GREMLIN Database
DLDH1 - Dihydrolipoyl dehydrogenase
UniProt: P21880 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 470 (444)
Sequences: 13103 (8563)
Seq/√Len: 406.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
180_V266_A4.0721.00
40_K118_E4.0131.00
300_D304_R3.9851.00
290_E298_K2.9161.00
123_D126_S2.8851.00
413_A427_L2.8521.00
10_T113_D2.8341.00
201_E234_E2.8141.00
178_K201_E2.7571.00
150_R280_D2.6871.00
375_D406_E2.6461.00
426_E445_H2.6391.00
10_T36_T2.6391.00
9_E141_K2.6201.00
203_V236_H2.5701.00
283_G286_Q2.5521.00
175_I200_T2.5191.00
9_E139_T2.4481.00
224_T228_K2.4181.00
128_R135_A2.4111.00
24_A144_I2.3901.00
375_D405_K2.3851.00
140_F143_A2.3371.00
178_K267_D2.2911.00
150_R278_N2.2751.00
217_K367_A2.2511.00
36_T115_V2.2501.00
152_I276_R2.2431.00
404_R407_D2.2341.00
243_G254_T2.2061.00
364_Y369_A2.1721.00
126_S137_T2.1661.00
120_Y128_R2.1631.00
13_L138_Y2.1521.00
364_Y372_E2.1401.00
245_E254_T2.1331.00
180_V205_L2.0931.00
415_I420_A2.0911.00
292_T296_I2.0811.00
333_A337_I2.0671.00
377_V405_K2.0521.00
12_T28_A2.0361.00
252_T263_T2.0171.00
122_V128_R2.0171.00
408_G438_E1.9931.00
409_L434_G1.9931.00
20_G313_I1.9931.00
242_K256_E1.9841.00
13_L127_V1.9841.00
13_L38_V1.9831.00
128_R137_T1.9741.00
189_T204_I1.9681.00
301_K343_E1.9671.00
165_N168_G1.9641.00
252_T265_D1.9521.00
77_T84_D1.9281.00
376_I402_I1.9041.00
122_V137_T1.8771.00
430_A435_M1.8371.00
150_R276_R1.8311.00
209_D238_N1.8101.00
236_H262_K1.8081.00
158_K243_G1.8071.00
180_V253_V1.7991.00
240_M256_E1.7941.00
245_E252_T1.7921.00
121_F143_A1.7731.00
366_E400_K1.7721.00
196_A201_E1.7671.00
84_D87_K1.7381.00
366_E370_K1.7351.00
15_I119_A1.7041.00
13_L140_F1.6981.00
247_R252_T1.6821.00
367_A371_E1.6821.00
145_I316_I1.6751.00
189_T355_S1.6711.00
254_T263_T1.6531.00
369_A376_I1.6471.00
401_L413_A1.6261.00
179_L195_Y1.6161.00
358_E421_S1.6121.00
130_M135_A1.6001.00
13_L36_T1.5991.00
126_S139_T1.5911.00
117_G129_V1.5851.00
11_D141_K1.5761.00
115_V138_Y1.5661.00
142_N309_N1.5621.00
179_L200_T1.5611.00
77_T82_T1.5511.00
210_E220_S1.5401.00
144_I337_I1.5381.00
164_L268_Y1.5381.00
218_Q380_K1.5101.00
164_L172_L1.5041.00
304_R308_P1.4881.00
177_K201_E1.4841.00
104_A116_K1.4761.00
197_N230_K1.4731.00
87_K90_E1.4651.00
247_R250_G1.4591.00
369_A402_I1.4491.00
401_L458_A1.4321.00
368_Q371_E1.4251.00
163_V244_V1.4251.00
311_Y336_A1.4231.00
374_L411_I1.4201.00
236_H239_A1.4171.00
207_G240_M1.4061.00
177_K267_D1.4041.00
38_V138_Y1.4011.00
12_T33_Q1.3981.00
255_F264_V1.3961.00
436_T439_D1.3911.00
142_N337_I1.3851.00
125_N309_N1.3841.00
121_F127_V1.3601.00
43_L114_V1.3531.00
222_L416_A1.3521.00
10_T115_V1.3481.00
303_C317_I1.3421.00
216_E400_K1.3281.00
304_R309_N1.3231.00
169_A195_Y1.3221.00
11_D34_K1.3091.00
147_T316_I1.3081.00
36_T138_Y1.3011.00
