GREMLIN Database
RS19 - 30S ribosomal protein S19
UniProt: P21476 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 92 (88)
Sequences: 1978 (770)
Seq/√Len: 82.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_D37_R4.3161.00
23_N47_H3.9131.00
30_V50_A3.3301.00
22_L47_H3.1391.00
53_D56_K2.8171.00
39_T70_K2.4391.00
33_T71_L2.3161.00
11_V41_F2.1311.00
49_I62_I2.0421.00
34_W57_H2.0401.00
16_M20_E1.8261.00
20_E43_Q1.7521.00
58_V75_A1.6701.00
84_A87_D1.6251.00
10_F14_H1.6211.00
51_V62_I1.6041.00
72_G77_T1.5441.00
10_F38_S1.4850.99
44_F49_I1.4700.99
51_V60_V1.4090.99
7_K11_V1.3450.99
53_D75_A1.3400.99
35_S38_S1.3320.99
21_K24_E1.3240.98
53_D58_V1.2970.98
22_L27_K1.2960.98
55_R79_T1.2680.98
48_T59_P1.2560.98
4_S8_G1.2290.98
30_V56_K1.2260.98
69_H73_E1.2230.97
4_S7_K1.2070.97
14_H37_R1.1950.97
23_N27_K1.1750.97
41_F65_D1.1270.96
41_F44_F1.1000.95
21_K25_T1.0480.94
17_T21_K1.0260.93
49_I59_P1.0000.92
20_E24_E0.9820.92
56_K79_T0.9820.92
43_Q64_E0.9750.91
50_A59_P0.9690.91
52_Y65_D0.9480.90
10_F35_S0.9450.90
41_F45_I0.9350.89
15_L71_L0.9180.89
69_H74_F0.9070.88
7_K10_F0.8990.88
2_A7_K0.8840.87
52_Y66_M0.8670.86
14_H35_S0.8670.86
32_K56_K0.8590.85
80_Y85_S0.8570.85
15_L38_S0.8550.85
56_K59_P0.8430.84
15_L33_T0.8320.83
28_K48_T0.8290.83
2_A37_R0.8290.83
36_R54_G0.8240.83
8_G12_D0.8240.83
21_K29_Q0.8040.81
16_M43_Q0.7920.80
28_K47_H0.7910.80
68_G73_E0.7910.80
44_F67_V0.7760.79
55_R58_V0.7760.79
48_T60_V0.7720.78
8_G64_E0.7550.77
5_L41_F0.7430.76
13_G17_T0.7400.75
53_D57_H0.7270.74
19_I47_H0.7230.74
44_F55_R0.7210.73
79_T82_G0.7150.73
32_K39_T0.7090.72
16_M41_F0.7080.72
6_K10_F0.7050.72
25_T84_A0.6920.70
65_D85_S0.6900.70
18_K31_V0.6890.70
57_H75_A0.6790.69
27_K61_F0.6740.68
84_A88_K0.6700.68
30_V59_P0.6640.67
23_N26_D0.6620.67
41_F53_D0.6600.67
20_E25_T0.6560.66
21_K87_D0.6540.66
4_S9_P0.6410.64
19_I49_I0.6380.64
22_L29_Q0.6380.64
2_A70_K0.6380.64
27_K47_H0.6340.64
31_V49_I0.6320.63
3_R36_R0.6320.63
12_D35_S0.6310.63
81_K84_A0.6260.63
17_T32_K0.6180.62
2_A39_T0.6180.62
43_Q57_H0.6160.61
24_E65_D0.6140.61
1_M7_K0.6070.60
6_K49_I0.6060.60
19_I23_N0.6050.60
43_Q65_D0.5980.59
69_H75_A0.5920.58
49_I71_L0.5830.57
78_R85_S0.5810.57
69_H72_G0.5800.57
15_L35_S0.5750.56
62_I71_L0.5670.55
24_E88_K0.5630.55
48_T51_V0.5610.54
55_R88_K0.5580.54
63_S67_V0.5560.54
29_Q59_P0.5450.52
53_D88_K0.5420.52
51_V84_A0.5410.52
10_F13_G0.5380.51
16_M23_N0.5380.51
49_I76_P0.5370.51
9_P12_D0.5320.51
6_K65_D0.5320.51
3_R54_G0.5270.50
43_Q75_A0.5230.49
1_M4_S0.5220.49
4_S76_P0.5170.49
31_V47_H0.5100.48
37_R70_K0.5070.47
74_F78_R0.5060.47
50_A74_F0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bbnS 1 1 100 0.033 Contact Map
4kiyS 1 0.8587 100 0.046 Contact Map
3a1pB 1 0.913 100 0.047 Contact Map
3j20T 1 0.913 100 0.106 Contact Map
4tp8S 1 0.8587 100 0.136 Contact Map
4ujpQ 1 0.9022 100 0.146 Contact Map
3zeyI 1 1 100 0.149 Contact Map
4bpeS 1 0.9022 100 0.159 Contact Map
3j7aX 1 0.7391 100 0.161 Contact Map
3j38P 1 0.8696 100 0.189 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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