GREMLIN Database
ODPB - Pyruvate dehydrogenase E1 component subunit beta
UniProt: P21882 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (300)
Sequences: 13970 (8083)
Seq/√Len: 466.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_D320_R4.4921.00
19_K47_E3.6031.00
223_E316_L3.2301.00
311_N314_D2.8751.00
205_L319_A2.7901.00
196_A246_T2.7711.00
67_A79_M2.7241.00
218_L233_V2.3961.00
15_R47_E2.3341.00
200_R221_A2.3131.00
200_R222_D2.2091.00
221_A233_V2.1451.00
223_E312_H2.1191.00
203_T230_S2.1121.00
219_K312_H2.0931.00
146_V157_L2.0921.00
15_R48_F2.0811.00
290_L321_K2.0341.00
312_H316_L2.0291.00
244_I276_E2.0211.00
206_S254_T1.9881.00
205_L231_A1.9591.00
306_S311_N1.9391.00
76_R110_T1.8861.00
248_I276_E1.8761.00
70_L75_F1.8591.00
279_D291_R1.8561.00
216_E312_H1.8361.00
223_E226_K1.8251.00
290_L318_T1.8111.00
204_D230_S1.7371.00
225_E230_S1.7331.00
204_D255_G1.7321.00
217_S260_V1.7261.00
19_K48_F1.7261.00
68_L98_M1.7201.00
232_E253_K1.7181.00
64_G98_M1.7031.00
232_E250_S1.6801.00
135_G263_A1.6761.00
200_R225_E1.6571.00
102_R142_G1.6511.00
232_E254_T1.6441.00
271_A275_A1.6361.00
209_T217_S1.6201.00
207_I217_S1.6191.00
265_K293_A1.6141.00
198_V232_E1.5961.00
316_L320_R1.5961.00
223_E313_K1.5881.00
248_I280_R1.5841.00
317_E321_K1.5771.00
143_I169_V1.5711.00
144_K164_D1.5671.00
16_T155_K1.5461.00
244_I280_R1.5401.00
201_E232_E1.5311.00
138_A272_N1.5221.00
98_M113_V1.5191.00
25_L70_L1.5161.00
219_K222_D1.5151.00
112_P161_A1.5131.00
144_K166_D1.4951.00
274_V289_V1.4951.00
78_V162_I1.4911.00
17_E159_I1.4851.00
249_A254_T1.4831.00
216_E219_K1.4821.00
161_A168_V1.4711.00
64_G113_V1.4461.00
209_T214_V1.4421.00
318_T321_K1.4181.00
138_A275_A1.4081.00
215_H219_K1.4051.00
208_I236_L1.3831.00
220_A316_L1.3781.00
196_A236_L1.3671.00
64_G79_M1.3661.00
222_D226_K1.3641.00
216_E315_V1.3571.00
207_I319_A1.3551.00
314_D318_T1.3511.00
137_V169_V1.3501.00
21_D76_R1.3431.00
306_S313_K1.3421.00
192_E195_K1.3411.00
13_A155_K1.3401.00
258_I322_V1.3371.00
234_V246_T1.3271.00
223_E227_D1.3201.00
13_A159_I1.2991.00
197_D235_D1.2941.00
144_K238_T1.2781.00
17_E163_R1.2761.00
18_L44_L1.2731.00
243_D276_E1.2701.00
76_R112_P1.2681.00
159_I163_R1.2661.00
110_T166_D1.2651.00
17_E24_V1.2581.00
64_G90_V1.2501.00
153_D235_D1.2491.00
27_F67_A1.2401.00
14_L78_V1.2391.00
277_I289_V1.2261.00
146_V238_T1.2151.00
8_Q12_D1.2121.00
236_L269_I1.2091.00
23_N75_F1.2031.00
