GREMLIN Database
IMDH - Inosine-5'-monophosphate dehydrogenase
UniProt: P21879 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 488 (472)
Sequences: 2843 (1082)
Seq/√Len: 49.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_I224_G6.5341.00
39_T275_N4.6971.00
78_I239_K4.2391.00
450_D453_A4.1351.00
190_D194_K4.0551.00
9_E462_R3.7201.00
102_L125_I3.6101.00
351_T442_G3.5921.00
214_S222_I3.3171.00
330_E333_K3.2931.00
288_R292_E3.2911.00
359_H455_R3.1531.00
55_T70_G3.1221.00
33_S41_K3.0661.00
35_E41_K3.0211.00
258_Q262_N2.9311.00
354_L439_L2.8691.00
165_A188_L2.8611.00
24_E258_Q2.7011.00
288_R330_E2.7001.00
71_I247_V2.6921.00
281_V287_T2.6801.00
241_V274_L2.6351.00
238_K242_E2.6211.00
453_A457_E2.6181.00
268_R276_I2.5651.00
237_V267_I2.5361.00
345_K468_L2.4801.00
22_K289_A2.4801.00
22_K258_Q2.4601.00
451_L455_R2.4141.00
286_A327_C2.3971.00
287_T327_C2.3871.00
449_K453_A2.3771.00
8_K326_D2.3701.00
46_V432_V2.3701.00
285_E459_Q2.3661.00
106_H110_D2.3551.00
224_G247_V2.3181.00
291_I331_A2.3131.00
37_T275_N2.3031.00
77_S80_Q2.2661.00
287_T291_I2.2661.00
281_V327_C2.2631.00
84_Q87_K2.2621.00
227_V237_V2.2611.00
151_M155_D2.2551.00
281_V286_A2.2531.00
268_R296_D2.2371.00
32_L436_V2.2231.00
363_L367_L2.1881.00
36_L247_V2.1761.00
170_T173_E2.1251.00
248_I274_L2.1231.00
146_I151_M2.1161.00
109_F113_H2.0971.00
237_V248_I2.0801.00
35_E335_G2.0591.00
363_L366_L2.0531.00
452_R456_E2.0081.00
125_I153_I2.0001.00
59_M428_V1.9780.99
262_N265_T1.9610.99
57_S84_Q1.9550.99
69_L247_V1.9400.99
102_L111_A1.9360.99
36_L277_I1.9280.99
102_L153_I1.9130.99
452_R455_R1.9080.99
418_I476_V1.9010.99
233_T263_T1.8990.99
109_F150_S1.8870.99
103_T106_H1.8870.99
350_I361_V1.8640.99
351_T454_L1.8580.99
395_A419_E1.8480.99
289_A292_E1.8260.99
331_A338_I1.8220.99
166_S191_D1.7740.99
287_T338_I1.7690.99
111_A138_I1.7650.99
267_I276_I1.7570.99
252_T260_V1.6880.98
250_I264_V1.6850.98
63_M432_V1.6820.98
264_V278_A1.6800.98
238_K270_T1.6750.98
85_V245_V1.6660.98
176_K180_K1.6630.98
105_D152_K1.6550.98
44_I436_V1.6520.98
104_P135_V1.6490.98
152_K155_D1.6260.98
102_L106_H1.6230.98
284_A330_E1.6150.98
238_K271_Y1.6120.98
46_V363_L1.6110.98
300_V338_I1.6090.98
47_I360_A1.5970.98
247_V277_I1.5940.98
37_T297_V1.5710.97
354_L451_L1.5660.97
253_A445_Y1.5500.97
113_H117_K1.5490.97
288_R333_K1.5490.97
71_I249_V1.5450.97
38_K337_T1.5400.97
166_S169_T1.5130.97
33_S43_N1.5110.97
133_K194_K1.5110.97
366_L435_L1.5100.97
276_I295_A1.4910.96