196_A233_V1.2991.00
27_R335_E1.2991.00
184_G211_I1.2981.00
378_A402_I1.2851.00
144_I313_I1.2791.00
121_F145_I1.2791.00
219_M416_A1.2771.00
93_A97_N1.2761.00
302_Q336_A1.2721.00
250_G265_D1.2711.00
64_R67_N1.2691.00
242_K254_T1.2611.00
375_D404_R1.2581.00
204_I235_I1.2551.00
203_V234_E1.2521.00
12_T144_I1.2501.00
50_V167_T1.2311.00
219_M398_F1.2281.00
215_F351_A1.2261.00
223_V416_A1.2261.00
70_H73_D1.2151.00
383_F417_G1.2051.00
239_A255_F1.2031.00
224_T235_I1.1991.00
205_L264_V1.1961.00
77_T87_K1.1961.00
287_V307_V1.1951.00
120_Y283_G1.1931.00
205_L255_F1.1831.00
256_E261_E1.1671.00
330_G334_A1.1661.00
89_Q93_A1.1641.00
218_Q400_K1.1611.00
399_M453_I1.1571.00
182_I269_V1.1561.00
206_E237_T1.1561.00
113_D136_Q1.1471.00
335_E342_A1.1471.00
210_E217_K1.1441.00
427_L454_T1.1431.00
359_L416_A1.1421.00
15_I145_I1.1391.00
401_L427_L1.1331.00
352_V446_A1.1331.00
307_V310_I1.1231.00
290_E306_N1.1221.00
215_F361_S1.1211.00
366_E378_A1.1211.00
164_L168_G1.1131.00
37_V107_L1.1041.00
425_S446_A1.0941.00
118_E281_E1.0941.00
34_K113_D1.0931.00
292_T298_K1.0891.00
162_R246_E1.0881.00
38_V119_A1.0851.00
225_R228_K1.0851.00
26_I110_N1.0831.00
226_R229_K1.0821.00
370_K376_I1.0821.00
369_A374_L1.0791.00
242_K261_E1.0751.00
351_A361_S1.0731.00
244_V269_V1.0711.00
332_I344_I1.0691.00
255_F262_K1.0641.00
433_G439_D1.0601.00
297_V316_I1.0591.00
254_T261_E1.0581.00
20_G326_A1.0581.00
360_A424_I1.0581.00
289_I297_V1.0571.00
284_L289_I1.0541.00
115_V136_Q1.0531.00
217_K221_S1.0531.00
122_V126_S1.0531.00
348_G431_I1.0411.00
404_R409_L1.0411.00
368_Q372_E1.0401.00
161_E246_E1.0401.00
120_Y130_M1.0401.00
244_V251_V1.0401.00
380_K398_F1.0331.00
90_E94_S1.0331.00
227_L233_V1.0311.00
223_V359_L1.0261.00
247_R265_D1.0231.00
178_K200_T1.0221.00
210_E224_T1.0161.00
292_T318_E1.0131.00
228_K234_E1.0081.00
156_N159_Y1.0051.00
33_Q141_K1.0041.00
224_T237_T1.0031.00
17_A43_L1.0011.00
229_K396_D1.0001.00
121_F140_F0.9991.00
85_F89_Q0.9971.00
419_S422_D0.9971.00
60_N64_R0.9961.00
352_V421_S0.9951.00
377_V408_G0.9891.00
189_T227_L0.9871.00
86_T173_K0.9861.00
365_T368_Q0.9851.00
17_A37_V0.9831.00
124_S309_N0.9791.00
130_M134_S0.9791.00
121_F287_V0.9781.00
164_L169_A0.9781.00
279_T291_M0.9761.00
179_L268_Y0.9741.00
31_L338_A0.9731.00
121_F286_Q0.9721.00
47_C52_C0.9721.00
366_E376_I0.9701.00
225_R229_K0.9651.00
179_L270_L0.9631.00
246_E251_V0.9601.00
104_A108_K0.9581.00
360_A420_A0.9571.00
299_T317_I0.9551.00
143_A310_I0.9551.00
320_P349_I0.9551.00
303_C333_A0.9531.00
299_T312_A0.9521.00
313_I333_A0.9521.00
68_A71_S0.9511.00
239_A260_E0.9511.00
245_E263_T0.9501.00
107_L112_V0.9481.00
33_Q338_A0.9461.00
66_E230_K0.9451.00
79_E82_T0.9451.00
31_L335_E0.9441.00
219_M414_Q0.9431.00
38_V117_G0.9421.00
298_K306_N0.9391.00
211_I224_T0.9361.00
374_L404_R0.9351.00
