GREMLIN Database
SYW - Tryptophan--tRNA ligase
UniProt: P21656 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (299)
Sequences: 5845 (2881)
Seq/√Len: 166.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_E213_Q4.8111.00
60_R298_D3.9111.00
86_A309_N3.6691.00
287_R290_E3.4161.00
4_T35_N3.2451.00
282_K286_D2.7811.00
296_E299_R2.6941.00
74_E303_E2.6911.00
261_Y272_D2.6211.00
100_I124_L2.6171.00
37_Y77_T2.5251.00
256_E260_K2.4661.00
32_H75_K2.4031.00
6_F39_C2.4001.00
140_D171_T2.3871.00
279_N282_K2.3541.00
51_D54_E2.3251.00
258_E262_E2.3131.00
296_E300_I2.3081.00
138_G171_T2.2981.00
146_E183_R2.2951.00
209_D217_K2.2831.00
215_E219_K2.2431.00
255_E258_E2.2011.00
255_E259_A2.1921.00
35_N77_T2.1701.00
64_A292_I2.1201.00
211_P278_V2.0901.00
219_K271_G2.0881.00
104_E124_L2.0811.00
149_K175_V2.0741.00
64_A297_L2.0391.00
267_G271_G1.9971.00
57_K61_N1.9941.00
253_T256_E1.9931.00
252_T256_E1.9621.00
286_D290_E1.9441.00
252_T260_K1.9371.00
226_E236_K1.8881.00
149_K177_I1.8461.00
259_A262_E1.8391.00
218_I277_V1.8381.00
209_D213_Q1.8151.00
121_S125_T1.8121.00
6_F41_V1.7971.00
160_E172_I1.7841.00
69_V284_I1.7611.00
215_E274_A1.7581.00
303_E306_E1.7531.00
63_A301_L1.7511.00
211_P282_K1.7021.00
290_E294_S1.6951.00
264_K268_E1.6831.00
135_L159_A1.6761.00
54_E57_K1.6681.00
71_L76_A1.6631.00
79_F137_Y1.6601.00
28_V32_H1.6391.00
214_L278_V1.6251.00
67_L291_L1.6191.00
103_L121_S1.6001.00
29_E33_D1.5951.00
206_T209_D1.5941.00
299_R303_E1.5701.00
87_H90_A1.5481.00
9_I66_Y1.5471.00
54_E58_N1.5421.00
285_Q289_Y1.5421.00
95_Q125_T1.5181.00
243_L257_L1.5181.00
259_A263_G1.5111.00
40_I63_A1.5091.00
63_A297_L1.4981.00
7_S22_G1.4901.00
25_K280_A1.4831.00
100_I104_E1.4671.00
83_E305_A1.4651.00
4_T37_Y1.4561.00
232_D240_S1.4511.00
65_L288_Y1.4391.00
131_A155_T1.4291.00
260_K272_D1.4271.00
302_D306_E1.4261.00
11_P40_I1.4081.00
253_T272_D1.4051.00
268_E271_G1.4051.00
303_E307_R1.3871.00
30_L176_K1.3611.00
274_A278_V1.3591.00
26_Q29_E1.3571.00
87_H137_Y1.3571.00
42_D82_S1.3551.00
295_E299_R1.3491.00
254_I258_E1.3291.00
215_E275_E1.3071.00
59_I80_I1.3051.00
256_E259_A1.3041.00
257_L261_Y1.3031.00
186_S198_D1.3011.00
249_L276_V1.2891.00
25_K29_E1.2861.00
43_Q88_A1.2851.00
99_Y102_E1.2841.00
243_L254_I1.2841.00
141_L176_K1.2651.00
211_P285_Q1.2591.00
53_L57_K1.2421.00
72_D75_K1.2331.00
42_D83_E1.2291.00
214_L281_L1.2241.00
