.5100.41
148_L166_V0.5090.41
18_R388_E0.5090.41
393_H425_E0.5060.41
55_E354_S0.5060.41
33_G275_R0.5060.41
24_H261_T0.5050.40
94_I221_A0.5050.40
25_I350_E0.5050.40
88_Q227_L0.5040.40
101_V193_L0.5040.40
187_S191_P0.5040.40
54_I263_Y0.5040.40
231_L235_S0.5040.40
61_H198_H0.5040.40
78_F83_T0.5040.40
435_V469_V0.5020.40
120_T436_M0.5020.40
431_I434_F0.5020.40
52_I324_K0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vycA 5 0.9857 100 0.424 Contact Map
3n75A 4 0.9796 100 0.44 Contact Map
1c4kA 2 0.9939 100 0.446 Contact Map
2x3lA 2 0.8551 100 0.45 Contact Map
4q6rA 2 0.8245 100 0.742 Contact Map
3mc6A 2 0.7694 100 0.748 Contact Map
4w8iA 2 0.6898 100 0.77 Contact Map
3bc8A 3 0.7592 100 0.784 Contact Map
3hl2A 3 0.7653 100 0.789 Contact Map
1jg8A 4 0.6612 100 0.807 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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