120_Y286_Q0.9351.00
15_I282_L0.9341.00
374_L402_I0.9331.00
211_I235_I0.9301.00
362_V431_I0.9301.00
425_S451_G0.9271.00
65_Y69_K0.9271.00
152_I273_V0.9221.00
182_I271_I0.9211.00
120_Y281_E0.9171.00
408_G437_A0.9151.00
121_F283_G0.9151.00
251_V269_V0.9131.00
364_Y368_Q0.9131.00
41_A50_V0.9121.00
435_M439_D0.9111.00
291_M298_K0.9101.00
333_A336_A0.9081.00
302_Q343_E0.9051.00
61_A88_V0.9041.00
174_E268_Y0.9031.00
246_E250_G0.9011.00
89_Q92_K0.9011.00
255_F261_E0.8991.00
124_S307_V0.8971.00
27_R31_L0.8911.00
94_S98_K0.8901.00
246_E249_D0.8901.00
304_R336_A0.8851.00
33_Q142_N0.8851.00
380_K400_K0.8831.00
287_V310_I0.8821.00
10_T34_K0.8801.00
210_E367_A0.8781.00
289_I307_V0.8771.00
226_R416_A0.8771.00
184_G206_E0.8711.00
219_M359_L0.8681.00
68_A78_A0.8671.00
180_V264_V0.8661.00
61_A91_W0.8651.00
211_I237_T0.8651.00
289_I306_N0.8641.00
236_H264_V0.8621.00
205_L236_H0.8611.00
288_G307_V0.8601.00
188_G206_E0.8601.00
332_I336_A0.8591.00
234_E262_K0.8581.00
49_N100_T0.8511.00
366_E402_I0.8491.00
62_G197_N0.8481.00
107_L114_V0.8471.00
182_I273_V0.8461.00
97_N101_G0.8461.00
72_D87_K0.8461.00
28_A334_A0.8461.00
23_V327_S0.8451.00
96_V99_L0.8441.00
66_E69_K0.8411.00
226_R396_D0.8411.00
277_P296_I0.8411.00
221_S225_R0.8411.00
186_Y353_V0.8391.00
205_L239_A0.8371.00
358_E419_S0.8361.00
142_N311_Y0.8351.00
365_T414_Q0.8341.00
362_V428_S0.8311.00
178_K265_D0.8291.00
13_L143_A0.8291.00
59_I194_A0.8271.00
222_L225_R0.8271.00
312_A316_I0.8261.00
236_H255_F0.8241.00
168_G171_A0.8181.00
239_A262_K0.8181.00
124_S288_G0.8171.00
163_V271_I0.8161.00
178_K203_V0.8161.00
410_V427_L0.8161.00
33_Q337_I0.8141.00
58_L89_Q0.8131.00
12_T334_A0.8111.00
283_G287_V0.8101.00
222_L226_R0.8101.00
181_V270_L0.8091.00
287_V306_N0.8081.00
303_C336_A0.8071.00
304_R311_Y0.8071.00
255_F260_E0.8051.00
178_K266_A0.8031.00
210_E221_S0.8021.00
103_V107_L0.7971.00
11_D33_Q0.7971.00
98_K390_L0.7941.00
293_D298_K0.7941.00
296_I321_P0.7931.00
14_V21_G0.7931.00
66_E197_N0.7891.00
178_K250_G0.7881.00
430_A440_I0.7851.00
156_N160_S0.7831.00
196_A230_K0.7831.00
144_I333_A0.7821.00
55_S191_L0.7821.00
90_E173_K0.7781.00
24_A330_G0.7781.00
69_K80_N0.7781.00
182_I241_A0.7761.00
426_E429_L0.7761.00
221_S224_T0.7731.00
435_M440_I0.7731.00
101_G104_A0.7731.00
63_H67_N0.7721.00
223_V355_S0.7701.00
105_G109_G0.7701.00
226_R230_K0.7691.00
27_R30_Q0.7641.00
370_K373_G0.7631.00
147_T282_L0.7621.00
24_A333_A0.7581.00
24_A334_A0.7571.00
162_R251_V0.7571.00
159_Y165_N0.7571.00
162_R268_Y0.7571.00
399_M415_I0.7561.00
15_I127_V0.7541.00
143_A309_N0.7511.00
325_K349_I0.7511.00
86_T90_E0.7511.00
160_S163_V0.7501.00
212_L223_V0.7501.00
432_E442_M0.7491.00
379_A457_A0.7481.00
125_N139_T0.7461.00
27_R334_A0.7451.00
427_L431_I0.7451.00
71_S78_A0.7431.00
207_G213_P0.7421.00
92_K96_V0.7381.00