246_Y273_L1.2221.00
79_F83_E1.2211.00
288_Y292_I1.2181.00
192_K198_D1.2101.00
61_N292_I1.2071.00
275_E279_N1.2031.00
289_Y292_I1.1911.00
100_I109_F1.1761.00
294_S299_R1.1681.00
156_R173_P1.1661.00
6_F37_Y1.1651.00
236_K239_V1.1491.00
273_L276_V1.1401.00
35_N307_R1.1341.00
9_I24_M1.1301.00
91_G95_Q1.1281.00
205_I218_I1.1211.00
62_L66_Y1.1161.00
306_E310_R1.1111.00
20_Y25_K1.1061.00
213_Q216_K1.1031.00
216_K220_S1.1011.00
15_V66_Y1.0971.00
8_G39_C1.0831.00
212_K215_E1.0801.00
6_F139_T1.0761.00
107_T111_D1.0741.00
230_K258_E1.0701.00
215_E278_V1.0630.99
85_P89_Q1.0610.99
31_Q76_A1.0530.99
24_M69_V1.0450.99
15_V62_L1.0190.99
251_N260_K1.0180.99
272_D276_V1.0140.99
261_Y269_F1.0120.99
101_G105_R1.0060.99
21_I249_L1.0040.99
98_A158_L1.0030.99
188_N200_N1.0020.99
21_I248_I0.9970.99
160_E164_K0.9920.99
58_N61_N0.9870.99
9_I22_G0.9860.99
219_K267_G0.9800.99
249_L280_A0.9750.99
113_S116_N0.9740.99
67_L300_I0.9700.99
64_A67_L0.9640.99
77_T307_R0.9520.99
134_I155_T0.9500.99
271_G275_E0.9490.99
210_E289_Y0.9450.99
250_G276_V0.9380.99
55_L59_I0.9360.99
215_E271_G0.9340.99
219_K274_A0.9280.99
9_I27_F0.9270.99
5_I141_L0.9240.99
11_P45_A0.9230.99
55_L58_N0.9200.98
7_S27_F0.9200.98
306_E309_N0.9170.98
61_N288_Y0.9080.98
188_N198_D0.9060.98
265_G268_E0.9050.98
260_K263_G0.9030.98
234_E240_S0.8930.98
131_A158_L0.8920.98
103_L128_P0.8900.98
159_A172_I0.8870.98
289_Y293_E0.8850.98
187_L217_K0.8840.98
121_S128_P0.8830.98
157_N160_E0.8820.98
286_D289_Y0.8740.98
206_T217_K0.8710.98
231_F240_S0.8670.98
94_M135_L0.8590.98
90_A132_A0.8580.98
207_L281_L0.8580.98
261_Y266_Y0.8540.98
80_I83_E0.8540.98
218_I273_L0.8430.97
278_V282_K0.8420.97
161_R165_K0.8420.97
52_R55_L0.8410.97
37_Y79_F0.8350.97
185_M228_I0.8350.97
27_F38_F0.8340.97
243_L258_E0.8340.97
8_G41_V0.8290.97
53_L56_R0.8290.97
211_P215_E0.8270.97
291_L294_S0.8250.97
295_E310_R0.8220.97
276_V279_N0.8200.97
227_G265_G0.8130.97
17_L249_L0.8110.97
42_D59_I0.8050.96
278_V285_Q0.8040.96
236_K240_S0.8020.96
237_P240_S0.7970.96
5_I34_Y0.7940.96
77_T80_I0.7910.96
292_I297_L0.7900.96
96_C122_G0.7900.96
230_K233_K0.7870.96
66_Y69_V0.7870.96
283_P286_D0.7860.96
238_G273_L0.7770.96
178_P182_A0.7730.96
95_Q121_S0.7710.96
162_F166_Y0.7700.95
276_V280_A0.7690.95
56_R59_I0.7680.95
140_D174_E0.7670.95
291_L296_E0.7650.95
237_P262_E0.7650.95
128_P158_L0.7630.95
187_L221_A0.7610.95
240_S261_Y0.7580.95
