GREMLIN Database
RS18 - 30S ribosomal protein S18
UniProt: P21475 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 79 (69)
Sequences: 1466 (634)
Seq/√Len: 76.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_N56_Y4.0921.00
19_T53_N3.8371.00
19_T56_Y3.2391.00
69_Q75_Y2.9421.00
52_T60_L2.7771.00
38_V73_L2.7001.00
16_C19_T2.6061.00
34_L73_L2.1401.00
16_C53_N2.1401.00
16_C56_Y1.8651.00
54_A58_R1.8321.00
26_I63_A1.8271.00
30_D33_L1.8061.00
17_Y21_N1.7901.00
44_I64_I1.6291.00
17_Y36_K1.6191.00
31_V72_L1.6021.00
17_Y52_T1.5160.99
26_I60_L1.3330.98
26_I70_M1.1760.96
18_F60_L1.1430.95
22_G26_I1.1320.95
23_I33_L1.1210.95
42_G49_V1.0960.94
23_I59_K1.0830.94
32_D35_K1.0340.92
14_K51_G1.0270.92
61_T69_Q0.9950.91
18_F56_Y0.9700.89
47_R69_Q0.9580.89
24_T33_L0.9450.88
35_K73_L0.8960.85
8_G13_R0.8950.85
27_D66_R0.8880.85
40_E48_R0.8720.84
45_L49_V0.8580.83
62_A66_R0.8140.79
18_F26_I0.8100.79
27_D63_A0.7900.77
38_V42_G0.7840.77
41_R47_R0.7830.77
35_K47_R0.7640.75
45_L50_T0.7640.75
63_A66_R0.7610.75
45_L69_Q0.7580.74
8_G11_K0.7580.74
69_Q76_V0.7560.74
34_L64_I0.7500.73
56_Y59_K0.7470.73
17_Y37_F0.7380.72
15_V18_F0.7260.71
17_Y32_D0.7200.70
25_H59_K0.7150.70
47_R76_V0.7110.69
40_E76_V0.7060.69
33_L72_L0.7050.69
35_K69_Q0.7000.68
28_Y76_V0.6990.68
37_F45_L0.6920.67
41_R70_M0.6910.67
35_K40_E0.6870.67
15_V25_H0.6820.66
60_L64_I0.6720.65
43_K48_R0.6670.65
30_D63_A0.6650.64
57_Q61_T0.6620.64
47_R54_A0.6560.63
18_F52_T0.6540.63
10_A13_R0.6470.62
55_K66_R0.6360.61
31_V39_S0.6310.60
52_T61_T0.6310.60
67_A71_A0.6290.60
37_F60_L0.6250.60
11_K49_V0.6170.59
23_I26_I0.6160.58
8_G17_Y0.6120.58
42_G58_R0.6100.58
15_V20_S0.6050.57
33_L60_L0.6020.57
12_R47_R0.6010.57
39_S45_L0.5990.56
27_D72_L0.5990.56
40_E49_V0.5960.56
31_V35_K0.5830.54
33_L63_A0.5760.53
37_F55_K0.5640.52
24_T31_V0.5500.50
17_Y39_S0.5440.49
38_V64_I0.5440.49
36_K45_L0.5400.49
14_K19_T0.5340.48
8_G75_Y0.5320.48
40_E43_K0.5260.47
38_V52_T0.5220.47
19_T51_G0.5160.46
39_S60_L0.5110.45
36_K61_T0.5110.45
13_R49_V0.5060.45
34_L37_F0.5060.45
46_P51_G0.5050.44
32_D50_T0.5050.44
11_K46_P0.5000.44
22_G53_N0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kiyR 1 0.6962 100 0.208 Contact Map
4rb5R 1 0.8354 100 0.216 Contact Map
5aj3p 1 1 100 0.222 Contact Map
3j7yr 1 0.9873 99.9 0.238 Contact Map
3bbnR 1 0.7215 99.9 0.245 Contact Map
5aj3R 1 0.962 99.9 0.265 Contact Map
4tp8R 1 0.6962 99.9 0.339 Contact Map
1ltrD 5 0.443 11.1 0.922 Contact Map
4ftfA 1 0.3671 10.7 0.922 Contact Map
1b44D 3 0.443 10.5 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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