447_H452_E0.7371.00
197_N356_E0.7341.00
369_A411_I0.7321.00
439_D442_M0.7321.00
28_A33_Q0.7301.00
382_P385_A0.7291.00
334_A338_A0.7281.00
189_T211_I0.7281.00
39_E42_T0.7261.00
345_D432_E0.7231.00
377_V403_T0.7231.00
227_L235_I0.7221.00
78_A81_V0.7211.00
241_A253_V0.7201.00
68_A76_I0.7191.00
41_A116_K0.7171.00
287_V291_M0.7171.00
117_G134_S0.7171.00
102_G106_L0.7171.00
188_G207_G0.7161.00
159_Y162_R0.7141.00
284_L291_M0.7131.00
401_L457_A0.7131.00
172_L268_Y0.7101.00
61_A74_M0.7061.00
347_L372_E0.7041.00
125_N307_V0.7021.00
208_G213_P0.7001.00
203_V266_A0.6961.00
328_Y331_K0.6951.00
194_A198_F0.6941.00
289_I310_I0.6931.00
124_S287_V0.6921.00
10_T13_L0.6921.00
410_V431_I0.6911.00
181_V188_G0.6891.00
251_V268_Y0.6861.00
209_D217_K0.6861.00
404_R411_I0.6851.00
429_L440_I0.6821.00
328_Y344_I0.6811.00
284_L287_V0.6811.00
335_E339_G0.6801.00
149_S275_R0.6791.00
92_K171_A0.6791.00
413_A431_I0.6770.99
335_E340_E0.6760.99
297_V312_A0.6760.99
216_E414_Q0.6750.99
215_F353_V0.6740.99
66_E70_H0.6730.99
383_F453_I0.6720.99
402_I405_K0.6720.99
422_D451_G0.6720.99
152_I156_N0.6710.99
279_T316_I0.6700.99
93_A171_A0.6700.99
296_I318_E0.6670.99
407_D434_G0.6670.99
154_L163_V0.6660.99
88_V198_F0.6650.99
42_T50_V0.6610.99
192_G204_I0.6600.99
11_D36_T0.6580.99
193_T197_N0.6550.99
329_E346_Y0.6540.99
429_L435_M0.6530.99
72_D77_T0.6510.99
193_T230_K0.6500.99
129_V138_Y0.6500.99
119_A127_V0.6450.99
303_C332_I0.6440.99
206_E213_P0.6440.99
244_V253_V0.6430.99
60_N63_H0.6420.99
429_L443_T0.6390.99
437_A441_A0.6390.99
415_I423_M0.6380.99
280_D285_E0.6370.99
409_L436_T0.6370.99
192_G233_V0.6360.99
403_T437_A0.6340.99
417_G420_A0.6320.99
193_T227_L0.6300.99
403_T408_G0.6240.99
94_S97_N0.6240.99
105_G108_K0.6230.99
325_K346_Y0.6230.99
91_W95_V0.6230.99
440_I458_A0.6230.99
389_A450_L0.6210.99
379_A403_T0.6190.99
413_A454_T0.6180.99
53_I387_G0.6160.99
26_I30_Q0.6160.99
167_T275_R0.6150.99
71_S74_M0.6140.99
117_G133_N0.6130.99
178_K196_A0.6110.99
86_T89_Q0.6110.99
154_L271_I0.6100.99
191_L194_A0.6090.99
394_E418_A0.6070.99
166_S275_R0.6060.99
222_L398_F0.6050.99
195_Y200_T0.6050.99
429_L433_G0.6040.99
313_I330_G0.6040.99
364_Y374_L0.6040.99
89_Q173_K0.6030.99
188_G272_T0.6030.99
70_H393_N0.6030.99
186_Y351_A0.6010.99
55_S59_I0.5990.99
104_A114_V0.5990.99
151_P166_S0.5950.99
103_V106_L0.5930.99
318_E321_P0.5910.99
68_A81_V0.5910.99
101_G105_G0.5900.99
172_L195_Y0.5880.99
46_V49_N0.5880.99
60_N392_L0.5880.99
74_M91_W0.5860.99
215_F359_L0.5850.99
90_E93_A0.5840.98
291_M297_V0.5830.98
39_E114_V0.5830.98
163_V269_V0.5800.98
297_V305_T0.5800.98
305_T312_A0.5800.98
189_T235_I0.5800.98
37_V112_V0.5790.98
38_V129_V0.5790.98
145_I297_V0.5760.98
29_A112_V0.5750.98
361_S414_Q0.5750.98
387_G391_S0.5740.98
348_G432_E0.5730.98
383_F450_L0.5730.98
387_G390_L0.5720.98