291_I336_K1.4830.96
232_D235_T1.4790.96
287_T331_A1.4650.96
332_R455_R1.4480.96
105_D154_S1.4470.96
367_L428_V1.4420.96
36_L224_G1.4400.96
80_Q84_Q1.4370.96
250_I278_A1.4340.95
442_G454_L1.4280.95
46_V367_L1.4190.95
167_V196_K1.4180.95
448_S458_A1.4100.95
47_I277_I1.4030.95
165_A169_T1.4020.95
138_I156_V1.3960.95
261_L265_T1.3950.95
413_F441_S1.3950.95
325_Y329_T1.3940.95
111_A115_M1.3620.94
284_A329_T1.3620.94
36_L360_A1.3610.94
278_A295_A1.3540.94
282_A318_V1.3500.94
288_R334_H1.3440.94
292_E334_H1.3410.94
173_E176_K1.3390.93
48_S55_T1.3280.93
237_V271_Y1.3130.93
377_T384_R1.2930.92
354_L455_R1.2860.92
127_N135_V1.2850.92
24_E449_K1.2840.92
291_I334_H1.2800.92
324_I340_A1.2700.92
39_T273_E1.2440.91
371_S424_Y1.2420.91
38_K296_D1.2370.90
331_A334_H1.2370.90
245_V274_L1.2240.90
103_T135_V1.2240.90
108_V146_I1.2210.90
297_V360_A1.2200.90
85_V225_A1.2100.89
179_Q182_K1.2090.89
418_I482_S1.2090.89
74_K259_G1.2050.89
312_V468_L1.1970.89
337_T359_H1.1950.89
354_L454_L1.1950.89
448_S453_A1.1940.89
59_M367_L1.1940.89
120_I123_V1.1920.89
371_S427_P1.1850.88
26_L259_G1.1770.88
36_L47_I1.1720.88
169_T173_E1.1710.88
328_A338_I1.1690.88
443_M451_L1.1480.87
284_A288_R1.1440.87
107_Q152_K1.1440.87
147_S176_K1.1430.87
148_D151_M1.1400.86
454_L458_A1.1400.86
36_L297_V1.1400.86
235_T238_K1.1300.86
32_L440_R1.1270.86
356_A460_F1.1230.86
31_D41_K1.1210.85
29_D449_K1.1180.85
217_I222_I1.1170.85
250_I267_I1.1170.85
48_S63_M1.1150.85
48_S70_G1.1150.85
350_I435_L1.1130.85
287_T330_E1.1030.85
266_K270_T1.0940.84
38_K336_K1.0910.84
355_A458_A1.0860.84
234_M266_K1.0860.84
37_T247_V1.0830.83
39_T217_I1.0810.83
18_L446_C1.0810.83
100_F125_I1.0780.83
34_V44_I1.0710.83
250_I260_V1.0670.83
112_E149_Y1.0600.82
50_G299_K1.0560.82
127_N131_D1.0470.81
13_F324_I1.0400.81
110_D113_H1.0390.81
473_P476_V1.0390.81
10_G461_I1.0380.81
21_A457_E1.0370.81
46_V436_V1.0350.81
123_V153_I1.0310.80
11_L462_R1.0200.80
127_N194_K1.0190.79
291_I330_E1.0180.79
329_T333_K1.0180.79
142_D187_P1.0140.79
297_V337_T1.0110.79
367_L432_V1.0090.79
57_S87_K1.0080.79
248_I252_T1.0060.79
291_I333_K1.0040.78
298_V331_A1.0040.78
237_V274_L1.0040.78
232_D263_T1.0030.78
423_P426_G1.0030.78
65_R91_S0.9990.78
268_R295_A0.9990.78
265_T269_E0.9930.78
171_L175_E0.9930.78
367_L467_G0.9870.77
189_V193_N0.9870.77
21_A459_Q0.9820.77
359_H452_R0.9810.77
131_D194_K0.9780.77
107_Q110_D0.9770.77
174_A186_L0.9670.76
47_I69_L0.9670.76
178_L186_L0.9620.75
332_R456_E0.9610.75
