GREMLIN Database
ODP2 - Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
UniProt: P21883 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 442 (409)
Sequences: 7374 (4568)
Seq/√Len: 225.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
338_G342_K3.7801.00
26_P58_E3.6081.00
327_K335_E3.5741.00
341_T345_E3.4151.00
283_K427_H3.3371.00
213_T302_H3.3091.00
57_L77_D3.2431.00
62_E65_T3.0681.00
390_E397_G3.0541.00
214_R297_E2.9671.00
24_V34_D2.9461.00
342_K352_E2.7961.00
24_V56_V2.7211.00
290_S301_K2.7081.00
153_K178_V2.6951.00
394_V399_I2.6521.00
277_L358_C2.6251.00
243_E391_K2.6161.00
156_D159_K2.6121.00
335_E338_G2.5831.00
23_F35_V2.5811.00
284_F427_H2.5671.00
274_V306_I2.5621.00
390_E403_P2.5001.00
31_D53_K2.4901.00
394_V401_A2.4771.00
58_E75_T2.4721.00
4_E75_T2.3731.00
237_H410_S2.3241.00
215_E300_Q2.3181.00
21_K63_E2.2981.00
223_A226_K2.2701.00
303_Y323_N2.2451.00
29_E55_K2.1991.00
327_K331_E2.1831.00
244_V407_L2.1591.00
60_K75_T2.1471.00
61_V71_Q2.0891.00
149_Y175_D2.0761.00
282_K325_D2.0691.00
4_E72_T2.0621.00
60_K72_T2.0531.00
25_K28_D2.0511.00
307_G318_V2.0291.00
281_L358_C2.0281.00
356_A379_E2.0141.00
245_D402_A1.9991.00
171_K175_D1.9881.00
217_M291_I1.9461.00
293_D296_D1.9451.00
159_K177_F1.9281.00
56_V74_I1.9281.00
278_T304_F1.9201.00
21_K38_E1.9071.00
274_V324_A1.8991.00
148_K152_E1.8761.00
214_R299_I1.8571.00
211_P302_H1.8431.00
305_N322_K1.8421.00
32_E53_K1.8351.00
31_D34_D1.8281.00
227_A230_N1.8061.00
223_A227_A1.7971.00
314_K346_G1.7961.00
56_V59_L1.7771.00
286_V300_Q1.7641.00
213_T300_Q1.7501.00
273_V385_I1.7201.00
19_I37_A1.7181.00
277_L428_I1.7131.00
274_V308_I1.7081.00
343_A348_L1.6831.00
222_K296_D1.6731.00
248_N251_A1.6711.00
220_I224_I1.6681.00
278_T324_A1.6591.00
258_Q261_A1.6521.00
61_V67_A1.6521.00
37_A73_I1.6501.00
308_I336_I1.6371.00
395_R398_E1.6271.00
274_V336_I1.6261.00
427_H430_R1.6251.00
230_N234_T1.6001.00
250_V269_Y1.5971.00
68_T71_Q1.5931.00
175_D179_N1.5911.00
260_A266_K1.5871.00
289_T300_Q1.5851.00
323_N326_R1.5791.00
150_A157_I1.5781.00
289_T415_M1.5721.00
23_F38_E1.5461.00
232_K237_H1.5411.00
142_A157_I1.5281.00
279_S431_L1.5201.00
255_Q436_Q1.5091.00
321_V335_E1.4991.00
149_Y174_I1.4881.00
241_M370_W1.4881.00
280_A428_I1.4861.00
221_R224_I1.4481.00
155_V160_V1.4451.00
172_E176_S1.4411.00
212_E299_I1.4321.00
373_P384_G1.4301.00
426_N430_R1.4271.00
247_T402_A1.4151.00
162_G169_V1.4131.00
26_P62_E1.4101.00
235_A375_I1.3911.00
380_V415_M1.3851.00
336_I340_A1.3811.00
391_K404_V1.3811.00
328_S331_E1.3761.00
274_V360_I1.3651.00
390_E401_A1.3391.00
392_A399_I1.3371.00