83_V88_V0.5720.98
60_N67_N0.5720.98
376_I405_K0.5720.98
348_G362_V0.5720.98
28_A35_V0.5710.98
157_F241_A0.5710.98
423_M450_L0.5700.98
230_K356_E0.5700.98
219_M222_L0.5660.98
302_Q341_P0.5650.98
244_V271_I0.5650.98
63_H356_E0.5640.98
299_T303_C0.5640.98
14_V35_V0.5630.98
428_S432_E0.5590.98
428_S443_T0.5570.98
121_F309_N0.5570.98
251_V254_T0.5550.98
304_R307_V0.5550.98
31_L340_E0.5540.98
42_T100_T0.5540.98
99_L390_L0.5540.98
46_V166_S0.5530.98
76_I83_V0.5530.98
328_Y332_I0.5520.98
176_P200_T0.5510.98
85_F173_K0.5510.98
388_R391_S0.5510.98
265_D268_Y0.5490.98
115_V129_V0.5480.98
401_L410_V0.5480.98
180_V269_V0.5480.98
87_K91_W0.5470.98
328_Y455_M0.5470.98
178_K268_Y0.5470.98
206_E241_A0.5460.98
166_S187_I0.5460.98
399_M457_A0.5460.98
14_V25_A0.5450.98
28_A337_I0.5440.98
9_E34_K0.5430.98
335_E341_P0.5410.98
331_K335_E0.5400.98
182_I205_L0.5390.97
376_I411_I0.5380.97
327_S455_M0.5380.97
379_A401_L0.5370.97
30_Q110_N0.5370.97
86_T174_E0.5360.97
59_I63_H0.5360.97
20_G146_A0.5360.97
212_L359_L0.5360.97
127_V309_N0.5360.97
43_L107_L0.5330.97
223_V227_L0.5320.97
42_T49_N0.5310.97
414_Q427_L0.5300.97
358_E450_L0.5300.97
348_G428_S0.5280.97
455_M459_E0.5280.97
193_T356_E0.5270.97
122_V286_Q0.5270.97
92_K170_L0.5270.97
431_I435_M0.5260.97
91_W393_N0.5250.97
205_L266_A0.5250.97
62_G198_F0.5250.97
97_N100_T0.5240.97
127_V133_N0.5210.97
336_A343_E0.5210.97
200_T267_D0.5200.97
149_S321_P0.5190.97
429_L445_H0.5190.97
73_D393_N0.5180.97
181_V191_L0.5180.97
311_Y337_I0.5170.97
43_L104_A0.5170.97
127_V138_Y0.5160.97
93_A96_V0.5160.97
364_Y412_G0.5140.97
188_G213_P0.5140.97
40_K278_N0.5140.97
313_I337_I0.5140.97
191_L270_L0.5140.97
53_I447_H0.5120.97
55_S194_A0.5120.97
438_E442_M0.5120.97
410_V413_A0.5110.97
151_P167_T0.5110.97
63_H358_E0.5100.97
432_E443_T0.5100.97
95_V99_L0.5100.97
142_N304_R0.5090.96
64_R71_S0.5080.96
125_N143_A0.5070.96
255_F263_T0.5050.96
374_L409_L0.5050.96
51_G187_I0.5050.96
281_E285_E0.5040.96
62_G65_Y0.5030.96
102_G105_G0.5030.96
352_V360_A0.5030.96
383_F399_M0.5030.96
356_E394_E0.5020.96
47_C56_K0.5020.96
317_I329_E0.5010.96
85_F175_I0.5010.96
234_E237_T0.5010.96
144_I334_A0.5010.96
426_E451_G0.5010.96
127_V143_A0.5010.96
325_K329_E0.5000.96
390_L395_T0.5000.96
167_T170_L0.5000.96
151_P165_N0.5000.96
413_A424_I0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 0.9915 100 0.197 Contact Map
3ladA 2 0.983 100 0.207 Contact Map
1zmdA 4 0.9851 100 0.215 Contact Map
3urhA 2 0.9723 100 0.222 Contact Map
1ebdA 2 0.966 100 0.223 Contact Map
1dxlA 2 0.9809 100 0.225 Contact Map
4jq9A 3 0.9872 100 0.228 Contact Map
3dk9A 2 0.9532 100 0.231 Contact Map
1lvlA 2 0.9638 100 0.232 Contact Map
3ic9A 2 0.9787 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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