448_S473_P0.9540.75
11_L321_I0.9520.75
284_A326_D0.9490.74
167_V191_D0.9480.74
312_V473_P0.9460.74
165_A177_I0.9460.74
264_V295_A0.9420.74
287_T298_V0.9350.73
265_T292_E0.9330.73
225_A245_V0.9310.73
327_C330_E0.9300.73
363_L435_L0.9290.73
102_L110_D0.9280.73
205_E209_E0.9280.73
227_V248_I0.9240.72
95_V188_L0.9240.72
361_V367_L0.9230.72
166_S173_E0.9220.72
83_E86_D0.9210.72
330_E334_H0.9190.72
104_P154_S0.9170.72
174_A187_P0.9160.72
370_T428_V0.9150.72
66_Q429_E0.9110.71
100_F120_I0.9090.71
448_S457_E0.9060.71
227_V233_T0.8990.70
354_L458_A0.8960.70
256_H289_A0.8950.70
261_L289_A0.8950.70
282_A302_I0.8940.70
274_L296_D0.8930.70
23_S254_H0.8930.70
268_R272_P0.8890.69
104_P138_I0.8870.69
321_I458_A0.8850.69
40_L222_I0.8840.69
332_R359_H0.8830.69
80_Q83_E0.8810.69
264_V276_I0.8800.69
21_A448_S0.8770.68
19_V23_S0.8750.68
163_V181_H0.8690.68
324_I338_I0.8660.67
237_V241_V0.8650.67
74_K400_G0.8600.67
69_L360_A0.8590.67
95_V101_F0.8550.66
119_R140_N0.8550.66
463_M468_L0.8540.66
102_L114_L0.8540.66
38_K275_N0.8490.66
331_A359_H0.8480.66
109_F149_Y0.8460.66
165_A187_P0.8430.65
35_E38_K0.8430.65
264_V286_A0.8410.65
275_N297_V0.8390.65
30_V450_D0.8360.65
110_D123_V0.8350.65
441_S444_G0.8340.65
227_V250_I0.8340.65
328_A335_G0.8340.65
261_L278_A0.8300.64
127_N133_K0.8290.64
413_F433_Y0.8260.64
53_T56_E0.8260.64
281_V298_V0.8240.64
281_V338_I0.8200.63
108_V151_M0.8190.63
363_L428_V0.8190.63
314_A471_S0.8170.63
380_Y421_R0.8170.63
428_V432_V0.8160.63
427_P430_E0.8160.63
46_V63_M0.8150.63
126_V132_Q0.8140.63
104_P126_V0.8110.62
106_H123_V0.8090.62
171_L177_I0.8030.62
103_T127_N0.8020.61
282_A327_C0.8020.61
134_L185_K0.7980.61
98_N195_L0.7960.61
327_C338_I0.7910.60
234_M270_T0.7910.60
262_N266_K0.7900.60
295_A298_V0.7870.60
59_M63_M0.7850.60
16_V356_A0.7820.59
105_D127_N0.7800.59
322_T326_D0.7750.59
112_E116_G0.7730.59
82_A239_K0.7720.59
233_T237_V0.7680.58
229_V413_F0.7660.58
322_T325_Y0.7660.58
112_E138_I0.7650.58
261_L286_A0.7650.58
205_E345_K0.7640.58
175_E207_V0.7630.58
21_A446_C0.7600.57
230_T233_T0.7580.57
239_K242_E0.7530.57
71_I253_A0.7520.57
378_E421_R0.7520.57
97_T218_H0.7490.56
28_R408_E0.7450.56
65_R430_E0.7450.56
19_V459_Q0.7440.56
241_V245_V0.7440.56
467_G471_S0.7440.56
263_T266_K0.7430.56
222_I247_V0.7420.55
154_S159_K0.7420.55
13_F302_I0.7420.55
331_A468_L0.7410.55
28_R409_E0.7400.55
167_V190_D0.7360.55
448_S456_E0.7360.55
102_L473_P0.7350.55
345_K400_G0.7340.55
63_M367_L0.7300.54
49_A299_K0.7290.54