43_G46_K1.2021.00
160_S193_L1.2011.00
94_V143_I1.1991.00
222_D225_E1.1901.00
198_V201_E1.1871.00
110_T165_N1.1851.00
274_V278_N1.1841.00
206_S250_S1.1831.00
249_A253_K1.1811.00
94_V115_I1.1801.00
258_I319_A1.1791.00
234_V250_S1.1781.00
17_E162_I1.1771.00
149_S214_V1.1771.00
153_D237_R1.1731.00
27_F56_T1.1681.00
102_R166_D1.1651.00
242_L247_I1.1601.00
261_Q270_A1.1511.00
248_I281_A1.1381.00
149_S235_D1.1351.00
208_I257_A1.1331.00
245_D249_A1.1311.00
26_V41_T1.1261.00
199_K214_V1.1261.00
207_I231_A1.1251.00
12_D155_K1.1181.00
248_I252_E1.1151.00
25_L75_F1.1051.00
202_G230_S1.0881.00
135_G139_Q1.0871.00
231_A319_A1.0811.00
17_E20_N1.0811.00
146_V168_V1.0801.00
115_I169_V1.0741.00
13_A16_T1.0661.00
116_R172_E1.0661.00
9_A151_P1.0611.00
71_G77_P1.0591.00
91_M136_L1.0571.00
21_D24_V1.0571.00
16_T159_I1.0571.00
213_M216_E1.0571.00
314_D317_E1.0491.00
198_V246_T1.0471.00
275_A291_R1.0441.00
274_V291_R1.0411.00
244_I248_I1.0401.00
195_K245_D1.0401.00
240_S296_D1.0391.00
12_D43_G1.0321.00
200_R230_S1.0301.00
290_L322_V1.0271.00
196_A234_V1.0241.00
12_D16_T1.0241.00
300_P307_V1.0191.00
269_I273_V1.0181.00
20_N159_I1.0181.00
257_A277_I1.0161.00
198_V234_V1.0131.00
191_I194_G1.0071.00
132_S294_A1.0011.00
67_A111_S1.0011.00
260_V315_V0.9931.00
85_G134_E0.9911.00
18_L24_V0.9891.00
276_E280_R0.9881.00
251_V277_I0.9871.00
61_S93_S0.9861.00
84_F171_L0.9851.00
16_T20_N0.9721.00
294_A308_W0.9711.00
210_Y239_V0.9701.00
258_I292_V0.9691.00
266_Q296_D0.9601.00
250_S253_K0.9571.00
227_D316_L0.9531.00
8_Q11_T0.9531.00
21_D162_I0.9501.00
144_K168_V0.9491.00
151_P179_S0.9491.00
270_A293_A0.9461.00
220_A315_V0.9411.00
282_I287_A0.9381.00
15_R19_K0.9361.00
270_A291_R0.9351.00
26_V31_V0.9311.00
206_S232_E0.9301.00
260_V289_V0.9291.00
99_A140_Q0.9261.00
309_L314_D0.9221.00
278_N289_V0.9221.00
259_V270_A0.9201.00
87_V115_I0.9191.00
76_R165_N0.9121.00
38_F41_T0.9121.00
313_K317_E0.9031.00
16_T19_K0.9031.00
206_S234_V0.9011.00
256_R322_V0.8991.00
149_S197_D0.8971.00
146_V193_L0.8951.00
297_T307_V0.8881.00
258_I261_Q0.8871.00
98_M111_S0.8871.00
135_G267_A0.8871.00
8_Q176_L0.8861.00
43_G47_E0.8821.00
63_I79_M0.8771.00
56_T66_L0.8731.00
288_P321_K0.8731.00
224_L319_A0.8711.00
32_G53_V0.8671.00
217_S233_V0.8601.00
42_E46_K0.8591.00
256_R288_P0.8571.00
23_N76_R0.8491.00
158_L170_F0.8471.00
184_V187_E0.8461.00
121_G305_E0.8381.00
249_A252_E0.8331.00
144_K241_P0.8321.00