298_D302_D0.7560.95
246_Y276_V0.7560.95
252_T257_L0.7560.95
98_A154_L0.7550.95
238_G258_E0.7540.95
65_L208_L0.7540.95
80_I301_L0.7520.95
30_L141_L0.7510.95
268_E272_D0.7510.95
74_E307_R0.7510.95
62_L65_L0.7510.95
212_K216_K0.7510.95
94_M128_P0.7440.95
250_G253_T0.7430.95
290_E293_E0.7420.94
14_S206_T0.7360.94
152_L175_V0.7350.94
299_R302_D0.7350.94
247_S254_I0.7340.94
131_A135_L0.7310.94
307_R310_R0.7280.94
247_S257_L0.7260.94
61_N64_A0.7260.94
290_E296_E0.7240.94
27_F66_Y0.7220.94
159_A163_N0.7210.94
34_Y141_L0.7110.93
99_Y120_V0.7100.93
17_L277_V0.7080.93
39_C79_F0.7070.93
208_L288_Y0.7070.93
19_N23_A0.7060.93
97_V165_K0.7060.93
299_R306_E0.7040.93
244_T247_S0.7030.93
283_P287_R0.7020.93
14_S208_L0.7020.93
278_V281_L0.6990.93
211_P281_L0.6950.92
95_Q128_P0.6940.92
295_E298_D0.6930.92
56_R60_R0.6930.92
243_L269_F0.6900.92
207_L284_I0.6820.92
223_T242_L0.6810.92
299_R310_R0.6770.91
230_K240_S0.6720.91
222_V238_G0.6700.91
187_L220_S0.6700.91
10_Q48_V0.6680.91
226_E230_K0.6680.91
7_S38_F0.6670.91
275_E278_V0.6670.91
30_L36_S0.6620.90
91_G125_T0.6620.90
102_E105_R0.6610.90
87_H136_L0.6570.90
266_Y269_F0.6550.90
242_L269_F0.6540.90
46_I50_Q0.6490.89
159_A170_F0.6450.89
88_A91_G0.6450.89
162_F169_I0.6430.89
305_A309_N0.6420.89
271_G274_A0.6420.89
231_F244_T0.6410.89
114_K118_A0.6400.89
60_R297_L0.6360.89
97_V161_R0.6350.88
178_P181_G0.6340.88
57_K60_R0.6330.88
23_A27_F0.6330.88
28_V31_Q0.6290.88
156_R174_E0.6270.88
94_M158_L0.6260.88
237_P258_E0.6260.88
233_K240_S0.6230.88
302_D310_R0.6230.88
51_D59_I0.6220.87
231_F234_E0.6220.87
91_G128_P0.6200.87
251_N255_E0.6190.87
10_Q62_L0.6180.87
63_A66_Y0.6170.87
14_S61_N0.6160.87
115_G118_A0.6150.87
94_M132_A0.6130.87
79_F87_H0.6120.87
85_P129_L0.6100.86
272_D275_E0.6100.86
253_T276_V0.6100.86
66_Y78_L0.6100.86
44_H129_L0.6070.86
281_L285_Q0.6060.86
304_G308_A0.6060.86
4_T138_G0.6050.86
240_S266_Y0.6040.86
107_T150_Q0.6040.86
185_M244_T0.6040.86
97_V162_F0.6040.86
116_N119_V0.6030.86
261_Y264_K0.6010.86
109_F113_S0.5990.85
142_V152_L0.5980.85
260_K269_F0.5980.85
77_T308_A0.5970.85
226_E265_G0.5950.85
227_G261_Y0.5930.85
29_E32_H0.5920.85
167_N174_E0.5920.85
43_Q93_M0.5910.85
185_M241_N0.5910.85
97_V158_L0.5900.85
15_V65_L0.5890.84
282_K285_Q0.5890.84
121_S124_L0.5890.84
138_G169_I0.5870.84
194_M197_S0.5870.84
92_W96_C0.5860.84
102_E161_R0.5830.84
246_Y269_F0.5820.84