43_N214_S0.7280.54
171_L204_I0.7270.54
115_M120_I0.7270.54
248_I314_A0.7260.54
83_E117_K0.7220.53
321_I356_A0.7220.53
10_G322_T0.7200.53
327_C331_A0.7190.53
59_M432_V0.7190.53
312_V461_I0.7170.53
115_M123_V0.7160.53
41_K222_I0.7140.53
193_N196_K0.7130.53
72_I85_V0.7110.52
347_S435_L0.7100.52
175_E182_K0.7080.52
350_I363_L0.7080.52
233_T252_T0.7070.52
261_L293_A0.7060.52
115_M186_L0.7060.52
86_D196_K0.7050.52
351_T354_L0.7010.51
191_D194_K0.7000.51
34_V451_L0.7000.51
370_T431_T0.7000.51
82_A86_D0.6970.51
284_A328_A0.6970.51
34_V277_I0.6940.51
36_L69_L0.6940.51
250_I276_I0.6930.51
90_R140_N0.6930.51
446_C458_A0.6920.50
174_A199_I0.6910.50
229_V233_T0.6910.50
142_D157_M0.6910.50
110_D153_I0.6890.50
95_V100_F0.6870.50
327_C359_H0.6870.50
81_Q245_V0.6830.49
32_L439_L0.6810.49
36_L322_T0.6800.49
411_K430_E0.6800.49
146_I149_Y0.6790.49
464_T467_G0.6790.49
304_P309_T0.6790.49
90_R385_F0.6780.49
82_A243_A0.6770.49
228_G232_D0.6770.49
77_S425_K0.6760.49
66_Q210_F0.6760.49
114_L123_V0.6760.49
25_V30_V0.6740.49
74_K302_I0.6730.48
134_L189_V0.6730.48
250_I287_T0.6730.48
112_E143_L0.6720.48
169_T177_I0.6720.48
252_T286_A0.6710.48
65_R473_P0.6710.48
32_L44_I0.6700.48
230_T411_K0.6700.48
326_D329_T0.6700.48
132_Q194_K0.6690.48
19_V302_I0.6680.48
19_V446_C0.6670.48
62_A432_V0.6670.48
229_V264_V0.6660.48
35_E359_H0.6650.48
112_E148_D0.6620.47
237_V276_I0.6610.47
166_S196_K0.6590.47
19_V46_V0.6590.47
314_A469_R0.6580.47
93_R418_I0.6580.47
37_T277_I0.6580.47
270_T273_E0.6580.47
165_A201_I0.6570.47
174_A198_L0.6560.47
296_D336_K0.6560.47
12_T321_I0.6550.47
234_M237_V0.6530.46
420_G476_V0.6530.46
350_I439_L0.6530.46
122_G185_K0.6510.46
378_E480_K0.6510.46
91_S210_F0.6500.46
379_I384_R0.6500.46
40_L247_V0.6480.46
414_V441_S0.6480.46
108_V156_V0.6460.46
387_V433_Y0.6450.46
229_V263_T0.6450.46
36_L42_L0.6440.46
103_T152_K0.6420.45
83_E87_K0.6420.45
62_A428_V0.6400.45
106_H154_S0.6380.45
103_T126_V0.6380.45
142_D158_T0.6380.45
50_G287_T0.6370.45
292_E333_K0.6370.45
49_A424_Y0.6370.45
252_T259_G0.6320.44
264_V367_L0.6320.44
112_E135_V0.6320.44
312_V471_S0.6310.44
38_K297_V0.6300.44
69_L297_V0.6300.44
91_S118_Y0.6300.44
106_H153_I0.6300.44
241_V271_Y0.6290.44
292_E330_E0.6280.44
63_M69_L0.6270.44
403_D407_Q0.6270.44
101_F188_L0.6270.44
103_T154_S0.6250.44
139_T158_T0.6240.43
345_K383_R0.6240.43
238_K241_V0.6230.43
235_T239_K0.6230.43
38_K47_I0.6220.43
259_G262_N0.6220.43
141_R185_K0.6200.43
258_Q265_T0.6200.43
176_K276_I0.6170.43
