GREMLIN Database
ODPA - Pyruvate dehydrogenase E1 component subunit alpha
UniProt: P21881 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (310)
Sequences: 5307 (3052)
Seq/√Len: 173.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_R323_D4.3571.00
313_S316_E3.6041.00
185_Y229_A3.5881.00
199_I255_A3.1261.00
252_R256_I3.0231.00
253_E257_N2.8461.00
234_V250_E2.7751.00
174_T202_V2.7521.00
314_E318_A2.7511.00
119_Y334_K2.6311.00
91_T173_Y2.6071.00
169_V252_R2.5181.00
195_K218_A2.4791.00
307_E314_E2.4541.00
235_Q267_L2.4371.00
74_R336_D2.4051.00
59_T109_P2.4001.00
102_L157_V2.3361.00
58_F327_E2.3311.00
254_R259_E2.3041.00
155_A187_G2.2871.00
45_T48_Q2.2371.00
345_D348_K2.2191.00
303_R307_E2.2081.00
161_L170_A2.2031.00
254_R262_T2.1961.00
333_K337_A2.1401.00
119_Y330_Q2.1031.00
312_W317_E2.0831.00
303_R321_I2.0691.00
96_E167_K2.0141.00
292_E295_Q2.0101.00
304_A308_N1.9841.00
161_L166_K1.9841.00
91_T248_T1.9781.00
319_K323_D1.9671.00
151_Y184_F1.9641.00
226_A233_G1.9531.00
184_F188_I1.9251.00
326_E330_Q1.9161.00
130_R349_I1.8881.00
303_R317_E1.8841.00
51_E55_R1.8141.00
240_D243_A1.8071.00
255_A262_T1.7991.00
202_V222_I1.7591.00
155_A200_F1.7451.00
239_M271_Y1.7351.00
98_E168_A1.7341.00
177_G208_A1.7141.00
236_V247_A1.7051.00
161_L168_A1.6911.00
201_V266_T1.6841.00
234_V247_A1.6531.00
91_T171_I1.6121.00
307_E317_E1.6021.00
46_D316_E1.6001.00
232_V254_R1.5561.00
316_E319_K1.5481.00
251_A262_T1.5371.00
158_A198_A1.5191.00
49_L306_L1.4971.00
91_T201_V1.4891.00
159_L163_K1.4771.00
52_L241_P1.4611.00
52_L93_F1.4531.00
330_Q334_K1.4431.00
334_K338_E1.4431.00
117_P120_Q1.4381.00
224_Q227_V1.4371.00
174_T178_G1.4321.00
204_N265_E1.4241.00
232_V260_G1.4241.00
151_Y187_G1.4061.00
50_K316_E1.4001.00
323_D327_E1.3941.00
305_F309_K1.3891.00
249_A253_E1.3761.00
46_D311_L1.3731.00
247_A264_I1.3681.00
322_E326_E1.3651.00
46_D50_K1.3531.00
57_V324_A1.3371.00
239_M268_T1.3331.00
300_V304_A1.3001.00
48_Q51_E1.2981.00
288_E291_N1.2931.00
188_I231_I1.2921.00
236_V243_A1.2911.00
223_A235_Q1.2761.00
293_W296_K1.2711.00
100_F161_L1.2671.00
202_V263_L1.2641.00
111_L140_A1.2601.00
287_K291_N1.2601.00
221_T224_Q1.2561.00
331_A335_A1.2461.00
64_Q82_A1.2411.00
132_N135_P1.2391.00
248_T264_I1.2391.00
171_I199_I1.2381.00
50_K312_W1.2351.00
315_E319_K1.2211.00
61_V325_K1.2181.00
97_K138_V1.2121.00
87_S266_T1.2121.00
182_G186_E1.2091.00
291_N295_Q1.2091.00
53_M57_V1.1921.00
342_K345_D1.1891.00
206_R267_L1.1881.00
245_Y249_A1.1871.00
77_F275_T1.1851.00