277_L424_A1.3331.00
254_K258_Q1.3321.00
286_V420_T1.3291.00
38_E47_E1.3291.00
407_L428_I1.3291.00
292_D297_E1.3271.00
257_K266_K1.3261.00
358_C381_A1.3171.00
221_R417_D1.3051.00
55_K77_D1.3021.00
229_V233_H1.2831.00
20_V45_V1.2811.00
212_E302_H1.2801.00
376_N379_E1.2701.00
307_G379_E1.2691.00
240_L421_A1.2681.00
226_K230_N1.2641.00
5_F74_I1.2611.00
383_L428_I1.2601.00
340_A344_R1.2501.00
214_R292_D1.2481.00
240_L411_F1.2401.00
284_F423_N1.2351.00
172_E175_D1.2311.00
216_K297_E1.2221.00
162_G168_R1.2201.00
392_A401_A1.2201.00
291_I415_M1.2031.00
235_A377_H1.1981.00
6_K72_T1.1951.00
240_L368_G1.1831.00
243_E369_Q1.1831.00
149_Y153_K1.1811.00
140_V169_V1.1781.00
246_V249_L1.1721.00
277_L381_A1.1491.00
155_V178_V1.1481.00
157_I169_V1.1461.00
239_T410_S1.1431.00
25_K59_L1.1421.00
292_D296_D1.1351.00
303_Y325_D1.1331.00
242_D429_K1.1291.00
292_D299_I1.1281.00
251_A254_K1.1271.00
249_L272_Y1.1151.00
385_I405_L1.1141.00
275_K279_S1.1131.00
251_A255_Q1.1121.00
427_H431_L1.1121.00
239_T372_T1.1101.00
212_E303_Y1.1101.00
305_N323_N1.1061.00
25_K63_E1.1011.00
287_L381_A1.0921.00
298_V415_M1.0911.00
16_E66_V1.0891.00
311_D423_N1.0831.00
274_V321_V1.0801.00
5_F36_L1.0751.00
349_A352_E1.0751.00
19_I61_V1.0671.00
55_K80_G1.0631.00
5_F76_F1.0571.00
153_K175_D1.0561.00
61_V65_T1.0561.00
238_V411_F1.0541.00
256_F267_L1.0471.00
388_I403_P1.0421.00
247_T403_P1.0411.00
358_C424_A1.0391.00
30_V50_S1.0351.00
254_K257_K1.0341.00
161_T177_F1.0331.00
305_N320_V1.0321.00
304_F325_D1.0211.00
22_W59_L1.0211.00
369_Q389_A1.0181.00
246_V388_I1.0181.00
36_L50_S1.0161.00
429_K433_N1.0161.00
26_P57_L1.0131.00
26_P59_L1.0071.00
393_I404_V1.0021.00
246_V405_L0.9971.00
250_V403_P0.9951.00
338_G341_T0.9911.00
14_I17_G0.9891.00
16_E68_T0.9821.00
419_A423_N0.9811.00
311_D419_A0.9761.00
241_M372_T0.9751.00
35_V47_E0.9741.00
393_I402_A0.9731.00
237_H375_I0.9731.00
395_R400_V0.9721.00
287_L416_I0.9611.00
30_V56_V0.9611.00
311_D366_A0.9601.00
176_S180_G0.9561.00
409_L425_L0.9541.00
342_K349_A0.9531.00
145_S171_K0.9531.00
244_V429_K0.9401.00
155_V174_I0.9351.00
240_L425_L0.9321.00
219_G222_K0.9271.00
59_L62_E0.9261.00
282_K304_F0.9221.00
7_L17_G0.9211.00
383_L409_L0.9171.00
176_S179_N0.9171.00
317_L353_M0.9160.99
247_T251_A0.9140.99
274_V332_I0.9130.99
279_S438_I0.9130.99
67_A71_Q0.9100.99
358_C409_L0.9090.99
18_E66_V0.9080.99
224_I228_M0.9050.99
323_N327_K0.9050.99
413_H418_G0.9020.99
240_L386_G0.9010.99
358_C383_L0.9000.99
317_L348_L0.9000.99
330_F334_D0.8980.99
39_V48_I0.8970.99
277_L383_L0.8940.99
23_F47_E0.8920.99
263_Q334_D0.8920.99