255_E262_E0.5800.84
168_D171_T0.5790.83
73_P300_I0.5780.83
95_Q120_V0.5780.83
147_D193_K0.5770.83
94_M171_T0.5770.83
290_E295_E0.5770.83
92_W122_G0.5760.83
162_F170_F0.5750.83
67_L78_L0.5750.83
101_G107_T0.5730.83
125_T128_P0.5720.83
141_L174_E0.5710.83
20_Y280_A0.5710.83
84_V305_A0.5700.83
301_L305_A0.5700.83
51_D58_N0.5660.82
9_I15_V0.5660.82
64_A288_Y0.5660.82
154_L158_L0.5590.81
46_I93_M0.5580.81
230_K236_K0.5570.81
115_G119_V0.5570.81
102_E157_N0.5560.81
110_K114_K0.5540.81
15_V19_N0.5530.81
109_F112_K0.5510.80
302_D305_A0.5500.80
211_P274_A0.5480.80
10_Q19_N0.5470.80
83_E302_D0.5470.80
113_S119_V0.5460.80
34_Y140_D0.5450.80
215_E218_I0.5450.80
211_P214_L0.5440.80
39_C139_T0.5430.79
113_S123_L0.5430.79
26_Q178_P0.5420.79
246_Y272_D0.5400.79
240_S254_I0.5390.79
58_N65_L0.5380.79
58_N62_L0.5370.79
57_K310_R0.5370.79
38_F76_A0.5320.78
106_M150_Q0.5310.78
49_P165_K0.5310.78
97_V166_Y0.5300.78
39_C133_D0.5300.78
52_R56_R0.5290.78
14_S58_N0.5290.78
91_G121_S0.5290.78
38_F71_L0.5290.78
184_I248_I0.5280.77
98_A102_E0.5240.77
87_H92_W0.5240.77
84_V136_L0.5240.77
199_P204_Y0.5240.77
209_D214_L0.5240.77
252_T255_E0.5230.77
265_G269_F0.5230.77
135_L170_F0.5220.77
36_S76_A0.5210.77
106_M154_L0.5200.76
218_I274_A0.5200.76
287_R291_L0.5180.76
15_V24_M0.5170.76
10_Q112_K0.5170.76
154_L157_N0.5160.76
166_Y173_P0.5150.76
295_E306_E0.5150.76
226_E264_K0.5150.76
155_T173_P0.5140.76
39_C137_Y0.5120.75
239_V258_E0.5120.75
108_Q112_K0.5120.75
225_S266_Y0.5110.75
7_S23_A0.5100.75
51_D55_L0.5090.75
183_R192_K0.5090.75
95_Q118_A0.5080.75
186_S189_D0.5070.75
257_L272_D0.5070.75
251_N254_I0.5060.74
84_V87_H0.5060.74
212_K267_G0.5060.74
277_V280_A0.5060.74
210_E285_Q0.5060.74
216_K267_G0.5050.74
228_I263_G0.5050.74
47_T126_Y0.5040.74
227_G231_F0.5040.74
136_L139_T0.5030.74
88_A92_W0.5020.74
214_L283_P0.5000.74
90_A93_M0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yy5A 2 0.997 100 0.13 Contact Map
3prhA 2 0.9576 100 0.142 Contact Map
1i6kA 2 0.9879 100 0.146 Contact Map
3n9iA 2 0.9909 100 0.152 Contact Map
3sz3A 2 0.997 100 0.17 Contact Map
2el7A 2 0.9333 100 0.23 Contact Map
3tzlA 2 0.9545 100 0.254 Contact Map
2g36A 2 0.9545 100 0.254 Contact Map
1yi8B 2 0.9758 100 0.269 Contact Map
2dlcX 2 0.8394 100 0.303 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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