318_A322_E1.1791.00
201_V248_T1.1771.00
55_R93_F1.1641.00
90_A244_V1.1551.00
315_E318_A1.1541.00
169_V255_A1.1501.00
57_V321_I1.1491.00
192_G231_I1.1471.00
333_K336_D1.1421.00
217_S222_I1.1211.00
94_A245_Y1.1191.00
190_F194_Y1.1171.00
291_N294_E1.1161.00
87_S201_V1.1141.00
129_F135_P1.1051.00
146_I149_A1.0931.00
94_A249_A1.0811.00
95_L171_I1.0711.00
65_R329_K1.0701.00
301_R305_F1.0701.00
242_L302_F1.0671.00
169_V199_I1.0641.00
155_A198_A1.0631.00
195_K260_G1.0611.00
69_L332_I1.0591.00
195_K259_E1.0571.00
95_L252_R1.0501.00
127_G130_R1.0501.00
329_K333_K1.0491.00
144_Q149_A1.0480.99
317_E321_I1.0470.99
171_I248_T1.0460.99
327_E331_A1.0440.99
61_V321_I1.0430.99
237_D243_A1.0420.99
130_R133_Q1.0410.99
131_G134_M1.0400.99
250_E253_E1.0310.99
57_V61_V1.0300.99
234_V262_T1.0290.99
58_F118_L1.0290.99
90_A241_P1.0280.99
129_F132_N1.0280.99
102_L141_L1.0270.99
180_S225_K1.0170.99
171_I201_V1.0160.99
118_L327_E1.0150.99
269_F293_W1.0140.99
49_L302_F1.0140.99
180_S216_Q1.0130.99
302_F306_L1.0080.99
93_F245_Y1.0010.99
157_V170_A0.9990.99
94_A252_R0.9970.99
61_V328_I0.9970.99
271_Y294_E0.9960.99
54_R58_F0.9880.99
46_D309_K0.9760.99
324_A328_I0.9680.99
233_G263_L0.9660.99
192_G230_G0.9660.99
53_M320_V0.9660.99
95_L101_V0.9650.99
128_H135_P0.9650.99
49_L242_L0.9620.99
251_A255_A0.9610.99
243_A246_A0.9560.99
199_I252_R0.9540.99
66_S125_S0.9510.99
312_W316_E0.9510.99
100_F141_L0.9430.99
169_V256_I0.9420.99
57_V299_L0.9410.99
167_K257_N0.9380.99
154_T198_A0.9360.99
119_Y338_E0.9360.99
56_M299_L0.9340.99
246_A250_E0.9320.99
98_E114_H0.9310.99
127_G133_Q0.9260.99
247_A251_A0.9260.99
148_G184_F0.9210.99
151_Y174_T0.9190.99
65_R68_S0.9170.99
98_E167_K0.9170.99
128_H133_Q0.9160.99
51_E93_F0.9160.99
162_K195_K0.9130.99
226_A231_I0.9110.99
288_E292_E0.9100.99
234_V264_I0.9080.99
55_R89_I0.9010.98
58_F324_A0.8960.98
304_A307_E0.8920.98
48_Q245_Y0.8900.98
303_R314_E0.8880.98
52_L245_Y0.8870.98
273_P281_P0.8860.98
44_L48_Q0.8850.98
127_G132_N0.8840.98
174_T179_A0.8830.98
148_G178_G0.8820.98
53_M303_R0.8820.98
188_I263_L0.8750.98
61_V64_Q0.8740.98
127_G135_P0.8710.98
65_R332_I0.8710.98
192_G195_K0.8700.98
207_Y289_I0.8690.98
154_T170_A0.8660.98
129_F133_Q0.8640.98
243_A247_A0.8640.98
221_T267_L0.8590.98
179_A184_F0.8510.98
77_F276_M0.8450.98
187_G200_F0.8450.98
51_E54_R0.8450.98
287_K290_E0.8440.98
130_R134_M0.8430.98
154_T172_T0.8420.98
285_R289_I0.8380.98
219_A224_Q0.8350.97
244_V266_T0.8320.97
70_N276_M0.8280.97
81_T109_P0.8250.97