150_A155_V0.8910.99
178_V181_G0.8900.99
321_V327_K0.8880.99
363_I371_F0.8850.99
157_I160_V0.8820.99
271_P332_I0.8810.99
174_I177_F0.8810.99
93_D96_K0.8780.99
164_G173_D0.8740.99
52_V76_F0.8730.99
19_I73_I0.8720.99
146_V171_K0.8710.99
229_V235_A0.8650.99
348_L353_M0.8640.99
239_T408_S0.8640.99
33_D49_P0.8550.99
245_D395_R0.8500.99
211_P303_Y0.8490.99
185_A188_Q0.8480.99
232_K236_P0.8480.99
59_L65_T0.8460.99
321_V336_I0.8450.99
232_K374_V0.8420.99
273_V405_L0.8410.99
279_S282_K0.8380.99
220_I312_T0.8350.99
222_K226_K0.8340.99
283_K431_L0.8340.99
150_A169_V0.8340.99
385_I407_L0.8330.99
212_E301_K0.8270.99
82_E86_F0.8260.99
7_L39_V0.8230.99
217_M298_V0.8230.99
273_V432_L0.8190.99
390_E396_D0.8190.99
122_K125_G0.8190.99
287_L380_V0.8160.99
50_S53_K0.8150.99
241_M408_S0.8110.99
150_A160_V0.8080.99
267_L271_P0.8070.99
90_D93_D0.8020.99
92_S95_A0.8000.99
10_I17_G0.7980.99
411_F421_A0.7970.99
89_S92_S0.7970.99
162_G167_G0.7960.99
369_Q406_A0.7940.99
255_Q434_D0.7920.99
146_V174_I0.7860.98
18_E64_G0.7860.98
163_S170_V0.7840.98
206_P209_E0.7750.98
244_V432_L0.7730.98
259_V437_L0.7720.98
32_E50_S0.7710.98
146_V150_A0.7680.98
338_G352_E0.7620.98
15_H68_T0.7590.98
9_D12_E0.7590.98
240_L363_I0.7580.98
324_A332_I0.7550.98
164_G167_G0.7540.98
305_N379_E0.7540.98
78_A81_Y0.7530.98
140_V158_R0.7530.98
118_Q121_A0.7520.98
279_S283_K0.7520.98
375_I381_A0.7510.98
118_Q122_K0.7500.98
252_H272_Y0.7490.98
30_V76_F0.7490.98
331_E334_D0.7480.98
118_Q123_A0.7450.98
153_K179_N0.7440.98
181_G184_E0.7440.98
232_K239_T0.7430.98
381_A416_I0.7430.98
142_A150_A0.7420.98
10_I48_I0.7410.98
10_I39_V0.7380.98
305_N352_E0.7370.98
331_E335_E0.7310.98
94_D97_T0.7290.97
243_E406_A0.7290.97
149_Y171_K0.7290.97
160_V177_F0.7270.97
342_K347_K0.7260.97
142_A169_V0.7240.97
29_E53_K0.7220.97
327_K338_G0.7220.97
24_V28_D0.7200.97
227_A376_N0.7200.97
163_S167_G0.7200.97
287_L420_T0.7190.97
86_F90_D0.7160.97
375_I410_S0.7150.97
286_V289_T0.7150.97
271_P329_V0.7140.97
273_V360_I0.7120.97
243_E389_A0.7120.97
9_D13_G0.7120.97
435_P438_I0.7110.97
269_Y388_I0.7110.97
356_A376_N0.7100.97
245_D393_I0.7100.97
398_E401_A0.7100.97
177_F181_G0.7100.97
260_A263_Q0.7100.97
342_K348_L0.7090.97
150_A156_D0.7080.97
363_I384_G0.7080.97
228_M318_V0.7080.97
179_N182_A0.7060.97
217_M293_D0.7050.97
265_I334_D0.7050.97
121_A124_T0.7050.97
320_V379_E0.7050.97
267_L272_Y0.7050.97
120_P124_T0.7030.97
390_E394_V0.7020.97
428_I432_L0.6990.97
246_V432_L0.6970.97
312_T317_L0.6950.97
142_A146_V0.6930.97
310_A344_R0.6900.97
395_R402_A0.6890.96
320_V355_G0.6890.96
381_A409_L0.6880.96