86_D117_K0.6160.43
187_P195_L0.6160.43
117_K265_T0.6150.43
96_I177_I0.6140.42
253_A314_A0.6130.42
245_V248_I0.6120.42
286_A289_A0.6110.42
111_A153_I0.6110.42
275_N337_T0.6100.42
297_V336_K0.6100.42
314_A463_M0.6090.42
75_N392_G0.6090.42
13_F121_S0.6080.42
174_A378_E0.6080.42
13_F340_A0.6080.42
40_L275_N0.6050.42
124_P195_L0.6040.41
288_R291_I0.6030.41
249_V253_A0.6030.41
36_L71_I0.6030.41
228_G237_V0.6020.41
95_V378_E0.6020.41
34_V360_A0.6020.41
127_N132_Q0.6000.41
19_V326_D0.5990.41
268_R297_V0.5980.41
101_F123_V0.5960.41
166_S192_Q0.5950.41
392_G405_Y0.5940.40
378_E385_F0.5930.40
62_A174_A0.5920.40
100_F123_V0.5920.40
106_H125_I0.5910.40
404_R420_G0.5900.40
169_T174_A0.5900.40
27_P75_N0.5860.40
258_Q261_L0.5860.40
366_L431_T0.5850.40
402_K409_E0.5850.40
234_M263_T0.5850.40
94_G215_K0.5840.40
282_A389_R0.5840.40
141_R184_E0.5830.39
397_M405_Y0.5820.39
62_A66_Q0.5810.39
314_A445_Y0.5810.39
135_V170_T0.5790.39
140_N174_A0.5790.39
34_V42_L0.5790.39
145_F389_R0.5790.39
193_N448_S0.5780.39
126_V194_K0.5770.39
232_D402_K0.5760.39
225_A240_L0.5750.39
284_A333_K0.5740.39
29_D58_A0.5740.39
276_I296_D0.5730.38
93_R96_I0.5730.38
72_I84_Q0.5720.38
143_L149_Y0.5700.38
217_I335_G0.5700.38
66_Q212_N0.5690.38
264_V293_A0.5690.38
298_V338_I0.5680.38
61_I164_T0.5680.38
397_M412_K0.5680.38
137_I158_T0.5670.38
222_I360_A0.5660.38
86_D118_Y0.5660.38
266_K269_E0.5640.38
35_E337_T0.5620.37
147_S264_V0.5610.37
252_T282_A0.5600.37
11_L16_V0.5600.37
62_A300_V0.5590.37
48_S54_V0.5590.37
260_V444_G0.5580.37
407_Q412_K0.5580.37
30_V189_V0.5580.37
102_L165_A0.5570.37
366_L425_K0.5570.37
139_T142_D0.5570.37
316_V461_I0.5560.37
381_Q473_P0.5560.37
324_I328_A0.5560.37
145_F179_Q0.5550.37
236_R420_G0.5550.37
115_M174_A0.5540.37
37_T40_L0.5530.37
111_A207_V0.5530.37
38_K333_K0.5520.36
46_V286_A0.5510.36
34_V336_K0.5510.36
210_F373_S0.5500.36
394_V464_T0.5500.36
69_L275_N0.5490.36
10_G462_R0.5490.36
34_V300_V0.5480.36
478_I481_E0.5480.36
242_E265_T0.5470.36
46_V361_V0.5470.36
175_E219_G0.5450.36
172_D175_E0.5450.36
173_E227_V0.5450.36
278_A297_V0.5440.36
250_I263_T0.5440.36
109_F117_K0.5430.36
222_I275_N0.5430.36
387_V421_R0.5430.36
281_V330_E0.5420.35
19_V461_I0.5420.35
18_L76_M0.5420.35
159_K162_L0.5410.35
306_S442_G0.5410.35
75_N444_G0.5400.35
439_L443_M0.5400.35
55_T63_M0.5400.35
269_E450_D0.5400.35
254_H444_G0.5390.35
140_N198_L0.5390.35
76_M399_K0.5380.35
281_V329_T0.5380.35
281_V377_T0.5380.35
71_I274_L0.5370.35