192_G218_A0.8210.97
269_F289_I0.8190.97
155_A196_A0.8140.97
240_D301_R0.8120.97
119_Y331_A0.8050.97
179_A222_I0.8040.97
101_V110_Q0.8000.97
67_I71_R0.7960.97
53_M321_I0.7950.97
130_R135_P0.7930.97
54_R320_V0.7930.97
111_L116_L0.7860.96
326_E329_K0.7850.96
312_W320_V0.7850.96
302_F305_F0.7840.96
199_I248_T0.7830.96
56_M86_A0.7810.96
221_T235_Q0.7750.96
330_Q333_K0.7750.96
110_Q173_Y0.7730.96
127_G131_G0.7720.96
133_Q142_S0.7710.96
327_E330_Q0.7670.96
158_A197_P0.7670.96
324_A327_E0.7640.96
306_L311_L0.7600.96
237_D301_R0.7580.96
199_I262_T0.7480.95
128_H349_I0.7470.95
55_R113_W0.7460.95
50_K54_R0.7440.95
206_R214_E0.7430.95
50_K306_L0.7390.95
44_L245_Y0.7390.95
130_R345_D0.7350.95
248_T252_R0.7350.95
254_R260_G0.7330.95
239_M301_R0.7320.95
292_E296_K0.7310.95
87_S268_T0.7300.95
325_K329_K0.7230.94
112_I118_L0.7220.94
319_K322_E0.7200.94
49_L311_L0.7170.94
290_E294_E0.7150.94
259_E262_T0.7150.94
123_L338_E0.7150.94
67_I276_M0.7140.94
251_A264_I0.7140.94
152_I183_D0.7100.94
301_R304_A0.7100.94
272_G276_M0.7090.94
122_F332_I0.7070.94
96_E168_A0.7070.94
139_N168_A0.7060.94
47_D51_E0.7060.94
254_R258_G0.7060.94
123_L334_K0.7020.93
251_A254_R0.7020.93
48_Q249_A0.7020.93
209_I275_T0.6990.93
86_A90_A0.6940.93
62_L122_F0.6930.93
147_I181_Q0.6930.93
242_L305_F0.6910.93
84_Q203_Q0.6890.93
240_D305_F0.6880.93
81_T88_Q0.6870.93
69_L126_R0.6860.93
141_L144_Q0.6810.92
318_A321_I0.6810.92
148_G151_Y0.6790.92
119_Y123_L0.6780.92
212_P215_K0.6770.92
48_Q93_F0.6760.92
174_T200_F0.6760.92
296_K301_R0.6710.92
321_I325_K0.6700.92
226_A263_L0.6670.92
54_R327_E0.6670.92
222_I263_L0.6660.91
173_Y201_V0.6650.91
158_A196_A0.6590.91
323_D326_E0.6590.91
96_E252_R0.6580.91
208_A216_Q0.6570.91
236_V264_I0.6560.91
82_A272_G0.6550.91
269_F290_E0.6520.91
193_A216_Q0.6490.90
90_A94_A0.6480.90
120_Q137_D0.6460.90
271_Y297_D0.6390.90
307_E313_S0.6380.90
282_T290_E0.6370.90
61_V324_A0.6370.90
180_S217_S0.6340.89
90_A248_T0.6260.89
65_R69_L0.6250.89
52_L242_L0.6250.89
89_I241_P0.6240.89
147_I178_G0.6220.88
92_H114_H0.6220.88
102_L150_Q0.6220.88
149_A153_Q0.6210.88
307_E312_W0.6190.88
105_Y150_Q0.6190.88
62_L121_A0.6140.88
120_Q123_L0.6120.88
320_V324_A0.6120.88
317_E320_V0.6120.88
184_F263_L0.6120.88
79_A108_V0.6120.88
112_I121_A0.6100.87
53_M317_E0.6030.87
334_K337_A0.6000.87
232_V262_T0.6000.87
158_A170_A0.5990.87
67_I272_G0.5990.87
176_D222_I0.5970.86
148_G181_Q0.5960.86
102_L153_Q0.5960.86
239_M269_F0.5960.86
105_Y275_T0.5950.86
127_G134_M0.5930.86