390_E398_E0.6880.96
234_T377_H0.6860.96
307_G356_A0.6860.96
242_D368_G0.6840.96
115_E125_G0.6830.96
57_L75_T0.6830.96
306_I358_C0.6810.96
246_V403_P0.6800.96
284_F420_T0.6790.96
370_W406_A0.6780.96
281_L304_F0.6770.96
305_N356_A0.6770.96
270_L273_V0.6770.96
322_K351_A0.6760.96
287_L424_A0.6760.96
20_V23_F0.6750.96
57_L79_P0.6750.96
26_P75_T0.6750.96
29_E79_P0.6720.96
119_E123_A0.6710.96
390_E399_I0.6690.96
146_V169_V0.6680.96
351_A354_K0.6670.96
363_I368_G0.6660.96
200_P203_A0.6660.96
350_P354_K0.6660.96
140_V157_I0.6650.96
322_K335_E0.6640.96
407_L425_L0.6610.96
434_D437_L0.6610.96
90_D94_D0.6600.96
94_D98_E0.6590.95
232_K410_S0.6590.95
243_E404_V0.6580.95
37_A48_I0.6580.95
232_K235_A0.6570.95
19_I59_L0.6560.95
215_E286_V0.6550.95
277_L280_A0.6540.95
145_S149_Y0.6530.95
127_G130_D0.6520.95
220_I314_K0.6520.95
182_A185_A0.6520.95
270_L308_I0.6480.95
248_N402_A0.6470.95
217_M292_D0.6470.95
134_V138_K0.6470.95
280_A427_H0.6450.95
23_F26_P0.6450.95
231_S237_H0.6450.95
17_G44_A0.6440.95
409_L421_A0.6400.95
10_I13_G0.6400.95
253_R257_K0.6400.95
198_A201_A0.6390.95
281_L424_A0.6370.95
162_G173_D0.6360.95
366_A422_Q0.6350.94
311_D420_T0.6350.94
359_T379_E0.6340.94
270_L365_S0.6320.94
24_V74_I0.6310.94
119_E124_T0.6280.94
120_P126_A0.6280.94
281_L287_L0.6270.94
257_K260_A0.6270.94
370_W408_S0.6270.94
369_Q387_R0.6240.94
116_Q120_P0.6230.94
217_M297_E0.6230.94
150_A174_I0.6130.93
33_D53_K0.6120.93
17_G41_N0.6110.93
395_R399_I0.6110.93
220_I223_A0.6110.93
391_K406_A0.6110.93
201_A204_P0.6100.93
204_P209_E0.6100.93
163_S173_D0.6100.93
79_P82_E0.6090.93
4_E60_K0.6090.93
124_T127_G0.6080.93
356_A377_H0.6070.93
164_G170_V0.6070.93
424_A428_I0.6040.93
65_T71_Q0.6040.93
50_S76_F0.6030.93
55_K79_P0.5980.93
84_L87_K0.5980.93
210_F302_H0.5970.93
211_P323_N0.5960.92
248_N436_Q0.5950.92
350_P353_M0.5950.92
117_A120_P0.5950.92
129_Q132_A0.5940.92
249_L432_L0.5930.92
6_K70_G0.5920.92
199_K203_A0.5910.92
203_A206_P0.5910.92
121_A127_G0.5900.92
320_V356_A0.5890.92
22_W61_V0.5890.92
335_E342_K0.5870.92
5_F51_P0.5870.92
202_A205_A0.5860.92
308_I360_I0.5860.92
231_S377_H0.5850.92
349_A354_K0.5840.92
91_E94_D0.5810.91
19_I67_A0.5780.91
29_E56_V0.5780.91
174_I178_V0.5770.91
20_V64_G0.5770.91
288_N357_S0.5770.91
24_V59_L0.5760.91
242_D425_L0.5750.91
210_F303_Y0.5720.91
392_A402_A0.5720.91
309_A316_L0.5700.91
372_T411_F0.5690.91
410_S422_Q0.5690.91
229_V236_P0.5690.91
36_L74_I0.5690.91
153_K181_G0.5670.90
276_A432_L0.5670.90
95_A98_E0.5650.90
205_A208_G0.5650.90
390_E395_R0.5620.90
337_N341_T0.5620.90
97_T131_Q0.5610.90
229_V232_K0.5610.90