377_T430_E0.5370.35
86_D125_I0.5370.35
455_R458_A0.5370.35
92_E215_K0.5360.35
262_N270_T0.5350.35
291_I337_T0.5340.35
190_D196_K0.5340.35
69_L224_G0.5340.35
76_M84_Q0.5330.35
27_P444_G0.5330.35
59_M62_A0.5320.35
86_D90_R0.5320.35
216_D220_R0.5320.35
28_R410_N0.5320.35
69_L222_I0.5320.35
450_D458_A0.5320.35
123_V210_F0.5300.34
231_G235_T0.5300.34
179_Q183_I0.5300.34
65_R458_A0.5300.34
304_P311_R0.5290.34
439_L462_R0.5290.34
49_A138_I0.5290.34
206_K215_K0.5290.34
169_T186_L0.5290.34
267_I449_K0.5280.34
65_R373_S0.5270.34
38_K334_H0.5270.34
171_L208_I0.5270.34
118_Y140_N0.5270.34
86_D123_V0.5270.34
153_I385_F0.5270.34
359_H459_Q0.5260.34
261_L264_V0.5260.34
52_D73_H0.5250.34
322_T381_Q0.5240.34
367_L423_P0.5230.34
271_Y274_L0.5230.34
63_M70_G0.5220.34
71_I277_I0.5220.34
30_V260_V0.5220.34
285_E289_A0.5220.34
442_G446_C0.5210.34
11_L210_F0.5200.33
107_Q150_S0.5190.33
59_M425_K0.5180.33
155_D180_K0.5170.33
158_T184_E0.5160.33
448_S454_L0.5160.33
214_S217_I0.5160.33
63_M66_Q0.5150.33
229_V259_G0.5150.33
224_G249_V0.5140.33
373_S410_N0.5140.33
57_S464_T0.5140.33
269_E292_E0.5140.33
133_K193_N0.5140.33
463_M471_S0.5130.33
329_T459_Q0.5130.33
314_A467_G0.5120.33
58_A457_E0.5120.33
8_K322_T0.5120.33
299_K311_R0.5110.33
69_L337_T0.5110.33
30_V47_I0.5110.33
35_E159_K0.5100.33
355_A477_Q0.5100.33
158_T162_L0.5100.33
138_I281_V0.5090.32
28_R446_C0.5090.32
172_D176_K0.5090.32
388_Y392_G0.5090.32
175_E204_I0.5080.32
96_I187_P0.5080.32
75_N405_Y0.5070.32
143_L418_I0.5060.32
132_Q351_T0.5060.32
33_S132_Q0.5060.32
433_Y441_S0.5060.32
112_E123_V0.5060.32
88_V246_D0.5050.32
148_D278_A0.5050.32
288_R329_T0.5050.32
414_V444_G0.5040.32
78_I82_A0.5040.32
182_K268_R0.5040.32
38_K335_G0.5040.32
151_M156_V0.5030.32
449_K457_E0.5030.32
59_M214_S0.5030.32
431_T435_L0.5030.32
38_K360_A0.5020.32
405_Y420_G0.5020.32
165_A168_G0.5020.32
28_R259_G0.5010.32
189_V196_K0.5010.32
37_T360_A0.5000.32
30_V448_S0.5000.32
237_V266_K0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3usbA 4 0.8914 100 0.433 Contact Map
2cu0A 4 0.7234 100 0.465 Contact Map
4af0A 3 0.7152 100 0.472 Contact Map
1vrdA 3 0.6578 100 0.473 Contact Map
1jcnA 6 0.7766 100 0.492 Contact Map
1zfjA 4 0.9734 100 0.499 Contact Map
1me8A 3 0.6988 100 0.531 Contact Map
4fxsA 3 0.9529 100 0.555 Contact Map
5ahnA 3 0.6086 100 0.558 Contact Map
4zqmA 3 0.666 100 0.629 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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