131_G135_P0.5920.86
285_R290_E0.5910.86
55_R58_F0.5900.86
102_L154_T0.5890.86
58_F112_I0.5890.86
124_F145_I0.5880.86
210_S276_M0.5850.85
209_I276_M0.5830.85
116_L138_V0.5770.84
84_Q186_E0.5770.84
57_V320_V0.5760.84
246_A249_A0.5730.84
130_R348_K0.5720.84
81_T108_V0.5720.84
158_A161_L0.5690.84
225_K228_A0.5690.84
52_L89_I0.5680.84
191_A200_F0.5660.83
128_H132_N0.5650.83
305_F311_L0.5640.83
80_P272_G0.5640.83
79_A145_I0.5630.83
67_I82_A0.5620.83
98_E166_K0.5600.83
92_H173_Y0.5590.83
129_F134_M0.5580.82
44_L49_L0.5580.82
62_L112_I0.5550.82
300_V303_R0.5540.82
335_A338_E0.5530.82
170_A198_A0.5500.82
53_M312_W0.5490.81
171_I252_R0.5480.81
136_D139_N0.5480.81
217_S225_K0.5480.81
101_V114_H0.5470.81
235_Q265_E0.5470.81
167_K252_R0.5460.81
329_K332_I0.5450.81
118_L328_I0.5440.81
103_P140_A0.5440.81
56_M302_F0.5440.81
331_A334_K0.5410.81
206_R213_V0.5400.80
54_R324_A0.5400.80
247_A250_E0.5400.80
63_D70_N0.5390.80
91_T264_I0.5390.80
84_Q104_G0.5390.80
214_E220_E0.5390.80
105_Y209_I0.5380.80
53_M299_L0.5370.80
122_F126_R0.5360.80
108_V133_Q0.5350.80
157_V160_G0.5350.80
82_A271_Y0.5350.80
303_R312_W0.5350.80
103_P107_D0.5340.80
114_H138_V0.5330.80
91_T199_I0.5330.80
236_V266_T0.5330.80
223_A233_G0.5300.79
219_A222_I0.5300.79
100_F168_A0.5240.78
131_G145_I0.5240.78
141_L157_V0.5230.78
101_V173_Y0.5220.78
62_L108_V0.5220.78
273_P282_T0.5210.78
231_I263_L0.5210.78
100_F139_N0.5200.78
232_V250_E0.5190.78
80_P273_P0.5180.78
104_G107_D0.5180.78
140_A143_P0.5170.77
231_I261_P0.5150.77
126_R336_D0.5140.77
101_V140_A0.5130.77
306_L312_W0.5130.77
100_F157_V0.5120.77
91_T110_Q0.5120.77
213_V217_S0.5120.77
237_D296_K0.5110.77
344_T348_K0.5100.77
178_G202_V0.5100.77
242_L246_A0.5090.76
104_G150_Q0.5090.76
201_V244_V0.5090.76
42_P246_A0.5090.76
126_R335_A0.5080.76
71_R276_M0.5060.76
79_A275_T0.5060.76
122_F335_A0.5060.76
161_L167_K0.5040.76
128_H131_G0.5030.76
204_N213_V0.5030.76
236_V244_V0.5020.75
77_F209_I0.5020.75
44_L246_A0.5020.75
62_L66_S0.5010.75
316_E320_V0.5010.75
144_Q150_Q0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bfdA 2 0.9326 100 0.269 Contact Map
1qs0A 2 0.9784 100 0.276 Contact Map
1umdA 2 0.9488 100 0.278 Contact Map
1w85A 2 0.9811 100 0.278 Contact Map
2ozlA 2 0.9461 100 0.349 Contact Map
2xt6A 2 0.9272 100 0.457 Contact Map
2yicA 2 0.9326 100 0.46 Contact Map
2jgdA 2 0.8949 100 0.472 Contact Map
3uk1A 2 0.8356 100 0.655 Contact Map
1itzA 2 0.8464 100 0.658 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0108 seconds.