7_L67_A0.5600.90
371_F386_G0.5600.90
395_R401_A0.5590.90
373_P408_S0.5590.90
225_A291_I0.5580.90
19_I51_P0.5570.90
183_Q186_A0.5570.90
430_R437_L0.5560.90
370_W373_P0.5560.90
279_S427_H0.5560.90
33_D146_V0.5550.90
7_L46_V0.5550.90
326_R331_E0.5550.90
215_E298_V0.5530.89
332_I339_L0.5520.89
260_A265_I0.5520.89
305_N318_V0.5510.89
310_A339_L0.5480.89
318_V379_E0.5480.89
384_G410_S0.5470.89
117_A122_K0.5470.89
60_K73_I0.5470.89
181_G185_A0.5460.89
155_V159_K0.5450.89
270_L360_I0.5450.89
14_I69_V0.5440.89
35_V38_E0.5430.89
236_P414_R0.5430.89
117_A121_A0.5420.88
120_P123_A0.5410.88
160_V174_I0.5410.88
88_G91_E0.5410.88
149_Y178_V0.5400.88
175_D178_V0.5400.88
281_L381_A0.5370.88
7_L73_I0.5370.88
40_Q219_G0.5360.88
115_E119_E0.5360.88
92_S96_K0.5350.88
373_P410_S0.5350.88
394_V402_A0.5330.88
227_A377_H0.5310.87
5_F56_V0.5310.87
60_K71_Q0.5300.87
386_G422_Q0.5290.87
304_F357_S0.5290.87
115_E118_Q0.5290.87
171_K174_I0.5280.87
278_T282_K0.5280.87
308_I321_V0.5280.87
394_V397_G0.5280.87
231_S235_A0.5280.87
86_F89_S0.5280.87
41_N44_A0.5270.87
11_G16_E0.5270.87
375_I378_P0.5260.87
369_Q391_K0.5250.87
239_T384_G0.5250.87
17_G39_V0.5250.87
85_Q89_S0.5240.87
88_G94_D0.5230.87
119_E128_Q0.5230.87
270_L362_N0.5230.87
82_E85_Q0.5220.87
280_A431_L0.5210.86
77_D83_D0.5210.86
271_P333_S0.5190.86
322_K352_E0.5190.86
268_T333_S0.5180.86
93_D97_T0.5180.86
389_A393_I0.5170.86
426_N429_K0.5160.86
117_A127_G0.5160.86
260_A330_F0.5140.86
216_K219_G0.5130.86
91_E95_A0.5120.85
82_E87_K0.5120.85
238_V421_A0.5110.85
397_G401_A0.5110.85
329_V439_L0.5110.85
125_G128_Q0.5110.85
125_G129_Q0.5100.85
334_D338_G0.5090.85
380_V416_I0.5090.85
87_K92_S0.5080.85
396_D401_A0.5070.85
221_R286_V0.5070.85
290_S380_V0.5070.85
116_Q119_E0.5070.85
363_I385_I0.5060.85
259_V263_Q0.5060.85
238_V372_T0.5060.85
278_T306_I0.5050.85
286_V415_M0.5050.85
270_L373_P0.5050.85
6_K71_Q0.5040.85
128_Q131_Q0.5040.85
241_M406_A0.5040.85
306_I332_I0.5040.85
247_T393_I0.5030.84
277_L281_L0.5020.84
245_D400_V0.5010.84
89_S94_D0.5000.84
122_K126_A0.5000.84
160_V169_V0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dvaI 1 0.095 100 0.17 Contact Map
2ii3A 4 0.5249 100 0.468 Contact Map
1dpbA 4 0.5498 100 0.477 Contact Map
4n72A 3 0.5543 100 0.478 Contact Map
1sczA 4 0.5249 100 0.482 Contact Map
3b8kA 1 0.5362 100 0.487 Contact Map
3maeA 3 0.5385 100 0.488 Contact Map
3l60A 3 0.5136 100 0.492 Contact Map
3rqcA 4 0.4977 100 0.507 Contact Map
2xt6A 2 0.4321 100 0.535 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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