205_L258_I0.8311.00
64_G115_I0.8301.00
94_V137_V0.8301.00
178_R215_H0.8291.00
100_R127_E0.8251.00
66_L70_L0.8211.00
138_A239_V0.8191.00
319_A322_V0.8181.00
303_Q306_S0.8161.00
25_L54_F0.8151.00
229_I320_R0.8131.00
143_I167_P0.8131.00
160_S192_E0.8111.00
87_V137_V0.8111.00
216_E311_N0.8101.00
27_F54_F0.8091.00
45_Q48_F0.8081.00
154_A172_E0.8041.00
259_V262_E0.8031.00
62_G66_L0.8021.00
224_L316_L0.8001.00
217_S261_Q0.8001.00
147_I210_Y0.7961.00
236_L239_V0.7961.00
87_V117_S0.7911.00
13_A17_E0.7901.00
242_L276_E0.7831.00
194_G197_D0.7831.00
98_M167_P0.7821.00
29_E39_R0.7811.00
247_I276_E0.7801.00
88_Y91_M0.7791.00
209_T213_M0.7771.00
26_V78_V0.7771.00
201_E253_K0.7751.00
84_F137_V0.7731.00
221_A225_E0.7721.00
243_D275_A0.7701.00
208_I234_V0.7641.00
306_S314_D0.7581.00
144_K193_L0.7581.00
112_P168_V0.7561.00
246_T250_S0.7561.00
13_A158_L0.7501.00
204_D229_I0.7501.00
219_K223_E0.7491.00
216_E305_E0.7481.00
304_A308_W0.7481.00
102_R165_N0.7461.00
48_F52_R0.7441.00
136_L140_Q0.7431.00
94_V113_V0.7421.00
156_G159_I0.7411.00
71_G111_S0.7401.00
159_I188_E0.7381.00
288_P318_T0.7371.00
225_E231_A0.7371.00
258_I290_L0.7331.00
183_E186_E0.7291.00
318_T322_V0.7241.00
85_G131_D0.7231.00
138_A267_A0.7221.00
45_Q53_V0.7221.00
29_E63_I0.7201.00
27_F66_L0.7171.00
144_K240_S0.7161.00
10_I80_E0.7131.00
173_H177_Y0.7121.00
160_S163_R0.7111.00
239_V243_D0.7111.00
150_T199_K0.7101.00
250_S254_T0.7091.00
200_R218_L0.7071.00
27_F63_I0.7061.00
67_A80_E0.7041.00
160_S190_T0.7001.00
11_T15_R0.6981.00
44_L53_V0.6971.00
152_Y185_P0.6971.00
99_A298_V0.6961.00
317_E320_R0.6931.00
127_E130_A0.6911.00
247_I277_I0.6901.00
278_N281_A0.6891.00
220_A260_V0.6811.00
65_G93_S0.6801.00
14_L41_T0.6801.00
248_I282_I0.6791.00
199_K218_L0.6781.00
292_V318_T0.6751.00
71_G109_W0.6751.00
220_A319_A0.6731.00
9_A13_A0.6711.00
124_H303_Q0.6681.00
72_L109_W0.6681.00
301_F305_E0.6651.00
206_S253_K0.6641.00
157_L237_R0.6631.00
146_V160_S0.6601.00
79_M113_V0.6601.00
210_Y236_L0.6601.00
265_K279_D0.6591.00
198_V249_A0.6581.00
32_G45_Q0.6571.00
272_N275_A0.6541.00
140_Q143_I0.6541.00
99_A143_I0.6491.00
265_K291_R0.6461.00
297_T308_W0.6431.00
152_Y156_G0.6421.00
204_D231_A0.6401.00
295_P308_W0.6371.00
83_F125_T0.6361.00
95_S140_Q0.6341.00
78_V158_L0.6300.99
22_E52_R0.6290.99
24_V162_I0.6260.99
7_I40_A0.6240.99
161_A170_F0.6190.99
257_A261_Q0.6150.99
183_E187_E0.6140.99
266_Q291_R0.6130.99
201_E249_A0.6100.99
92_D96_G0.6090.99
156_G160_S0.6030.99
146_V161_A0.6020.99
163_R188_E0.6020.99
134_E171_L0.5990.99
156_G190_T0.5990.99
70_L77_P0.5990.99
178_R219_K0.5980.99
258_I262_E0.5950.99
90_V94_V0.5940.99
251_V257_A0.5930.99
195_K243_D0.5930.99
295_P314_D0.5930.99
261_Q268_G0.5930.99
152_Y179_S0.5920.99
270_A275_A0.5900.99
54_F66_L0.5890.99
138_A145_V0.5880.99
10_I158_L0.5870.99
159_I190_T0.5870.99
31_V83_F0.5860.99
244_I279_D0.5860.99
185_P189_Y0.5850.99
255_G286_E0.5850.99
43_G55_D0.5820.99
145_V169_V0.5790.99
59_A62_G0.5790.99
24_V78_V0.5790.99
91_M139_Q0.5790.99
257_A289_V0.5770.99
198_V250_S0.5740.99
209_T236_L0.5730.99
135_G264_Q0.5720.99
259_V289_V0.5700.99
101_M109_W0.5700.99
214_V233_V0.5700.99
292_V310_P0.5700.99
138_A269_I0.5680.99
255_G258_I0.5680.99
18_L53_V0.5660.99
303_Q307_V0.5660.99
33_V55_D0.5630.99
310_P314_D0.5620.99
144_K194_G0.5610.99
155_K159_I0.5570.99
206_S257_A0.5560.99
213_M260_V0.5560.99
282_I288_P0.5550.99
64_G81_I0.5540.99
259_V273_V0.5530.99
164_D168_V0.5530.99
299_F308_W0.5530.99
76_R162_I0.5510.99
149_S153_D0.5510.99
156_G188_E0.5500.99
224_L231_A0.5480.99
206_S256_R0.5470.99
112_P158_L0.5470.99
72_L101_M0.5470.99
114_T161_A0.5460.99
220_A312_H0.5450.99
147_I211_G0.5440.98
132_S264_Q0.5430.98
112_P170_F0.5430.98
271_A291_R0.5410.98
238_T241_P0.5410.98
202_G225_E0.5410.98
147_I212_A0.5400.98
268_G271_A0.5390.98
212_A216_E0.5390.98
173_H212_A0.5390.98
194_G238_T0.5380.98
121_G304_A0.5340.98
45_Q50_E0.5340.98
21_D163_R0.5320.98
15_R53_V0.5300.98
305_E310_P0.5300.98
6_M177_Y0.5300.98
309_L318_T0.5290.98
313_K316_L0.5280.98
272_N291_R0.5270.98
279_D290_L0.5270.98
88_Y136_L0.5250.98
224_L229_I0.5230.98
201_E230_S0.5230.98
259_V291_R0.5210.98
164_D193_L0.5210.98
166_D244_I0.5210.98
134_E261_Q0.5210.98
221_A231_A0.5110.98
157_L168_V0.5090.98
144_K244_I0.5070.98
152_Y189_Y0.5070.98
239_V269_I0.5010.97
207_I258_I0.5000.97
137_V143_I0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w85B 2 0.9877 100 0.211 Contact Map
1umdB 2 0.9846 100 0.222 Contact Map
1ik6A 3 0.8554 100 0.223 Contact Map
2ozlB 2 1 100 0.232 Contact Map
2bfdB 2 0.9938 100 0.248 Contact Map
1qs0B 2 0.9846 100 0.251 Contact Map
2o1xA 2 0.9262 100 0.257 Contact Map
4kxvA 2 0.9292 100 0.268 Contact Map
2o1sA 2 0.92 100 0.27 Contact Map
1gpuA 2 0.9077 100 0.314 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0099 seconds.